
PMC:7091888 / 19817-21584
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
853 | 1435-1440 | Gene | denotes | hDPP4 | Gene:1803 |
854 | 6-16 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
855 | 53-61 | Species | denotes | SARS-CoV | Tax:694009 |
856 | 67-75 | Species | denotes | MERS-CoV | Tax:1335626 |
857 | 123-131 | Species | denotes | SARS-CoV | Tax:694009 |
858 | 161-171 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
859 | 211-219 | Species | denotes | SARS-CoV | Tax:694009 |
860 | 264-274 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
861 | 339-347 | Species | denotes | SARS-CoV | Tax:694009 |
862 | 362-367 | Species | denotes | mouse | Tax:10090 |
863 | 378-388 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
864 | 418-428 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
865 | 595-603 | Species | denotes | SARS-CoV | Tax:694009 |
866 | 993-1001 | Species | denotes | SARS-CoV | Tax:694009 |
867 | 1016-1021 | Species | denotes | mouse | Tax:10090 |
868 | 1035-1045 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
869 | 1091-1099 | Species | denotes | SARS-CoV | Tax:694009 |
870 | 1139-1149 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
871 | 1255-1263 | Species | denotes | SARS-CoV | Tax:694009 |
872 | 1373-1378 | Species | denotes | mouse | Tax:10090 |
873 | 1562-1572 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
874 | 1588-1596 | Species | denotes | SARS-CoV | Tax:694009 |
875 | 1644-1652 | Species | denotes | SARS-CoV | Tax:694009 |
876 | 1698-1708 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
877 | 460-468 | Species | denotes | SARS-CoV | Tax:694009 |
878 | 635-643 | Species | denotes | SARS-CoV | Tax:694009 |
879 | 776-784 | Species | denotes | SARS-CoV | Tax:694009 |
880 | 1058-1067 | Disease | denotes | infection | MESH:D007239 |
881 | 1162-1171 | Disease | denotes | infection | MESH:D007239 |
882 | 1276-1285 | Disease | denotes | infection | MESH:D007239 |
883 | 1401-1431 | Disease | denotes | MERS-CoV pseudovirus infection | MESH:D018352 |
884 | 1542-1551 | Disease | denotes | infection | MESH:D007239 |
885 | 1734-1766 | Disease | denotes | SARS-CoV-2 pseudovirus infection | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T154 | 473-476 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T155 | 482-490 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T156 | 567-570 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T157 | 648-651 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T158 | 653-661 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T159 | 724-727 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T160 | 789-792 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T161 | 847-850 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
T162 | 852-860 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T163 | 1192-1200 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T164 | 1311-1319 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T165 | 1452-1457 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T166 | 1478-1486 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T343 | 6-14 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T344 | 6-10 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T345 | 53-61 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T346 | 53-57 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T347 | 123-131 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T348 | 123-127 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T349 | 161-169 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T350 | 161-165 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T351 | 211-219 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T352 | 211-215 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T353 | 264-272 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T354 | 264-268 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T355 | 339-347 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T356 | 339-343 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T357 | 378-386 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T358 | 378-382 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T359 | 418-426 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T360 | 418-422 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T361 | 460-468 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T362 | 460-464 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T363 | 595-603 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T364 | 595-599 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T365 | 635-643 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T366 | 635-639 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T367 | 776-784 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T368 | 776-780 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T369 | 993-1001 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T370 | 993-997 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T371 | 1035-1043 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T372 | 1035-1039 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T373 | 1058-1067 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T374 | 1091-1099 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T375 | 1091-1095 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T376 | 1139-1147 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T377 | 1139-1143 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T378 | 1162-1171 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T379 | 1255-1263 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T380 | 1255-1259 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T381 | 1276-1285 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T382 | 1422-1431 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T383 | 1542-1551 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T384 | 1562-1570 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T385 | 1562-1566 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T386 | 1588-1596 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T387 | 1588-1592 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T388 | 1644-1652 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T389 | 1644-1648 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T390 | 1698-1706 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T391 | 1698-1702 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T392 | 1734-1742 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T393 | 1734-1738 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T394 | 1757-1766 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T379 | 76-78 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
T380 | 199-207 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T381 | 362-367 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T382 | 913-914 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T383 | 981-989 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T384 | 1016-1021 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T385 | 1177-1178 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T386 | 1373-1378 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T387 | 1452-1457 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T388 | 1463-1464 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T119 | 0-275 | Sentence | denotes | Since SARS-CoV-2 is more phylogenetically related to SARS-CoV than MERS-CoV,22 we further detected the cross-reactivity of SARS-CoV RBD-specific antibodies with SARS-CoV-2 RBD and cross-neutralizing activity of SARS-CoV RBD-specific antibodies against pseudotyped SARS-CoV-2. |
T120 | 276-393 | Sentence | denotes | First, we performed an ELISA to detect the cross-reactivity of SARS-CoV RBD-immunized mouse sera with SARS-CoV-2 RBD. |
T121 | 394-581 | Sentence | denotes | The results showed that SARS-CoV-2 RBD reacted strongly with anti-SARS-CoV RBD IgG with antibody titer of 1:2.4 × 104 (Fig. 4d), but it did not react with anti-MERS-CoV RBD IgG (Fig. 4e). |
T122 | 582-668 | Sentence | denotes | As expected, SARS-CoV RBD reacted strongly with anti-SARS-CoV RBD IgG (antibody titer: |
T123 | 669-738 | Sentence | denotes | 1:1.4 × 105) (Fig. 4d), but not with anti-MERS-CoV RBD IgG (Fig. 4e). |
T124 | 739-867 | Sentence | denotes | MERS-CoV RBD did not react with anti-SARS-CoV RBD IgG (Fig. 4d), but instead reacted with anti-MERS-CoV RBD IgG (antibody titer: |
T125 | 868-891 | Sentence | denotes | 1:1.3 × 105) (Fig. 4e). |
T126 | 892-1068 | Sentence | denotes | Second, we performed a pseudovirus neutralization assay to detect the cross-neutralizing activity of SARS-CoV RBD-immunized mouse sera against SARS-CoV-2 pseudovirus infection. |
T127 | 1069-1350 | Sentence | denotes | Results revealed that SARS-CoV RBD-specific antisera could neutralize SARS-CoV-2 pseudovirus infection with a neutralizing antibody titer of 1:323, while these antisera could neutralize SARS-CoV pseudovirus infection with higher neutralizing antibody titer (1:1.2 × 104) (Fig. 4f). |
T128 | 1351-1619 | Sentence | denotes | MERS-CoV RBD-inducing mouse sera only neutralized MERS-CoV pseudovirus infection in hDPP4-expressing cells with a neutralizing antibody titer of 1:4 × 104 (Fig. 4g), but failed to neutralize infection by either SARS-CoV-2 pseudovirus or SARS-CoV pseudovirus (Fig. 4f). |
T129 | 1620-1767 | Sentence | denotes | These data suggest that SARS-CoV RBD-specific antibodies can cross-react with SARS-CoV-2 RBD and cross-neutralize SARS-CoV-2 pseudovirus infection. |