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PMC:7091888 / 19817-21584 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
853 1435-1440 Gene denotes hDPP4 Gene:1803
854 6-16 Species denotes SARS-CoV-2 Tax:2697049
855 53-61 Species denotes SARS-CoV Tax:694009
856 67-75 Species denotes MERS-CoV Tax:1335626
857 123-131 Species denotes SARS-CoV Tax:694009
858 161-171 Species denotes SARS-CoV-2 Tax:2697049
859 211-219 Species denotes SARS-CoV Tax:694009
860 264-274 Species denotes SARS-CoV-2 Tax:2697049
861 339-347 Species denotes SARS-CoV Tax:694009
862 362-367 Species denotes mouse Tax:10090
863 378-388 Species denotes SARS-CoV-2 Tax:2697049
864 418-428 Species denotes SARS-CoV-2 Tax:2697049
865 595-603 Species denotes SARS-CoV Tax:694009
866 993-1001 Species denotes SARS-CoV Tax:694009
867 1016-1021 Species denotes mouse Tax:10090
868 1035-1045 Species denotes SARS-CoV-2 Tax:2697049
869 1091-1099 Species denotes SARS-CoV Tax:694009
870 1139-1149 Species denotes SARS-CoV-2 Tax:2697049
871 1255-1263 Species denotes SARS-CoV Tax:694009
872 1373-1378 Species denotes mouse Tax:10090
873 1562-1572 Species denotes SARS-CoV-2 Tax:2697049
874 1588-1596 Species denotes SARS-CoV Tax:694009
875 1644-1652 Species denotes SARS-CoV Tax:694009
876 1698-1708 Species denotes SARS-CoV-2 Tax:2697049
877 460-468 Species denotes SARS-CoV Tax:694009
878 635-643 Species denotes SARS-CoV Tax:694009
879 776-784 Species denotes SARS-CoV Tax:694009
880 1058-1067 Disease denotes infection MESH:D007239
881 1162-1171 Disease denotes infection MESH:D007239
882 1276-1285 Disease denotes infection MESH:D007239
883 1401-1431 Disease denotes MERS-CoV pseudovirus infection MESH:D018352
884 1542-1551 Disease denotes infection MESH:D007239
885 1734-1766 Disease denotes SARS-CoV-2 pseudovirus infection MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T154 473-476 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T155 482-490 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T156 567-570 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T157 648-651 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T158 653-661 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T159 724-727 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T160 789-792 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T161 847-850 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T162 852-860 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T163 1192-1200 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T164 1311-1319 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T165 1452-1457 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T166 1478-1486 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T343 6-14 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T344 6-10 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T345 53-61 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T346 53-57 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T347 123-131 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T348 123-127 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T349 161-169 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T350 161-165 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T351 211-219 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T352 211-215 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T353 264-272 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T354 264-268 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T355 339-347 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T356 339-343 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T357 378-386 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T358 378-382 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T359 418-426 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T360 418-422 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T361 460-468 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T362 460-464 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T363 595-603 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T364 595-599 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T365 635-643 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T366 635-639 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T367 776-784 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T368 776-780 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T369 993-1001 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T370 993-997 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T371 1035-1043 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T372 1035-1039 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T373 1058-1067 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T374 1091-1099 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T375 1091-1095 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T376 1139-1147 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T377 1139-1143 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T378 1162-1171 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T379 1255-1263 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T380 1255-1259 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T381 1276-1285 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T382 1422-1431 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T383 1542-1551 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T384 1562-1570 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T385 1562-1566 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T386 1588-1596 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T387 1588-1592 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T388 1644-1652 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T389 1644-1648 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 1698-1706 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T391 1698-1702 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T392 1734-1742 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T393 1734-1738 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T394 1757-1766 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T379 76-78 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T380 199-207 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T381 362-367 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T382 913-914 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T383 981-989 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T384 1016-1021 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T385 1177-1178 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T386 1373-1378 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T387 1452-1457 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T388 1463-1464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T119 0-275 Sentence denotes Since SARS-CoV-2 is more phylogenetically related to SARS-CoV than MERS-CoV,22 we further detected the cross-reactivity of SARS-CoV RBD-specific antibodies with SARS-CoV-2 RBD and cross-neutralizing activity of SARS-CoV RBD-specific antibodies against pseudotyped SARS-CoV-2.
T120 276-393 Sentence denotes First, we performed an ELISA to detect the cross-reactivity of SARS-CoV RBD-immunized mouse sera with SARS-CoV-2 RBD.
T121 394-581 Sentence denotes The results showed that SARS-CoV-2 RBD reacted strongly with anti-SARS-CoV RBD IgG with antibody titer of 1:2.4 × 104 (Fig. 4d), but it did not react with anti-MERS-CoV RBD IgG (Fig. 4e).
T122 582-668 Sentence denotes As expected, SARS-CoV RBD reacted strongly with anti-SARS-CoV RBD IgG (antibody titer:
T123 669-738 Sentence denotes 1:1.4 × 105) (Fig. 4d), but not with anti-MERS-CoV RBD IgG (Fig. 4e).
T124 739-867 Sentence denotes MERS-CoV RBD did not react with anti-SARS-CoV RBD IgG (Fig. 4d), but instead reacted with anti-MERS-CoV RBD IgG (antibody titer:
T125 868-891 Sentence denotes 1:1.3 × 105) (Fig. 4e).
T126 892-1068 Sentence denotes Second, we performed a pseudovirus neutralization assay to detect the cross-neutralizing activity of SARS-CoV RBD-immunized mouse sera against SARS-CoV-2 pseudovirus infection.
T127 1069-1350 Sentence denotes Results revealed that SARS-CoV RBD-specific antisera could neutralize SARS-CoV-2 pseudovirus infection with a neutralizing antibody titer of 1:323, while these antisera could neutralize SARS-CoV pseudovirus infection with higher neutralizing antibody titer (1:1.2 × 104) (Fig. 4f).
T128 1351-1619 Sentence denotes MERS-CoV RBD-inducing mouse sera only neutralized MERS-CoV pseudovirus infection in hDPP4-expressing cells with a neutralizing antibody titer of 1:4 × 104 (Fig. 4g), but failed to neutralize infection by either SARS-CoV-2 pseudovirus or SARS-CoV pseudovirus (Fig. 4f).
T129 1620-1767 Sentence denotes These data suggest that SARS-CoV RBD-specific antibodies can cross-react with SARS-CoV-2 RBD and cross-neutralize SARS-CoV-2 pseudovirus infection.