PMC:7091888 / 178-1411
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
30 | 661-692 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
31 | 694-698 | Gene | denotes | ACE2 | Gene:59272 |
32 | 777-781 | Gene | denotes | ACE2 | Gene:59272 |
33 | 898-902 | Gene | denotes | ACE2 | Gene:59272 |
34 | 347-352 | Gene | denotes | spike | Gene:43740568 |
35 | 588-589 | Gene | denotes | S | Gene:43740568 |
36 | 227-274 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
37 | 276-286 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
38 | 303-325 | Species | denotes | 2019 novel coronavirus | Tax:2697049 |
39 | 327-336 | Species | denotes | 2019-nCoV | Tax:2697049 |
40 | 343-346 | Species | denotes | CoV | Tax:11118 |
41 | 577-587 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
42 | 647-652 | Species | denotes | human | Tax:9606 |
43 | 711-721 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
44 | 796-804 | Species | denotes | SARS-CoV | Tax:694009 |
45 | 863-873 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
46 | 882-890 | Species | denotes | SARS-CoV | Tax:694009 |
47 | 968-976 | Species | denotes | SARS-CoV | Tax:694009 |
48 | 1024-1034 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
49 | 1052-1060 | Species | denotes | SARS-CoV | Tax:694009 |
50 | 1105-1115 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
51 | 1153-1161 | Species | denotes | SARS-CoV | Tax:694009 |
52 | 1199-1209 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
53 | 16-40 | Disease | denotes | Coronavirus Disease 2019 | MESH:C000657245 |
54 | 42-50 | Disease | denotes | COVID-19 | MESH:C000657245 |
55 | 193-202 | Disease | denotes | infection | MESH:D007239 |
56 | 943-952 | Disease | denotes | infection | MESH:D007239 |
57 | 1214-1232 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T2 | 357-364 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T3 | 590-597 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T4 | 621-628 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T5 | 914-919 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T6 | 961-966 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T7 | 1039-1046 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 16-40 | Disease | denotes | Coronavirus Disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T2 | 42-50 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 193-202 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T4 | 227-274 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T5 | 227-260 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T6 | 276-284 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T7 | 276-280 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T8 | 577-585 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T9 | 577-581 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T10 | 711-719 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T11 | 711-715 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T12 | 796-804 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T13 | 796-800 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T14 | 863-871 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T15 | 863-867 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T16 | 882-890 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T17 | 882-886 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T18 | 943-952 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T19 | 968-976 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T20 | 968-972 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T21 | 1024-1032 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T22 | 1024-1028 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T23 | 1052-1060 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T24 | 1052-1056 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T25 | 1105-1113 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T26 | 1105-1109 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T27 | 1153-1161 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T28 | 1153-1157 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T29 | 1199-1207 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T30 | 1199-1203 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T31 | 1214-1232 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
T32 | 1214-1218 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T33 | 1223-1232 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2 | 52-55 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T3 | 62-63 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T4 | 449-450 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 647-652 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T6 | 657-660 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
T7 | 914-919 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T8 | 961-966 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T3 | 357-364 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T4 | 495-505 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T5 | 590-597 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T6 | 621-628 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T7 | 661-672 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T8 | 1039-1046 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3 | 0-338 | Sentence | denotes | The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). |
T4 | 339-519 | Sentence | denotes | The CoV spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. |
T5 | 520-710 | Sentence | denotes | Here, we identified the receptor-binding domain (RBD) in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. |
T6 | 711-967 | Sentence | denotes | SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and, hence, attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells, thus inhibiting their infection to host cells. |
T7 | 968-1233 | Sentence | denotes | SARS-CoV RBD-specific antibodies could cross-react with SARS-CoV-2 RBD protein, and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2, suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. |