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PMC:7081066 / 1354-3222 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
91 463-479 Gene denotes envelope protein Gene:64006
92 503-508 Gene denotes spike Gene:43740568
93 730-761 Gene denotes angiotensin-converting enzyme 2 Gene:59272
94 763-767 Gene denotes ACE2 Gene:59272
95 912-918 Gene denotes CD209L Gene:10332
96 960-964 Gene denotes ACE2 Gene:59272
97 1821-1826 Gene denotes spike Gene:43740568
98 1863-1867 Gene denotes ACE2 Gene:59272
99 453-461 Gene denotes membrane Gene:43740571
100 1184-1192 Gene denotes membrane Gene:43740571
101 701-706 Gene denotes spike Gene:43740568
102 446-451 Gene denotes spike Gene:43740568
103 0-45 Species denotes Severe Acute Respiratory Syndrome Coronavirus Tax:694009
104 47-55 Species denotes SARS-CoV Tax:694009
105 94-105 Species denotes Coronavirus Tax:11118
106 107-115 Species denotes MERS-CoV Tax:1335626
107 146-163 Species denotes novel Coronavirus Tax:2697049
108 165-175 Species denotes SARS-CoV-2 Tax:2697049
109 191-204 Species denotes Coronaviridae Tax:11118
110 219-234 Species denotes Betacoronavirus Tax:694002
111 690-700 Species denotes SARS-CoV-2 Tax:2697049
112 941-949 Species denotes SARS-CoV Tax:694009
113 1015-1023 Species denotes SARS-CoV Tax:694009
114 1093-1103 Species denotes SARS-CoV-2 Tax:2697049
115 1810-1820 Species denotes SARS-CoV-2 Tax:2697049
116 1843-1848 Species denotes human Tax:9606
117 1278-1293 Disease denotes viral infection MESH:D001102

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T5 362-365 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 432-440 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T7 472-479 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T8 509-516 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 707-715 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T10 1163-1170 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T11 1179-1183 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 1184-1201 Body_part denotes membrane receptor http://purl.org/sig/ont/fma/fma0326969
T13 1385-1392 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 1393-1400 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 1827-1834 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 1849-1853 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T8 0-33 Disease denotes Severe Acute Respiratory Syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T9 47-55 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 165-173 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 681-685 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T12 690-698 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 941-949 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 1015-1023 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 1093-1101 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1278-1293 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T17 1284-1293 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18 1810-1818 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T14 241-244 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T15 318-325 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T16 331-332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 379-381 http://purl.obolibrary.org/obo/CLO_0007074 denotes Kb
T18 379-381 http://purl.obolibrary.org/obo/CLO_0051988 denotes Kb
T19 453-461 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T20 569-570 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 849-850 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 1179-1183 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T23 1184-1192 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T24 1205-1206 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 1843-1853 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T6 432-440 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T7 472-479 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T8 509-516 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 707-715 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T10 730-741 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T11 1163-1170 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 1385-1392 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 1393-1400 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 1526-1532 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T15 1827-1834 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1278-1293 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T14 0-297 Sentence denotes Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and the recently identified novel Coronavirus (SARS-CoV-2) belong to the Coronaviridae family, genus Betacoronavirus, that has been related to important epidemiological outbreaks.
T15 298-382 Sentence denotes These are enveloped viruses with a positive-sense single-strand RNA of around 32 Kb.
T16 383-498 Sentence denotes The viral particles contain four main structural proteins: the spike, membrane, envelope protein, and nucleocapsid.
T17 499-641 Sentence denotes The spike protein protrudes from the envelope of the virion and plays a pivotal role in the receptor host selectivity and cellular attachment.
T18 642-812 Sentence denotes Strong scientific evidence showed that SARS and SARS-CoV-2 spike proteins interact with angiotensin-converting enzyme 2 (ACE2) (Chen et al 2020[2]; Wan et al., 2020[16]).
T19 813-950 Sentence denotes Also, other cellular receptors play a secondary role in the viral attachment, as the C-type lectin CD209L, and DC-SIGN binds to SARS-CoV.
T20 951-1246 Sentence denotes However, ACE2 appears to be the key functional receptor for the SARS-CoV (Coutard et al., 2020[3]; Satija and Lal, 2007[12]) and probably for SARS-CoV-2 (Walls et al., 2020[15]) The interaction between the viral protein and its cell membrane receptor is a critical step in the replication cycle.
T21 1247-1332 Sentence denotes Furthermore, the efficiency of viral infection is strongly dependent on this process.
T22 1333-1414 Sentence denotes Several physicochemical factors are associated with protein-protein interactions.
T23 1415-1546 Sentence denotes These factors are determined by the nature of residues and the type of chemical interactions occurring between ligand and receptor.
T24 1547-1712 Sentence denotes Thus, the presence of residues that produce an energetically favored interaction (lower free energy) may drive binding kinetics and finally lead to the fusion event.
T25 1713-1868 Sentence denotes Based on that, this study aimed to evaluate the energetic profile of the interaction between the SARS-CoV-2 spike protein and the human cell receptor ACE2.

MyTest

Id Subject Object Predicate Lexical cue
32210742-17470909-29811226 1071-1073 17470909 denotes 12

2_test

Id Subject Object Predicate Lexical cue
32210742-17470909-29811226 1071-1073 17470909 denotes 12