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PMC:7081066 / 125-1339 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
36 857-861 Gene denotes ACE2 Gene:59272
37 1051-1056 Gene denotes spike Gene:43740568
38 1078-1082 Gene denotes ACE2 Gene:59272
39 1134-1138 Gene denotes ACE2 Gene:59272
40 785-790 Gene denotes spike Gene:43740568
41 1124-1129 Gene denotes spike Gene:43740568
42 851-856 Gene denotes spike Gene:43740568
43 586-591 Gene denotes spike Gene:43740568
44 5-10 Species denotes human Tax:9606
45 144-150 Species denotes people Tax:9606
46 237-243 Species denotes humans Tax:9606
47 496-506 Species denotes SARS-CoV-2 Tax:2697049
48 607-617 Species denotes SARS-CoV-2 Tax:2697049
49 641-646 Species denotes human Tax:9606
50 650-655 Species denotes human Tax:9606
51 840-850 Species denotes SARS-CoV-2 Tax:2697049
52 952-955 Species denotes CoV Tax:11118
53 1040-1050 Species denotes SARS-Cov-2 Tax:2697049
54 1072-1077 Species denotes human Tax:9606
55 1120-1123 Species denotes CoV Tax:11118
56 1193-1203 Species denotes SARS-CoV-2 Tax:2697049
57 1207-1213 Species denotes humans Tax:9606
58 11-25 Disease denotes viral diseases MESH:D001102
59 49-57 Disease denotes zoonotic MESH:D015047
60 102-110 Disease denotes zoonotic MESH:D015047
61 224-233 Disease denotes mortality MESH:D003643
62 389-397 Disease denotes zoonotic MESH:D015047
63 467-475 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 266-274 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T3 592-599 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 1057-1064 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p24367s19 888-897 NegReg denotes reduction
p24367s22 905-919 MPA denotes binding energy

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 11-25 Disease denotes viral diseases http://purl.obolibrary.org/obo/MONDO_0005108
T3 496-504 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 607-615 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 840-848 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1040-1044 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 1193-1201 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T2 5-10 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 30-31 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 47-48 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 237-243 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T6 512-515 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T7 641-649 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human to
T8 650-655 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T9 740-742 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T10 886-887 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1015-1016 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1072-1077 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T13 1207-1213 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 266-274 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T3 292-299 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T4 592-599 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T5 1057-1064 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-64 Sentence denotes Many human viral diseases are a consequence of a zoonotic event.
T5 65-244 Sentence denotes Some of the diseases caused by these zoonotic events have affected millions of people around the world, some of which have resulted in high rates of morbidity/mortality in humans.
T6 245-363 Sentence denotes Changes in the viral proteins that function as ligands of the host receptor may promote the spillover between species.
T7 364-507 Sentence denotes The most recent of these zoonotic events that have caused an ongoing epidemic of high magnitude is the Covid-19 epidemics caused by SARS-CoV-2.
T8 508-669 Sentence denotes The aim of this study was to determine the mutation(s) in the sequence of the spike protein of the SARS-CoV-2 that might be favoring human to human transmission.
T9 670-791 Sentence denotes An in silico approach was performed, and changes were detected in the S1 subunit of the receptor-binding domain of spike.
T10 792-973 Sentence denotes The observed changes have significant effect on SARS-CoV-2 spike/ACE2 interaction and produce a reduction in the binding energy, compared to the one of the Bat-CoV to this receptor.
T11 974-1139 Sentence denotes The data presented in this study suggest a higher affinity of the SARS-Cov-2 spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike and ACE2.
T12 1140-1214 Sentence denotes This could be the cause of the rapid viral spread of SARS-CoV-2 in humans.