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PMC:7081066 / 11189-12901 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
331 935-939 Gene denotes ACE2 Gene:59272
332 1085-1089 Gene denotes ACE2 Gene:59272
333 1171-1176 Gene denotes spike Gene:43740568
334 1355-1360 Gene denotes spike Gene:43740568
335 1439-1444 Gene denotes spike Gene:43740568
336 497-502 Gene denotes spike Gene:43740568
337 18-28 Species denotes SARS-CoV-2 Tax:2697049
338 196-209 Species denotes coronaviruses Tax:11118
339 245-255 Species denotes SARS-CoV-2 Tax:2697049
340 291-310 Species denotes Rhinolophus affinis Tax:59477
341 422-427 Species denotes human Tax:9606
342 486-491 Species denotes human Tax:9606
343 558-566 Species denotes SARS-CoV Tax:694009
344 571-581 Species denotes SARS-CoV-2 Tax:2697049
345 754-764 Species denotes SARS-CoV-2 Tax:2697049
346 815-834 Species denotes Rhinolophus affinis Tax:59477
347 1106-1116 Species denotes SARS-CoV-2 Tax:2697049
348 1188-1198 Species denotes SARS-CoV-2 Tax:2697049
349 1617-1625 Species denotes SARS-CoV Tax:694009
350 1630-1640 Species denotes SARS-CoV-2 Tax:2697049
351 351-359 Chemical denotes Pangolin
352 1488-1497 Disease denotes infection MESH:D007239
353 1683-1691 Disease denotes zoonotic MESH:D015047

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T50 161-168 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 646-653 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T52 710-721 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T53 889-900 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T54 1177-1184 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T55 1246-1256 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T56 1361-1368 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T57 1445-1452 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T58 18-26 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T59 245-253 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 558-566 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 571-579 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 754-762 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 1106-1114 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 1188-1196 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 1488-1497 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 1617-1625 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 1630-1638 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T62 29-32 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T63 127-129 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T64 140-141 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 397-398 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 422-427 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T67 428-433 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T68 478-481 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T69 486-491 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T70 694-697 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T71 791-798 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T72 981-983 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T73 1072-1079 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T68 161-168 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 646-653 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 710-721 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T71 710-715 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T72 716-721 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T73 889-900 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T74 889-894 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T75 895-900 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T76 1177-1184 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 1246-1256 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T78 1246-1251 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T79 1252-1256 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T80 1361-1368 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 1445-1452 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T95 0-59 Sentence denotes The origin of the SARS-CoV-2 has been not fully elucidated.
T96 60-320 Sentence denotes While this study was in course, another study of Wong et al. (2020[18]), showed a high similarity at protein level in the RBD among the coronaviruses isolated from the recent outbreak (SARS-CoV-2), those isolated from pangolin and Rhinolophus affinis (RaTG13).
T97 321-492 Sentence denotes The authors also suggest that Pangolin might be the intermediate host, with a 98 % identity with the human virus, at the receptor binding motif, between the bat and human.
T98 493-641 Sentence denotes The spike model of RaTG13 is quite similar to that obtained from SARS-CoV and SARS-CoV-2 and the loops in the RBD are also present (data not shown).
T99 642-722 Sentence denotes The protein sequence of the receptor binding motif, has 5 important amino acids.
T100 723-986 Sentence denotes When comparing the sequence of SARS-CoV-2 with that of the isolated viruses of pangolin and Rhinolophus affinis, 1 and 4 differences are observed respectively in the amino acids considered key for the union with ACE2 (Yan et al., 2020[20]; Wong et al., 2020[18]).
T101 987-1138 Sentence denotes These differences should mean slightly less favorable binding energies between these viruses with ACE2 compared to the SARS-CoV-2, shown in this study.
T102 1139-1369 Sentence denotes Thus, the loops observed in the spike protein of SARS-CoV-2 could play an important role together with the amino acid substitutions, being an interesting clue to determine the host receptor specificity for the viral spike protein.
T103 1370-1527 Sentence denotes Altogether, structural changes and residues composition in the viral spike protein could be associated with increased infection kinetics and viral spreading.
T104 1528-1712 Sentence denotes Comparative studies to determine the impact in vitro of the mutation and loops in RBD of SARS-CoV and SARS-CoV-2 are required in order to predict possible zoonotic event in the future.