PMC:7081066
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id | tao:has_standard_notation |
---|---|---|---|---|---|---|
4 | 78-82 | Gene | denotes | ACE2 | Gene:59272 | |
5 | 30-35 | Gene | denotes | spike | Gene:43740568 | |
6 | 19-29 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
7 | 72-77 | Species | denotes | human | Tax:9606 | |
36 | 982-986 | Gene | denotes | ACE2 | Gene:59272 | |
37 | 1176-1181 | Gene | denotes | spike | Gene:43740568 | |
38 | 1203-1207 | Gene | denotes | ACE2 | Gene:59272 | |
39 | 1259-1263 | Gene | denotes | ACE2 | Gene:59272 | |
40 | 910-915 | Gene | denotes | spike | Gene:43740568 | |
41 | 1249-1254 | Gene | denotes | spike | Gene:43740568 | |
42 | 976-981 | Gene | denotes | spike | Gene:43740568 | |
43 | 711-716 | Gene | denotes | spike | Gene:43740568 | |
44 | 130-135 | Species | denotes | human | Tax:9606 | |
45 | 269-275 | Species | denotes | people | Tax:9606 | |
46 | 362-368 | Species | denotes | humans | Tax:9606 | |
47 | 621-631 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
48 | 732-742 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
49 | 766-771 | Species | denotes | human | Tax:9606 | |
50 | 775-780 | Species | denotes | human | Tax:9606 | |
51 | 965-975 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
52 | 1077-1080 | Species | denotes | CoV | Tax:11118 | |
53 | 1165-1175 | Species | denotes | SARS-Cov-2 | Tax:2697049 | |
54 | 1197-1202 | Species | denotes | human | Tax:9606 | |
55 | 1245-1248 | Species | denotes | CoV | Tax:11118 | |
56 | 1318-1328 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
57 | 1332-1338 | Species | denotes | humans | Tax:9606 | |
58 | 136-150 | Disease | denotes | viral diseases | MESH:D001102 | |
59 | 174-182 | Disease | denotes | zoonotic | MESH:D015047 | |
60 | 227-235 | Disease | denotes | zoonotic | MESH:D015047 | |
61 | 349-358 | Disease | denotes | mortality | MESH:D003643 | |
62 | 514-522 | Disease | denotes | zoonotic | MESH:D015047 | |
63 | 592-600 | Disease | denotes | Covid-19 | MESH:C000657245 | |
91 | 1817-1833 | Gene | denotes | envelope protein | Gene:64006 | |
92 | 1857-1862 | Gene | denotes | spike | Gene:43740568 | |
93 | 2084-2115 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 | |
94 | 2117-2121 | Gene | denotes | ACE2 | Gene:59272 | |
95 | 2266-2272 | Gene | denotes | CD209L | Gene:10332 | |
96 | 2314-2318 | Gene | denotes | ACE2 | Gene:59272 | |
97 | 3175-3180 | Gene | denotes | spike | Gene:43740568 | |
98 | 3217-3221 | Gene | denotes | ACE2 | Gene:59272 | |
99 | 1807-1815 | Gene | denotes | membrane | Gene:43740571 | |
100 | 2538-2546 | Gene | denotes | membrane | Gene:43740571 | |
101 | 2055-2060 | Gene | denotes | spike | Gene:43740568 | |
102 | 1800-1805 | Gene | denotes | spike | Gene:43740568 | |
103 | 1354-1399 | Species | denotes | Severe Acute Respiratory Syndrome Coronavirus | Tax:694009 | |
104 | 1401-1409 | Species | denotes | SARS-CoV | Tax:694009 | |
105 | 1448-1459 | Species | denotes | Coronavirus | Tax:11118 | |
106 | 1461-1469 | Species | denotes | MERS-CoV | Tax:1335626 | |
107 | 1500-1517 | Species | denotes | novel Coronavirus | Tax:2697049 | |
108 | 1519-1529 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
109 | 1545-1558 | Species | denotes | Coronaviridae | Tax:11118 | |
110 | 1573-1588 | Species | denotes | Betacoronavirus | Tax:694002 | |
111 | 2044-2054 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
112 | 2295-2303 | Species | denotes | SARS-CoV | Tax:694009 | |
113 | 2369-2377 | Species | denotes | SARS-CoV | Tax:694009 | |
114 | 2447-2457 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
115 | 3164-3174 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
116 | 3197-3202 | Species | denotes | human | Tax:9606 | |
117 | 2632-2647 | Disease | denotes | viral infection | MESH:D001102 | |
122 | 3464-3469 | Gene | denotes | spike | Gene:43740568 | |
123 | 3566-3571 | Gene | denotes | spike | Gene:43740568 | |
124 | 3487-3496 | Species | denotes | SARS-CoV2 | Tax:2697049 | |
125 | 3595-3600 | Gene | denotes | spike | Gene:43740568 | |
138 | 3665-3670 | Gene | denotes | spike | Gene:43740568 | |
139 | 4038-4043 | Gene | denotes | spike | Gene:43740568 | |
140 | 3979-3984 | Gene | denotes | spike | Gene:43740568 | |
141 | 3684-3694 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
142 | 3716-3719 | Species | denotes | CoV | Tax:11118 | |
143 | 3968-3978 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
144 | 4029-4037 | Species | denotes | SARS-CoV | Tax:694009 | |
145 | 4096-4099 | Species | denotes | CoV | Tax:11118 | |
146 | 4255-4263 | Chemical | denotes | Hydrogen | MESH:D006859 | |
147 | 4384-4389 | Chemical | denotes | water | MESH:D014867 | |
148 | 4557-4562 | Chemical | denotes | water | MESH:D014867 | |
149 | 4831-4837 | Disease | denotes | CHARMM | ||
159 | 5218-5222 | Gene | denotes | ACE2 | Gene:59272 | |
160 | 5494-5498 | Gene | denotes | ACE2 | Gene:59272 | |
161 | 5633-5638 | Gene | denotes | spike | Gene:43740568 | |
162 | 5662-5666 | Gene | denotes | ACE2 | Gene:59272 | |
163 | 5484-5489 | Gene | denotes | spike | Gene:43740568 | |
164 | 5323-5328 | Gene | denotes | spike | Gene:43740568 | |
165 | 5192-5197 | Gene | denotes | spike | Gene:43740568 | |
166 | 5183-5191 | Species | denotes | SARS-CoV | Tax:694009 | |
167 | 5312-5322 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
170 | 6011-6016 | Gene | denotes | spike | Gene:43740568 | |
171 | 6029-6038 | Species | denotes | SARS-CoVs | Tax:694009 | |
193 | 6089-6094 | Gene | denotes | spike | Gene:43740568 | |
194 | 6704-6709 | Gene | denotes | spike | Gene:43740568 | |
195 | 6503-6508 | Gene | denotes | spike | Gene:43740568 | |
196 | 6116-6126 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
197 | 6135-6139 | Species | denotes | CoVs | Tax:11118 | |
198 | 6141-6149 | Species | denotes | SARS-CoV | Tax:694009 | |
199 | 6263-6273 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
200 | 6285-6288 | Species | denotes | CoV | Tax:11118 | |
201 | 6352-6360 | Species | denotes | SARS-CoV | Tax:694009 | |
202 | 6376-6379 | Species | denotes | CoV | Tax:11118 | |
203 | 6383-6402 | Species | denotes | Rhinolophus affinis | Tax:59477 | |
204 | 6521-6524 | Species | denotes | CoV | Tax:11118 | |
205 | 6532-6542 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
206 | 6720-6728 | Species | denotes | SARS-CoV | Tax:694009 | |
207 | 6737-6740 | Species | denotes | CoV | Tax:11118 | |
208 | 6746-6765 | Species | denotes | Rhinolophus sinicus | Tax:89399 | |
209 | 6824-6834 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
210 | 6914-6924 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
211 | 6941-6944 | Species | denotes | CoV | Tax:11118 | |
212 | 6950-6969 | Species | denotes | Rhinolophus affinis | Tax:59477 | |
213 | 7019-7024 | Species | denotes | CoV-2 | Tax:2697049 | |
216 | 7118-7123 | Gene | denotes | Spike | Gene:43740568 | |
217 | 7124-7128 | Gene | denotes | ACE2 | Gene:59272 | |
249 | 7169-7174 | Gene | denotes | spike | Gene:43740568 | |
250 | 7361-7365 | Gene | denotes | ACE2 | Gene:59272 | |
251 | 8301-8305 | Gene | denotes | ACE2 | Gene:59272 | |
252 | 8674-8678 | Gene | denotes | ACE2 | Gene:59272 | |
253 | 9238-9243 | Gene | denotes | spike | Gene:43740568 | |
254 | 9549-9553 | Gene | denotes | ACE2 | Gene:59272 | |
255 | 10009-10014 | Gene | denotes | spike | Gene:43740568 | |
256 | 7186-7194 | Species | denotes | SARS-CoV | Tax:694009 | |
257 | 7222-7225 | Species | denotes | CoV | Tax:11118 | |
258 | 7259-7262 | Species | denotes | CoV | Tax:11118 | |
259 | 7266-7285 | Species | denotes | Rhinolophus sinicus | Tax:89399 | |
260 | 7291-7301 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
261 | 7355-7360 | Species | denotes | human | Tax:9606 | |
262 | 7725-7735 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
263 | 7740-7748 | Species | denotes | SARS-CoV | Tax:694009 | |
264 | 7911-7919 | Species | denotes | SARS-CoV | Tax:694009 | |
265 | 8062-8072 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
266 | 8150-8155 | Species | denotes | human | Tax:9606 | |
267 | 8206-8214 | Species | denotes | SARS-CoV | Tax:694009 | |
268 | 8295-8300 | Species | denotes | human | Tax:9606 | |
269 | 8395-8400 | Species | denotes | human | Tax:9606 | |
270 | 8440-8450 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
271 | 8545-8555 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
272 | 9052-9057 | Species | denotes | human | Tax:9606 | |
273 | 9282-9290 | Species | denotes | SARS-CoV | Tax:694009 | |
274 | 9443-9453 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
275 | 9750-9760 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
276 | 9797-9805 | Species | denotes | SARS-CoV | Tax:694009 | |
277 | 7975-7984 | Disease | denotes | infection | MESH:D007239 | |
278 | 8402-8407 | Mutation | denotes | K479N | p.K479N | |
279 | 8412-8417 | Mutation | denotes | S487T | p.S487T | |
294 | 10171-10176 | Gene | denotes | spike | Gene:43740568 | |
295 | 10437-10441 | Gene | denotes | CCR5 | Gene:1234 | |
296 | 10445-10450 | Gene | denotes | CXCR4 | Gene:7852 | |
297 | 10620-10624 | Gene | denotes | ACE2 | Gene:59272 | |
298 | 10783-10787 | Gene | denotes | ACE2 | Gene:59272 | |
299 | 10099-10109 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
300 | 10130-10139 | Species | denotes | SARS-CoVs | Tax:694009 | |
301 | 10144-10152 | Species | denotes | SARS-CoV | Tax:694009 | |
302 | 10614-10619 | Species | denotes | human | Tax:9606 | |
303 | 10728-10738 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
304 | 11024-11034 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
305 | 11047-11055 | Species | denotes | SARS-CoV | Tax:694009 | |
306 | 10301-10314 | Disease | denotes | HIV infection | MESH:D015658 | |
307 | 11133-11142 | Disease | denotes | infection | MESH:D007239 | |
331 | 12124-12128 | Gene | denotes | ACE2 | Gene:59272 | |
332 | 12274-12278 | Gene | denotes | ACE2 | Gene:59272 | |
333 | 12360-12365 | Gene | denotes | spike | Gene:43740568 | |
334 | 12544-12549 | Gene | denotes | spike | Gene:43740568 | |
335 | 12628-12633 | Gene | denotes | spike | Gene:43740568 | |
336 | 11686-11691 | Gene | denotes | spike | Gene:43740568 | |
337 | 11207-11217 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
338 | 11385-11398 | Species | denotes | coronaviruses | Tax:11118 | |
339 | 11434-11444 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
340 | 11480-11499 | Species | denotes | Rhinolophus affinis | Tax:59477 | |
341 | 11611-11616 | Species | denotes | human | Tax:9606 | |
342 | 11675-11680 | Species | denotes | human | Tax:9606 | |
343 | 11747-11755 | Species | denotes | SARS-CoV | Tax:694009 | |
344 | 11760-11770 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
345 | 11943-11953 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
346 | 12004-12023 | Species | denotes | Rhinolophus affinis | Tax:59477 | |
347 | 12295-12305 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
348 | 12377-12387 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
349 | 12806-12814 | Species | denotes | SARS-CoV | Tax:694009 | |
350 | 12819-12829 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
351 | 11540-11548 | Chemical | denotes | Pangolin | ||
352 | 12677-12686 | Disease | denotes | infection | MESH:D007239 | |
353 | 12872-12880 | Disease | denotes | zoonotic | MESH:D015047 | |
404 | 13023-13027 | Gene | denotes | ACE2 | Gene:59272 | |
405 | 13013-13018 | Gene | denotes | spike | Gene:43740568 | |
407 | 13093-13096 | Species | denotes | CoV | Tax:11118 | |
411 | 13226-13231 | Gene | denotes | spike | Gene:43740568 | |
412 | 13236-13240 | Gene | denotes | ACE2 | Gene:59272 | |
413 | 13140-13142 | Mutation | denotes | ΔG | c.delG | |
419 | 13502-13507 | Gene | denotes | spike | Gene:43740568 | |
420 | 13318-13323 | Gene | denotes | spike | Gene:43740568 | |
421 | 13285-13295 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
422 | 13306-13317 | Species | denotes | coronavirus | Tax:11118 | |
423 | 13491-13501 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
434 | 13585-13590 | Gene | denotes | spike | Gene:43740568 | |
435 | 13848-13852 | Gene | denotes | ACE2 | Gene:59272 | |
436 | 13621-13631 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
437 | 13650-13663 | Species | denotes | Coronaviruses | Tax:11118 | |
438 | 13713-13723 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
439 | 13740-13743 | Species | denotes | CoV | Tax:11118 | |
440 | 13772-13780 | Species | denotes | SARS-CoV | Tax:694009 | |
441 | 13933-13942 | Species | denotes | SARS-CoV2 | Tax:2697049 | |
442 | 13725-13733 | CellLine | denotes | MN938384 | CVCL:U508 | |
443 | 13745-13753 | CellLine | denotes | MN996532 | CVCL:U508 | |
454 | 14036-14041 | Gene | denotes | spike | Gene:43740568 | |
455 | 14078-14082 | Gene | denotes | ACE2 | Gene:59272 | |
456 | 14180-14185 | Gene | denotes | spike | Gene:43740568 | |
457 | 14004-14015 | Species | denotes | Coronavirus | Tax:11118 | |
458 | 14112-14115 | Species | denotes | CoV | Tax:11118 | |
459 | 14120-14128 | Species | denotes | SARS-CoV | Tax:694009 | |
460 | 14137-14147 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
461 | 14296-14304 | Species | denotes | SARS-CoV | Tax:694009 | |
462 | 14332-14342 | Species | denotes | SARS-CoV-2 | Tax:2697049 | |
463 | 14016-14021 | Gene | denotes | spike | Gene:43740568 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 36-43 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T2 | 391-399 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T3 | 717-724 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T4 | 1182-1189 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T5 | 1716-1719 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T6 | 1786-1794 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T7 | 1826-1833 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T8 | 1863-1870 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T9 | 2061-2069 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T10 | 2517-2524 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T11 | 2533-2537 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T12 | 2538-2555 | Body_part | denotes | membrane receptor | http://purl.org/sig/ont/fma/fma0326969 |
T13 | 2739-2746 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T14 | 2747-2754 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T15 | 3181-3188 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T16 | 3203-3207 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T17 | 3470-3477 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T18 | 3520-3527 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T19 | 3572-3579 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T20 | 3601-3608 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T21 | 3612-3619 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
T22 | 3671-3678 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T23 | 4044-4051 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T24 | 4082-4086 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
T25 | 4223-4230 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T26 | 4346-4353 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T27 | 4469-4476 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T28 | 4477-4485 | Body_part | denotes | backbone | http://purl.org/sig/ont/fma/fma13478 |
T29 | 4577-4584 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T30 | 5137-5144 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
T31 | 5145-5152 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T32 | 5264-5271 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
T33 | 5342-5349 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
T34 | 5639-5646 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T35 | 6017-6025 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T36 | 6095-6102 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T37 | 6710-6718 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T38 | 6852-6862 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T39 | 7049-7059 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T40 | 7175-7182 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T41 | 9244-9251 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T42 | 9626-9633 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T43 | 9634-9641 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T44 | 10015-10022 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T45 | 10044-10054 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T46 | 10177-10184 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T47 | 10301-10304 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T48 | 10387-10395 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T49 | 10918-10928 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T50 | 11350-11357 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T51 | 11835-11842 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T52 | 11899-11910 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
T53 | 12078-12089 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
T54 | 12366-12373 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T55 | 12435-12445 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T56 | 12550-12557 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T57 | 12634-12641 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T58 | 13054-13061 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T59 | 13062-13069 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T60 | 13324-13332 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T61 | 13508-13515 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T62 | 13534-13542 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T63 | 13591-13598 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T64 | 13801-13812 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
T65 | 13890-13900 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T66 | 13962-13972 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T67 | 14022-14030 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T68 | 14042-14061 | Body_part | denotes | proteins in complex | http://purl.org/sig/ont/fma/fma67906 |
T69 | 14186-14194 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 4082-4086 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
LitCovid_AGAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
p24367s19 | 1013-1022 | NegReg | denotes | reduction |
p24367s22 | 1030-1044 | MPA | denotes | binding energy |
p24456s3 | 10420-10435 | MPA | denotes | co-receptor use |
p24456s14 | 10467-10485 | MPA | denotes | viral pathogenesis |
p24458s16 | 10748-10757 | PosReg | denotes | promoting |
p24458s18 | 10762-10773 | MPA | denotes | interaction |
p24458s24 | 10798-10807 | PosReg | denotes | improving |
p24458s26 | 10812-10819 | MPA | denotes | binding |
p24459s14 | 11002-11020 | MPA | denotes | binding affinities |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 19-27 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T2 | 136-150 | Disease | denotes | viral diseases | http://purl.obolibrary.org/obo/MONDO_0005108 |
T3 | 621-629 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T4 | 732-740 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T5 | 965-973 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T6 | 1165-1169 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T7 | 1318-1326 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T8 | 1354-1387 | Disease | denotes | Severe Acute Respiratory Syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T9 | 1401-1409 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T10 | 1519-1527 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T11 | 2035-2039 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T12 | 2044-2052 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T13 | 2295-2303 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T14 | 2369-2377 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T15 | 2447-2455 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T16 | 2632-2647 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
T17 | 2638-2647 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T18 | 3164-3172 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T19 | 3487-3491 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T20 | 3561-3565 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T21 | 3684-3692 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T22 | 3968-3976 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T23 | 4029-4037 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T24 | 5183-5191 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T25 | 5312-5320 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T26 | 6029-6033 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T27 | 6116-6124 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T28 | 6141-6149 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T29 | 6263-6271 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T30 | 6352-6360 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T31 | 6532-6540 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T32 | 6720-6728 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T33 | 6824-6832 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T34 | 6914-6922 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T35 | 7186-7194 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T36 | 7291-7299 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T37 | 7725-7733 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T38 | 7740-7748 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T39 | 7911-7919 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T40 | 7975-7984 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T41 | 8062-8070 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T42 | 8206-8214 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T43 | 8440-8448 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T44 | 8545-8553 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T45 | 9282-9290 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T46 | 9443-9451 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T47 | 9750-9758 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T48 | 9797-9805 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T49 | 10099-10107 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T50 | 10130-10134 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T51 | 10144-10152 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T52 | 10301-10314 | Disease | denotes | HIV infection | http://purl.obolibrary.org/obo/MONDO_0005109 |
T53 | 10305-10314 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T54 | 10728-10736 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T55 | 11024-11032 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T56 | 11047-11055 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T57 | 11133-11142 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T58 | 11207-11215 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T59 | 11434-11442 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T60 | 11747-11755 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T61 | 11760-11768 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T62 | 11943-11951 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T63 | 12295-12303 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T64 | 12377-12385 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T65 | 12677-12686 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T66 | 12806-12814 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T67 | 12819-12827 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T68 | 13029-13033 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T69 | 13080-13083 | Disease | denotes | PPC | http://purl.obolibrary.org/obo/MONDO_0015686 |
T70 | 13285-13293 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T71 | 13491-13499 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T72 | 13621-13629 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T73 | 13713-13721 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T74 | 13772-13780 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T75 | 13933-13937 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T76 | 14120-14128 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T77 | 14137-14145 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T78 | 14296-14304 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T79 | 14332-14340 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 72-77 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T2 | 130-135 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T3 | 155-156 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T4 | 172-173 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T5 | 362-368 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
T6 | 637-640 | http://purl.obolibrary.org/obo/PR_000001343 | denotes | aim |
T7 | 766-774 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human to |
T8 | 775-780 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T9 | 865-867 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T10 | 1011-1012 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T11 | 1140-1141 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T12 | 1197-1202 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T13 | 1332-1338 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
T14 | 1595-1598 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T15 | 1672-1679 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T16 | 1685-1686 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T17 | 1733-1735 | http://purl.obolibrary.org/obo/CLO_0007074 | denotes | Kb |
T18 | 1733-1735 | http://purl.obolibrary.org/obo/CLO_0051988 | denotes | Kb |
T19 | 1807-1815 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T20 | 1923-1924 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T21 | 2203-2204 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T22 | 2533-2537 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T23 | 2538-2546 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T24 | 2559-2560 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T25 | 3197-3207 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cell |
T26 | 4376-4377 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T27 | 4382-4383 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | Å |
T28 | 4617-4619 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
T29 | 4688-4690 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
T30 | 4844-4849 | http://purl.obolibrary.org/obo/UBERON_0007688 | denotes | field |
T31 | 4982-4984 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
T32 | 5601-5602 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T33 | 5725-5727 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T34 | 6279-6280 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T35 | 6437-6442 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T36 | 6462-6464 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T37 | 6512-6520 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | this Bat |
T38 | 6625-6627 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
T39 | 6778-6786 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaled |
T40 | 6815-6820 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T41 | 7015-7018 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAS |
T42 | 7355-7360 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T43 | 7577-7578 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T44 | 7895-7902 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T45 | 8150-8155 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T46 | 8295-8300 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T47 | 8361-8362 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T48 | 8395-8400 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T49 | 8419-8421 | http://purl.obolibrary.org/obo/CLO_0001022 | denotes | Li |
T50 | 8419-8421 | http://purl.obolibrary.org/obo/CLO_0007314 | denotes | Li |
T51 | 8722-8723 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T52 | 8922-8923 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T53 | 9052-9057 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T54 | 9068-9075 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T55 | 9098-9101 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
T56 | 9102-9107 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T57 | 10213-10214 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T58 | 10215-10220 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T59 | 10318-10319 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T60 | 10614-10619 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T61 | 11182-11187 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T62 | 11218-11221 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T63 | 11316-11318 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T64 | 11329-11330 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T65 | 11586-11587 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T66 | 11611-11616 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T67 | 11617-11622 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T68 | 11667-11670 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
T69 | 11675-11680 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T70 | 11883-11886 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T71 | 11980-11987 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T72 | 12170-12172 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T73 | 12261-12268 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T74 | 14042-14061 | http://purl.obolibrary.org/obo/GO_0043234 | denotes | proteins in complex |
T75 | 14105-14106 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T76 | 14117-14118 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T77 | 14149-14150 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T78 | 14214-14215 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T79 | 14216-14218 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 36-43 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T2 | 391-399 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T3 | 417-424 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
T4 | 717-724 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T5 | 1182-1189 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T6 | 1786-1794 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T7 | 1826-1833 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T8 | 1863-1870 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T9 | 2061-2069 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T10 | 2084-2095 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T11 | 2517-2524 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T12 | 2739-2746 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T13 | 2747-2754 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T14 | 2880-2886 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
T15 | 3181-3188 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T16 | 3470-3477 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T17 | 3520-3527 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T18 | 3572-3579 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T19 | 3601-3608 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T20 | 3612-3619 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
T21 | 3671-3678 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T22 | 4044-4051 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T23 | 4223-4230 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T24 | 4255-4263 | Chemical | denotes | Hydrogen | http://purl.obolibrary.org/obo/CHEBI_18276 |
T25 | 4264-4269 | Chemical | denotes | atoms | http://purl.obolibrary.org/obo/CHEBI_33250 |
T26 | 4346-4353 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T27 | 4384-4389 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
T28 | 4469-4476 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T29 | 4557-4562 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
T30 | 4563-4572 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T31 | 4577-4584 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T32 | 4617-4619 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
T33 | 4688-4690 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
T34 | 4982-4984 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
T35 | 5137-5144 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
T36 | 5145-5152 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T37 | 5264-5271 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
T38 | 5342-5349 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
T39 | 5625-5631 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
T40 | 5639-5646 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T41 | 6017-6025 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T42 | 6095-6102 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T43 | 6710-6718 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T44 | 6852-6862 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T45 | 6852-6857 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T46 | 6858-6862 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T47 | 7049-7059 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T48 | 7049-7054 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T49 | 7055-7059 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T50 | 7175-7182 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T51 | 7579-7583 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
T52 | 8029-8031 | Chemical | denotes | Lu | http://purl.obolibrary.org/obo/CHEBI_33382 |
T53 | 8316-8318 | Chemical | denotes | Lu | http://purl.obolibrary.org/obo/CHEBI_33382 |
T54 | 8419-8421 | Chemical | denotes | Li | http://purl.obolibrary.org/obo/CHEBI_30145 |
T55 | 9244-9251 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T56 | 9626-9633 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T57 | 9634-9641 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T58 | 10015-10022 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T59 | 10044-10054 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T60 | 10044-10049 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T61 | 10050-10054 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T62 | 10177-10184 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T63 | 10387-10395 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T64 | 10865-10870 | Chemical | denotes | atoms | http://purl.obolibrary.org/obo/CHEBI_33250 |
T65 | 10918-10928 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T66 | 10918-10923 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T67 | 10924-10928 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T68 | 11350-11357 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T69 | 11835-11842 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T70 | 11899-11910 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
T71 | 11899-11904 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T72 | 11905-11910 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
T73 | 12078-12089 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
T74 | 12078-12083 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T75 | 12084-12089 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
T76 | 12366-12373 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T77 | 12435-12445 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T78 | 12435-12440 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T79 | 12441-12445 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T80 | 12550-12557 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T81 | 12634-12641 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T82 | 13054-13061 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T83 | 13062-13069 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T84 | 13324-13332 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T85 | 13508-13515 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T86 | 13534-13542 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T87 | 13591-13598 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T88 | 13801-13812 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
T89 | 13801-13806 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T90 | 13807-13812 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
T91 | 13890-13900 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T92 | 13890-13895 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T93 | 13896-13900 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T94 | 13962-13972 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T95 | 13962-13967 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T96 | 13968-13972 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T97 | 14022-14030 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T98 | 14042-14050 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T99 | 14186-14194 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 2632-2647 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
T2 | 10202-10209 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
T3 | 10262-10274 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
T4 | 10350-10357 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
T5 | 10445-10450 | http://purl.obolibrary.org/obo/GO_0038147 | denotes | CXCR4 |
T6 | 10473-10485 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-92 | Sentence | denotes | Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: |
T2 | 93-114 | Sentence | denotes | An in silico analysis |
T3 | 116-124 | Sentence | denotes | Abstract |
T4 | 125-189 | Sentence | denotes | Many human viral diseases are a consequence of a zoonotic event. |
T5 | 190-369 | Sentence | denotes | Some of the diseases caused by these zoonotic events have affected millions of people around the world, some of which have resulted in high rates of morbidity/mortality in humans. |
T6 | 370-488 | Sentence | denotes | Changes in the viral proteins that function as ligands of the host receptor may promote the spillover between species. |
T7 | 489-632 | Sentence | denotes | The most recent of these zoonotic events that have caused an ongoing epidemic of high magnitude is the Covid-19 epidemics caused by SARS-CoV-2. |
T8 | 633-794 | Sentence | denotes | The aim of this study was to determine the mutation(s) in the sequence of the spike protein of the SARS-CoV-2 that might be favoring human to human transmission. |
T9 | 795-916 | Sentence | denotes | An in silico approach was performed, and changes were detected in the S1 subunit of the receptor-binding domain of spike. |
T10 | 917-1098 | Sentence | denotes | The observed changes have significant effect on SARS-CoV-2 spike/ACE2 interaction and produce a reduction in the binding energy, compared to the one of the Bat-CoV to this receptor. |
T11 | 1099-1264 | Sentence | denotes | The data presented in this study suggest a higher affinity of the SARS-Cov-2 spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike and ACE2. |
T12 | 1265-1339 | Sentence | denotes | This could be the cause of the rapid viral spread of SARS-CoV-2 in humans. |
T13 | 1341-1353 | Sentence | denotes | Introduction |
T14 | 1354-1651 | Sentence | denotes | Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and the recently identified novel Coronavirus (SARS-CoV-2) belong to the Coronaviridae family, genus Betacoronavirus, that has been related to important epidemiological outbreaks. |
T15 | 1652-1736 | Sentence | denotes | These are enveloped viruses with a positive-sense single-strand RNA of around 32 Kb. |
T16 | 1737-1852 | Sentence | denotes | The viral particles contain four main structural proteins: the spike, membrane, envelope protein, and nucleocapsid. |
T17 | 1853-1995 | Sentence | denotes | The spike protein protrudes from the envelope of the virion and plays a pivotal role in the receptor host selectivity and cellular attachment. |
T18 | 1996-2166 | Sentence | denotes | Strong scientific evidence showed that SARS and SARS-CoV-2 spike proteins interact with angiotensin-converting enzyme 2 (ACE2) (Chen et al 2020[2]; Wan et al., 2020[16]). |
T19 | 2167-2304 | Sentence | denotes | Also, other cellular receptors play a secondary role in the viral attachment, as the C-type lectin CD209L, and DC-SIGN binds to SARS-CoV. |
T20 | 2305-2600 | Sentence | denotes | However, ACE2 appears to be the key functional receptor for the SARS-CoV (Coutard et al., 2020[3]; Satija and Lal, 2007[12]) and probably for SARS-CoV-2 (Walls et al., 2020[15]) The interaction between the viral protein and its cell membrane receptor is a critical step in the replication cycle. |
T21 | 2601-2686 | Sentence | denotes | Furthermore, the efficiency of viral infection is strongly dependent on this process. |
T22 | 2687-2768 | Sentence | denotes | Several physicochemical factors are associated with protein-protein interactions. |
T23 | 2769-2900 | Sentence | denotes | These factors are determined by the nature of residues and the type of chemical interactions occurring between ligand and receptor. |
T24 | 2901-3066 | Sentence | denotes | Thus, the presence of residues that produce an energetically favored interaction (lower free energy) may drive binding kinetics and finally lead to the fusion event. |
T25 | 3067-3222 | Sentence | denotes | Based on that, this study aimed to evaluate the energetic profile of the interaction between the SARS-CoV-2 spike protein and the human cell receptor ACE2. |
T26 | 3224-3245 | Sentence | denotes | Materials and Methods |
T27 | 3247-3264 | Sentence | denotes | Sequence analysis |
T28 | 3265-3402 | Sentence | denotes | Sequences analyzed were individually retrieved from GenBank (accession numbers are shown in the phylogenetic tree, see Figure 1(Fig. 1)). |
T29 | 3403-3610 | Sentence | denotes | The sequence used for the modeling process and construct the spike protein model of SARS-CoV2 were obtained from the protein database and correspond to 6ACC (SARS spike protein) and 6ACD (Bat-spike protein). |
T30 | 3612-3628 | Sentence | denotes | Protein modeling |
T31 | 3629-3870 | Sentence | denotes | Homology structural models of viral spike protein from SARS-CoV-2 (QHO62112.1) and Bat-CoV (AAZ67052.1) were built by using the tools of the SWISS-MODEL modeling server and the DeepView/Swiss-PdbViewer 4.01 software (Arnold et al., 2006[1]). |
T32 | 3871-3948 | Sentence | denotes | Several models were obtained and the quality of each structure was evaluated. |
T33 | 3949-4068 | Sentence | denotes | The best model for SARS-CoV-2 spike was obtained using the crystal structure of SARS-CoV spike protein (PDB code 6ACC). |
T34 | 4069-4183 | Sentence | denotes | On the other hand, for Bat-CoV, the best model was obtained using as template the crystal structure PDB code 6ACD. |
T35 | 4184-4254 | Sentence | denotes | These models were subjected to further protein structure optimization. |
T36 | 4255-4341 | Sentence | denotes | Hydrogen atoms were added and the partial charges were assigned for energy refinement. |
T37 | 4342-4394 | Sentence | denotes | The protein model was embedded in a 100 Å water box. |
T38 | 4395-4585 | Sentence | denotes | Then, energy minimization was performed while applying constraints to the protein backbone to preserve global folding and optimizing the relative position of the water molecules and protein. |
T39 | 4586-4683 | Sentence | denotes | The obtained systems underwent MD simulations using NAMD as described by Ortega et al. (2019[8]). |
T40 | 4684-4830 | Sentence | denotes | All MD simulations described in this study were performed with NAMD 2.12 (Phillips et al., 2005[10]), Vega ZZ 3.1.0.21 (Pedretti et al., 2004[9]). |
T41 | 4831-4916 | Sentence | denotes | CHARMM force field (Vanommeslaeghe et al., 2010[14]) and Gasteiger charges were used. |
T42 | 4917-4997 | Sentence | denotes | The obtained structures represent the lowest energy frame of the MD simulations. |
T43 | 4998-5135 | Sentence | denotes | The quality of the models was established with ProSA (Wiederstein and Sippl, 2007[17]) and PROCHECK programs (Laskowski et al., 1993[4]). |
T44 | 5137-5160 | Sentence | denotes | Protein-protein docking |
T45 | 5161-5282 | Sentence | denotes | Crystal structure for SARS-CoV spike (PDB code 6ACK) and ACE2 (PDB code 1R42) were downloaded from the Protein Data Bank. |
T46 | 5283-5341 | Sentence | denotes | Also, the homology model for SARS-CoV-2 spike was assayed. |
T47 | 5342-5397 | Sentence | denotes | Protein preparation was carried out as described above. |
T48 | 5398-5547 | Sentence | denotes | Then, binding patterns and affinity estimations for the interaction between the viral spike and ACE2 receptor were performed using molecular docking. |
T49 | 5548-5730 | Sentence | denotes | This process was performed through two steps; first, a blind docking between ligand (spike protein) and receptor (ACE2) was performed using Z-dock software (Pierce et al., 2014[11]). |
T50 | 5731-5854 | Sentence | denotes | Then, the resulting docking data were processed and analyzed by using the tools of PRODIGY software (Xue et al., 2016[19]). |
T51 | 5855-5975 | Sentence | denotes | Finally, results were clustered and analyzed considering binding energies and main interacting residues in each complex. |
T52 | 5977-5984 | Sentence | denotes | Results |
T53 | 5986-6059 | Sentence | denotes | Homology analysis of the spike proteins of SARS-CoVs and related Bat-CoVs |
T54 | 6060-6179 | Sentence | denotes | Phylogenetic analysis of the spike protein sequences of SARS-CoV-2 and Bat-CoVs, SARS-CoV is shown in Figure 1(Fig. 1). |
T55 | 6180-6467 | Sentence | denotes | The results are in agreement with recent reports of an independent introduction of SARS-CoV-2 from a Bat-CoV, different from the spillover which led to the introduction of SARS-CoV, being the Bat-CoV of Rhinolophus affinis the probable ancestor of this new virus (Wong et al., 2020[18]). |
T56 | 6468-6584 | Sentence | denotes | Indeed, the sequences of the whole spike of this Bat-CoV and of SARS-CoV-2 share 97.7 % identity (Figure 1(Fig. 1)). |
T57 | 6585-6719 | Sentence | denotes | More divergence is found however in the S1 subunit, particularly in the Receptor Binding Domain (RBD) of the different spike proteins. |
T58 | 6720-6925 | Sentence | denotes | SARS-CoV and Bat-CoV from Rhinolophus sinicus (originally signaled as the most closely related virus to SARS-CoV-2) exhibit several amino acid substitutions and deletions in the RBD compared to SARS-CoV-2. |
T59 | 6926-7093 | Sentence | denotes | The RBD of Bat-CoV from Rhinolophus affinis, although more closely related to the one of SAS-CoV-2, also displayed several amino acid substitutions (Figure 2(Fig. 2)). |
T60 | 7095-7138 | Sentence | denotes | Structural analysis of Spike-ACE2 complexes |
T61 | 7139-7380 | Sentence | denotes | The crystal structures of the spike protein of SARS-CoV and homology models of Bat-CoV (accession number MG772933), Bat-CoV of Rhinolophus sinicus, and SARS-CoV-2 interacting with the putative binding domain site in human ACE2 were analyzed. |
T62 | 7381-7453 | Sentence | denotes | The interaction pattern between the three viral spikes is quite similar. |
T63 | 7454-7681 | Sentence | denotes | The main region of interaction with the putative cellular receptor counter-part is formed by fifteen residues ordered into a beta-sheet conformation surrounded by two capping loops (Figure 3(Fig. 3) and Supplementary Figure 1). |
T64 | 7682-7903 | Sentence | denotes | Interestingly, sequence comparison between SARS-CoV-2 and SARS-CoV revealed that the residues present in the receptor-interacting motive are highly conserved with 70 % identity, sharing nine residues between both viruses. |
T65 | 7904-8049 | Sentence | denotes | In the SARS-CoV RBD are present residues that allowed the interspecies infection, known as Y442, L472, N479, D480, and T487 (Lu et al., 2015[6]). |
T66 | 8050-8202 | Sentence | denotes | However, in SARS-CoV-2, slight modification of some residues could improve the interaction with the human cellular receptor: L455, F486, Q493, and N501. |
T67 | 8203-8336 | Sentence | denotes | In SARS-CoV, two main residues (479 and 487) have been associated to the recognition of the human ACE2 receptor (Lu et al., 2015[6]). |
T68 | 8337-8432 | Sentence | denotes | These residues suffered a punctual mutation from civet to human, K479N and S487T (Li, 2013[5]). |
T69 | 8433-8523 | Sentence | denotes | In the SARS-CoV-2, the residues corresponding to N479 correspond to Q493 and T487 to N501. |
T70 | 8524-8636 | Sentence | denotes | These changes in the SARS-CoV-2 represent energetically favorable changes for the interaction with the receptor. |
T71 | 8637-8798 | Sentence | denotes | The local environment present in the ACE2 receptor allows these mutations to produce a significant number of electrostatic stabilizing interactions (Table 1(Tab. |
T72 | 8799-8803 | Sentence | denotes | 1)). |
T73 | 8804-8993 | Sentence | denotes | Furthermore, as mentioned previously, the presence of the two capping loops in the binding domain is likely producing a stabilization effect over the interaction with the cellular receptor. |
T74 | 8994-9108 | Sentence | denotes | Our models showed that these capping loops appear in both human-infecting viruses but are absent in the bat virus. |
T75 | 9109-9278 | Sentence | denotes | The data showed here strongly suggest that these capping loops produce an increase in the electrostatic interactions between the spike protein and the cellular receptor. |
T76 | 9279-9515 | Sentence | denotes | In SARS-CoV, the residues present in these capping loops showing direct interaction with the receptor are R426, S432, T433, Y436, P462, D463, S472, and N473 and in SARS-CoV-2 are V445, Y449, Y473, Q474, A475, E484, G485, F486, and N487. |
T77 | 9516-9588 | Sentence | denotes | The counter-pairs located in the ACE2 receptor are shown in Table 1(Tab. |
T78 | 9589-9592 | Sentence | denotes | 1). |
T79 | 9593-9664 | Sentence | denotes | Altogether, the higher number of protein-protein contacts (Table 2(Tab. |
T80 | 9665-9836 | Sentence | denotes | 2)) and the longer capping loops could explain the increase in binding affinities in SARS-CoV-2 (-15.7 Kcal/mol) in comparison with SARS-CoV (-14.1 Kcal/mol) (Table 3(Tab. |
T81 | 9837-9841 | Sentence | denotes | 3)). |
T82 | 9842-10023 | Sentence | denotes | Thus, these loops could play an important role together with the punctual mutations being an interesting clue to determine the host receptor specificity for the viral spike protein. |
T83 | 10025-10035 | Sentence | denotes | Discussion |
T84 | 10036-10153 | Sentence | denotes | Several amino acid substitutions in RBD were identified in the SARS-CoV-2 RBD compared to Bat-SARS-CoVs and SARS-CoV. |
T85 | 10154-10300 | Sentence | denotes | Mutations in the spike protein could change the tropism of a virus, including new hosts or increasing viral pathogenesis (Shang et al., 2020[13]). |
T86 | 10301-10396 | Sentence | denotes | HIV infection is a good model of change in viral tropism by mutations in the envelope proteins. |
T87 | 10397-10503 | Sentence | denotes | These mutations switch co-receptor use (CCR5 to CXCR4) increasing the viral pathogenesis (Mosier 2009[7]). |
T88 | 10504-10683 | Sentence | denotes | Interestingly, our data showed that these changes are not only related to the ability of interaction with the human ACE2 receptor but also for improving this receptor recognition. |
T89 | 10684-10894 | Sentence | denotes | The presence of two loops around the RBD of SARS-CoV-2 might be promoting the interaction with the ACE2 receptor, improving the binding to this receptor by increasing the number of atoms involved (Tables 1(Tab. |
T90 | 10895-10908 | Sentence | denotes | 1) and 2(Tab. |
T91 | 10909-10913 | Sentence | denotes | 2)). |
T92 | 10914-11069 | Sentence | denotes | The amino acid substitutions and the longer capping loops could explain the increase in binding affinities in SARS-CoV-2 compared to SARS-CoV (Table 1(Tab. |
T93 | 11070-11074 | Sentence | denotes | 1)). |
T94 | 11075-11188 | Sentence | denotes | Higher affinity values might be related to the dynamic of infection and the rapid spread observed for this virus. |
T95 | 11189-11248 | Sentence | denotes | The origin of the SARS-CoV-2 has been not fully elucidated. |
T96 | 11249-11509 | Sentence | denotes | While this study was in course, another study of Wong et al. (2020[18]), showed a high similarity at protein level in the RBD among the coronaviruses isolated from the recent outbreak (SARS-CoV-2), those isolated from pangolin and Rhinolophus affinis (RaTG13). |
T97 | 11510-11681 | Sentence | denotes | The authors also suggest that Pangolin might be the intermediate host, with a 98 % identity with the human virus, at the receptor binding motif, between the bat and human. |
T98 | 11682-11830 | Sentence | denotes | The spike model of RaTG13 is quite similar to that obtained from SARS-CoV and SARS-CoV-2 and the loops in the RBD are also present (data not shown). |
T99 | 11831-11911 | Sentence | denotes | The protein sequence of the receptor binding motif, has 5 important amino acids. |
T100 | 11912-12175 | Sentence | denotes | When comparing the sequence of SARS-CoV-2 with that of the isolated viruses of pangolin and Rhinolophus affinis, 1 and 4 differences are observed respectively in the amino acids considered key for the union with ACE2 (Yan et al., 2020[20]; Wong et al., 2020[18]). |
T101 | 12176-12327 | Sentence | denotes | These differences should mean slightly less favorable binding energies between these viruses with ACE2 compared to the SARS-CoV-2, shown in this study. |
T102 | 12328-12558 | Sentence | denotes | Thus, the loops observed in the spike protein of SARS-CoV-2 could play an important role together with the amino acid substitutions, being an interesting clue to determine the host receptor specificity for the viral spike protein. |
T103 | 12559-12716 | Sentence | denotes | Altogether, structural changes and residues composition in the viral spike protein could be associated with increased infection kinetics and viral spreading. |
T104 | 12717-12901 | Sentence | denotes | Comparative studies to determine the impact in vitro of the mutation and loops in RBD of SARS-CoV and SARS-CoV-2 are required in order to predict possible zoonotic event in the future. |
T105 | 12903-12925 | Sentence | denotes | Supplementary Material |
T106 | 12926-12951 | Sentence | denotes | Supplementary information |
T107 | 12953-13034 | Sentence | denotes | Table 1 Residues involved in the Interaction between viral spike and ACE2 (SARS) |
T108 | 13035-13112 | Sentence | denotes | Table 2 Number of protein-protein contacts (PPC) between CoV spikes and ACE2 |
T109 | 13113-13249 | Sentence | denotes | Table 3 Binding affinity (ΔG) and dissociation constant (Kd) predicted values for the interaction between viral spike and ACE2 receptor |
T110 | 13250-13333 | Sentence | denotes | Figure 1 Phylogenetic analysis of SARS-CoV-2 and other coronavirus spike proteins. |
T111 | 13334-13415 | Sentence | denotes | Phylogenetic tree constructed with Poisson correction and 100 bootstrap replicas. |
T112 | 13416-13468 | Sentence | denotes | The sequences are named with their accession number. |
T113 | 13469-13543 | Sentence | denotes | Percent homology with SARS-CoV-2 spike protein is shown for some proteins. |
T114 | 13544-13664 | Sentence | denotes | Figure 2 Receptor Binding Domain of the spike protein sequence alignment of SARS-CoV-2 and other related Coronaviruses. |
T115 | 13665-13792 | Sentence | denotes | Sequence aligment for the interacting domain of SARS-CoV-2 (MN938384), Bat-CoV (MN996532 and MG772933) and SARS-CoV (NC004718). |
T116 | 13793-13993 | Sentence | denotes | The key amino acids described for the interaction with ACE2 are shown in red, and in blue others amino acid related with the interaction in SARS-CoV2. (Lines (-) = same amino acid, dots (.) =deletion) |
T117 | 13994-14031 | Sentence | denotes | Figure 3 Coronavirus spike proteins. |
T118 | 14032-14148 | Sentence | denotes | The spike proteins in complex with the RBD of ACE2 (dark pink) are shown A) Bat-CoV, B) SARS-CoV, and C) SARS-CoV-2. |
T119 | 14149-14250 | Sentence | denotes | A comparison between the three spike proteins are shown in D and a 45 degree turn is also shown in E. |
T120 | 14251-14375 | Sentence | denotes | The location of the main residues mutated in SARS-CoV (position 479 and 487) and SARS-CoV-2 are shown in F (green and blue). |
MyTest
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32210742-17470909-29811226 | 2425-2427 | 17470909 | denotes | 12 |
32210742-16301204-29811227 | 3866-3867 | 16301204 | denotes | 1 |
32210742-31762727-29811228 | 4679-4680 | 31762727 | denotes | 8 |
32210742-16222654-29811229 | 4780-4782 | 16222654 | denotes | 10 |
32210742-15368917-29811230 | 4826-4827 | 15368917 | denotes | 9 |
32210742-19575467-29811231 | 4879-4881 | 19575467 | denotes | 14 |
32210742-17517781-29811232 | 5080-5082 | 17517781 | denotes | 17 |
32210742-24532726-29811233 | 5725-5727 | 24532726 | denotes | 11 |
32210742-27503228-29811234 | 5849-5851 | 27503228 | denotes | 19 |
32210742-26206723-29811235 | 8045-8046 | 26206723 | denotes | 6 |
32210742-26206723-29811236 | 8332-8333 | 26206723 | denotes | 6 |
32210742-23994189-29811237 | 8428-8429 | 23994189 | denotes | 5 |
32210742-32150576-29811238 | 10295-10297 | 32150576 | denotes | 13 |
32210742-19339951-29811239 | 10499-10500 | 19339951 | denotes | 7 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32210742-17470909-29811226 | 2425-2427 | 17470909 | denotes | 12 |
32210742-16301204-29811227 | 3866-3867 | 16301204 | denotes | 1 |
32210742-31762727-29811228 | 4679-4680 | 31762727 | denotes | 8 |
32210742-16222654-29811229 | 4780-4782 | 16222654 | denotes | 10 |
32210742-15368917-29811230 | 4826-4827 | 15368917 | denotes | 9 |
32210742-19575467-29811231 | 4879-4881 | 19575467 | denotes | 14 |
32210742-17517781-29811232 | 5080-5082 | 17517781 | denotes | 17 |
32210742-24532726-29811233 | 5725-5727 | 24532726 | denotes | 11 |
32210742-27503228-29811234 | 5849-5851 | 27503228 | denotes | 19 |
32210742-26206723-29811235 | 8045-8046 | 26206723 | denotes | 6 |
32210742-26206723-29811236 | 8332-8333 | 26206723 | denotes | 6 |
32210742-23994189-29811237 | 8428-8429 | 23994189 | denotes | 5 |
32210742-32150576-29811238 | 10295-10297 | 32150576 | denotes | 13 |
32210742-19339951-29811239 | 10499-10500 | 19339951 | denotes | 7 |