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PMC:7081066 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
4 78-82 Gene denotes ACE2 Gene:59272
5 30-35 Gene denotes spike Gene:43740568
6 19-29 Species denotes SARS-CoV-2 Tax:2697049
7 72-77 Species denotes human Tax:9606
36 982-986 Gene denotes ACE2 Gene:59272
37 1176-1181 Gene denotes spike Gene:43740568
38 1203-1207 Gene denotes ACE2 Gene:59272
39 1259-1263 Gene denotes ACE2 Gene:59272
40 910-915 Gene denotes spike Gene:43740568
41 1249-1254 Gene denotes spike Gene:43740568
42 976-981 Gene denotes spike Gene:43740568
43 711-716 Gene denotes spike Gene:43740568
44 130-135 Species denotes human Tax:9606
45 269-275 Species denotes people Tax:9606
46 362-368 Species denotes humans Tax:9606
47 621-631 Species denotes SARS-CoV-2 Tax:2697049
48 732-742 Species denotes SARS-CoV-2 Tax:2697049
49 766-771 Species denotes human Tax:9606
50 775-780 Species denotes human Tax:9606
51 965-975 Species denotes SARS-CoV-2 Tax:2697049
52 1077-1080 Species denotes CoV Tax:11118
53 1165-1175 Species denotes SARS-Cov-2 Tax:2697049
54 1197-1202 Species denotes human Tax:9606
55 1245-1248 Species denotes CoV Tax:11118
56 1318-1328 Species denotes SARS-CoV-2 Tax:2697049
57 1332-1338 Species denotes humans Tax:9606
58 136-150 Disease denotes viral diseases MESH:D001102
59 174-182 Disease denotes zoonotic MESH:D015047
60 227-235 Disease denotes zoonotic MESH:D015047
61 349-358 Disease denotes mortality MESH:D003643
62 514-522 Disease denotes zoonotic MESH:D015047
63 592-600 Disease denotes Covid-19 MESH:C000657245
91 1817-1833 Gene denotes envelope protein Gene:64006
92 1857-1862 Gene denotes spike Gene:43740568
93 2084-2115 Gene denotes angiotensin-converting enzyme 2 Gene:59272
94 2117-2121 Gene denotes ACE2 Gene:59272
95 2266-2272 Gene denotes CD209L Gene:10332
96 2314-2318 Gene denotes ACE2 Gene:59272
97 3175-3180 Gene denotes spike Gene:43740568
98 3217-3221 Gene denotes ACE2 Gene:59272
99 1807-1815 Gene denotes membrane Gene:43740571
100 2538-2546 Gene denotes membrane Gene:43740571
101 2055-2060 Gene denotes spike Gene:43740568
102 1800-1805 Gene denotes spike Gene:43740568
103 1354-1399 Species denotes Severe Acute Respiratory Syndrome Coronavirus Tax:694009
104 1401-1409 Species denotes SARS-CoV Tax:694009
105 1448-1459 Species denotes Coronavirus Tax:11118
106 1461-1469 Species denotes MERS-CoV Tax:1335626
107 1500-1517 Species denotes novel Coronavirus Tax:2697049
108 1519-1529 Species denotes SARS-CoV-2 Tax:2697049
109 1545-1558 Species denotes Coronaviridae Tax:11118
110 1573-1588 Species denotes Betacoronavirus Tax:694002
111 2044-2054 Species denotes SARS-CoV-2 Tax:2697049
112 2295-2303 Species denotes SARS-CoV Tax:694009
113 2369-2377 Species denotes SARS-CoV Tax:694009
114 2447-2457 Species denotes SARS-CoV-2 Tax:2697049
115 3164-3174 Species denotes SARS-CoV-2 Tax:2697049
116 3197-3202 Species denotes human Tax:9606
117 2632-2647 Disease denotes viral infection MESH:D001102
122 3464-3469 Gene denotes spike Gene:43740568
123 3566-3571 Gene denotes spike Gene:43740568
124 3487-3496 Species denotes SARS-CoV2 Tax:2697049
125 3595-3600 Gene denotes spike Gene:43740568
138 3665-3670 Gene denotes spike Gene:43740568
139 4038-4043 Gene denotes spike Gene:43740568
140 3979-3984 Gene denotes spike Gene:43740568
141 3684-3694 Species denotes SARS-CoV-2 Tax:2697049
142 3716-3719 Species denotes CoV Tax:11118
143 3968-3978 Species denotes SARS-CoV-2 Tax:2697049
144 4029-4037 Species denotes SARS-CoV Tax:694009
145 4096-4099 Species denotes CoV Tax:11118
146 4255-4263 Chemical denotes Hydrogen MESH:D006859
147 4384-4389 Chemical denotes water MESH:D014867
148 4557-4562 Chemical denotes water MESH:D014867
149 4831-4837 Disease denotes CHARMM
159 5218-5222 Gene denotes ACE2 Gene:59272
160 5494-5498 Gene denotes ACE2 Gene:59272
161 5633-5638 Gene denotes spike Gene:43740568
162 5662-5666 Gene denotes ACE2 Gene:59272
163 5484-5489 Gene denotes spike Gene:43740568
164 5323-5328 Gene denotes spike Gene:43740568
165 5192-5197 Gene denotes spike Gene:43740568
166 5183-5191 Species denotes SARS-CoV Tax:694009
167 5312-5322 Species denotes SARS-CoV-2 Tax:2697049
170 6011-6016 Gene denotes spike Gene:43740568
171 6029-6038 Species denotes SARS-CoVs Tax:694009
193 6089-6094 Gene denotes spike Gene:43740568
194 6704-6709 Gene denotes spike Gene:43740568
195 6503-6508 Gene denotes spike Gene:43740568
196 6116-6126 Species denotes SARS-CoV-2 Tax:2697049
197 6135-6139 Species denotes CoVs Tax:11118
198 6141-6149 Species denotes SARS-CoV Tax:694009
199 6263-6273 Species denotes SARS-CoV-2 Tax:2697049
200 6285-6288 Species denotes CoV Tax:11118
201 6352-6360 Species denotes SARS-CoV Tax:694009
202 6376-6379 Species denotes CoV Tax:11118
203 6383-6402 Species denotes Rhinolophus affinis Tax:59477
204 6521-6524 Species denotes CoV Tax:11118
205 6532-6542 Species denotes SARS-CoV-2 Tax:2697049
206 6720-6728 Species denotes SARS-CoV Tax:694009
207 6737-6740 Species denotes CoV Tax:11118
208 6746-6765 Species denotes Rhinolophus sinicus Tax:89399
209 6824-6834 Species denotes SARS-CoV-2 Tax:2697049
210 6914-6924 Species denotes SARS-CoV-2 Tax:2697049
211 6941-6944 Species denotes CoV Tax:11118
212 6950-6969 Species denotes Rhinolophus affinis Tax:59477
213 7019-7024 Species denotes CoV-2 Tax:2697049
216 7118-7123 Gene denotes Spike Gene:43740568
217 7124-7128 Gene denotes ACE2 Gene:59272
249 7169-7174 Gene denotes spike Gene:43740568
250 7361-7365 Gene denotes ACE2 Gene:59272
251 8301-8305 Gene denotes ACE2 Gene:59272
252 8674-8678 Gene denotes ACE2 Gene:59272
253 9238-9243 Gene denotes spike Gene:43740568
254 9549-9553 Gene denotes ACE2 Gene:59272
255 10009-10014 Gene denotes spike Gene:43740568
256 7186-7194 Species denotes SARS-CoV Tax:694009
257 7222-7225 Species denotes CoV Tax:11118
258 7259-7262 Species denotes CoV Tax:11118
259 7266-7285 Species denotes Rhinolophus sinicus Tax:89399
260 7291-7301 Species denotes SARS-CoV-2 Tax:2697049
261 7355-7360 Species denotes human Tax:9606
262 7725-7735 Species denotes SARS-CoV-2 Tax:2697049
263 7740-7748 Species denotes SARS-CoV Tax:694009
264 7911-7919 Species denotes SARS-CoV Tax:694009
265 8062-8072 Species denotes SARS-CoV-2 Tax:2697049
266 8150-8155 Species denotes human Tax:9606
267 8206-8214 Species denotes SARS-CoV Tax:694009
268 8295-8300 Species denotes human Tax:9606
269 8395-8400 Species denotes human Tax:9606
270 8440-8450 Species denotes SARS-CoV-2 Tax:2697049
271 8545-8555 Species denotes SARS-CoV-2 Tax:2697049
272 9052-9057 Species denotes human Tax:9606
273 9282-9290 Species denotes SARS-CoV Tax:694009
274 9443-9453 Species denotes SARS-CoV-2 Tax:2697049
275 9750-9760 Species denotes SARS-CoV-2 Tax:2697049
276 9797-9805 Species denotes SARS-CoV Tax:694009
277 7975-7984 Disease denotes infection MESH:D007239
278 8402-8407 Mutation denotes K479N p.K479N
279 8412-8417 Mutation denotes S487T p.S487T
294 10171-10176 Gene denotes spike Gene:43740568
295 10437-10441 Gene denotes CCR5 Gene:1234
296 10445-10450 Gene denotes CXCR4 Gene:7852
297 10620-10624 Gene denotes ACE2 Gene:59272
298 10783-10787 Gene denotes ACE2 Gene:59272
299 10099-10109 Species denotes SARS-CoV-2 Tax:2697049
300 10130-10139 Species denotes SARS-CoVs Tax:694009
301 10144-10152 Species denotes SARS-CoV Tax:694009
302 10614-10619 Species denotes human Tax:9606
303 10728-10738 Species denotes SARS-CoV-2 Tax:2697049
304 11024-11034 Species denotes SARS-CoV-2 Tax:2697049
305 11047-11055 Species denotes SARS-CoV Tax:694009
306 10301-10314 Disease denotes HIV infection MESH:D015658
307 11133-11142 Disease denotes infection MESH:D007239
331 12124-12128 Gene denotes ACE2 Gene:59272
332 12274-12278 Gene denotes ACE2 Gene:59272
333 12360-12365 Gene denotes spike Gene:43740568
334 12544-12549 Gene denotes spike Gene:43740568
335 12628-12633 Gene denotes spike Gene:43740568
336 11686-11691 Gene denotes spike Gene:43740568
337 11207-11217 Species denotes SARS-CoV-2 Tax:2697049
338 11385-11398 Species denotes coronaviruses Tax:11118
339 11434-11444 Species denotes SARS-CoV-2 Tax:2697049
340 11480-11499 Species denotes Rhinolophus affinis Tax:59477
341 11611-11616 Species denotes human Tax:9606
342 11675-11680 Species denotes human Tax:9606
343 11747-11755 Species denotes SARS-CoV Tax:694009
344 11760-11770 Species denotes SARS-CoV-2 Tax:2697049
345 11943-11953 Species denotes SARS-CoV-2 Tax:2697049
346 12004-12023 Species denotes Rhinolophus affinis Tax:59477
347 12295-12305 Species denotes SARS-CoV-2 Tax:2697049
348 12377-12387 Species denotes SARS-CoV-2 Tax:2697049
349 12806-12814 Species denotes SARS-CoV Tax:694009
350 12819-12829 Species denotes SARS-CoV-2 Tax:2697049
351 11540-11548 Chemical denotes Pangolin
352 12677-12686 Disease denotes infection MESH:D007239
353 12872-12880 Disease denotes zoonotic MESH:D015047
404 13023-13027 Gene denotes ACE2 Gene:59272
405 13013-13018 Gene denotes spike Gene:43740568
407 13093-13096 Species denotes CoV Tax:11118
411 13226-13231 Gene denotes spike Gene:43740568
412 13236-13240 Gene denotes ACE2 Gene:59272
413 13140-13142 Mutation denotes ΔG c.delG
419 13502-13507 Gene denotes spike Gene:43740568
420 13318-13323 Gene denotes spike Gene:43740568
421 13285-13295 Species denotes SARS-CoV-2 Tax:2697049
422 13306-13317 Species denotes coronavirus Tax:11118
423 13491-13501 Species denotes SARS-CoV-2 Tax:2697049
434 13585-13590 Gene denotes spike Gene:43740568
435 13848-13852 Gene denotes ACE2 Gene:59272
436 13621-13631 Species denotes SARS-CoV-2 Tax:2697049
437 13650-13663 Species denotes Coronaviruses Tax:11118
438 13713-13723 Species denotes SARS-CoV-2 Tax:2697049
439 13740-13743 Species denotes CoV Tax:11118
440 13772-13780 Species denotes SARS-CoV Tax:694009
441 13933-13942 Species denotes SARS-CoV2 Tax:2697049
442 13725-13733 CellLine denotes MN938384 CVCL:U508
443 13745-13753 CellLine denotes MN996532 CVCL:U508
454 14036-14041 Gene denotes spike Gene:43740568
455 14078-14082 Gene denotes ACE2 Gene:59272
456 14180-14185 Gene denotes spike Gene:43740568
457 14004-14015 Species denotes Coronavirus Tax:11118
458 14112-14115 Species denotes CoV Tax:11118
459 14120-14128 Species denotes SARS-CoV Tax:694009
460 14137-14147 Species denotes SARS-CoV-2 Tax:2697049
461 14296-14304 Species denotes SARS-CoV Tax:694009
462 14332-14342 Species denotes SARS-CoV-2 Tax:2697049
463 14016-14021 Gene denotes spike Gene:43740568

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 36-43 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 391-399 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T3 717-724 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 1182-1189 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T5 1716-1719 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 1786-1794 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T7 1826-1833 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T8 1863-1870 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 2061-2069 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T10 2517-2524 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T11 2533-2537 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 2538-2555 Body_part denotes membrane receptor http://purl.org/sig/ont/fma/fma0326969
T13 2739-2746 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 2747-2754 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 3181-3188 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 3203-3207 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T17 3470-3477 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 3520-3527 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 3572-3579 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T20 3601-3608 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 3612-3619 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T22 3671-3678 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 4044-4051 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T24 4082-4086 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T25 4223-4230 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 4346-4353 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 4469-4476 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T28 4477-4485 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T29 4577-4584 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 5137-5144 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T31 5145-5152 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T32 5264-5271 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T33 5342-5349 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T34 5639-5646 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 6017-6025 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T36 6095-6102 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 6710-6718 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T38 6852-6862 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T39 7049-7059 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T40 7175-7182 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T41 9244-9251 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T42 9626-9633 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 9634-9641 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 10015-10022 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T45 10044-10054 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T46 10177-10184 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 10301-10304 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T48 10387-10395 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T49 10918-10928 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T50 11350-11357 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T51 11835-11842 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T52 11899-11910 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T53 12078-12089 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T54 12366-12373 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T55 12435-12445 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T56 12550-12557 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T57 12634-12641 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T58 13054-13061 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T59 13062-13069 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T60 13324-13332 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T61 13508-13515 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T62 13534-13542 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T63 13591-13598 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T64 13801-13812 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T65 13890-13900 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T66 13962-13972 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T67 14022-14030 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T68 14042-14061 Body_part denotes proteins in complex http://purl.org/sig/ont/fma/fma67906
T69 14186-14194 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4082-4086 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p24367s19 1013-1022 NegReg denotes reduction
p24367s22 1030-1044 MPA denotes binding energy
p24456s3 10420-10435 MPA denotes co-receptor use
p24456s14 10467-10485 MPA denotes viral pathogenesis
p24458s16 10748-10757 PosReg denotes promoting
p24458s18 10762-10773 MPA denotes interaction
p24458s24 10798-10807 PosReg denotes improving
p24458s26 10812-10819 MPA denotes binding
p24459s14 11002-11020 MPA denotes binding affinities

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 19-27 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 136-150 Disease denotes viral diseases http://purl.obolibrary.org/obo/MONDO_0005108
T3 621-629 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 732-740 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 965-973 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1165-1169 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 1318-1326 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1354-1387 Disease denotes Severe Acute Respiratory Syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T9 1401-1409 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 1519-1527 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 2035-2039 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T12 2044-2052 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 2295-2303 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 2369-2377 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 2447-2455 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 2632-2647 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T17 2638-2647 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18 3164-3172 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 3487-3491 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T20 3561-3565 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T21 3684-3692 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 3968-3976 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 4029-4037 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 5183-5191 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 5312-5320 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 6029-6033 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T27 6116-6124 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 6141-6149 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 6263-6271 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 6352-6360 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 6532-6540 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 6720-6728 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 6824-6832 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 6914-6922 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 7186-7194 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 7291-7299 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 7725-7733 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 7740-7748 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 7911-7919 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 7975-7984 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 8062-8070 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 8206-8214 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 8440-8448 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 8545-8553 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 9282-9290 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 9443-9451 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 9750-9758 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 9797-9805 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 10099-10107 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 10130-10134 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T51 10144-10152 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 10301-10314 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T53 10305-10314 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 10728-10736 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 11024-11032 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T56 11047-11055 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 11133-11142 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58 11207-11215 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T59 11434-11442 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 11747-11755 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 11760-11768 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 11943-11951 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 12295-12303 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 12377-12385 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 12677-12686 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 12806-12814 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 12819-12827 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 13029-13033 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T69 13080-13083 Disease denotes PPC http://purl.obolibrary.org/obo/MONDO_0015686
T70 13285-13293 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T71 13491-13499 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T72 13621-13629 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 13713-13721 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T74 13772-13780 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 13933-13937 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T76 14120-14128 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 14137-14145 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 14296-14304 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 14332-14340 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 72-77 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T2 130-135 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T3 155-156 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 172-173 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 362-368 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T6 637-640 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T7 766-774 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human to
T8 775-780 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T9 865-867 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T10 1011-1012 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1140-1141 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1197-1202 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T13 1332-1338 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T14 1595-1598 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T15 1672-1679 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T16 1685-1686 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 1733-1735 http://purl.obolibrary.org/obo/CLO_0007074 denotes Kb
T18 1733-1735 http://purl.obolibrary.org/obo/CLO_0051988 denotes Kb
T19 1807-1815 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T20 1923-1924 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 2203-2204 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T22 2533-2537 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T23 2538-2546 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T24 2559-2560 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 3197-3207 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cell
T26 4376-4377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 4382-4383 http://purl.obolibrary.org/obo/CLO_0001020 denotes Å
T28 4617-4619 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T29 4688-4690 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T30 4844-4849 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T31 4982-4984 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T32 5601-5602 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 5725-5727 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T34 6279-6280 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 6437-6442 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T36 6462-6464 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T37 6512-6520 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes this Bat
T38 6625-6627 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T39 6778-6786 http://purl.obolibrary.org/obo/SO_0000418 denotes signaled
T40 6815-6820 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T41 7015-7018 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAS
T42 7355-7360 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T43 7577-7578 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T44 7895-7902 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T45 8150-8155 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T46 8295-8300 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T47 8361-8362 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 8395-8400 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T49 8419-8421 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T50 8419-8421 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T51 8722-8723 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 8922-8923 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 9052-9057 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T54 9068-9075 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T55 9098-9101 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T56 9102-9107 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T57 10213-10214 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 10215-10220 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T59 10318-10319 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 10614-10619 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T61 11182-11187 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T62 11218-11221 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T63 11316-11318 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T64 11329-11330 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 11586-11587 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 11611-11616 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T67 11617-11622 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T68 11667-11670 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T69 11675-11680 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T70 11883-11886 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T71 11980-11987 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T72 12170-12172 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T73 12261-12268 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T74 14042-14061 http://purl.obolibrary.org/obo/GO_0043234 denotes proteins in complex
T75 14105-14106 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T76 14117-14118 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T77 14149-14150 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T78 14214-14215 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 14216-14218 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 36-43 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 391-399 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T3 417-424 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T4 717-724 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T5 1182-1189 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 1786-1794 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T7 1826-1833 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T8 1863-1870 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 2061-2069 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T10 2084-2095 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T11 2517-2524 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 2739-2746 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 2747-2754 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 2880-2886 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T15 3181-3188 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T16 3470-3477 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 3520-3527 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18 3572-3579 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 3601-3608 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 3612-3619 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T21 3671-3678 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 4044-4051 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23 4223-4230 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 4255-4263 Chemical denotes Hydrogen http://purl.obolibrary.org/obo/CHEBI_18276
T25 4264-4269 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T26 4346-4353 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T27 4384-4389 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T28 4469-4476 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T29 4557-4562 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T30 4563-4572 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T31 4577-4584 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 4617-4619 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T33 4688-4690 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T34 4982-4984 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T35 5137-5144 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T36 5145-5152 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37 5264-5271 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T38 5342-5349 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T39 5625-5631 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T40 5639-5646 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 6017-6025 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T42 6095-6102 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 6710-6718 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T44 6852-6862 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T45 6852-6857 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T46 6858-6862 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T47 7049-7059 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T48 7049-7054 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T49 7055-7059 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T50 7175-7182 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T51 7579-7583 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T52 8029-8031 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T53 8316-8318 Chemical denotes Lu http://purl.obolibrary.org/obo/CHEBI_33382
T54 8419-8421 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T55 9244-9251 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56 9626-9633 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T57 9634-9641 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T58 10015-10022 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T59 10044-10054 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T60 10044-10049 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T61 10050-10054 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T62 10177-10184 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T63 10387-10395 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T64 10865-10870 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T65 10918-10928 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T66 10918-10923 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T67 10924-10928 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T68 11350-11357 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 11835-11842 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 11899-11910 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T71 11899-11904 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T72 11905-11910 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T73 12078-12089 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T74 12078-12083 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T75 12084-12089 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T76 12366-12373 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 12435-12445 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T78 12435-12440 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T79 12441-12445 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T80 12550-12557 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 12634-12641 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T82 13054-13061 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T83 13062-13069 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T84 13324-13332 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T85 13508-13515 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T86 13534-13542 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T87 13591-13598 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 13801-13812 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T89 13801-13806 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T90 13807-13812 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T91 13890-13900 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T92 13890-13895 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T93 13896-13900 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T94 13962-13972 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T95 13962-13967 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T96 13968-13972 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T97 14022-14030 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T98 14042-14050 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T99 14186-14194 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 2632-2647 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T2 10202-10209 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T3 10262-10274 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T4 10350-10357 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T5 10445-10450 http://purl.obolibrary.org/obo/GO_0038147 denotes CXCR4
T6 10473-10485 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor:
T2 93-114 Sentence denotes An in silico analysis
T3 116-124 Sentence denotes Abstract
T4 125-189 Sentence denotes Many human viral diseases are a consequence of a zoonotic event.
T5 190-369 Sentence denotes Some of the diseases caused by these zoonotic events have affected millions of people around the world, some of which have resulted in high rates of morbidity/mortality in humans.
T6 370-488 Sentence denotes Changes in the viral proteins that function as ligands of the host receptor may promote the spillover between species.
T7 489-632 Sentence denotes The most recent of these zoonotic events that have caused an ongoing epidemic of high magnitude is the Covid-19 epidemics caused by SARS-CoV-2.
T8 633-794 Sentence denotes The aim of this study was to determine the mutation(s) in the sequence of the spike protein of the SARS-CoV-2 that might be favoring human to human transmission.
T9 795-916 Sentence denotes An in silico approach was performed, and changes were detected in the S1 subunit of the receptor-binding domain of spike.
T10 917-1098 Sentence denotes The observed changes have significant effect on SARS-CoV-2 spike/ACE2 interaction and produce a reduction in the binding energy, compared to the one of the Bat-CoV to this receptor.
T11 1099-1264 Sentence denotes The data presented in this study suggest a higher affinity of the SARS-Cov-2 spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike and ACE2.
T12 1265-1339 Sentence denotes This could be the cause of the rapid viral spread of SARS-CoV-2 in humans.
T13 1341-1353 Sentence denotes Introduction
T14 1354-1651 Sentence denotes Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and the recently identified novel Coronavirus (SARS-CoV-2) belong to the Coronaviridae family, genus Betacoronavirus, that has been related to important epidemiological outbreaks.
T15 1652-1736 Sentence denotes These are enveloped viruses with a positive-sense single-strand RNA of around 32 Kb.
T16 1737-1852 Sentence denotes The viral particles contain four main structural proteins: the spike, membrane, envelope protein, and nucleocapsid.
T17 1853-1995 Sentence denotes The spike protein protrudes from the envelope of the virion and plays a pivotal role in the receptor host selectivity and cellular attachment.
T18 1996-2166 Sentence denotes Strong scientific evidence showed that SARS and SARS-CoV-2 spike proteins interact with angiotensin-converting enzyme 2 (ACE2) (Chen et al 2020[2]; Wan et al., 2020[16]).
T19 2167-2304 Sentence denotes Also, other cellular receptors play a secondary role in the viral attachment, as the C-type lectin CD209L, and DC-SIGN binds to SARS-CoV.
T20 2305-2600 Sentence denotes However, ACE2 appears to be the key functional receptor for the SARS-CoV (Coutard et al., 2020[3]; Satija and Lal, 2007[12]) and probably for SARS-CoV-2 (Walls et al., 2020[15]) The interaction between the viral protein and its cell membrane receptor is a critical step in the replication cycle.
T21 2601-2686 Sentence denotes Furthermore, the efficiency of viral infection is strongly dependent on this process.
T22 2687-2768 Sentence denotes Several physicochemical factors are associated with protein-protein interactions.
T23 2769-2900 Sentence denotes These factors are determined by the nature of residues and the type of chemical interactions occurring between ligand and receptor.
T24 2901-3066 Sentence denotes Thus, the presence of residues that produce an energetically favored interaction (lower free energy) may drive binding kinetics and finally lead to the fusion event.
T25 3067-3222 Sentence denotes Based on that, this study aimed to evaluate the energetic profile of the interaction between the SARS-CoV-2 spike protein and the human cell receptor ACE2.
T26 3224-3245 Sentence denotes Materials and Methods
T27 3247-3264 Sentence denotes Sequence analysis
T28 3265-3402 Sentence denotes Sequences analyzed were individually retrieved from GenBank (accession numbers are shown in the phylogenetic tree, see Figure 1(Fig. 1)).
T29 3403-3610 Sentence denotes The sequence used for the modeling process and construct the spike protein model of SARS-CoV2 were obtained from the protein database and correspond to 6ACC (SARS spike protein) and 6ACD (Bat-spike protein).
T30 3612-3628 Sentence denotes Protein modeling
T31 3629-3870 Sentence denotes Homology structural models of viral spike protein from SARS-CoV-2 (QHO62112.1) and Bat-CoV (AAZ67052.1) were built by using the tools of the SWISS-MODEL modeling server and the DeepView/Swiss-PdbViewer 4.01 software (Arnold et al., 2006[1]).
T32 3871-3948 Sentence denotes Several models were obtained and the quality of each structure was evaluated.
T33 3949-4068 Sentence denotes The best model for SARS-CoV-2 spike was obtained using the crystal structure of SARS-CoV spike protein (PDB code 6ACC).
T34 4069-4183 Sentence denotes On the other hand, for Bat-CoV, the best model was obtained using as template the crystal structure PDB code 6ACD.
T35 4184-4254 Sentence denotes These models were subjected to further protein structure optimization.
T36 4255-4341 Sentence denotes Hydrogen atoms were added and the partial charges were assigned for energy refinement.
T37 4342-4394 Sentence denotes The protein model was embedded in a 100 Å water box.
T38 4395-4585 Sentence denotes Then, energy minimization was performed while applying constraints to the protein backbone to preserve global folding and optimizing the relative position of the water molecules and protein.
T39 4586-4683 Sentence denotes The obtained systems underwent MD simulations using NAMD as described by Ortega et al. (2019[8]).
T40 4684-4830 Sentence denotes All MD simulations described in this study were performed with NAMD 2.12 (Phillips et al., 2005[10]), Vega ZZ 3.1.0.21 (Pedretti et al., 2004[9]).
T41 4831-4916 Sentence denotes CHARMM force field (Vanommeslaeghe et al., 2010[14]) and Gasteiger charges were used.
T42 4917-4997 Sentence denotes The obtained structures represent the lowest energy frame of the MD simulations.
T43 4998-5135 Sentence denotes The quality of the models was established with ProSA (Wiederstein and Sippl, 2007[17]) and PROCHECK programs (Laskowski et al., 1993[4]).
T44 5137-5160 Sentence denotes Protein-protein docking
T45 5161-5282 Sentence denotes Crystal structure for SARS-CoV spike (PDB code 6ACK) and ACE2 (PDB code 1R42) were downloaded from the Protein Data Bank.
T46 5283-5341 Sentence denotes Also, the homology model for SARS-CoV-2 spike was assayed.
T47 5342-5397 Sentence denotes Protein preparation was carried out as described above.
T48 5398-5547 Sentence denotes Then, binding patterns and affinity estimations for the interaction between the viral spike and ACE2 receptor were performed using molecular docking.
T49 5548-5730 Sentence denotes This process was performed through two steps; first, a blind docking between ligand (spike protein) and receptor (ACE2) was performed using Z-dock software (Pierce et al., 2014[11]).
T50 5731-5854 Sentence denotes Then, the resulting docking data were processed and analyzed by using the tools of PRODIGY software (Xue et al., 2016[19]).
T51 5855-5975 Sentence denotes Finally, results were clustered and analyzed considering binding energies and main interacting residues in each complex.
T52 5977-5984 Sentence denotes Results
T53 5986-6059 Sentence denotes Homology analysis of the spike proteins of SARS-CoVs and related Bat-CoVs
T54 6060-6179 Sentence denotes Phylogenetic analysis of the spike protein sequences of SARS-CoV-2 and Bat-CoVs, SARS-CoV is shown in Figure 1(Fig. 1).
T55 6180-6467 Sentence denotes The results are in agreement with recent reports of an independent introduction of SARS-CoV-2 from a Bat-CoV, different from the spillover which led to the introduction of SARS-CoV, being the Bat-CoV of Rhinolophus affinis the probable ancestor of this new virus (Wong et al., 2020[18]).
T56 6468-6584 Sentence denotes Indeed, the sequences of the whole spike of this Bat-CoV and of SARS-CoV-2 share 97.7 % identity (Figure 1(Fig. 1)).
T57 6585-6719 Sentence denotes More divergence is found however in the S1 subunit, particularly in the Receptor Binding Domain (RBD) of the different spike proteins.
T58 6720-6925 Sentence denotes SARS-CoV and Bat-CoV from Rhinolophus sinicus (originally signaled as the most closely related virus to SARS-CoV-2) exhibit several amino acid substitutions and deletions in the RBD compared to SARS-CoV-2.
T59 6926-7093 Sentence denotes The RBD of Bat-CoV from Rhinolophus affinis, although more closely related to the one of SAS-CoV-2, also displayed several amino acid substitutions (Figure 2(Fig. 2)).
T60 7095-7138 Sentence denotes Structural analysis of Spike-ACE2 complexes
T61 7139-7380 Sentence denotes The crystal structures of the spike protein of SARS-CoV and homology models of Bat-CoV (accession number MG772933), Bat-CoV of Rhinolophus sinicus, and SARS-CoV-2 interacting with the putative binding domain site in human ACE2 were analyzed.
T62 7381-7453 Sentence denotes The interaction pattern between the three viral spikes is quite similar.
T63 7454-7681 Sentence denotes The main region of interaction with the putative cellular receptor counter-part is formed by fifteen residues ordered into a beta-sheet conformation surrounded by two capping loops (Figure 3(Fig. 3) and Supplementary Figure 1).
T64 7682-7903 Sentence denotes Interestingly, sequence comparison between SARS-CoV-2 and SARS-CoV revealed that the residues present in the receptor-interacting motive are highly conserved with 70 % identity, sharing nine residues between both viruses.
T65 7904-8049 Sentence denotes In the SARS-CoV RBD are present residues that allowed the interspecies infection, known as Y442, L472, N479, D480, and T487 (Lu et al., 2015[6]).
T66 8050-8202 Sentence denotes However, in SARS-CoV-2, slight modification of some residues could improve the interaction with the human cellular receptor: L455, F486, Q493, and N501.
T67 8203-8336 Sentence denotes In SARS-CoV, two main residues (479 and 487) have been associated to the recognition of the human ACE2 receptor (Lu et al., 2015[6]).
T68 8337-8432 Sentence denotes These residues suffered a punctual mutation from civet to human, K479N and S487T (Li, 2013[5]).
T69 8433-8523 Sentence denotes In the SARS-CoV-2, the residues corresponding to N479 correspond to Q493 and T487 to N501.
T70 8524-8636 Sentence denotes These changes in the SARS-CoV-2 represent energetically favorable changes for the interaction with the receptor.
T71 8637-8798 Sentence denotes The local environment present in the ACE2 receptor allows these mutations to produce a significant number of electrostatic stabilizing interactions (Table 1(Tab.
T72 8799-8803 Sentence denotes 1)).
T73 8804-8993 Sentence denotes Furthermore, as mentioned previously, the presence of the two capping loops in the binding domain is likely producing a stabilization effect over the interaction with the cellular receptor.
T74 8994-9108 Sentence denotes Our models showed that these capping loops appear in both human-infecting viruses but are absent in the bat virus.
T75 9109-9278 Sentence denotes The data showed here strongly suggest that these capping loops produce an increase in the electrostatic interactions between the spike protein and the cellular receptor.
T76 9279-9515 Sentence denotes In SARS-CoV, the residues present in these capping loops showing direct interaction with the receptor are R426, S432, T433, Y436, P462, D463, S472, and N473 and in SARS-CoV-2 are V445, Y449, Y473, Q474, A475, E484, G485, F486, and N487.
T77 9516-9588 Sentence denotes The counter-pairs located in the ACE2 receptor are shown in Table 1(Tab.
T78 9589-9592 Sentence denotes 1).
T79 9593-9664 Sentence denotes Altogether, the higher number of protein-protein contacts (Table 2(Tab.
T80 9665-9836 Sentence denotes 2)) and the longer capping loops could explain the increase in binding affinities in SARS-CoV-2 (-15.7 Kcal/mol) in comparison with SARS-CoV (-14.1 Kcal/mol) (Table 3(Tab.
T81 9837-9841 Sentence denotes 3)).
T82 9842-10023 Sentence denotes Thus, these loops could play an important role together with the punctual mutations being an interesting clue to determine the host receptor specificity for the viral spike protein.
T83 10025-10035 Sentence denotes Discussion
T84 10036-10153 Sentence denotes Several amino acid substitutions in RBD were identified in the SARS-CoV-2 RBD compared to Bat-SARS-CoVs and SARS-CoV.
T85 10154-10300 Sentence denotes Mutations in the spike protein could change the tropism of a virus, including new hosts or increasing viral pathogenesis (Shang et al., 2020[13]).
T86 10301-10396 Sentence denotes HIV infection is a good model of change in viral tropism by mutations in the envelope proteins.
T87 10397-10503 Sentence denotes These mutations switch co-receptor use (CCR5 to CXCR4) increasing the viral pathogenesis (Mosier 2009[7]).
T88 10504-10683 Sentence denotes Interestingly, our data showed that these changes are not only related to the ability of interaction with the human ACE2 receptor but also for improving this receptor recognition.
T89 10684-10894 Sentence denotes The presence of two loops around the RBD of SARS-CoV-2 might be promoting the interaction with the ACE2 receptor, improving the binding to this receptor by increasing the number of atoms involved (Tables 1(Tab.
T90 10895-10908 Sentence denotes 1) and 2(Tab.
T91 10909-10913 Sentence denotes 2)).
T92 10914-11069 Sentence denotes The amino acid substitutions and the longer capping loops could explain the increase in binding affinities in SARS-CoV-2 compared to SARS-CoV (Table 1(Tab.
T93 11070-11074 Sentence denotes 1)).
T94 11075-11188 Sentence denotes Higher affinity values might be related to the dynamic of infection and the rapid spread observed for this virus.
T95 11189-11248 Sentence denotes The origin of the SARS-CoV-2 has been not fully elucidated.
T96 11249-11509 Sentence denotes While this study was in course, another study of Wong et al. (2020[18]), showed a high similarity at protein level in the RBD among the coronaviruses isolated from the recent outbreak (SARS-CoV-2), those isolated from pangolin and Rhinolophus affinis (RaTG13).
T97 11510-11681 Sentence denotes The authors also suggest that Pangolin might be the intermediate host, with a 98 % identity with the human virus, at the receptor binding motif, between the bat and human.
T98 11682-11830 Sentence denotes The spike model of RaTG13 is quite similar to that obtained from SARS-CoV and SARS-CoV-2 and the loops in the RBD are also present (data not shown).
T99 11831-11911 Sentence denotes The protein sequence of the receptor binding motif, has 5 important amino acids.
T100 11912-12175 Sentence denotes When comparing the sequence of SARS-CoV-2 with that of the isolated viruses of pangolin and Rhinolophus affinis, 1 and 4 differences are observed respectively in the amino acids considered key for the union with ACE2 (Yan et al., 2020[20]; Wong et al., 2020[18]).
T101 12176-12327 Sentence denotes These differences should mean slightly less favorable binding energies between these viruses with ACE2 compared to the SARS-CoV-2, shown in this study.
T102 12328-12558 Sentence denotes Thus, the loops observed in the spike protein of SARS-CoV-2 could play an important role together with the amino acid substitutions, being an interesting clue to determine the host receptor specificity for the viral spike protein.
T103 12559-12716 Sentence denotes Altogether, structural changes and residues composition in the viral spike protein could be associated with increased infection kinetics and viral spreading.
T104 12717-12901 Sentence denotes Comparative studies to determine the impact in vitro of the mutation and loops in RBD of SARS-CoV and SARS-CoV-2 are required in order to predict possible zoonotic event in the future.
T105 12903-12925 Sentence denotes Supplementary Material
T106 12926-12951 Sentence denotes Supplementary information
T107 12953-13034 Sentence denotes Table 1 Residues involved in the Interaction between viral spike and ACE2 (SARS)
T108 13035-13112 Sentence denotes Table 2 Number of protein-protein contacts (PPC) between CoV spikes and ACE2
T109 13113-13249 Sentence denotes Table 3 Binding affinity (ΔG) and dissociation constant (Kd) predicted values for the interaction between viral spike and ACE2 receptor
T110 13250-13333 Sentence denotes Figure 1 Phylogenetic analysis of SARS-CoV-2 and other coronavirus spike proteins.
T111 13334-13415 Sentence denotes Phylogenetic tree constructed with Poisson correction and 100 bootstrap replicas.
T112 13416-13468 Sentence denotes The sequences are named with their accession number.
T113 13469-13543 Sentence denotes Percent homology with SARS-CoV-2 spike protein is shown for some proteins.
T114 13544-13664 Sentence denotes Figure 2 Receptor Binding Domain of the spike protein sequence alignment of SARS-CoV-2 and other related Coronaviruses.
T115 13665-13792 Sentence denotes Sequence aligment for the interacting domain of SARS-CoV-2 (MN938384), Bat-CoV (MN996532 and MG772933) and SARS-CoV (NC004718).
T116 13793-13993 Sentence denotes The key amino acids described for the interaction with ACE2 are shown in red, and in blue others amino acid related with the interaction in SARS-CoV2. (Lines (-) = same amino acid, dots (.) =deletion)
T117 13994-14031 Sentence denotes Figure 3 Coronavirus spike proteins.
T118 14032-14148 Sentence denotes The spike proteins in complex with the RBD of ACE2 (dark pink) are shown A) Bat-CoV, B) SARS-CoV, and C) SARS-CoV-2.
T119 14149-14250 Sentence denotes A comparison between the three spike proteins are shown in D and a 45 degree turn is also shown in E.
T120 14251-14375 Sentence denotes The location of the main residues mutated in SARS-CoV (position 479 and 487) and SARS-CoV-2 are shown in F (green and blue).

MyTest

Id Subject Object Predicate Lexical cue
32210742-17470909-29811226 2425-2427 17470909 denotes 12
32210742-16301204-29811227 3866-3867 16301204 denotes 1
32210742-31762727-29811228 4679-4680 31762727 denotes 8
32210742-16222654-29811229 4780-4782 16222654 denotes 10
32210742-15368917-29811230 4826-4827 15368917 denotes 9
32210742-19575467-29811231 4879-4881 19575467 denotes 14
32210742-17517781-29811232 5080-5082 17517781 denotes 17
32210742-24532726-29811233 5725-5727 24532726 denotes 11
32210742-27503228-29811234 5849-5851 27503228 denotes 19
32210742-26206723-29811235 8045-8046 26206723 denotes 6
32210742-26206723-29811236 8332-8333 26206723 denotes 6
32210742-23994189-29811237 8428-8429 23994189 denotes 5
32210742-32150576-29811238 10295-10297 32150576 denotes 13
32210742-19339951-29811239 10499-10500 19339951 denotes 7

2_test

Id Subject Object Predicate Lexical cue
32210742-17470909-29811226 2425-2427 17470909 denotes 12
32210742-16301204-29811227 3866-3867 16301204 denotes 1
32210742-31762727-29811228 4679-4680 31762727 denotes 8
32210742-16222654-29811229 4780-4782 16222654 denotes 10
32210742-15368917-29811230 4826-4827 15368917 denotes 9
32210742-19575467-29811231 4879-4881 19575467 denotes 14
32210742-17517781-29811232 5080-5082 17517781 denotes 17
32210742-24532726-29811233 5725-5727 24532726 denotes 11
32210742-27503228-29811234 5849-5851 27503228 denotes 19
32210742-26206723-29811235 8045-8046 26206723 denotes 6
32210742-26206723-29811236 8332-8333 26206723 denotes 6
32210742-23994189-29811237 8428-8429 23994189 denotes 5
32210742-32150576-29811238 10295-10297 32150576 denotes 13
32210742-19339951-29811239 10499-10500 19339951 denotes 7