PMC:7079862 / 21388-22484
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7079862","sourcedb":"PMC","sourceid":"7079862","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7079862","text":"Macrolide antibiotics, due to putative anti-inflammatory and possible antiviral effects, have been studied in patients with RVIs but with inconsistent results. In an open-label RCT of hospitalized patients with influenza (n = 107), early combination therapy with clarithromycin, naproxen, and oseltamivir was associated with reduced mortality and hospital length of stay compared to oseltamivir monotherapy [22]. On the other hand, in a multicenter observational study (n = 733), macrolides were not associated with improved survival in critically ill patients with influenza A(H1N1)pdm09 [23]. In patients with MERS (n = 349), macrolide therapy is not associated with a reduction in 90-day mortality or improvement in MERS-CoV RNA clearance [24]. A study of clarithromycin combined with the cyclooxygenase inhibitor flufenamic acid in hospitalized patients with influenza is underway (NCT03238612). In addition, macrolides are also examined in one of the domains of the REMAP-CAP trial (Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia, 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