> top > docs > PMC:7079563 > spans > 15532-20186 > annotations

PMC:7079563 / 15532-20186 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
482 1687-1691 Gene denotes ACE2 Gene:59272
483 1765-1768 Gene denotes Cat Gene:12359
484 2649-2652 Gene denotes Cat Gene:12359
485 1692-1712 Species denotes African green monkey Tax:9534
486 1724-1734 Species denotes R. sinicus Tax:89399
487 1736-1741 Species denotes Swine Tax:9823
488 1742-1758 Species denotes Malayan pangolin Tax:9974
489 1759-1764 Species denotes Mouse Tax:10090
490 1769-1774 Species denotes Camel Tax:9837
491 1780-1789 Species denotes Bos mutus Tax:72004
492 1790-1809 Species denotes Erinaceus europaeus Tax:9365
493 1810-1825 Species denotes Cavia porcellus Tax:10141
494 1826-1848 Species denotes Phascolarctos cinereus Tax:38626
495 1849-1869 Species denotes Sarcophilus harrisii Tax:9305
496 1870-1881 Species denotes Tiger Snake Tax:8663
497 1882-1893 Species denotes Parus major Tax:9157
498 1894-1907 Species denotes Gallus gallus Tax:9031
499 1908-1913 Species denotes Human Tax:9606
500 2016-2036 Species denotes African green monkey Tax:9534
501 2237-2247 Species denotes R. sinicus Tax:89399
502 2339-2344 Species denotes Swine Tax:9823
503 2436-2452 Species denotes Malayan pangolin Tax:9974
504 2548-2553 Species denotes Mouse Tax:10090
505 2748-2753 Species denotes Camel Tax:9837
506 2947-2956 Species denotes Bos mutus Tax:72004
507 3050-3069 Species denotes Erinaceus europaeus Tax:9365
508 3165-3180 Species denotes Cavia porcellus Tax:10141
509 3275-3297 Species denotes Phascolarctos cinereus Tax:38626
510 3393-3413 Species denotes Sarcophilus harrisii Tax:9305
511 3509-3520 Species denotes Tiger Snake Tax:8663
512 3611-3622 Species denotes Parus major Tax:9157
513 3712-3725 Species denotes Gallus gallus Tax:9031
515 1594-1598 Gene denotes ACE2 Gene:59272
530 4014-4017 Gene denotes cat Gene:12359
531 3839-3844 Species denotes human Tax:9606
532 3906-3915 Species denotes R.sinicus Tax:89399
533 3931-3936 Species denotes swine Tax:9823
534 3955-3971 Species denotes Malayan pangolin Tax:9974
535 3990-3995 Species denotes mouse Tax:10090
536 4036-4041 Species denotes camel Tax:9837
537 4083-4092 Species denotes Bos mutus Tax:72004
538 4111-4130 Species denotes Erinaceus europaeus Tax:9365
539 4149-4171 Species denotes Phascolarctos cinereus Tax:38626
540 4190-4210 Species denotes Sarcophilus harrisii Tax:9305
541 4229-4240 Species denotes tiger Snake Tax:8663
542 4259-4270 Species denotes Parus major Tax:9157
543 4289-4302 Species denotes Gallus gallus Tax:9031
547 4349-4353 Gene denotes ACE2 Gene:59272
548 4359-4365 Species denotes humans Tax:9606
549 4478-4484 Species denotes humans Tax:9606
588 153-158 Gene denotes spike Gene:43740568
589 234-239 Gene denotes furin Gene:5045
590 317-322 Gene denotes Spike Gene:43740568
591 540-545 Gene denotes spike Gene:43740568
592 858-862 Gene denotes ACE2 Gene:59272
593 905-909 Gene denotes ACE2 Gene:59272
594 967-971 Gene denotes ACE2 Gene:100144303
595 986-990 Gene denotes ACE2 Gene:70008
596 1048-1052 Gene denotes ACE2 Gene:59272
597 1227-1231 Gene denotes ACE2 Gene:70008
598 1257-1261 Gene denotes ACE2 Gene:59272
599 1303-1308 Gene denotes spike Gene:43740568
600 1341-1345 Gene denotes ACE2 Gene:59272
601 1359-1363 Gene denotes ACE2 Gene:59272
602 1369-1373 Gene denotes ACE2 Gene:59272
603 1434-1438 Gene denotes ACE2 Gene:59272
604 1450-1454 Gene denotes ACE2 Gene:59272
605 1365-1368 Gene denotes cat Gene:847
606 53-66 Species denotes coronaviruses Tax:11118
607 335-340 Species denotes clove Tax:219868
608 523-534 Species denotes coronavirus Tax:694448
609 668-679 Species denotes coronavirus Tax:694448
610 813-822 Species denotes 2019-nCoV Tax:2697049
611 867-875 Species denotes SARS-CoV Tax:694009
612 899-904 Species denotes human Tax:9606
613 911-920 Species denotes 2019-nCoV Tax:2697049
614 937-951 Species denotes horseshoe bats Tax:49442
615 963-966 Species denotes pig Tax:9823
616 980-985 Species denotes mouse Tax:10090
617 1042-1047 Species denotes human Tax:9606
618 1084-1098 Species denotes horseshoe bats Tax:49442
619 1107-1110 Species denotes pig Tax:9823
620 1115-1120 Species denotes mouse Tax:10090
621 1221-1226 Species denotes mouse Tax:10090
622 1251-1256 Species denotes human Tax:9606
623 1335-1340 Species denotes human Tax:9606
624 1428-1433 Species denotes human Tax:9606
625 1497-1506 Species denotes 2019-nCoV Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T25 85-89 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 159-166 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 297-315 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T28 511-519 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T29 546-553 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 576-586 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T31 837-841 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T32 1560-1570 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T33 1663-1673 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T34 4435-4445 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T68 867-875 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 1780-1783 Disease denotes Bos http://purl.obolibrary.org/obo/MONDO_0008157
T70 2947-2950 Disease denotes Bos http://purl.obolibrary.org/obo/MONDO_0008157
T71 4083-4086 Disease denotes Bos http://purl.obolibrary.org/obo/MONDO_0008157

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T89 85-89 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T90 306-315 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T91 326-327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 409-411 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T93 469-470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 482-484 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T95 482-484 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T96 554-557 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T97 659-664 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T98 703-705 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T99 718-719 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 837-841 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T101 899-904 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T102 947-951 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T103 980-985 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T104 1042-1047 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T105 1053-1056 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T106 1094-1098 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T107 1115-1120 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T108 1221-1226 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T109 1251-1256 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T110 1335-1340 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T111 1428-1433 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T112 1706-1712 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T113 1759-1764 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T114 1769-1774 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes Camel
T115 1775-1779 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes Goat
T116 1810-1825 http://purl.obolibrary.org/obo/NCBITaxon_10141 denotes Cavia porcellus
T117 1894-1907 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Gallus gallus
T118 1908-1913 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T119 2030-2036 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T120 2548-2553 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T121 2748-2753 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes Camel
T122 2848-2852 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes Goat
T123 3165-3180 http://purl.obolibrary.org/obo/NCBITaxon_10141 denotes Cavia porcellus
T124 3712-3725 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Gallus gallus
T125 3839-3844 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T126 3860-3866 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T127 3901-3904 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T128 3990-3995 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T129 4036-4041 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camel
T130 4060-4064 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T131 4289-4302 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Gallus gallus
T132 4359-4365 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T133 4370-4372 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T134 4379-4386 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T135 4478-4484 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T136 4495-4502 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T13 159-166 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 182-186 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T15 482-484 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T16 511-519 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T17 546-553 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18 576-586 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T19 576-581 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T20 582-586 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T21 1365-1368 Chemical denotes cat http://purl.obolibrary.org/obo/CHEBI_32402
T22 1560-1570 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T23 1560-1565 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T24 1566-1570 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T25 1663-1673 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T26 1663-1668 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T27 1669-1673 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T28 4014-4017 Chemical denotes cat http://purl.obolibrary.org/obo/CHEBI_32402
T29 4435-4445 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T30 4435-4440 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T31 4441-4445 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4 197-208 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T117 0-32 Sentence denotes 3.2 Receptor usage of 2019-nCoV
T118 33-114 Sentence denotes The prerequisite of coronaviruses invading the host-cell is to bind to receptors.
T119 115-316 Sentence denotes Following receptor binding, the viral spike protein is cleaved via acid-dependent proteolysis by cathepsin, TMPRRS2 or furin protease, followed by fusion of the viral envelop to the cellular membranes.
T120 317-492 Sentence denotes Spike is a large, clove-shaped trimer, which can be cleaved by proteases into an N-terminal S1 subunit containing the receptor binding domain (RBD) and a C-terminal S2 region.
T121 493-783 Sentence denotes Compared to other proteins of coronavirus, the spike protein has the most variable amino acid sequences which results from the strongest positive selection among all genes of coronavirus to adapt to its hosts [27].The RBD is a major determinant of host range and cross-species transmission.
T122 784-890 Sentence denotes Recently results showed that 2019-nCoV uses the same cell entry receptor, ACE2, as SARS-CoV [21,24,20,28].
T123 891-1017 Sentence denotes Besides human ACE2, 2019-nCoV can use Chinese horseshoe bats, civet, or pig ACE2 but not mouse ACE2 as an entry receptor [24].
T124 1018-1314 Sentence denotes One explanation is that human ACE2 has high homology with Chinese horseshoe bats, civet, pig and mouse, which are 80.75%, 83.48%, 81.37%, 82.11% respectively (Table 2 ), while the residues 82 and 353 of mouse ACE2 are different from human ACE2 which are important residues for bind to spike [29].
T125 1315-1411 Sentence denotes But the homology of human ACE2 and pangolin ACE2, cat ACE2 are also high with 84.84% and 85.22%.
T126 1412-1484 Sentence denotes The homology of human ACE2 with other ACE2 varies from 59.73% to 83.23%.
T127 1485-1538 Sentence denotes In summary, 2019-nCoV may have extensive host ranges.
T128 1539-1547 Sentence denotes Fig. 2 .
T129 1548-1623 Sentence denotes Table 2 The amino acid sequence identities of ACE2 among different species.
T130 1624-1691 Sentence denotes Species Pairwise identities (%) of the amino acid sequences of ACE2
T131 1692-1907 Sentence denotes African green monkey Civet Bat (R. sinicus) Swine Malayan pangolin Mouse Cat Camel Goat Bos mutus Erinaceus europaeus Cavia porcellus Phascolarctos cinereus Sarcophilus harrisii Tiger Snake Parus major Gallus gallus
T132 1908-2015 Sentence denotes Human 93.93 83.48 80.75 81.37 84.84 82.11 85.22 83.23 81.61 81.24 79.01 77.29 71.17 70.51 59.73 67.08 65.31
T133 2016-2131 Sentence denotes African green monkey 81.78 79.93 79.93 83.77 81.78 83.15 81.91 81.41 80.92 77.94 76.85 70.38 69.84 59.21 65.6 64.13
T134 2132-2231 Sentence denotes Civet 81.78 81.49 82.73 85.59 81.61 93.29 83.85 81.86 81.74 79.75 75.55 71.66 71.63 59.6 67.44 66.3
T135 2232-2338 Sentence denotes Bat (R. sinicus) 79.93 81.49 80 82.86 78.26 83.73 81.37 80.37 80 78.51 74.56 69.68 70.02 58.61 65.11 65.19
T136 2339-2435 Sentence denotes Swine 79.93 82.73 80 82.61 80.62 83.98 89.81 87.7 87.58 77.64 75.3 71.17 71.01 61.09 66.95 65.56
T137 2436-2547 Sentence denotes Malayan pangolin 83.77 85.59 82.86 82.61 82.73 87.33 84.72 82.11 81.86 80.87 77.17 71.66 70.89 59.6 67.44 65.07
T138 2548-2648 Sentence denotes Mouse 81.78 81.61 78.26 80.62 82.73 81.74 80.99 80.12 80.37 78.63 78.16 71.05 71.13 61.21 67.2 66.17
T139 2649-2747 Sentence denotes Cat 83.15 93.29 83.73 83.98 87.33 81.74 85.71 83.23 83.11 81.49 76.42 72.65 72.25 59.6 67.81 66.79
T140 2748-2847 Sentence denotes Camel 81.91 83.85 81.37 89.81 84.72 80.99 85.71 88.2 88.57 79.25 77.29 71.79 72.12 61.34 67.2 66.42
T141 2848-2946 Sentence denotes Goat 81.41 81.86 80.37 87.7 82.11 80.12 83.23 88.2 97.76 78.14 76.54 72.04 71.38 60.84 66.09 65.44
T142 2947-3049 Sentence denotes Bos mutus 80.92 81.74 80 87.58 81.86 80.37 83.11 88.57 97.76 78.39 77.04 71.42 71.01 61.09 66.09 65.31
T143 3050-3164 Sentence denotes Erinaceus europaeus 77.94 79.75 78.51 77.64 80.87 78.63 81.49 79.25 78.14 78.39 74.56 70.67 69.65 60.59 68.8 66.42
T144 3165-3274 Sentence denotes Cavia porcellus 76.85 75.55 74.56 75.3 77.17 78.16 76.42 77.29 76.54 77.04 74.56 66.61 66.82 59.38 63.9 63.12
T145 3275-3392 Sentence denotes Phascolarctos cinereus 70.38 71.66 69.68 71.17 71.66 71.05 72.65 71.79 72.04 71.42 70.67 66.61 81.92 60.7 67.08 64.83
T146 3393-3508 Sentence denotes Sarcophilus harrisii 69.84 71.63 70.02 71.01 70.89 71.13 72.25 72.12 71.38 71.01 69.65 66.82 81.92 60.9 64.62 63.84
T147 3509-3610 Sentence denotes Tiger Snake 59.21 59.6 58.61 61.09 59.6 61.21 59.6 61.34 60.84 61.09 60.59 59.38 60.7 60.9 64.5 63.71
T148 3611-3711 Sentence denotes Parus major 65.6 67.44 65.11 66.95 67.44 67.2 67.81 67.2 66.09 66.09 68.8 63.9 67.08 64.62 64.5 82.2
T149 3712-3819 Sentence denotes Gallus gallus 64.13 66.3 65.19 65.56 65.07 66.17 66.79 66.42 65.44 65.31 66.42 63.12 64.83 63.84 63.71 82.2
T150 3820-4316 Sentence denotes Accession numbers: human (NP_068576.1), monkey (AY996037.1), civet (AAX63775.1), bat (R.sinicus) (AGZ48803.1), swine (NP_001116542.1), Malayan pangolin (XP_017505752.1), mouse (NP_001123985.1), cat (NP_001034545.1), camel (XP_010991717.1), goat (NP_001277036.1), Bos mutus (XP_005903173.1), Erinaceus europaeus (XP_007538670.1), Phascolarctos cinereus (XP_020863153.1), Sarcophilus harrisii (XP_031814825.1), tiger Snake (XP_026530754.1), Parus major (XP_015486815.1), Gallus gallus (QEQ50331.1).
T151 4317-4387 Sentence denotes Fig. 2 Phylogenetic analysis of ACE2 from humans and 18 other animals.
T152 4388-4565 Sentence denotes The tree was constructed based on the complete amino acid sequences of ACE2s derived from humans and other animals by using the neighbor-joining (NJ) method with 1000 bootstrap.
T153 4566-4616 Sentence denotes The accession numbers were as the same as Table 2.
T154 4617-4654 Sentence denotes Bootstrap values above 50 were shown.