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PMC:7079563 / 13832-21435 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
403 574-582 Gene denotes Envelope Gene:43740570
404 113-122 Species denotes 2019-nCoV Tax:2697049
405 157-172 Species denotes Betacoronavirus Tax:694002
406 229-242 Species denotes Coronaviridae Tax:11118
407 328-341 Species denotes coronaviruses Tax:11118
408 343-352 Species denotes 2019-nCoV Tax:2697049
409 455-466 Species denotes coronavirus Tax:694448
417 1267-1276 Species denotes 2019-nCoV Tax:2697049
418 1359-1368 Species denotes 2019-nCoV Tax:2697049
419 1381-1385 Species denotes CoVs Tax:11118
420 1459-1468 Species denotes 2019-nCoV Tax:2697049
421 1565-1576 Species denotes coronavirus Tax:694448
422 1578-1602 Species denotes SARS-related coronavirus Tax:694009
423 1629-1633 Species denotes CoVs Tax:11118
437 730-739 Species denotes 2019-nCoV Tax:2697049
438 770-778 Species denotes SARS-CoV Tax:694009
439 805-808 Species denotes CoV Tax:11118
440 853-862 Species denotes 2019-nCoV Tax:2697049
441 896-905 Species denotes SARSr-CoV Tax:694009
442 910-918 Species denotes SARS-CoV Tax:694009
443 981-994 Species denotes coronaviruses Tax:11118
444 1000-1003 Species denotes CoV Tax:11118
445 1111-1120 Species denotes 2019-nCoV Tax:2697049
446 1140-1164 Species denotes SARS related coronavirus Tax:694009
447 1166-1175 Species denotes SARSr-CoV Tax:694009
448 809-815 CellLine denotes RaTG13 CVCL:AR51
449 1004-1010 CellLine denotes RaTG13 CVCL:AR51
482 3387-3391 Gene denotes ACE2 Gene:59272
483 3465-3468 Gene denotes Cat Gene:12359
484 4349-4352 Gene denotes Cat Gene:12359
485 3392-3412 Species denotes African green monkey Tax:9534
486 3424-3434 Species denotes R. sinicus Tax:89399
487 3436-3441 Species denotes Swine Tax:9823
488 3442-3458 Species denotes Malayan pangolin Tax:9974
489 3459-3464 Species denotes Mouse Tax:10090
490 3469-3474 Species denotes Camel Tax:9837
491 3480-3489 Species denotes Bos mutus Tax:72004
492 3490-3509 Species denotes Erinaceus europaeus Tax:9365
493 3510-3525 Species denotes Cavia porcellus Tax:10141
494 3526-3548 Species denotes Phascolarctos cinereus Tax:38626
495 3549-3569 Species denotes Sarcophilus harrisii Tax:9305
496 3570-3581 Species denotes Tiger Snake Tax:8663
497 3582-3593 Species denotes Parus major Tax:9157
498 3594-3607 Species denotes Gallus gallus Tax:9031
499 3608-3613 Species denotes Human Tax:9606
500 3716-3736 Species denotes African green monkey Tax:9534
501 3937-3947 Species denotes R. sinicus Tax:89399
502 4039-4044 Species denotes Swine Tax:9823
503 4136-4152 Species denotes Malayan pangolin Tax:9974
504 4248-4253 Species denotes Mouse Tax:10090
505 4448-4453 Species denotes Camel Tax:9837
506 4647-4656 Species denotes Bos mutus Tax:72004
507 4750-4769 Species denotes Erinaceus europaeus Tax:9365
508 4865-4880 Species denotes Cavia porcellus Tax:10141
509 4975-4997 Species denotes Phascolarctos cinereus Tax:38626
510 5093-5113 Species denotes Sarcophilus harrisii Tax:9305
511 5209-5220 Species denotes Tiger Snake Tax:8663
512 5311-5322 Species denotes Parus major Tax:9157
513 5412-5425 Species denotes Gallus gallus Tax:9031
515 3294-3298 Gene denotes ACE2 Gene:59272
530 5714-5717 Gene denotes cat Gene:12359
531 5539-5544 Species denotes human Tax:9606
532 5606-5615 Species denotes R.sinicus Tax:89399
533 5631-5636 Species denotes swine Tax:9823
534 5655-5671 Species denotes Malayan pangolin Tax:9974
535 5690-5695 Species denotes mouse Tax:10090
536 5736-5741 Species denotes camel Tax:9837
537 5783-5792 Species denotes Bos mutus Tax:72004
538 5811-5830 Species denotes Erinaceus europaeus Tax:9365
539 5849-5871 Species denotes Phascolarctos cinereus Tax:38626
540 5890-5910 Species denotes Sarcophilus harrisii Tax:9305
541 5929-5940 Species denotes tiger Snake Tax:8663
542 5959-5970 Species denotes Parus major Tax:9157
543 5989-6002 Species denotes Gallus gallus Tax:9031
547 6049-6053 Gene denotes ACE2 Gene:59272
548 6059-6065 Species denotes humans Tax:9606
549 6178-6184 Species denotes humans Tax:9606
588 1853-1858 Gene denotes spike Gene:43740568
589 1934-1939 Gene denotes furin Gene:5045
590 2017-2022 Gene denotes Spike Gene:43740568
591 2240-2245 Gene denotes spike Gene:43740568
592 2558-2562 Gene denotes ACE2 Gene:59272
593 2605-2609 Gene denotes ACE2 Gene:59272
594 2667-2671 Gene denotes ACE2 Gene:100144303
595 2686-2690 Gene denotes ACE2 Gene:70008
596 2748-2752 Gene denotes ACE2 Gene:59272
597 2927-2931 Gene denotes ACE2 Gene:70008
598 2957-2961 Gene denotes ACE2 Gene:59272
599 3003-3008 Gene denotes spike Gene:43740568
600 3041-3045 Gene denotes ACE2 Gene:59272
601 3059-3063 Gene denotes ACE2 Gene:59272
602 3069-3073 Gene denotes ACE2 Gene:59272
603 3134-3138 Gene denotes ACE2 Gene:59272
604 3150-3154 Gene denotes ACE2 Gene:59272
605 3065-3068 Gene denotes cat Gene:847
606 1753-1766 Species denotes coronaviruses Tax:11118
607 2035-2040 Species denotes clove Tax:219868
608 2223-2234 Species denotes coronavirus Tax:694448
609 2368-2379 Species denotes coronavirus Tax:694448
610 2513-2522 Species denotes 2019-nCoV Tax:2697049
611 2567-2575 Species denotes SARS-CoV Tax:694009
612 2599-2604 Species denotes human Tax:9606
613 2611-2620 Species denotes 2019-nCoV Tax:2697049
614 2637-2651 Species denotes horseshoe bats Tax:49442
615 2663-2666 Species denotes pig Tax:9823
616 2680-2685 Species denotes mouse Tax:10090
617 2742-2747 Species denotes human Tax:9606
618 2784-2798 Species denotes horseshoe bats Tax:49442
619 2807-2810 Species denotes pig Tax:9823
620 2815-2820 Species denotes mouse Tax:10090
621 2921-2926 Species denotes mouse Tax:10090
622 2951-2956 Species denotes human Tax:9606
623 3035-3040 Species denotes human Tax:9606
624 3128-3133 Species denotes human Tax:9606
625 3197-3206 Species denotes 2019-nCoV Tax:2697049
644 6569-6590 Species denotes environmental samples Tax:33858
645 6636-6645 Species denotes 2019-nCoV Tax:2697049
646 6860-6865 Species denotes human Tax:9606
647 6916-6921 Species denotes human Tax:9606
648 6947-6955 Species denotes SARS-CoV Tax:694009
649 6960-6968 Species denotes MERS-CoV Tax:1335626
650 7033-7039 Species denotes humans Tax:9606
651 7073-7079 Species denotes camels Tax:9837
652 7106-7115 Species denotes 2019-nCoV Tax:2697049
653 7172-7178 Species denotes humans Tax:9606
654 7261-7270 Species denotes 2019-nCoV Tax:2697049
655 7429-7435 Species denotes humans Tax:9606
656 7502-7511 Species denotes 2019-nCoV Tax:2697049
657 7525-7528 Species denotes CoV Tax:11118
658 7591-7597 Species denotes humans Tax:9606
659 6433-6452 Disease denotes 2019-nCoV pneumonia MESH:C000657245
660 7410-7428 Disease denotes 2019-nCoV infected MESH:C000657245
661 7582-7590 Disease denotes infected MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T18 96-102 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T19 401-404 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T20 514-520 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T21 678-694 Body_part denotes structural genes http://purl.org/sig/ont/fma/fma74402
T22 717-723 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T23 1050-1060 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T24 1189-1196 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T25 1785-1789 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 1859-1866 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 1997-2015 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T28 2211-2219 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T29 2246-2253 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 2276-2286 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T31 2537-2541 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T32 3260-3270 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T33 3363-3373 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T34 6135-6145 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T14 628-632 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T63 770-778 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 910-918 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 971-975 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T66 1140-1144 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T67 1578-1582 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T68 2567-2575 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 3480-3483 Disease denotes Bos http://purl.obolibrary.org/obo/MONDO_0008157
T70 4647-4650 Disease denotes Bos http://purl.obolibrary.org/obo/MONDO_0008157
T71 5783-5786 Disease denotes Bos http://purl.obolibrary.org/obo/MONDO_0008157
T72 6443-6452 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T73 6947-6955 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T74 7410-7428 Disease denotes 2019-nCoV infected http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T77 445-446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 521-533 http://purl.obolibrary.org/obo/OBI_0000245 denotes organization
T79 587-595 http://purl.obolibrary.org/obo/UBERON_0000158 denotes Membrane
T80 625-626 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T81 628-632 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T82 648-653 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T83 689-694 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T84 801-804 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T85 967-970 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T86 996-999 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T87 1015-1018 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T88 1138-1139 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 1785-1789 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T90 2006-2015 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T91 2026-2027 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 2109-2111 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T93 2169-2170 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 2182-2184 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T95 2182-2184 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T96 2254-2257 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T97 2359-2364 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T98 2403-2405 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T99 2418-2419 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T100 2537-2541 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T101 2599-2604 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T102 2647-2651 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T103 2680-2685 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T104 2742-2747 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T105 2753-2756 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T106 2794-2798 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T107 2815-2820 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T108 2921-2926 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T109 2951-2956 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T110 3035-3040 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T111 3128-3133 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T112 3406-3412 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T113 3459-3464 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T114 3469-3474 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes Camel
T115 3475-3479 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes Goat
T116 3510-3525 http://purl.obolibrary.org/obo/NCBITaxon_10141 denotes Cavia porcellus
T117 3594-3607 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Gallus gallus
T118 3608-3613 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T119 3730-3736 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T120 4248-4253 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T121 4448-4453 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes Camel
T122 4548-4552 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes Goat
T123 4865-4880 http://purl.obolibrary.org/obo/NCBITaxon_10141 denotes Cavia porcellus
T124 5412-5425 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Gallus gallus
T125 5539-5544 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T126 5560-5566 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T127 5601-5604 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T128 5690-5695 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T129 5736-5741 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camel
T130 5760-5764 http://purl.obolibrary.org/obo/NCBITaxon_9925 denotes goat
T131 5989-6002 http://purl.obolibrary.org/obo/NCBITaxon_9031 denotes Gallus gallus
T132 6059-6065 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T133 6070-6072 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T134 6079-6086 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T135 6178-6184 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T136 6195-6202 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T137 6680-6681 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 6698-6705 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T139 6791-6795 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T140 6811-6815 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T141 6860-6865 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T142 6898-6903 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T143 6909-6912 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T144 6916-6924 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human is
T145 6985-6989 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T146 7033-7039 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T147 7073-7079 http://purl.obolibrary.org/obo/NCBITaxon_9837 denotes camels
T148 7140-7151 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat but was
T149 7172-7178 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T150 7238-7240 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T151 7244-7246 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T152 7271-7274 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T153 7429-7435 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T154 7440-7443 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T155 7521-7524 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T156 7591-7597 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T157 7599-7601 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T9 484-492 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T10 1019-1021 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T11 1050-1060 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T12 1189-1196 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 1859-1866 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 1882-1886 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T15 2182-2184 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T16 2211-2219 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T17 2246-2253 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T18 2276-2286 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T19 2276-2281 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T20 2282-2286 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T21 3065-3068 Chemical denotes cat http://purl.obolibrary.org/obo/CHEBI_32402
T22 3260-3270 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T23 3260-3265 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T24 3266-3270 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T25 3363-3373 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T26 3363-3368 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T27 3369-3373 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T28 5714-5717 Chemical denotes cat http://purl.obolibrary.org/obo/CHEBI_32402
T29 6135-6145 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T30 6135-6140 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T31 6141-6145 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T4 1897-1908 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T103 0-50 Sentence denotes 3 Biological features and origin of the 2019-nCoV
T104 52-78 Sentence denotes 3.1 Genomics of 2019-nCoV
T105 79-308 Sentence denotes According to the genome analysis, 2019-nCoV belongs to Sarbecovirus subgenus, Betacoronavirus genus of the subfamily Orthocoronavirinae in the family Coronaviridae of the suborder cornidovirineae of the order Nidovirales [20,26].
T106 309-509 Sentence denotes Similarly to other coronaviruses, 2019-nCoV is an enveloped, single-stranded positive-sense RNA (+ssRNA) with around 29,900 nt, showing a typical coronavirus appearance under electron microscopy [20].
T107 510-729 Sentence denotes The genome organization is 5′-leader-UTR-replicase-S (Spike)-E (Envelope)-M (Membrane)-N (Nucleocapsid)-3′UTRpoly (A) tail with accessory genes interspersed within the structural genes and the 3′ end of the genome [26].
T108 730-821 Sentence denotes 2019-nCoV shares 79.5% nt identity with SARS-CoV and 96% identity with bat-CoV-RaTG13 [20].
T109 822-1100 Sentence denotes The genetic characteristics of 2019-nCoV are significantly different from SARSr-CoV and SARS-CoV, which are closely related only to the specific bat SARS-like coronaviruses, bat-CoV-RaTG13 and bat-SL-CoVZC45, with 96% and 86.9% nucleotide sequence identities, respectively [20].
T110 1101-1230 Sentence denotes Therefore 2019-nCoV is considered as a SARS related coronavirus (SARSr-CoV) by pairwise protein sequence analysis (Fig. 1 ) [20].
T111 1231-1277 Sentence denotes Fig. 1 The evolutionary position of 2019-nCoV.
T112 1278-1448 Sentence denotes The phylogenetic tree was constructed based on the complete genomic sequences of 2019-nCoV and related CoVs by using the neighbor-joining (NJ) method with 1000 bootstrap.
T113 1449-1528 Sentence denotes The novel 2019-nCoV detected strains were indicated in bold with solid squares.
T114 1529-1603 Sentence denotes Abbreviations are as follows: SARSr coronavirus, SARS-related coronavirus.
T115 1604-1660 Sentence denotes The accession numbers of CoVs were showed in the figure.
T116 1661-1698 Sentence denotes Bootstrap values above 50 were shown.
T117 1700-1732 Sentence denotes 3.2 Receptor usage of 2019-nCoV
T118 1733-1814 Sentence denotes The prerequisite of coronaviruses invading the host-cell is to bind to receptors.
T119 1815-2016 Sentence denotes Following receptor binding, the viral spike protein is cleaved via acid-dependent proteolysis by cathepsin, TMPRRS2 or furin protease, followed by fusion of the viral envelop to the cellular membranes.
T120 2017-2192 Sentence denotes Spike is a large, clove-shaped trimer, which can be cleaved by proteases into an N-terminal S1 subunit containing the receptor binding domain (RBD) and a C-terminal S2 region.
T121 2193-2483 Sentence denotes Compared to other proteins of coronavirus, the spike protein has the most variable amino acid sequences which results from the strongest positive selection among all genes of coronavirus to adapt to its hosts [27].The RBD is a major determinant of host range and cross-species transmission.
T122 2484-2590 Sentence denotes Recently results showed that 2019-nCoV uses the same cell entry receptor, ACE2, as SARS-CoV [21,24,20,28].
T123 2591-2717 Sentence denotes Besides human ACE2, 2019-nCoV can use Chinese horseshoe bats, civet, or pig ACE2 but not mouse ACE2 as an entry receptor [24].
T124 2718-3014 Sentence denotes One explanation is that human ACE2 has high homology with Chinese horseshoe bats, civet, pig and mouse, which are 80.75%, 83.48%, 81.37%, 82.11% respectively (Table 2 ), while the residues 82 and 353 of mouse ACE2 are different from human ACE2 which are important residues for bind to spike [29].
T125 3015-3111 Sentence denotes But the homology of human ACE2 and pangolin ACE2, cat ACE2 are also high with 84.84% and 85.22%.
T126 3112-3184 Sentence denotes The homology of human ACE2 with other ACE2 varies from 59.73% to 83.23%.
T127 3185-3238 Sentence denotes In summary, 2019-nCoV may have extensive host ranges.
T128 3239-3247 Sentence denotes Fig. 2 .
T129 3248-3323 Sentence denotes Table 2 The amino acid sequence identities of ACE2 among different species.
T130 3324-3391 Sentence denotes Species Pairwise identities (%) of the amino acid sequences of ACE2
T131 3392-3607 Sentence denotes African green monkey Civet Bat (R. sinicus) Swine Malayan pangolin Mouse Cat Camel Goat Bos mutus Erinaceus europaeus Cavia porcellus Phascolarctos cinereus Sarcophilus harrisii Tiger Snake Parus major Gallus gallus
T132 3608-3715 Sentence denotes Human 93.93 83.48 80.75 81.37 84.84 82.11 85.22 83.23 81.61 81.24 79.01 77.29 71.17 70.51 59.73 67.08 65.31
T133 3716-3831 Sentence denotes African green monkey 81.78 79.93 79.93 83.77 81.78 83.15 81.91 81.41 80.92 77.94 76.85 70.38 69.84 59.21 65.6 64.13
T134 3832-3931 Sentence denotes Civet 81.78 81.49 82.73 85.59 81.61 93.29 83.85 81.86 81.74 79.75 75.55 71.66 71.63 59.6 67.44 66.3
T135 3932-4038 Sentence denotes Bat (R. sinicus) 79.93 81.49 80 82.86 78.26 83.73 81.37 80.37 80 78.51 74.56 69.68 70.02 58.61 65.11 65.19
T136 4039-4135 Sentence denotes Swine 79.93 82.73 80 82.61 80.62 83.98 89.81 87.7 87.58 77.64 75.3 71.17 71.01 61.09 66.95 65.56
T137 4136-4247 Sentence denotes Malayan pangolin 83.77 85.59 82.86 82.61 82.73 87.33 84.72 82.11 81.86 80.87 77.17 71.66 70.89 59.6 67.44 65.07
T138 4248-4348 Sentence denotes Mouse 81.78 81.61 78.26 80.62 82.73 81.74 80.99 80.12 80.37 78.63 78.16 71.05 71.13 61.21 67.2 66.17
T139 4349-4447 Sentence denotes Cat 83.15 93.29 83.73 83.98 87.33 81.74 85.71 83.23 83.11 81.49 76.42 72.65 72.25 59.6 67.81 66.79
T140 4448-4547 Sentence denotes Camel 81.91 83.85 81.37 89.81 84.72 80.99 85.71 88.2 88.57 79.25 77.29 71.79 72.12 61.34 67.2 66.42
T141 4548-4646 Sentence denotes Goat 81.41 81.86 80.37 87.7 82.11 80.12 83.23 88.2 97.76 78.14 76.54 72.04 71.38 60.84 66.09 65.44
T142 4647-4749 Sentence denotes Bos mutus 80.92 81.74 80 87.58 81.86 80.37 83.11 88.57 97.76 78.39 77.04 71.42 71.01 61.09 66.09 65.31
T143 4750-4864 Sentence denotes Erinaceus europaeus 77.94 79.75 78.51 77.64 80.87 78.63 81.49 79.25 78.14 78.39 74.56 70.67 69.65 60.59 68.8 66.42
T144 4865-4974 Sentence denotes Cavia porcellus 76.85 75.55 74.56 75.3 77.17 78.16 76.42 77.29 76.54 77.04 74.56 66.61 66.82 59.38 63.9 63.12
T145 4975-5092 Sentence denotes Phascolarctos cinereus 70.38 71.66 69.68 71.17 71.66 71.05 72.65 71.79 72.04 71.42 70.67 66.61 81.92 60.7 67.08 64.83
T146 5093-5208 Sentence denotes Sarcophilus harrisii 69.84 71.63 70.02 71.01 70.89 71.13 72.25 72.12 71.38 71.01 69.65 66.82 81.92 60.9 64.62 63.84
T147 5209-5310 Sentence denotes Tiger Snake 59.21 59.6 58.61 61.09 59.6 61.21 59.6 61.34 60.84 61.09 60.59 59.38 60.7 60.9 64.5 63.71
T148 5311-5411 Sentence denotes Parus major 65.6 67.44 65.11 66.95 67.44 67.2 67.81 67.2 66.09 66.09 68.8 63.9 67.08 64.62 64.5 82.2
T149 5412-5519 Sentence denotes Gallus gallus 64.13 66.3 65.19 65.56 65.07 66.17 66.79 66.42 65.44 65.31 66.42 63.12 64.83 63.84 63.71 82.2
T150 5520-6016 Sentence denotes Accession numbers: human (NP_068576.1), monkey (AY996037.1), civet (AAX63775.1), bat (R.sinicus) (AGZ48803.1), swine (NP_001116542.1), Malayan pangolin (XP_017505752.1), mouse (NP_001123985.1), cat (NP_001034545.1), camel (XP_010991717.1), goat (NP_001277036.1), Bos mutus (XP_005903173.1), Erinaceus europaeus (XP_007538670.1), Phascolarctos cinereus (XP_020863153.1), Sarcophilus harrisii (XP_031814825.1), tiger Snake (XP_026530754.1), Parus major (XP_015486815.1), Gallus gallus (QEQ50331.1).
T151 6017-6087 Sentence denotes Fig. 2 Phylogenetic analysis of ACE2 from humans and 18 other animals.
T152 6088-6265 Sentence denotes The tree was constructed based on the complete amino acid sequences of ACE2s derived from humans and other animals by using the neighbor-joining (NJ) method with 1000 bootstrap.
T153 6266-6316 Sentence denotes The accession numbers were as the same as Table 2.
T154 6317-6354 Sentence denotes Bootstrap values above 50 were shown.
T155 6356-6380 Sentence denotes 3.3 Origin of 2019-nCoV
T156 6381-6541 Sentence denotes The epidemiological investigation of early cases of 2019-nCoV pneumonia showed that many cases had been exposed to the Huanan Seafood Market in Wuhan [2,24,20].
T157 6542-6804 Sentence denotes In addition, 33 of the 585 environmental samples from Huanan Seafood Market were positive for 2019-nCoV; however, that market was trading a variety of live animals, such as hedgehog, badger, snake, and bird (turtledoves), probably pangolin, but not bats [24,30].
T158 6805-6938 Sentence denotes Thus, bats are less likely to have direct contact with human, and direct transmission of the virus from bat to human is unlikely [1].
T159 6939-7094 Sentence denotes Indeed, SARS-CoV and MERS-CoV originated from bats, the natural reservoir, but transmitted to humans via intermediate host civets and camels, respectively.
T160 7095-7249 Sentence denotes Therefore, 2019-nCoV may also originate from bat but was then transmitted to humans via an intermediate host in the market [[31], [32], [33], [34], [35]].
T161 7250-7436 Sentence denotes Currently, 2019-nCoV has been isolated from pangolins and it was found that the genomic seuqence of the isolated strain had 99% identity with that of currently 2019-nCoV infected humans.
T162 7437-7603 Sentence denotes It has been proposed that the transmission and evolution path of 2019-nCoV was from bat-CoV to pangolins (the intermediate hosts), from where it infected humans [36].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T26 6443-6452 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32087334-31978945-69695010 6532-6533 31978945 denotes 2
32087334-30531947-69695011 6935-6936 30531947 denotes 1
32087334-23075143-69695012 7220-7222 23075143 denotes 31
32087334-12958366-69695013 7226-7228 12958366 denotes 32
32087334-24172901-69695014 7232-7234 24172901 denotes 33
32087334-24896817-69695015 7238-7240 24896817 denotes 34
32087334-24675934-69695016 7244-7246 24675934 denotes 35