> top > docs > PMC:7077337 > spans > 38244-42146 > annotations

PMC:7077337 / 38244-42146 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1094 30-35 Species denotes Women Tax:9606
1095 60-71 Species denotes Coronavirus Tax:694448
1103 253-259 Species denotes humans Tax:9606
1104 332-345 Species denotes coronaviruses Tax:11118
1105 436-444 Species denotes SARS-CoV Tax:694009
1106 497-502 Species denotes human Tax:9606
1107 601-607 Species denotes humans Tax:9606
1108 227-249 Disease denotes coronavirus infections MESH:D018352
1109 503-512 Disease denotes infection MESH:D007239
1116 673-678 Species denotes women Tax:9606
1117 769-778 Species denotes 2019-nCoV Tax:2697049
1118 863-868 Species denotes women Tax:9606
1119 996-1001 Species denotes women Tax:9606
1120 1134-1139 Species denotes women Tax:9606
1121 1150-1157 Species denotes infants Tax:9606
1123 1550-1567 Species denotes Wuhan coronavirus Tax:2697049
1126 1673-1677 Species denotes nCoV Tax:2697049
1127 1817-1833 Species denotes MERS coronavirus Tax:1335626
1133 1901-1918 Species denotes novel coronavirus Tax:2697049
1134 2191-2199 Species denotes MERS-CoV Tax:1335626
1135 2242-2250 Species denotes MERS-CoV Tax:1335626
1136 2501-2509 Species denotes MERS-CoV Tax:1335626
1137 2591-2600 Species denotes 2019-nCoV Tax:2697049
1150 2951-2966 Species denotes new coronavirus Tax:2697049
1151 3153-3162 Species denotes 2019-nCoV Tax:2697049
1152 3378-3383 Species denotes women Tax:9606
1153 3475-3480 Species denotes women Tax:9606
1154 3531-3536 Species denotes women Tax:9606
1155 3561-3566 Species denotes ZEBOV Tax:186538
1156 3585-3596 Species denotes Ebola virus Tax:1570291
1157 3761-3766 Species denotes women Tax:9606
1158 3882-3901 Species denotes novel coronaviruses Tax:2697049
1159 3732-3742 Disease denotes infections MESH:D007239
1160 3746-3750 Disease denotes SARS MESH:D045169
1161 3869-3878 Disease denotes infection MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T85 368-374 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T86 2391-2399 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T65 368-374 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T257 239-252 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T258 436-444 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T259 436-440 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T260 503-512 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T261 1673-1682 Disease denotes nCoV-2019 http://purl.obolibrary.org/obo/MONDO_0100096
T262 3585-3590 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T263 3732-3742 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T264 3746-3750 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T265 3869-3878 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T266 58-59 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T267 192-193 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 253-259 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T269 382-385 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T270 412-413 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 461-467 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T272 497-502 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T273 601-607 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T274 617-618 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T275 1522-1523 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T276 1683-1688 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T277 2338-2341 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T278 2613-2614 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 2687-2700 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizations
T280 2835-2836 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T281 2896-2897 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 2949-2950 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 3013-3014 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T284 3238-3245 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T285 3274-3275 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T286 3317-3318 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T287 3591-3596 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T288 3617-3618 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T289 3805-3806 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T20 1050-1055 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T21 2182-2185 Chemical denotes TPP http://purl.obolibrary.org/obo/CHEBI_35033|http://purl.obolibrary.org/obo/CHEBI_52279|http://purl.obolibrary.org/obo/CHEBI_9532

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T28 1969-1978 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T263 0-3 Sentence denotes 12.
T264 4-79 Sentence denotes Participation of Pregnant Women in the Development of a Coronavirus Vaccine
T265 80-260 Sentence denotes It is beyond the scope of this communication to discuss the various technical challenges inherent in developing a safe and efficacious vaccine for coronavirus infections in humans.
T266 261-634 Sentence denotes There are clearly challenges to this endeavor—protective antibodies to coronaviruses are not long-lasting, tissue damage has been reported to occur as a result of exposure to SARS-CoV, development of animal models that closely resemble human infection are limited, and the extensive time and expense necessary to perform clinical trials in humans, to name a few [66,67,68].
T267 635-779 Sentence denotes It is vitally important that pregnant women be considered in the design, clinical trial, and implementation of vaccine candidates for 2019-nCoV.
T268 780-979 Sentence denotes In examining the history of vaccine design, it is clear that the needs of pregnant women have rarely been prioritized in either the preclinical development or the clinical trial phases of production.
T269 980-1114 Sentence denotes Today, pregnant women are usually excluded from experimental trial of drugs and vaccines that do not target obstetric conditions [69].
T270 1115-1407 Sentence denotes Excluding pregnant women and their infants from participation in vaccine development and implementation undermines ethical principles of justice—fairness, equity, and maximization of benefit—and potentially places their health at risk during outbreaks and other health emergencies [69,70,71].
T271 1408-1568 Sentence denotes On 23 January 2020 the Coalition for Epidemic Preparedness Innovations (CEPI) announced three programs to develop a vaccine against the novel Wuhan coronavirus.
T272 1569-1634 Sentence denotes The Chief Executive Officer of CEPI, Richard Hatchett, said [72]:
T273 1635-1756 Sentence denotes “Given the rapid global spread of the nCoV-2019 virus the world needs to act quickly and in unity to tackle this disease.
T274 1757-1896 Sentence denotes Our intention with this work is to leverage our work on the MERS coronavirus and rapid response platforms to speed up vaccine development.”
T275 1897-2004 Sentence denotes The novel coronavirus is the first epidemic disease to emerge since the formation of CEPI in Davos in 2017.
T276 2005-2127 Sentence denotes CEPI was created with the express intent to enable speedy research and development of vaccines against emerging pathogens.
T277 2128-2319 Sentence denotes In May 2017, WHO released the Target Product Profile (TPP) for MERS-CoV vaccines, following the prioritization of MERS-CoV as one of eight priority pathogens for prevention of epidemics [73].
T278 2320-2529 Sentence denotes CEPI and partners aim to use existing platforms—that is, the existing “backbone” that can be adapted for use against new pathogens—that are currently in preclinical development for MERS-CoV vaccine candidates.
T279 2530-2834 Sentence denotes Following the WHO declaration on 30 January that the current 2019-nCoV outbreak is a public health emergency of international concern (PHEIC), global health organizations and researchers will be further mobilized—bolstered by new mechanisms for action and greater resources—to stop the spread of disease.
T280 2835-3052 Sentence denotes A critical question that must be answered at this stage—with a clear view of the potential deleterious effects of a new coronavirus in pregnancy—is will maternal immunization be a priority in research and development?
T281 3053-3232 Sentence denotes As of the PHEIC declaration, 12 groups have announced that they are developing new vaccines against 2019-nCoV and seven others announced initiatives to develop new therapies [74].
T282 3233-3392 Sentence denotes Safe testing of experimental vaccines in a pregnant population is difficult and, as a result, vaccines are not typically developed with pregnant women in mind.
T283 3393-3645 Sentence denotes To date, very few clinical trials for vaccines have proactively included pregnant women [75], and the exclusion of pregnant and lactating women from receiving the rVSV-ZEBOV vaccine through 3 Ebola virus epidemics serves as a recent example [69,70,71].
T284 3646-3902 Sentence denotes Given the potential severity in pregnancy, as demonstrated by this review of maternal infections of SARS and MERS, women who are pregnant should be considered a priority population in all efforts to prepare for and prevent infection by novel coronaviruses.

2_test

Id Subject Object Predicate Lexical cue
32050635-17041137-144359602 624-626 17041137 denotes 66
32050635-18258008-144359603 627-629 18258008 denotes 67