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PMC:7077191 / 22432-23593 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
688 93-124 Gene denotes angiotensin-converting enzyme 2 Gene:59272
689 126-130 Gene denotes ACE2 Gene:59272
690 258-262 Gene denotes ACE2 Gene:103231639
691 429-434 Gene denotes spike Gene:43740568
692 446-450 Gene denotes ACE2 Gene:59272
693 579-583 Gene denotes ACE2 Gene:59272
694 623-637 Gene denotes angiotensin II Gene:183
695 660-663 Gene denotes ACE Gene:1636
696 869-873 Gene denotes ACE2 Gene:59272
697 894-898 Gene denotes ACE2 Gene:59272
698 1029-1033 Gene denotes ACE2 Gene:59272
699 1105-1109 Gene denotes ACE2 Gene:103231639
700 970-971 Gene denotes S Gene:43740568
701 227-228 Gene denotes S Gene:43740568
702 0-3 Species denotes CoV Tax:11118
703 57-60 Species denotes CoV Tax:11118
704 156-164 Species denotes SARS-CoV Tax:694009
705 358-366 Species denotes SARS-CoV Tax:694009
706 523-538 Disease denotes alveolar injury MESH:D000080902
707 939-947 Disease denotes syncytia

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T71 19-24 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T72 63-70 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T73 184-189 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T74 229-236 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T75 392-406 Body_part denotes alveolar cells http://purl.org/sig/ont/fma/fma62499
T76 401-406 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T77 435-442 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T78 523-531 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T79 831-835 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T80 913-918 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T81 953-958 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T82 972-979 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T83 1077-1082 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T84 1084-1094 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T85 1149-1154 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T22 831-835 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T287 156-164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T288 156-160 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T289 358-366 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T290 358-362 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T291 532-538 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T292 546-550 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T213 19-24 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T214 176-189 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero-E6 cells
T215 401-406 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T216 831-835 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T217 831-835 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T218 911-918 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T219 953-958 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T220 985-990 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T221 1075-1082 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T222 1141-1154 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero-E6 cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T103 63-70 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T104 93-104 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T105 229-236 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T106 435-442 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T107 623-637 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T110 623-634 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T111 635-637 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T112 696-710 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T115 696-707 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T116 708-710 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T117 972-979 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T11 1120-1137 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T12 1120-1137 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T205 0-190 Sentence denotes CoV can enter host cells through the interaction between CoV S protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which is isolated from SARS-CoV–permissive Vero-E6 cells.
T206 191-276 Sentence denotes The receptor-binding motif (RBM) of S protein can directly contact ACE2 [47,101,102].
T207 277-413 Sentence denotes AEC2 have been identified to be key binding residues and functional receptor for SARS-CoV, and it can also protect alveolar cells [103].
T208 414-556 Sentence denotes The binding of spike protein to ACE2 and the subsequent downregulation of this receptor contribute to severe alveolar injury during SARS [49].
T209 557-893 Sentence denotes The downregulation of ACE2 results in the excessive production of angiotensin II by the related enzyme ACE, and the stimulation of type 1A angiotensin II receptor (AGTR1A) can lead to the increase of pulmonary vascular permeability, which potentially explains the increased lung pathology when the expression of ACE2 is decreased [104].
T210 894-980 Sentence denotes ACE2-transfected T cells form multinucleated syncytia with cells expressing S protein.
T211 981-1083 Sentence denotes The virus was shown to replicate effectively in ACE2-transfected, but not in mock-transfected T cells.
T212 1084-1161 Sentence denotes Antibodies targeting ACE2 can block viral replication in Vero-E6 cells [105].

2_test

Id Subject Object Predicate Lexical cue
32098422-32007627-144407027 264-266 32007627 denotes 47
32098422-25445340-144407028 267-270 25445340 denotes 101
32098422-32015507-144407029 271-274 32015507 denotes 102
32098422-16007097-144407030 408-411 16007097 denotes 103
32098422-16001071-144407031 888-891 16001071 denotes 104
32098422-14647384-144407032 1156-1159 14647384 denotes 105