PMC:7077191 / 18157-18969 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"527","span":{"begin":389,"end":392},"obj":"Gene"},{"id":"528","span":{"begin":398,"end":401},"obj":"Gene"},{"id":"529","span":{"begin":641,"end":646},"obj":"Gene"},{"id":"530","span":{"begin":651,"end":655},"obj":"Gene"},{"id":"531","span":{"begin":578,"end":581},"obj":"Gene"},{"id":"532","span":{"begin":499,"end":502},"obj":"Gene"},{"id":"533","span":{"begin":384,"end":387},"obj":"Gene"},{"id":"534","span":{"begin":570,"end":571},"obj":"Gene"},{"id":"535","span":{"begin":50,"end":60},"obj":"Species"},{"id":"536","span":{"begin":65,"end":73},"obj":"Species"},{"id":"537","span":{"begin":136,"end":146},"obj":"Species"},{"id":"538","span":{"begin":151,"end":159},"obj":"Species"},{"id":"539","span":{"begin":300,"end":308},"obj":"Species"},{"id":"540","span":{"begin":313,"end":323},"obj":"Species"},{"id":"541","span":{"begin":733,"end":743},"obj":"Species"},{"id":"542","span":{"begin":748,"end":756},"obj":"Species"},{"id":"543","span":{"begin":801,"end":811},"obj":"Species"}],"attributes":[{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"Gene:5961"},{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Gene:343035"},{"id":"A529","pred":"tao:has_database_id","subj":"529","obj":"Gene:43740574"},{"id":"A530","pred":"tao:has_database_id","subj":"530","obj":"Gene:43740577"},{"id":"A531","pred":"tao:has_database_id","subj":"531","obj":"Gene:83552"},{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"Gene:7275"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"Gene:5158"},{"id":"A534","pred":"tao:has_database_id","subj":"534","obj":"Gene:43740568"},{"id":"A535","pred":"tao:has_database_id","subj":"535","obj":"Tax:2697049"},{"id":"A536","pred":"tao:has_database_id","subj":"536","obj":"Tax:694009"},{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"Tax:2697049"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"Tax:694009"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"Tax:694009"},{"id":"A540","pred":"tao:has_database_id","subj":"540","obj":"Tax:2697049"},{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"Tax:2697049"},{"id":"A542","pred":"tao:has_database_id","subj":"542","obj":"Tax:694009"},{"id":"A543","pred":"tao:has_database_id","subj":"543","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"We also performed comparative genomic analyses of SARS-CoV-2 and SARS-CoV by zpicture. The results showed that the genomic sequences of SARS-CoV-2 and SARS-CoV have extremely high homology at the nucleotide level (Figure 4a,b). There are six regions of difference (RD) in the genome sequence between SARS-CoV and SARS-CoV-2, and the RDs are named according to the order of discovery. RD1, RD2, and RD3 (448nt, 55nt, and 278nt, respectively) are partial coding sequences of the orf lab gene; RD4 and RD5 (315nt and 80nt, respectively) are partial coding sequences of the S gene; RD6 is 214nt in size and is part of the coding sequence of the orf7b and orf8 genes. These RDs may provide new molecular markers for the identification of SARS-CoV-2 and SARS-CoV, and also help to develop new drugs against SARS-CoV-2."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T34","span":{"begin":196,"end":206},"obj":"Body_part"},{"id":"T35","span":{"begin":276,"end":282},"obj":"Body_part"},{"id":"T36","span":{"begin":485,"end":489},"obj":"Body_part"},{"id":"T37","span":{"begin":572,"end":576},"obj":"Body_part"}],"attributes":[{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"We also performed comparative genomic analyses of SARS-CoV-2 and SARS-CoV by zpicture. The results showed that the genomic sequences of SARS-CoV-2 and SARS-CoV have extremely high homology at the nucleotide level (Figure 4a,b). There are six regions of difference (RD) in the genome sequence between SARS-CoV and SARS-CoV-2, and the RDs are named according to the order of discovery. RD1, RD2, and RD3 (448nt, 55nt, and 278nt, respectively) are partial coding sequences of the orf lab gene; RD4 and RD5 (315nt and 80nt, respectively) are partial coding sequences of the S gene; RD6 is 214nt in size and is part of the coding sequence of the orf7b and orf8 genes. These RDs may provide new molecular markers for the identification of SARS-CoV-2 and SARS-CoV, and also help to develop new drugs against SARS-CoV-2."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T196","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"T197","span":{"begin":50,"end":54},"obj":"Disease"},{"id":"T198","span":{"begin":65,"end":73},"obj":"Disease"},{"id":"T199","span":{"begin":65,"end":69},"obj":"Disease"},{"id":"T200","span":{"begin":136,"end":144},"obj":"Disease"},{"id":"T201","span":{"begin":136,"end":140},"obj":"Disease"},{"id":"T202","span":{"begin":151,"end":159},"obj":"Disease"},{"id":"T203","span":{"begin":151,"end":155},"obj":"Disease"},{"id":"T204","span":{"begin":265,"end":267},"obj":"Disease"},{"id":"T205","span":{"begin":300,"end":308},"obj":"Disease"},{"id":"T206","span":{"begin":300,"end":304},"obj":"Disease"},{"id":"T207","span":{"begin":313,"end":321},"obj":"Disease"},{"id":"T208","span":{"begin":313,"end":317},"obj":"Disease"},{"id":"T209","span":{"begin":733,"end":741},"obj":"Disease"},{"id":"T210","span":{"begin":733,"end":737},"obj":"Disease"},{"id":"T211","span":{"begin":748,"end":756},"obj":"Disease"},{"id":"T212","span":{"begin":748,"end":752},"obj":"Disease"},{"id":"T213","span":{"begin":801,"end":809},"obj":"Disease"},{"id":"T214","span":{"begin":801,"end":805},"obj":"Disease"}],"attributes":[{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A198","pred":"mondo_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A199","pred":"mondo_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A200","pred":"mondo_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A201","pred":"mondo_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0009973"},{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A206","pred":"mondo_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A208","pred":"mondo_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A209","pred":"mondo_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A210","pred":"mondo_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A211","pred":"mondo_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A212","pred":"mondo_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A213","pred":"mondo_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"We also performed comparative genomic analyses of SARS-CoV-2 and SARS-CoV by zpicture. The results showed that the genomic sequences of SARS-CoV-2 and SARS-CoV have extremely high homology at the nucleotide level (Figure 4a,b). There are six regions of difference (RD) in the genome sequence between SARS-CoV and SARS-CoV-2, and the RDs are named according to the order of discovery. RD1, RD2, and RD3 (448nt, 55nt, and 278nt, respectively) are partial coding sequences of the orf lab gene; RD4 and RD5 (315nt and 80nt, respectively) are partial coding sequences of the S gene; RD6 is 214nt in size and is part of the coding sequence of the orf7b and orf8 genes. These RDs may provide new molecular markers for the identification of SARS-CoV-2 and SARS-CoV, and also help to develop new drugs against SARS-CoV-2."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T173","span":{"begin":165,"end":174},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T174","span":{"begin":224,"end":225},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T175","span":{"begin":265,"end":267},"obj":"http://purl.obolibrary.org/obo/CLO_0008770"},{"id":"T176","span":{"begin":485,"end":489},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T177","span":{"begin":572,"end":576},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T178","span":{"begin":656,"end":661},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"}],"text":"We also performed comparative genomic analyses of SARS-CoV-2 and SARS-CoV by zpicture. The results showed that the genomic sequences of SARS-CoV-2 and SARS-CoV have extremely high homology at the nucleotide level (Figure 4a,b). There are six regions of difference (RD) in the genome sequence between SARS-CoV and SARS-CoV-2, and the RDs are named according to the order of discovery. RD1, RD2, and RD3 (448nt, 55nt, and 278nt, respectively) are partial coding sequences of the orf lab gene; RD4 and RD5 (315nt and 80nt, respectively) are partial coding sequences of the S gene; RD6 is 214nt in size and is part of the coding sequence of the orf7b and orf8 genes. These RDs may provide new molecular markers for the identification of SARS-CoV-2 and SARS-CoV, and also help to develop new drugs against SARS-CoV-2."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T63","span":{"begin":196,"end":206},"obj":"Chemical"},{"id":"T64","span":{"begin":265,"end":267},"obj":"Chemical"},{"id":"T65","span":{"begin":787,"end":792},"obj":"Chemical"}],"attributes":[{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_73812"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"We also performed comparative genomic analyses of SARS-CoV-2 and SARS-CoV by zpicture. The results showed that the genomic sequences of SARS-CoV-2 and SARS-CoV have extremely high homology at the nucleotide level (Figure 4a,b). There are six regions of difference (RD) in the genome sequence between SARS-CoV and SARS-CoV-2, and the RDs are named according to the order of discovery. RD1, RD2, and RD3 (448nt, 55nt, and 278nt, respectively) are partial coding sequences of the orf lab gene; RD4 and RD5 (315nt and 80nt, respectively) are partial coding sequences of the S gene; RD6 is 214nt in size and is part of the coding sequence of the orf7b and orf8 genes. These RDs may provide new molecular markers for the identification of SARS-CoV-2 and SARS-CoV, and also help to develop new drugs against SARS-CoV-2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T174","span":{"begin":0,"end":86},"obj":"Sentence"},{"id":"T175","span":{"begin":87,"end":227},"obj":"Sentence"},{"id":"T176","span":{"begin":228,"end":383},"obj":"Sentence"},{"id":"T177","span":{"begin":384,"end":662},"obj":"Sentence"},{"id":"T178","span":{"begin":663,"end":812},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We also performed comparative genomic analyses of SARS-CoV-2 and SARS-CoV by zpicture. The results showed that the genomic sequences of SARS-CoV-2 and SARS-CoV have extremely high homology at the nucleotide level (Figure 4a,b). There are six regions of difference (RD) in the genome sequence between SARS-CoV and SARS-CoV-2, and the RDs are named according to the order of discovery. RD1, RD2, and RD3 (448nt, 55nt, and 278nt, respectively) are partial coding sequences of the orf lab gene; RD4 and RD5 (315nt and 80nt, respectively) are partial coding sequences of the S gene; RD6 is 214nt in size and is part of the coding sequence of the orf7b and orf8 genes. These RDs may provide new molecular markers for the identification of SARS-CoV-2 and SARS-CoV, and also help to develop new drugs against SARS-CoV-2."}