PMC:7075884 / 4817-6532
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 230 | 1561-1564 | Gene | denotes | C13 | Gene:3229 |
| 231 | 1466-1469 | Gene | denotes | C15 | Gene:51316 |
| 232 | 747-750 | Gene | denotes | C17 | Gene:54360 |
| 233 | 740-743 | Gene | denotes | C15 | Gene:51316 |
| 234 | 733-736 | Gene | denotes | C13 | Gene:3229 |
| 235 | 762-766 | Species | denotes | HCMV | Tax:10359 |
| 236 | 972-976 | Species | denotes | HCMV | Tax:10359 |
| 237 | 1170-1174 | Species | denotes | HCMV | Tax:10359 |
| 238 | 1497-1501 | Species | denotes | HCMV | Tax:10359 |
| 239 | 1570-1574 | Species | denotes | HCMV | Tax:10359 |
| 240 | 1647-1651 | Species | denotes | HCMV | Tax:10359 |
| 241 | 716-731 | Chemical | denotes | Ginkgolic Acids | MESH:C112485 |
| 242 | 987-991 | Chemical | denotes | BI-6 | MESH:C118647 |
| 243 | 1091-1093 | Chemical | denotes | GA | MESH:C112485 |
| 244 | 1373-1375 | Chemical | denotes | GA | MESH:C112485 |
| 245 | 1490-1493 | Chemical | denotes | GCV | MESH:D015774 |
| 246 | 1558-1560 | Chemical | denotes | GA | MESH:C112485 |
| 247 | 1625-1631 | Chemical | denotes | GA C17 | |
| 248 | 910-918 | Disease | denotes | infected | MESH:D007239 |
| 249 | 1095-1110 | Disease | denotes | Viral infection | MESH:D001102 |
| 250 | 1379-1388 | Disease | denotes | infection | MESH:D007239 |
| 251 | 1516-1525 | Disease | denotes | infection | MESH:D007239 |
| 252 | 1579-1588 | Disease | denotes | infection | MESH:D007239 |
| 253 | 1656-1665 | Disease | denotes | infection | MESH:D007239 |
| 254 | 843-857 | CellLine | denotes | human foreskin | CVCL:3285 |
| 255 | 871-874 | CellLine | denotes | HFF | CVCL:3285 |
| 266 | 226-237 | Species | denotes | HCMV strain | Tax:10359 |
| 267 | 455-465 | Chemical | denotes | MEM medium | |
| 268 | 539-549 | Chemical | denotes | MEM medium | |
| 269 | 633-635 | Chemical | denotes | GA | MESH:C112485 |
| 270 | 21-29 | Disease | denotes | toxicity | MESH:D064420 |
| 271 | 212-220 | Disease | denotes | infected | MESH:D007239 |
| 272 | 400-408 | Disease | denotes | toxicity | MESH:D064420 |
| 273 | 621-629 | Disease | denotes | toxicity | MESH:D064420 |
| 274 | 44-49 | CellLine | denotes | HEp-2 | CVCL:1906 |
| 275 | 423-426 | CellLine | denotes | HFF | CVCL:3285 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T20 | 50-55 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T21 | 97-102 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T22 | 171-176 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T23 | 206-211 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T24 | 353-358 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T25 | 427-432 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T26 | 655-660 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T27 | 849-857 | Body_part | denotes | foreskin | http://purl.org/sig/ont/fma/fma19639 |
| T28 | 858-869 | Body_part | denotes | fibroblasts | http://purl.org/sig/ont/fma/fma63877 |
| T29 | 904-909 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T30 | 935-939 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T31 | 1396-1400 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T32 | 1506-1510 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T33 | 1637-1641 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 97-102 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T2 | 353-358 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T3 | 655-660 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T25 | 1095-1110 | Disease | denotes | Viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T26 | 1101-1110 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T27 | 1379-1388 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T28 | 1516-1525 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T29 | 1579-1588 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T30 | 1656-1665 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T56 | 44-49 | http://purl.obolibrary.org/obo/CLO_0003707 | denotes | HEp-2 |
| T57 | 44-49 | http://purl.obolibrary.org/obo/CLO_0050927 | denotes | HEp-2 |
| T58 | 50-55 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T59 | 171-176 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T60 | 206-211 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T61 | 379-381 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T62 | 423-426 | http://purl.obolibrary.org/obo/CLO_0052986 | denotes | HFF |
| T63 | 427-432 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T64 | 608-616 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T65 | 747-752 | http://purl.obolibrary.org/obo/CLO_0002099 | denotes | C17:1 |
| T66 | 770-771 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T67 | 826-827 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T68 | 843-848 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T69 | 849-869 | http://purl.obolibrary.org/obo/CL_1001608 | denotes | foreskin fibroblasts |
| T70 | 871-874 | http://purl.obolibrary.org/obo/CLO_0052986 | denotes | HFF |
| T71 | 904-909 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T72 | 935-939 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T73 | 996-997 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T74 | 1334-1335 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T75 | 1396-1400 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T76 | 1406-1411 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T77 | 1427-1430 | http://purl.obolibrary.org/obo/CLO_0053478 | denotes | GFP |
| T78 | 1502-1505 | http://purl.obolibrary.org/obo/CLO_0053478 | denotes | GFP |
| T79 | 1506-1510 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T80 | 1575-1578 | http://purl.obolibrary.org/obo/CLO_0053478 | denotes | GFP |
| T81 | 1628-1633 | http://purl.obolibrary.org/obo/CLO_0002099 | denotes | C17:1 |
| T82 | 1637-1641 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T83 | 1652-1655 | http://purl.obolibrary.org/obo/CLO_0053478 | denotes | GFP |
| T84 | 1668-1669 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T85 | 1708-1714 | http://purl.obolibrary.org/obo/UBERON_0007688 | denotes | fields |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T111 | 0-2 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T114 | 38-40 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T117 | 372-374 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T120 | 417-419 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T123 | 633-635 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T126 | 733-738 | Chemical | denotes | C13:0 | http://purl.obolibrary.org/obo/CHEBI_45919 |
| T127 | 740-745 | Chemical | denotes | C15:1 | http://purl.obolibrary.org/obo/CHEBI_75088 |
| T128 | 740-743 | Chemical | denotes | C15 | http://purl.obolibrary.org/obo/CHEBI_42504 |
| T129 | 747-752 | Chemical | denotes | C17:1 | http://purl.obolibrary.org/obo/CHEBI_36001 |
| T130 | 1019-1023 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T131 | 1091-1093 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T134 | 1373-1375 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T137 | 1463-1465 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T140 | 1466-1471 | Chemical | denotes | C15:1 | http://purl.obolibrary.org/obo/CHEBI_75088 |
| T141 | 1466-1469 | Chemical | denotes | C15 | http://purl.obolibrary.org/obo/CHEBI_42504 |
| T142 | 1558-1560 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T145 | 1561-1566 | Chemical | denotes | C13:0 | http://purl.obolibrary.org/obo/CHEBI_45919 |
| T146 | 1625-1627 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T149 | 1628-1633 | Chemical | denotes | C17:1 | http://purl.obolibrary.org/obo/CHEBI_36001 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T22 | 814-823 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T23 | 1095-1110 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | Viral infection |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T35 | 0-16 | Sentence | denotes | GA IC50 vs. EC50 |
| T36 | 17-202 | Sentence | denotes | The toxicity EC50 of GA on HEp-2 cells in MEM supplemented with 1% fetal bovine serum (FBS) was 27.63 ± 2.21 μM (Fig. S1A) or 63.5 ± 3.2 μM (Fig. S1B) on cells supplemented with 5% FBS. |
| T37 | 203-395 | Sentence | denotes | In cells infected with HCMV strain CH19 and supplemented with 1% FBS, the 50% inhibitory concentration (IC50) was 6.83 ± 1.08 μM, and with 10% bovine serum, the IC50 of GA was 41 μM (Fig. 1A). |
| T38 | 396-576 | Sentence | denotes | The toxicity EC50 of GA on HFF cells was 14.00 μM ± 0.1 in MEM medium supplemented with 1% FBS (Fig. S1C), and 137.04 μM ± 10.44 (Fig. S1D) in MEM medium supplemented with 10% FBS. |
| T39 | 577-706 | Sentence | denotes | The results indicated that the activity and toxicity of GA is affected by the serum concentration in the medium (see discussion). |
| T40 | 707-1094 | Sentence | denotes | Figure 1 Ginkgolic Acids (C13:0, C15:1, C17:1) inhibit HCMV in a dose-dependent manner and prevents plaque formation. (A) Monolayers of human foreskin fibroblasts (HFF) were inoculated with 50–100 cells infected with one of two cell-associated clinical isolates of HCMV (CH19 and BI-6) in a total of 4 wells per drug concentration followed by treatment with medium containing 0–10 µM GA. |
| T41 | 1095-1242 | Sentence | denotes | Viral infection was allowed to progress for 7 days when the mean number of HCMV plaques per concentration was counted, and the IC50 was determined. |
| T42 | 1243-1715 | Sentence | denotes | The effects of different concentrations of FBS and time delay on the IC50 are also shown. (B) Dose-dependent inhibitory effect of GA on infection by the cell-free virus strain PT30CMV-GFP. (C) Inhibitory effect of 10 µM GA C15:1 compared to 16 µM GCV on HCMV-GFP cell-free infection. (D) Inhibitory effect of 10 µM GA C13:0 on HCMV-GFP infection, and (E) Inhibitory effect of 10 µM GA C17:1 on cell-free HCMV-GFP infection. (B–E) representing average of 20 scanned fields. |