PMC:7075884 / 24339-25050 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"887","span":{"begin":444,"end":463},"obj":"Gene"},{"id":"888","span":{"begin":559,"end":564},"obj":"Gene"},{"id":"889","span":{"begin":597,"end":601},"obj":"Gene"},{"id":"890","span":{"begin":37,"end":40},"obj":"Gene"},{"id":"891","span":{"begin":27,"end":30},"obj":"Gene"},{"id":"892","span":{"begin":20,"end":23},"obj":"Gene"},{"id":"893","span":{"begin":659,"end":661},"obj":"Gene"},{"id":"894","span":{"begin":83,"end":89},"obj":"Species"},{"id":"895","span":{"begin":281,"end":297},"obj":"Species"},{"id":"896","span":{"begin":302,"end":323},"obj":"Species"},{"id":"897","span":{"begin":4,"end":19},"obj":"Chemical"},{"id":"898","span":{"begin":378,"end":380},"obj":"Chemical"},{"id":"899","span":{"begin":612,"end":620},"obj":"Chemical"},{"id":"900","span":{"begin":213,"end":235},"obj":"Disease"},{"id":"901","span":{"begin":237,"end":250},"obj":"Disease"},{"id":"902","span":{"begin":252,"end":272},"obj":"Disease"},{"id":"903","span":{"begin":334,"end":340},"obj":"Disease"}],"attributes":[{"id":"A887","pred":"tao:has_database_id","subj":"887","obj":"Gene:2194"},{"id":"A888","pred":"tao:has_database_id","subj":"888","obj":"Gene:6774"},{"id":"A889","pred":"tao:has_database_id","subj":"889","obj":"Gene:5728"},{"id":"A890","pred":"tao:has_database_id","subj":"890","obj":"Gene:54360"},{"id":"A891","pred":"tao:has_database_id","subj":"891","obj":"Gene:51316"},{"id":"A892","pred":"tao:has_database_id","subj":"892","obj":"Gene:3229"},{"id":"A893","pred":"tao:has_database_id","subj":"893","obj":"Gene:351"},{"id":"A894","pred":"tao:has_database_id","subj":"894","obj":"Tax:3311"},{"id":"A895","pred":"tao:has_database_id","subj":"895","obj":"Tax:562"},{"id":"A896","pred":"tao:has_database_id","subj":"896","obj":"Tax:1280"},{"id":"A897","pred":"tao:has_database_id","subj":"897","obj":"MESH:C112485"},{"id":"A898","pred":"tao:has_database_id","subj":"898","obj":"MESH:C112485"},{"id":"A899","pred":"tao:has_database_id","subj":"899","obj":"MESH:D014443"},{"id":"A900","pred":"tao:has_database_id","subj":"900","obj":"MESH:D002318"},{"id":"A901","pred":"tao:has_database_id","subj":"901","obj":"MESH:D015658"},{"id":"A902","pred":"tao:has_database_id","subj":"902","obj":"MESH:D001424"},{"id":"A903","pred":"tao:has_database_id","subj":"903","obj":"MESH:D009369"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T194","span":{"begin":237,"end":240},"obj":"Body_part"},{"id":"T195","span":{"begin":444,"end":454},"obj":"Body_part"},{"id":"T196","span":{"begin":513,"end":520},"obj":"Body_part"},{"id":"T197","span":{"begin":612,"end":620},"obj":"Body_part"}],"attributes":[{"id":"A194","pred":"fma_id","subj":"T194","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A195","pred":"fma_id","subj":"T195","obj":"http://purl.org/sig/ont/fma/fma82738"},{"id":"A196","pred":"fma_id","subj":"T196","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A197","pred":"fma_id","subj":"T197","obj":"http://purl.org/sig/ont/fma/fma82768"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T61","span":{"begin":213,"end":235},"obj":"Disease"},{"id":"T62","span":{"begin":237,"end":250},"obj":"Disease"},{"id":"T63","span":{"begin":241,"end":250},"obj":"Disease"},{"id":"T64","span":{"begin":252,"end":272},"obj":"Disease"}],"attributes":[{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0005109"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005113"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T379","span":{"begin":37,"end":42},"obj":"http://purl.obolibrary.org/obo/CLO_0002099"},{"id":"T380","span":{"begin":116,"end":124},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T381","span":{"begin":131,"end":134},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T382","span":{"begin":354,"end":357},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T383","span":{"begin":499,"end":509},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T384","span":{"begin":565,"end":575},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T385","span":{"begin":659,"end":660},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T618","span":{"begin":14,"end":19},"obj":"Chemical"},{"id":"T619","span":{"begin":20,"end":25},"obj":"Chemical"},{"id":"T620","span":{"begin":27,"end":32},"obj":"Chemical"},{"id":"T621","span":{"begin":27,"end":30},"obj":"Chemical"},{"id":"T622","span":{"begin":37,"end":42},"obj":"Chemical"},{"id":"T623","span":{"begin":128,"end":130},"obj":"Chemical"},{"id":"T626","span":{"begin":378,"end":380},"obj":"Chemical"},{"id":"T629","span":{"begin":444,"end":454},"obj":"Chemical"},{"id":"T630","span":{"begin":450,"end":454},"obj":"Chemical"},{"id":"T631","span":{"begin":513,"end":520},"obj":"Chemical"},{"id":"T632","span":{"begin":612,"end":620},"obj":"Chemical"}],"attributes":[{"id":"A618","pred":"chebi_id","subj":"T618","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A619","pred":"chebi_id","subj":"T619","obj":"http://purl.obolibrary.org/obo/CHEBI_45919"},{"id":"A620","pred":"chebi_id","subj":"T620","obj":"http://purl.obolibrary.org/obo/CHEBI_75088"},{"id":"A621","pred":"chebi_id","subj":"T621","obj":"http://purl.obolibrary.org/obo/CHEBI_42504"},{"id":"A622","pred":"chebi_id","subj":"T622","obj":"http://purl.obolibrary.org/obo/CHEBI_36001"},{"id":"A623","pred":"chebi_id","subj":"T623","obj":"http://purl.obolibrary.org/obo/CHEBI_5206"},{"id":"A624","pred":"chebi_id","subj":"T623","obj":"http://purl.obolibrary.org/obo/CHEBI_73855"},{"id":"A625","pred":"chebi_id","subj":"T623","obj":"http://purl.obolibrary.org/obo/CHEBI_5354"},{"id":"A626","pred":"chebi_id","subj":"T626","obj":"http://purl.obolibrary.org/obo/CHEBI_5206"},{"id":"A627","pred":"chebi_id","subj":"T626","obj":"http://purl.obolibrary.org/obo/CHEBI_73855"},{"id":"A628","pred":"chebi_id","subj":"T626","obj":"http://purl.obolibrary.org/obo/CHEBI_5354"},{"id":"A629","pred":"chebi_id","subj":"T629","obj":"http://purl.obolibrary.org/obo/CHEBI_35366"},{"id":"A630","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A631","pred":"chebi_id","subj":"T631","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A632","pred":"chebi_id","subj":"T632","obj":"http://purl.obolibrary.org/obo/CHEBI_17895"},{"id":"A633","pred":"chebi_id","subj":"T632","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T113","span":{"begin":102,"end":124},"obj":"http://purl.obolibrary.org/obo/GO_0016209"},{"id":"T114","span":{"begin":521,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0016791"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"LitCovid-sentences","denotations":[{"id":"T176","span":{"begin":0,"end":97},"obj":"Sentence"},{"id":"T177","span":{"begin":98,"end":350},"obj":"Sentence"},{"id":"T178","span":{"begin":351,"end":711},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":213,"end":235},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001626"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}

{"project":"2_test","denotations":[{"id":"32179788-22847190-138463431","span":{"begin":340,"end":341},"obj":"22847190"},{"id":"32179788-24457153-138463432","span":{"begin":342,"end":343},"obj":"24457153"},{"id":"32179788-15592576-138463433","span":{"begin":344,"end":346},"obj":"15592576"},{"id":"32179788-20948210-138463434","span":{"begin":347,"end":349},"obj":"20948210"},{"id":"32179788-22380770-138463435","span":{"begin":463,"end":465},"obj":"22380770"},{"id":"32179788-24998427-138463436","span":{"begin":495,"end":497},"obj":"24998427"},{"id":"32179788-11698056-138463437","span":{"begin":540,"end":542},"obj":"11698056"},{"id":"32179788-27833555-138463438","span":{"begin":709,"end":710},"obj":"27833555"}],"text":"The Ginkgolic acids C13:0, C15:1 and C17:1 are commercially available compounds of Ginkgo leaves. The antioxidative activity of GA has been reported to have multiple therapeutic effects including the treatment of cardiovascular disease, HIV infection, bacterial infections such as Escherichia coli and Staphylococcus aureus, and some tumors7,8,19,20. It has been suggested that GA may operate by several other pathways including: inhibition of fatty acid synthase10; non-specific SIRT inhibition11; activation of protein phosphatase type-2C12; suppression of STAT3 activation through induction of PTEN and SHP-1 Tyrosine Phosphatase21, and protection against Aβ-induced synaptic dysfunction in the hippocampus6."}