PMC:7075884 / 22335-23459
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 803 | 816-825 | Gene | denotes | Lanes 1–4 | |
| 804 | 1044-1051 | Gene | denotes | β-Actin | Gene:728378 |
| 805 | 1056-1060 | Gene | denotes | US11 | Gene:2703439 |
| 806 | 839-848 | Gene | denotes | Lanes 5–8 | |
| 807 | 21-26 | Species | denotes | HSV-1 | Tax:10298 |
| 808 | 719-724 | Species | denotes | HSV-1 | Tax:10298 |
| 809 | 84-88 | Species | denotes | HCMV | Tax:10359 |
| 810 | 127-131 | Species | denotes | HCMV | Tax:10359 |
| 811 | 9-11 | Chemical | denotes | GA | MESH:C112485 |
| 812 | 121-123 | Chemical | denotes | GA | MESH:C112485 |
| 813 | 225-227 | Chemical | denotes | GA | MESH:C112485 |
| 814 | 459-461 | Chemical | denotes | GA | MESH:C112485 |
| 815 | 812-814 | Chemical | denotes | GA | MESH:C112485 |
| 816 | 705-713 | Disease | denotes | infected | MESH:D007239 |
| 817 | 316-319 | CellLine | denotes | HFF | CVCL:3285 |
| 818 | 678-683 | CellLine | denotes | HEp-2 | CVCL:1906 |
| 819 | 691-695 | CellLine | denotes | 293T | CVCL:0063 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T174 | 62-69 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T175 | 92-95 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T176 | 132-135 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T177 | 263-266 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T178 | 275-278 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T179 | 383-387 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T180 | 389-392 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T181 | 899-904 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T182 | 948-952 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T183 | 1046-1051 | Body_part | denotes | Actin | http://purl.org/sig/ont/fma/fma67843 |
| T184 | 1083-1090 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T341 | 108-109 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T342 | 316-319 | http://purl.obolibrary.org/obo/CLO_0052986 | denotes | HFF |
| T343 | 383-387 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T344 | 416-417 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T345 | 537-541 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T346 | 678-683 | http://purl.obolibrary.org/obo/CLO_0003707 | denotes | HEp-2 |
| T347 | 678-683 | http://purl.obolibrary.org/obo/CLO_0050927 | denotes | HEp-2 |
| T348 | 685-686 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T349 | 691-695 | http://purl.obolibrary.org/obo/CLO_0050894 | denotes | 293T |
| T350 | 691-695 | http://purl.obolibrary.org/obo/CLO_0051650 | denotes | 293T |
| T351 | 691-695 | http://purl.obolibrary.org/obo/CLO_0052052 | denotes | 293T |
| T352 | 861-866 | http://purl.obolibrary.org/obo/CLO_0001405 | denotes | 5, 11 |
| T353 | 899-904 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T354 | 924-925 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T355 | 948-952 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T580 | 9-11 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T583 | 62-69 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T584 | 92-95 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T585 | 121-123 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T588 | 132-135 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T589 | 225-227 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T592 | 263-266 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T593 | 275-278 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T594 | 389-392 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T595 | 459-461 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T598 | 812-814 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T601 | 1083-1090 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T92 | 42-79 | http://purl.obolibrary.org/obo/GO_1904972 | denotes | inhibition of viral protein synthesis |
| T93 | 56-79 | http://purl.obolibrary.org/obo/GO_0019081 | denotes | viral protein synthesis |
| T94 | 62-79 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein synthesis |
| T95 | 70-79 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T96 | 92-105 | http://purl.obolibrary.org/obo/GO_0071897 | denotes | DNA synthesis |
| T97 | 96-105 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T98 | 132-145 | http://purl.obolibrary.org/obo/GO_0071897 | denotes | DNA synthesis |
| T99 | 136-145 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T100 | 147-164 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | Viral replication |
| T101 | 147-164 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | Viral replication |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T161 | 0-146 | Sentence | denotes | Figure 7 GA inhibits HSV-1 replication by inhibition of viral protein synthesis and HCMV by DNA synthesis. (A) Effect of GA on HCMV DNA synthesis. |
| T162 | 147-274 | Sentence | denotes | Viral replication is inhibited in the presence of increasing concentration of GA, as determined by decreasing viral DNA copies. |
| T163 | 275-388 | Sentence | denotes | DNA was extracted from 4 pooled wells of HFF at 7 dpi, then analyzed by qPCR targeting the viral polymerase gene. |
| T164 | 389-559 | Sentence | denotes | DNA copies were reduced in a dose dependent manner by the addition of GA to culture medium as determined by ANOVA analysis with pairwise post-hoc t-test analysis in SPSS. |
| T165 | 560-658 | Sentence | denotes | Data are presented as mean percent of control. (*5 µM p = 0.014, 8 µM p = 0.003, 10 µM p = 0.002). |
| T166 | 659-850 | Sentence | denotes | 6 well cultures of HEp-2 (B) or 293T (C) were infected with HSV-1 strain F at an MOI of 1 for 2 hours, then washed with 199V and supplemented with 10 µM GA (Lanes 1–4) or vehicle (Lanes 5–8). |
| T167 | 851-1061 | Sentence | denotes | Mock (M), 5, 11 and 24 hours after inoculation, cells were collected and a fraction of the total cell lysate was subject to Western Blot analysis using antibodies directed against ICP8, ICP27, β-Actin and US11. |
| T168 | 1062-1124 | Sentence | denotes | Normalized ratios of protein expression are in the bar graphs. |