PMC:7075884 / 20053-21577
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 746 | 1063-1067 | Species | denotes | EBOV | Tax:1570291 |
| 747 | 26-28 | Chemical | denotes | GA | MESH:C112485 |
| 748 | 64-66 | Chemical | denotes | GA | MESH:C112485 |
| 749 | 132-134 | Chemical | denotes | GA | MESH:C112485 |
| 750 | 152-154 | Chemical | denotes | GA | MESH:C112485 |
| 751 | 179-181 | Chemical | denotes | GA | MESH:C112485 |
| 752 | 310-312 | Chemical | denotes | GA | MESH:C112485 |
| 753 | 408-410 | Chemical | denotes | GA | MESH:C112485 |
| 754 | 524-526 | Chemical | denotes | GA | MESH:C112485 |
| 755 | 652-654 | Chemical | denotes | GA | MESH:C112485 |
| 756 | 704-706 | Chemical | denotes | GA | MESH:C112485 |
| 757 | 772-774 | Chemical | denotes | GA | MESH:C112485 |
| 758 | 962-964 | Chemical | denotes | GA | MESH:C112485 |
| 759 | 1059-1061 | Chemical | denotes | GA | MESH:C112485 |
| 760 | 1168-1170 | Chemical | denotes | GA | MESH:C112485 |
| 761 | 1202-1212 | Chemical | denotes | oleic acid | MESH:D019301 |
| 762 | 1338-1340 | Chemical | denotes | GA | MESH:C112485 |
| 763 | 1390-1392 | Chemical | denotes | GA | MESH:C112485 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T161 | 252-257 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T162 | 1086-1093 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T163 | 1148-1152 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T164 | 1153-1157 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T325 | 69-70 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T326 | 252-257 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T327 | 367-368 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T328 | 702-703 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T329 | 782-791 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T330 | 1127-1128 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T331 | 1148-1152 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T332 | 1153-1157 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T492 | 9-11 | Chemical | denotes | OA | http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196 |
| T494 | 26-28 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T497 | 64-66 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T500 | 132-134 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T503 | 152-154 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T506 | 179-181 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T509 | 310-312 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T512 | 337-345 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T513 | 376-384 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T514 | 408-410 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T517 | 467-475 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T518 | 524-526 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T521 | 652-654 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T524 | 677-685 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T525 | 704-706 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T528 | 723-731 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T529 | 772-774 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T532 | 823-831 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T533 | 962-964 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T536 | 1034-1042 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T537 | 1059-1061 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T540 | 1068-1070 | Chemical | denotes | GP | http://purl.obolibrary.org/obo/CHEBI_70744 |
| T541 | 1086-1093 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T542 | 1168-1170 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T545 | 1202-1212 | Chemical | denotes | oleic acid | http://purl.obolibrary.org/obo/CHEBI_16196 |
| T546 | 1208-1212 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T547 | 1214-1216 | Chemical | denotes | OA | http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196 |
| T549 | 1241-1244 | Chemical | denotes | dye | http://purl.obolibrary.org/obo/CHEBI_37958 |
| T550 | 1338-1340 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
| T553 | 1376-1378 | Chemical | denotes | OA | http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196 |
| T555 | 1390-1392 | Chemical | denotes | GA | http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T80 | 633-646 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
| T81 | 988-1001 | http://purl.obolibrary.org/obo/GO_0045851 | denotes | acidification |
| T82 | 1148-1164 | http://purl.obolibrary.org/obo/GO_0140253 | denotes | cell-cell fusion |
| T83 | 1148-1164 | http://purl.obolibrary.org/obo/GO_0045026 | denotes | cell-cell fusion |
| T84 | 1153-1164 | http://purl.obolibrary.org/obo/GO_0000768 | denotes | cell fusion |
| T85 | 1153-1164 | http://purl.obolibrary.org/obo/GO_0000747 | denotes | cell fusion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T137 | 0-135 | Sentence | denotes | Figure 6 OA together with GA abolished the inhibitory effect of GA. (A) Dissecting the stages of fusion affected by the presence of GA. |
| T138 | 136-171 | Sentence | denotes | Bar 1, control: GA was not present. |
| T139 | 172-224 | Sentence | denotes | Bar 2: GA was maintained throughout the experiments. |
| T140 | 225-231 | Sentence | denotes | Bar 3: |
| T141 | 232-313 | Sentence | denotes | Effector and target cells were incubated for 30 min. in the presence of 10 µM GA. |
| T142 | 314-447 | Sentence | denotes | The neutral pH bathing solution was then replaced by a pH 5.7 solution, which did not contain GA, and this was maintained for 10 min. |
| T143 | 448-552 | Sentence | denotes | The low pH bathing solution was replaced by one at neutral pH, also without GA, and fusion was measured. |
| T144 | 553-559 | Sentence | denotes | Bar 4: |
| T145 | 560-832 | Sentence | denotes | The same protocol was followed as for experiments of bar 3, but prior to acidification, the GA-containing neutral pH solution was replaced by a GA-free neutral pH solution that was maintained for 10 min to allow GA in the membranes to dissociate into the aqueous solution. |
| T146 | 833-894 | Sentence | denotes | This almost restored the extent of fusion to that of control. |
| T147 | 895-901 | Sentence | denotes | Bar 5: |
| T148 | 902-1002 | Sentence | denotes | The same protocol as for experiments of bar 3 was used, but GA was maintained through acidification. |
| T149 | 1003-1062 | Sentence | denotes | The subsequent neutral pH wash solution did not contain GA. |
| T150 | 1063-1218 | Sentence | denotes | EBOV GP was the fusion protein for these experiments. (n = 3). (B) The inhibition of cell-cell fusion by GA is reversed by the presence of oleic acid (OA). |
| T151 | 1219-1232 | Sentence | denotes | Upper panels: |
| T152 | 1233-1356 | Sentence | denotes | Massive dye mixing was observed for control (left image), but none was observed in the presence of 10 µM GA (middle image). |
| T153 | 1357-1465 | Sentence | denotes | Addition of 250 µM OA along with GA (right image), resulted in the same degree of fusion as for the control. |
| T154 | 1466-1524 | Sentence | denotes | Extent of fusion is quantified in the bar graphs. (n = 3). |