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PMC:7075884 / 18875-21577 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
746 2241-2245 Species denotes EBOV Tax:1570291
747 1204-1206 Chemical denotes GA MESH:C112485
748 1242-1244 Chemical denotes GA MESH:C112485
749 1310-1312 Chemical denotes GA MESH:C112485
750 1330-1332 Chemical denotes GA MESH:C112485
751 1357-1359 Chemical denotes GA MESH:C112485
752 1488-1490 Chemical denotes GA MESH:C112485
753 1586-1588 Chemical denotes GA MESH:C112485
754 1702-1704 Chemical denotes GA MESH:C112485
755 1830-1832 Chemical denotes GA MESH:C112485
756 1882-1884 Chemical denotes GA MESH:C112485
757 1950-1952 Chemical denotes GA MESH:C112485
758 2140-2142 Chemical denotes GA MESH:C112485
759 2237-2239 Chemical denotes GA MESH:C112485
760 2346-2348 Chemical denotes GA MESH:C112485
761 2380-2390 Chemical denotes oleic acid MESH:D019301
762 2516-2518 Chemical denotes GA MESH:C112485
763 2568-2570 Chemical denotes GA MESH:C112485
774 5-7 Chemical denotes GA MESH:C112485
775 75-77 Chemical denotes GA MESH:C112485
776 254-259 Chemical denotes lipid MESH:D008055
777 550-552 Chemical denotes GA MESH:C112485
778 733-756 Chemical denotes lysophosphatidylcholine MESH:D008244
779 758-761 Chemical denotes LPC MESH:D008244
780 861-871 Chemical denotes oleic acid MESH:D019301
781 1070-1072 Chemical denotes GA MESH:C112485
782 1108-1110 Chemical denotes GA MESH:C112485
783 1138-1140 Chemical denotes GA MESH:C112485

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T156 160-167 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T157 254-259 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T158 443-450 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T159 505-513 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T160 855-860 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T161 1430-1435 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T162 2264-2271 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T163 2326-2330 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T164 2331-2335 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T318 104-105 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T319 282-291 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T320 458-467 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T321 877-880 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T322 881-882 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T323 904-912 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T324 1158-1166 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T325 1247-1248 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T326 1430-1435 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T327 1545-1546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 1880-1881 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T329 1960-1969 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T330 2305-2306 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T331 2326-2330 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T332 2331-2335 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T455 5-7 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T458 75-77 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T461 160-167 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T462 254-259 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T463 443-450 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T464 482-484 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T467 505-513 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T468 550-552 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T471 733-756 Chemical denotes lysophosphatidylcholine http://purl.obolibrary.org/obo/CHEBI_60479
T472 758-761 Chemical denotes LPC http://purl.obolibrary.org/obo/CHEBI_11502|http://purl.obolibrary.org/obo/CHEBI_16728|http://purl.obolibrary.org/obo/CHEBI_17504|http://purl.obolibrary.org/obo/CHEBI_60479
T476 855-860 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T477 861-871 Chemical denotes oleic acid http://purl.obolibrary.org/obo/CHEBI_16196
T478 867-871 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T479 873-875 Chemical denotes OA http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196
T481 1053-1055 Chemical denotes OA http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196
T483 1070-1072 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T486 1108-1110 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T489 1138-1140 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T492 1187-1189 Chemical denotes OA http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196
T494 1204-1206 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T497 1242-1244 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T500 1310-1312 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T503 1330-1332 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T506 1357-1359 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T509 1488-1490 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T512 1515-1523 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T513 1554-1562 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T514 1586-1588 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T517 1645-1653 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T518 1702-1704 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T521 1830-1832 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T524 1855-1863 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T525 1882-1884 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T528 1901-1909 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T529 1950-1952 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T532 2001-2009 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T533 2140-2142 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T536 2212-2220 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T537 2237-2239 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T540 2246-2248 Chemical denotes GP http://purl.obolibrary.org/obo/CHEBI_70744
T541 2264-2271 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T542 2346-2348 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T545 2380-2390 Chemical denotes oleic acid http://purl.obolibrary.org/obo/CHEBI_16196
T546 2386-2390 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T547 2392-2394 Chemical denotes OA http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196
T549 2419-2422 Chemical denotes dye http://purl.obolibrary.org/obo/CHEBI_37958
T550 2516-2518 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T553 2554-2556 Chemical denotes OA http://purl.obolibrary.org/obo/CHEBI_138856|http://purl.obolibrary.org/obo/CHEBI_16196
T555 2568-2570 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T78 904-922 http://purl.obolibrary.org/obo/GO_0097753 denotes membrane curvature
T79 1158-1176 http://purl.obolibrary.org/obo/GO_0097753 denotes membrane curvature
T80 1811-1824 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T81 2166-2179 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T82 2326-2342 http://purl.obolibrary.org/obo/GO_0140253 denotes cell-cell fusion
T83 2326-2342 http://purl.obolibrary.org/obo/GO_0045026 denotes cell-cell fusion
T84 2331-2342 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T85 2331-2342 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T130 0-124 Sentence denotes When GA was removed, fusion was restored (Fig. 6A, Bar 4), indicating that GA interferes with fusion in a reversible manner.
T131 125-377 Sentence denotes Viral fusion, regardless of fusion protein, proceeds through the creation of hemifusion, an intermediate state in which proximal lipid monolayer leaflets of membranes, in contact with one another, have merged, but the distal monolayers remain distinct.
T132 378-525 Sentence denotes Because inhibition of fusion was universal, independent of viral protein, it is extremely unlikely that GA targeted the fusion proteins themselves.
T133 526-652 Sentence denotes This is consistent with GA inhibiting the creation of the hemifusion intermediate, and universal inhibition would be expected.
T134 653-828 Sentence denotes It is well known that agents conferring positive spontaneous curvature, such as lysophosphatidylcholine (LPC), inhibit fusion induced by viral and non-viral fusion proteins17.
T135 829-1036 Sentence denotes Likewise, the cone-shaped lipid oleic acid (OA) has a negative spontaneous membrane curvature, which favors hemifusion when present in the outer bilayer, and its presence relieves the inhibition of fusion18.
T136 1037-1177 Sentence denotes The addition of OA together with GA abolished the inhibitory effect of GA (Fig. 6B), indicating that GA induces positive membrane curvature.
T137 1178-1313 Sentence denotes Figure 6 OA together with GA abolished the inhibitory effect of GA. (A) Dissecting the stages of fusion affected by the presence of GA.
T138 1314-1349 Sentence denotes Bar 1, control: GA was not present.
T139 1350-1402 Sentence denotes Bar 2: GA was maintained throughout the experiments.
T140 1403-1409 Sentence denotes Bar 3:
T141 1410-1491 Sentence denotes Effector and target cells were incubated for 30 min. in the presence of 10 µM GA.
T142 1492-1625 Sentence denotes The neutral pH bathing solution was then replaced by a pH 5.7 solution, which did not contain GA, and this was maintained for 10 min.
T143 1626-1730 Sentence denotes The low pH bathing solution was replaced by one at neutral pH, also without GA, and fusion was measured.
T144 1731-1737 Sentence denotes Bar 4:
T145 1738-2010 Sentence denotes The same protocol was followed as for experiments of bar 3, but prior to acidification, the GA-containing neutral pH solution was replaced by a GA-free neutral pH solution that was maintained for 10 min to allow GA in the membranes to dissociate into the aqueous solution.
T146 2011-2072 Sentence denotes This almost restored the extent of fusion to that of control.
T147 2073-2079 Sentence denotes Bar 5:
T148 2080-2180 Sentence denotes The same protocol as for experiments of bar 3 was used, but GA was maintained through acidification.
T149 2181-2240 Sentence denotes The subsequent neutral pH wash solution did not contain GA.
T150 2241-2396 Sentence denotes EBOV GP was the fusion protein for these experiments. (n = 3). (B) The inhibition of cell-cell fusion by GA is reversed by the presence of oleic acid (OA).
T151 2397-2410 Sentence denotes Upper panels:
T152 2411-2534 Sentence denotes Massive dye mixing was observed for control (left image), but none was observed in the presence of 10 µM GA (middle image).
T153 2535-2643 Sentence denotes Addition of 250 µM OA along with GA (right image), resulted in the same degree of fusion as for the control.
T154 2644-2702 Sentence denotes Extent of fusion is quantified in the bar graphs. (n = 3).

2_test

Id Subject Object Predicate Lexical cue
32179788-17043140-138463429 825-827 17043140 denotes 17
32179788-14527322-138463430 1033-1035 14527322 denotes 18