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PMC:7075884 / 1855-4343 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
110 698-701 Gene denotes C17 Gene:54360
111 687-690 Gene denotes C15 Gene:51316
112 680-683 Gene denotes C13 Gene:3229
113 86-99 Species denotes Ginkgo biloba Tax:3311
114 101-114 Species denotes Ginkgo biloba Tax:3311
115 13-28 Chemical denotes Ginkgolic acids MESH:C112485
116 33-44 Chemical denotes alkylphenol
117 260-279 Chemical denotes terpine trilactones
118 281-302 Chemical denotes ginkgolide A, B, C, J
119 308-318 Chemical denotes bilobalide MESH:C073710
120 321-341 Chemical denotes flavonoid glycosides
121 343-352 Chemical denotes quercetin MESH:D011794
122 357-362 Chemical denotes rutin MESH:D012431
123 376-391 Chemical denotes Ginkgolic acids MESH:C112485
124 394-409 Chemical denotes Ginkgolic acids MESH:C112485
125 435-465 Chemical denotes 2-hydroxy-6-alkylbenzoic acids
126 526-533 Chemical denotes carbons MESH:D002244
127 549-555 Chemical denotes carbon MESH:D002244
128 622-636 Chemical denotes Ginkgolic acid MESH:C112485
129 638-640 Chemical denotes GA MESH:C112485
139 885-889 Gene denotes AMPK Gene:5564
140 922-931 Gene denotes amyloid-β Gene:351
141 933-935 Gene denotes Aβ Gene:351
142 1294-1313 Gene denotes fatty acid synthase Gene:2194
143 1089-1105 Species denotes Escherichia coli Tax:562
144 1110-1131 Species denotes Staphylococcus aureus Tax:1280
145 717-719 Chemical denotes GA MESH:C112485
146 1043-1045 Chemical denotes GA MESH:C112485
147 1156-1158 Chemical denotes GA MESH:C112485
170 1454-1476 Species denotes Herpes simplex virus 1 Tax:10298
171 1478-1483 Species denotes HSV-1 Tax:10298
172 1486-1507 Species denotes Human cytomegalovirus Tax:10359
173 1520-1530 Species denotes Zika virus Tax:64320
174 1532-1536 Species denotes ZIKV Tax:64320
175 2131-2136 Species denotes human Tax:9606
176 2169-2173 Species denotes ZIKV Tax:64320
177 2180-2184 Species denotes EBOV Tax:1570291
178 2190-2207 Species denotes influenza A virus Tax:11320
179 2226-2262 Species denotes Venezuelan equine encephalitis virus Tax:11036
180 2264-2268 Species denotes VEEV Tax:11036
181 2274-2294 Species denotes Semliki Forest virus Tax:11033
182 2318-2344 Species denotes vesicular stomatitis virus Tax:11276
183 1509-1513 Species denotes HCMV Tax:10359
184 1663-1673 Species denotes adenovirus Tax:10508
185 2209-2212 Species denotes IAV Tax:11320
186 2296-2299 Species denotes SFV Tax:11033
187 2346-2349 Species denotes VSV Tax:11276
188 2375-2378 Species denotes EBV Tax:10376
189 1418-1420 Chemical denotes GA MESH:C112485
190 2427-2429 Chemical denotes GA MESH:C112485
191 1941-1954 Disease denotes viral disease MESH:D001102

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T11 868-876 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T12 984-987 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T13 1017-1020 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T14 1294-1304 Body_part denotes fatty acid http://purl.org/sig/ont/fma/fma82738
T15 1367-1374 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 2175-2178 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p19178s17 824-833 NegReg denotes decreased
p19178s18 834-844 MPA denotes expression

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T15 922-929 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T16 1454-1468 Disease denotes Herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T17 1520-1524 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661
T18 1941-1954 Disease denotes viral disease http://purl.obolibrary.org/obo/MONDO_0005108
T19 2190-2199 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T20 2226-2256 Disease denotes Venezuelan equine encephalitis http://purl.obolibrary.org/obo/MONDO_0006005
T21 2244-2256 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T22 2318-2338 Disease denotes vesicular stomatitis http://purl.obolibrary.org/obo/MONDO_0025028
T23 2328-2338 Disease denotes stomatitis http://purl.obolibrary.org/obo/MONDO_0004842

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T23 292-293 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T24 295-296 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T25 414-415 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 698-703 http://purl.obolibrary.org/obo/CLO_0002099 denotes C17:1
T27 711-713 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T28 720-723 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T29 890-900 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T30 933-934 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T31 997-1005 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T32 1072-1080 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T33 1221-1229 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T34 1257-1259 http://purl.obolibrary.org/obo/CLO_0002857 denotes E1
T35 1353-1363 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T36 1437-1445 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T37 1469-1474 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 1486-1491 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T39 1525-1530 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T40 1625-1626 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 1783-1791 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T42 2023-2024 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 2131-2136 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T44 2147-2154 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T45 2200-2201 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T46 2202-2207 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T47 2237-2243 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes equine
T48 2257-2262 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T49 2289-2294 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T50 2339-2344 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T51 2368-2373 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T39 23-28 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T40 281-291 Chemical denotes ginkgolide http://purl.obolibrary.org/obo/CHEBI_136909
T41 308-318 Chemical denotes bilobalide http://purl.obolibrary.org/obo/CHEBI_3103
T42 321-330 Chemical denotes flavonoid http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T44 331-341 Chemical denotes glycosides http://purl.obolibrary.org/obo/CHEBI_24400
T45 343-352 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T47 357-362 Chemical denotes rutin http://purl.obolibrary.org/obo/CHEBI_28527
T48 404-409 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T49 416-423 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T50 437-444 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T51 460-465 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T52 549-555 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T54 622-636 Chemical denotes Ginkgolic acid http://purl.obolibrary.org/obo/CHEBI_5354
T55 632-636 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T56 638-640 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T59 680-685 Chemical denotes C13:0 http://purl.obolibrary.org/obo/CHEBI_45919
T60 687-692 Chemical denotes C15:1 http://purl.obolibrary.org/obo/CHEBI_75088
T61 687-690 Chemical denotes C15 http://purl.obolibrary.org/obo/CHEBI_42504
T62 698-703 Chemical denotes C17:1 http://purl.obolibrary.org/obo/CHEBI_36001
T63 717-719 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T66 868-876 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T67 1043-1045 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T70 1156-1158 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T73 1294-1304 Chemical denotes fatty acid http://purl.obolibrary.org/obo/CHEBI_35366
T74 1300-1304 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T75 1367-1374 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T76 1418-1420 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T79 1427-1436 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T80 1679-1688 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T81 1773-1782 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T82 2064-2066 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354
T85 2222-2224 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T86 2427-2429 Chemical denotes GA http://purl.obolibrary.org/obo/CHEBI_5206|http://purl.obolibrary.org/obo/CHEBI_73855|http://purl.obolibrary.org/obo/CHEBI_5354

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T14 811-822 http://purl.obolibrary.org/obo/GO_0008610 denotes lipogenesis
T15 885-889 http://purl.obolibrary.org/obo/GO_0050405 denotes AMPK
T16 885-889 http://purl.obolibrary.org/obo/GO_0047322 denotes AMPK
T17 885-889 http://purl.obolibrary.org/obo/GO_0004691 denotes AMPK
T18 988-1005 http://purl.obolibrary.org/obo/GO_0008233 denotes protease activity
T19 1198-1209 http://purl.obolibrary.org/obo/GO_0016925 denotes SUMOylation
T20 1240-1249 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T21 1375-1386 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T14 0-12 Sentence denotes Introduction
T15 13-100 Sentence denotes Ginkgolic acids are alkylphenol constituents of the leaves and fruits of Ginkgo biloba.
T16 101-225 Sentence denotes Ginkgo biloba extracts (GBE) have been used as herbal supplements since at least the 16th century and remain widely in use1.
T17 226-393 Sentence denotes Major constituents of GBE include terpine trilactones (ginkgolide A, B, C, J, and bilobalide), flavonoid glycosides (quercetin and rutin), as well as Ginkgolic acids2.
T18 394-534 Sentence denotes Ginkgolic acids are a mixture of several 2-hydroxy-6-alkylbenzoic acids in which the most common alkyl chains contain 13, 15, or 17 carbons.
T19 535-615 Sentence denotes The 15 and 17 carbon chains are unsaturated at positions 8 and 10, respectively.
T20 616-716 Sentence denotes The 3 Ginkgolic acid (GA) structures are, therefore, designated C13:0, C15:1, and C17:1 (Table S1)3.
T21 717-1042 Sentence denotes GA has shown pleiotropic effects in vitro, including: antitumor effects through inhibition of lipogenesis; decreased expression of invasion associated proteins through AMPK activation; potential rescue of amyloid-β (Aβ) induced synaptic impairment; and inhibition of HIV protease activity as well as HIV viral replication4–7.
T22 1043-1133 Sentence denotes GA was also reported to have activity against Escherichia coli and Staphylococcus aureus8.
T23 1134-1397 Sentence denotes Several ways in which GA works have been suggested including by SUMOylation inhibition activity; blocking formation of the E1-SUMO intermediate9; inhibition of fatty acid synthase10; non-specific SIRT inhibition11; and activation of protein phosphatase type-2C12.
T24 1398-1580 Sentence denotes Here we report that GA shows antiviral activity against Herpes simplex virus 1 (HSV-1), Human cytomegalovirus (HCMV), and Zika virus (ZIKV) primarily through viral fusion inhibition.
T25 1581-1674 Sentence denotes In addition, we show inhibition of entry of a replication-defective non-enveloped adenovirus.
T26 1675-1741 Sentence denotes The antiviral effects were observed below the cytotoxic threshold.
T27 1742-2014 Sentence denotes We believe that broad spectrum antiviral activity is achieved through the inhibition of viral entry and that this effect could be therapeutically utilized systemically in the context of severe acute viral disease, or topically for the treatment of cutaneous viral lesions.
T28 2015-2381 Sentence denotes We show a broad spectrum of fusion inhibition by GA of all three classes of fusion proteins13 including: pathogenic human enveloped viruses from Class I (ZIKV, HIV, EBOV, and influenza A virus (IAV)), Class II (Venezuelan equine encephalitis virus (VEEV) and Semliki Forest virus (SFV)), and Class III (vesicular stomatitis virus (VSV) and Epstein Barr virus (EBV)).
T29 2382-2488 Sentence denotes Taken together, our experiments suggest that GA inhibits viral entry by blocking the initial fusion event.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 2244-2256 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T2 2328-2338 Phenotype denotes stomatitis http://purl.obolibrary.org/obo/HP_0010280

2_test

Id Subject Object Predicate Lexical cue
32179788-26392712-138463415 223-224 26392712 denotes 1
32179788-19195661-138463416 391-392 19195661 denotes 2
32179788-10766484-138463417 714-715 10766484 denotes 3
32179788-25895130-138463418 1038-1039 25895130 denotes 4
32179788-29113214-138463418 1038-1039 29113214 denotes 4
32179788-27833555-138463418 1038-1039 27833555 denotes 4
32179788-22847190-138463418 1038-1039 22847190 denotes 4
32179788-24457153-138463419 1131-1132 24457153 denotes 8
32179788-19246003-138463420 1277-1278 19246003 denotes 9
32179788-22380770-138463421 1313-1315 22380770 denotes 10
32179788-24998427-138463422 1345-1347 24998427 denotes 11
32179788-11698056-138463423 1394-1396 11698056 denotes 12
32179788-25866377-138463424 2106-2108 25866377 denotes 13