PMC:7075271 / 93-2971
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 12 | 42-47 | Species | denotes | human | Tax:9606 |
| 13 | 70-80 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 14 | 340-350 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 15 | 494-504 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 16 | 13-21 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 17 | 48-66 | Disease | denotes | infectious disease | MESH:D003141 |
| 18 | 139-147 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 19 | 386-394 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 37 | 846-856 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 38 | 913-921 | Species | denotes | patients | Tax:9606 |
| 39 | 1009-1016 | Species | denotes | patient | Tax:9606 |
| 40 | 1203-1213 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 41 | 1353-1361 | Species | denotes | patients | Tax:9606 |
| 42 | 1433-1441 | Species | denotes | patients | Tax:9606 |
| 43 | 699-720 | Disease | denotes | hepatic abnormalities | MESH:D056486 |
| 44 | 751-760 | Disease | denotes | infection | MESH:D007239 |
| 45 | 766-774 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 46 | 957-983 | Disease | denotes | steatosis and liver injury | MESH:D005234 |
| 47 | 1022-1030 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 48 | 1051-1065 | Disease | denotes | liver injuries | MESH:D017093 |
| 49 | 1126-1144 | Disease | denotes | acute renal injury | MESH:D058186 |
| 50 | 1155-1163 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 51 | 1219-1231 | Disease | denotes | inflammation | MESH:D007249 |
| 52 | 1367-1385 | Disease | denotes | acute renal injury | MESH:D058186 |
| 53 | 1400-1409 | Disease | denotes | mortality | MESH:D003643 |
| 72 | 1541-1549 | Species | denotes | patients | Tax:9606 |
| 73 | 1613-1621 | Species | denotes | SARS-CoV | Tax:694009 |
| 74 | 1626-1634 | Species | denotes | MERS-CoV | Tax:1335626 |
| 75 | 1640-1661 | Chemical | denotes | chloroquine phosphate | MESH:C023676 |
| 76 | 1802-1813 | Chemical | denotes | Oseltamivir | MESH:D053139 |
| 77 | 1815-1836 | Chemical | denotes | Lopinavir / Ritonavir | MESH:C558899 |
| 78 | 1838-1847 | Chemical | denotes | Ribavirin | MESH:D012254 |
| 79 | 1853-1874 | Chemical | denotes | Chloroquine Phosphate | MESH:C023676 |
| 80 | 1878-1905 | Chemical | denotes | Hydroxy Chloroquine Sulfate | MESH:D006886 |
| 81 | 1997-2008 | Chemical | denotes | Oseltamivir | MESH:D053139 |
| 82 | 2010-2019 | Chemical | denotes | Ribavirin | MESH:D012254 |
| 83 | 2051-2072 | Chemical | denotes | Lopinavir / Ritonavir | MESH:C558899 |
| 84 | 2074-2095 | Chemical | denotes | Chloroquine Phosphate | MESH:C023676 |
| 85 | 2100-2127 | Chemical | denotes | Hydroxy Chloroquine Sulfate | MESH:D006886 |
| 86 | 1489-1497 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 87 | 1785-1793 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 88 | 2158-2173 | Disease | denotes | renal excretion | MESH:D007674 |
| 89 | 2338-2346 | Disease | denotes | toxicity | MESH:D064420 |
| 96 | 2447-2455 | Species | denotes | patients | Tax:9606 |
| 97 | 2594-2602 | Species | denotes | patients | Tax:9606 |
| 98 | 2682-2690 | Species | denotes | patients | Tax:9606 |
| 99 | 2461-2469 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 100 | 2696-2704 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 101 | 2736-2762 | Disease | denotes | liver and kidney disorders | MESH:D007674 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T128 | 13-21 | SP_7 | denotes | COVID-19 |
| T127 | 42-47 | SP_6;NCBITaxon:9606 | denotes | human |
| T126 | 70-80 | SP_7 | denotes | SARS-CoV-2 |
| T125 | 139-147 | SP_7 | denotes | COVID-19 |
| T124 | 340-350 | SP_7 | denotes | SARS-CoV-2 |
| T123 | 386-394 | SP_7 | denotes | COVID-19 |
| T122 | 412-417 | UBERON:0000170 | denotes | lungs |
| T121 | 430-435 | UBERON:0000062 | denotes | organ |
| T120 | 494-504 | SP_7 | denotes | SARS-CoV-2 |
| T119 | 526-532 | UBERON:0000062 | denotes | organs |
| T118 | 544-549 | UBERON:0002107 | denotes | liver |
| T117 | 554-561 | UBERON:0002113 | denotes | kidneys |
| T116 | 584-594 | GO:0008152 | denotes | metabolism |
| T115 | 599-608 | GO:0007588 | denotes | excretion |
| T114 | 699-706 | UBERON:0002107 | denotes | hepatic |
| T113 | 766-774 | SP_7 | denotes | COVID-19 |
| T112 | 846-856 | SP_7 | denotes | SARS-CoV-2 |
| T111 | 864-869 | UBERON:0002107 | denotes | liver |
| T110 | 971-976 | UBERON:0002107 | denotes | liver |
| T109 | 991-996 | UBERON:0002107 | denotes | liver |
| T108 | 1022-1030 | SP_7 | denotes | COVID-19 |
| T107 | 1051-1056 | UBERON:0002107 | denotes | liver |
| T106 | 1132-1137 | UBERON:0002113 | denotes | renal |
| T105 | 1155-1163 | SP_7 | denotes | COVID-19 |
| T104 | 1203-1213 | SP_7 | denotes | SARS-CoV-2 |
| T103 | 1291-1298 | UBERON:0002113 | denotes | kidneys |
| T102 | 1373-1378 | UBERON:0002113 | denotes | renal |
| T101 | 1489-1497 | SP_7 | denotes | COVID-19 |
| T100 | 1613-1621 | SP_10 | denotes | SARS-CoV |
| T99 | 1626-1634 | SP_9 | denotes | MERS-CoV |
| T98 | 1640-1651 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | chloroquine |
| T97 | 1652-1661 | CHEBI:18367;CHEBI:18367 | denotes | phosphate |
| T96 | 1745-1754 | CHEBI:23888;CHEBI:23888 | denotes | Medicines |
| T95 | 1785-1793 | SP_7 | denotes | COVID-19 |
| T94 | 1802-1813 | CHEBI:7798;CHEBI:7798 | denotes | Oseltamivir |
| T92 | 1827-1836 | DG_30 | denotes | Ritonavir |
| T91 | 1838-1847 | CHEBI:63580;CHEBI:63580;DG_29 | denotes | Ribavirin |
| T90 | 1853-1864 | CHEBI:3638;CHEBI:3638;DG_10 | denotes | Chloroquine |
| T89 | 1878-1885 | CHEBI:43176;CHEBI:43176 | denotes | Hydroxy |
| T88 | 1886-1897 | DG_10;CHEBI:50178;CHEBI:50178 | denotes | Chloroquine |
| T87 | 1898-1905 | CHEBI:50178;CHEBI:50178 | denotes | Sulfate |
| T86 | 1934-1945 | GO:0008152 | denotes | metabolized |
| T85 | 1953-1958 | UBERON:0002107 | denotes | liver |
| T84 | 1972-1983 | CHEBI:25212;CHEBI:25212 | denotes | metabolites |
| T83 | 1997-2008 | CHEBI:7798;CHEBI:7798 | denotes | Oseltamivir |
| T82 | 2010-2019 | CHEBI:85129;CHEBI:85129;DG_29 | denotes | Ribavirin |
| T81 | 2036-2047 | CHEBI:25212;CHEBI:25212 | denotes | metabolites |
| T80 | 2051-2060 | DG_23 | denotes | Lopinavir |
| T79 | 2063-2072 | DG_30 | denotes | Ritonavir |
| T78 | 2074-2085 | CHEBI:3638;CHEBI:3638;DG_10 | denotes | Chloroquine |
| T77 | 2100-2107 | CHEBI:43176;CHEBI:43176 | denotes | Hydroxy |
| T76 | 2108-2119 | DG_10;CHEBI:50178;CHEBI:50178 | denotes | Chloroquine |
| T75 | 2120-2127 | CHEBI:50178;CHEBI:50178 | denotes | Sulfate |
| T74 | 2145-2150 | UBERON:0001088 | denotes | urine |
| T73 | 2158-2163 | UBERON:0002113 | denotes | renal |
| T72 | 2164-2173 | GO:0007588 | denotes | excretion |
| T71 | 2200-2205 | UBERON:0002107 | denotes | liver |
| T70 | 2210-2217 | UBERON:0002113 | denotes | kidneys |
| T69 | 2229-2239 | GO:0008152 | denotes | metabolism |
| T68 | 2241-2250 | GO:0007588 | denotes | excretion |
| T67 | 2294-2305 | CHEBI:23888;CHEBI:23888 | denotes | medications |
| T66 | 2411-2416 | UBERON:0002107 | denotes | liver |
| T65 | 2421-2428 | UBERON:0002113 | denotes | kidneys |
| T64 | 2461-2469 | SP_7 | denotes | COVID-19 |
| T63 | 2523-2532 | CHEBI:23888;CHEBI:23888 | denotes | medicines |
| T62 | 2576-2580 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T61 | 2652-2657 | UBERON:0002107 | denotes | liver |
| T60 | 2662-2668 | UBERON:0002113 | denotes | kidney |
| T59 | 2696-2704 | SP_7 | denotes | COVID-19 |
| T58 | 2736-2741 | UBERON:0002107 | denotes | liver |
| T57 | 2746-2752 | UBERON:0002113 | denotes | kidney |
| T56 | 2863-2867 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T93 | 1815-1824 | DG_23 | denotes | Lopinavir |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T3 | 412-417 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T4 | 430-435 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T5 | 544-549 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T6 | 554-561 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T7 | 864-869 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T8 | 971-976 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T9 | 991-996 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T10 | 1051-1056 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T11 | 1291-1298 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T12 | 1953-1958 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T13 | 2145-2150 | Body_part | denotes | urine | http://purl.org/sig/ont/fma/fma12274 |
| T14 | 2200-2205 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T15 | 2210-2217 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T16 | 2411-2416 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T17 | 2421-2428 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T18 | 2652-2657 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T19 | 2662-2668 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T20 | 2736-2741 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T21 | 2746-2752 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T3 | 430-435 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T4 | 526-532 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T5 | 544-549 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T6 | 864-869 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T7 | 971-976 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 991-996 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T9 | 1051-1056 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T10 | 1953-1958 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 2145-2150 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T12 | 2200-2205 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T13 | 2411-2416 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T14 | 2652-2657 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T15 | 2662-2668 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T16 | 2736-2741 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T17 | 2746-2752 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p19006s9 | 2222-2228 | NegReg | denotes | impair |
| p19006s10 | 2229-2239 | MPA | denotes | metabolism |
| p19006s12 | 2241-2250 | MPA | denotes | excretion |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T2 | 13-21 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 48-66 | Disease | denotes | infectious disease | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T4 | 70-78 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T5 | 139-147 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 340-348 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T7 | 386-394 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T8 | 494-502 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T9 | 751-760 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T10 | 766-774 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T11 | 846-854 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T12 | 957-976 | Disease | denotes | steatosis and liver | http://purl.obolibrary.org/obo/MONDO_0004790|http://purl.obolibrary.org/obo/MONDO_0009220 |
| T14 | 977-983 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T15 | 1022-1030 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T16 | 1138-1144 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T17 | 1155-1163 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T18 | 1203-1211 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T19 | 1219-1231 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T20 | 1379-1385 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T21 | 1489-1497 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T22 | 1613-1621 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T23 | 1785-1793 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T24 | 2186-2192 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T25 | 2461-2469 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T26 | 2696-2704 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T27 | 2746-2762 | Disease | denotes | kidney disorders | http://purl.obolibrary.org/obo/MONDO_0005240 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7 | 25-26 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 42-47 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T9 | 93-96 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T10 | 231-243 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | Organization |
| T11 | 250-253 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T12 | 263-264 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T13 | 318-319 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 412-417 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T15 | 430-435 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T16 | 526-532 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organs |
| T17 | 544-549 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T18 | 544-549 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T19 | 554-561 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T20 | 554-561 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T21 | 554-561 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T22 | 864-869 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T23 | 864-869 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T24 | 971-976 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T25 | 971-976 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T26 | 991-996 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T27 | 991-996 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T28 | 1007-1008 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T29 | 1051-1056 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T30 | 1051-1056 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T31 | 1259-1260 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T32 | 1291-1298 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T33 | 1291-1298 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T34 | 1291-1298 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T35 | 1300-1304 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 3, 4 |
| T36 | 1391-1392 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T37 | 1708-1711 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T38 | 1727-1728 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T39 | 1953-1958 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T40 | 1953-1958 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T41 | 2200-2205 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T42 | 2200-2205 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T43 | 2210-2217 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T44 | 2210-2217 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T45 | 2210-2217 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T46 | 2411-2416 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T47 | 2411-2416 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T48 | 2421-2428 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T49 | 2421-2428 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T50 | 2421-2428 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T51 | 2607-2608 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T52 | 2652-2657 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T53 | 2652-2657 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T54 | 2662-2668 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T55 | 2662-2668 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T56 | 2662-2668 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T57 | 2736-2741 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T58 | 2736-2741 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T59 | 2746-2752 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T60 | 2746-2752 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T61 | 2746-2752 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T2 | 1640-1651 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T3 | 1652-1661 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T7 | 1674-1682 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T8 | 1802-1813 | Chemical | denotes | Oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
| T9 | 1815-1824 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T10 | 1853-1864 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T11 | 1865-1874 | Chemical | denotes | Phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26078 |
| T13 | 1886-1897 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T14 | 1898-1905 | Chemical | denotes | Sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T15 | 1972-1983 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T16 | 1997-2008 | Chemical | denotes | Oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
| T17 | 2036-2047 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T18 | 2051-2060 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T19 | 2074-2085 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T20 | 2086-2095 | Chemical | denotes | Phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26078 |
| T22 | 2108-2119 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T23 | 2120-2127 | Chemical | denotes | Sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T24 | 2576-2580 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T25 | 2863-2867 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 584-594 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T2 | 599-608 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
| T3 | 1219-1231 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T4 | 2164-2173 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
| T5 | 2229-2239 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T6 | 2241-2250 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 0-12 | Sentence | denotes | Dear Editor, |
| T3 | 13-138 | Sentence | denotes | COVID-19 is a newly emerging human infectious disease of SARS-CoV-2 origin that has affected many countries around the world. |
| T4 | 139-351 | Sentence | denotes | COVID-19 is now rapidly spreading worldwide, and this letter is written as the World Health Organization (WHO) has declared a global emergency on January 31st amid concerns about a growing outbreak of SARS-CoV-2. |
| T5 | 352-655 | Sentence | denotes | Most of the published articles on COVID-19 have highlighted lungs as the main organ involved in the disease, while few articles have reported SARS-CoV-2 involvement in other organs, including liver and kidneys, which can impair the metabolism and excretion of the medications taken to treat the disease. |
| T6 | 656-926 | Sentence | denotes | According to Zhang et al. the incidence of hepatic abnormalities significantly increases after infection with COVID-19 and during the course of the disease, which may indicate the effect of SARS-CoV-2 on the liver or side effects of the medications used by patients (1). |
| T7 | 927-1035 | Sentence | denotes | Also, Xu et al. have reported steatosis and liver injury in the liver biopsy of a patient with COVID-19 (2). |
| T8 | 1036-1306 | Sentence | denotes | In addition to liver injuries, some articles have also reported an increased incidence of acute renal injury following COVID-19, which could be due to the presence of SARS-CoV-2, the inflammation induced by the disease, or a synergistic effect of both on kidneys (3, 4). |
| T9 | 1307-1446 | Sentence | denotes | Additionally, Cheng et al. have reported that patients with acute renal injury have a higher mortality rate compared to other patients (3). |
| T10 | 1447-1744 | Sentence | denotes | There is currently no definitive cure for COVID-19, and the treatment regimens prescribed for patients are the main treatments that have previously been effective in SARS-CoV and MERS-CoV, and chloroquine phosphate is the only medicine whose therapeutic effect has been proven by a clinical trial. |
| T11 | 1745-1906 | Sentence | denotes | Medicines currently prescribed to treat COVID-19 include Oseltamivir, Lopinavir / Ritonavir, Ribavirin, and Chloroquine Phosphate or Hydroxy Chloroquine Sulfate. |
| T12 | 1907-1959 | Sentence | denotes | All of these medicines are metabolized in the liver. |
| T13 | 1960-2174 | Sentence | denotes | Most of the metabolites derived from Oseltamivir, Ribavirin and some of the metabolites of Lopinavir / Ritonavir, Chloroquine Phosphate and Hydroxy Chloroquine Sulfate are found in the urine due to renal excretion. |
| T14 | 2175-2384 | Sentence | denotes | Therefore, injury to the liver and kidneys can impair metabolism, excretion, dosing and expected concentrations of the medications, which can increase the risk of toxicity using the aforementioned medications. |
| T15 | 2385-2603 | Sentence | denotes | According to the reports, liver and kidneys can be damaged in patients with COVID-19, which may make reaching the therapeutic dose of the medicines difficult and increase the risk of adverse drug reactions in patients. |
| T16 | 2604-2878 | Sentence | denotes | As a result, frequent and careful monitoring of liver and kidney functions in patients with COVID-19 can lead to early diagnosis of liver and kidney disorders, and also help in achieving the optimal therapeutic concentrations and reducing the risk of adverse drug reactions. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 957-966 | Phenotype | denotes | steatosis | http://purl.obolibrary.org/obo/HP_0001397 |
| T2 | 2568-2590 | Phenotype | denotes | adverse drug reactions | http://purl.obolibrary.org/obo/HP_0020172 |
| T3 | 2855-2877 | Phenotype | denotes | adverse drug reactions | http://purl.obolibrary.org/obo/HP_0020172 |