PMC:7075271
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2 | 0-25 | Disease | denotes | Liver and Kidney Injuries | MESH:D056486 |
| 3 | 29-37 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 12 | 135-140 | Species | denotes | human | Tax:9606 |
| 13 | 163-173 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 14 | 433-443 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 15 | 587-597 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 16 | 106-114 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 17 | 141-159 | Disease | denotes | infectious disease | MESH:D003141 |
| 18 | 232-240 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 19 | 479-487 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 37 | 939-949 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 38 | 1006-1014 | Species | denotes | patients | Tax:9606 |
| 39 | 1102-1109 | Species | denotes | patient | Tax:9606 |
| 40 | 1296-1306 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 41 | 1446-1454 | Species | denotes | patients | Tax:9606 |
| 42 | 1526-1534 | Species | denotes | patients | Tax:9606 |
| 43 | 792-813 | Disease | denotes | hepatic abnormalities | MESH:D056486 |
| 44 | 844-853 | Disease | denotes | infection | MESH:D007239 |
| 45 | 859-867 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 46 | 1050-1076 | Disease | denotes | steatosis and liver injury | MESH:D005234 |
| 47 | 1115-1123 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 48 | 1144-1158 | Disease | denotes | liver injuries | MESH:D017093 |
| 49 | 1219-1237 | Disease | denotes | acute renal injury | MESH:D058186 |
| 50 | 1248-1256 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 51 | 1312-1324 | Disease | denotes | inflammation | MESH:D007249 |
| 52 | 1460-1478 | Disease | denotes | acute renal injury | MESH:D058186 |
| 53 | 1493-1502 | Disease | denotes | mortality | MESH:D003643 |
| 72 | 1634-1642 | Species | denotes | patients | Tax:9606 |
| 73 | 1706-1714 | Species | denotes | SARS-CoV | Tax:694009 |
| 74 | 1719-1727 | Species | denotes | MERS-CoV | Tax:1335626 |
| 75 | 1733-1754 | Chemical | denotes | chloroquine phosphate | MESH:C023676 |
| 76 | 1895-1906 | Chemical | denotes | Oseltamivir | MESH:D053139 |
| 77 | 1908-1929 | Chemical | denotes | Lopinavir / Ritonavir | MESH:C558899 |
| 78 | 1931-1940 | Chemical | denotes | Ribavirin | MESH:D012254 |
| 79 | 1946-1967 | Chemical | denotes | Chloroquine Phosphate | MESH:C023676 |
| 80 | 1971-1998 | Chemical | denotes | Hydroxy Chloroquine Sulfate | MESH:D006886 |
| 81 | 2090-2101 | Chemical | denotes | Oseltamivir | MESH:D053139 |
| 82 | 2103-2112 | Chemical | denotes | Ribavirin | MESH:D012254 |
| 83 | 2144-2165 | Chemical | denotes | Lopinavir / Ritonavir | MESH:C558899 |
| 84 | 2167-2188 | Chemical | denotes | Chloroquine Phosphate | MESH:C023676 |
| 85 | 2193-2220 | Chemical | denotes | Hydroxy Chloroquine Sulfate | MESH:D006886 |
| 86 | 1582-1590 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 87 | 1878-1886 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 88 | 2251-2266 | Disease | denotes | renal excretion | MESH:D007674 |
| 89 | 2431-2439 | Disease | denotes | toxicity | MESH:D064420 |
| 96 | 2540-2548 | Species | denotes | patients | Tax:9606 |
| 97 | 2687-2695 | Species | denotes | patients | Tax:9606 |
| 98 | 2775-2783 | Species | denotes | patients | Tax:9606 |
| 99 | 2554-2562 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 100 | 2789-2797 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 101 | 2829-2855 | Disease | denotes | liver and kidney disorders | MESH:D007674 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T128 | 106-114 | SP_7 | denotes | COVID-19 |
| T127 | 135-140 | SP_6;NCBITaxon:9606 | denotes | human |
| T126 | 163-173 | SP_7 | denotes | SARS-CoV-2 |
| T125 | 232-240 | SP_7 | denotes | COVID-19 |
| T124 | 433-443 | SP_7 | denotes | SARS-CoV-2 |
| T123 | 479-487 | SP_7 | denotes | COVID-19 |
| T122 | 505-510 | UBERON:0000170 | denotes | lungs |
| T121 | 523-528 | UBERON:0000062 | denotes | organ |
| T120 | 587-597 | SP_7 | denotes | SARS-CoV-2 |
| T119 | 619-625 | UBERON:0000062 | denotes | organs |
| T118 | 637-642 | UBERON:0002107 | denotes | liver |
| T117 | 647-654 | UBERON:0002113 | denotes | kidneys |
| T116 | 677-687 | GO:0008152 | denotes | metabolism |
| T115 | 692-701 | GO:0007588 | denotes | excretion |
| T114 | 792-799 | UBERON:0002107 | denotes | hepatic |
| T113 | 859-867 | SP_7 | denotes | COVID-19 |
| T112 | 939-949 | SP_7 | denotes | SARS-CoV-2 |
| T111 | 957-962 | UBERON:0002107 | denotes | liver |
| T110 | 1064-1069 | UBERON:0002107 | denotes | liver |
| T109 | 1084-1089 | UBERON:0002107 | denotes | liver |
| T108 | 1115-1123 | SP_7 | denotes | COVID-19 |
| T107 | 1144-1149 | UBERON:0002107 | denotes | liver |
| T106 | 1225-1230 | UBERON:0002113 | denotes | renal |
| T105 | 1248-1256 | SP_7 | denotes | COVID-19 |
| T104 | 1296-1306 | SP_7 | denotes | SARS-CoV-2 |
| T103 | 1384-1391 | UBERON:0002113 | denotes | kidneys |
| T102 | 1466-1471 | UBERON:0002113 | denotes | renal |
| T101 | 1582-1590 | SP_7 | denotes | COVID-19 |
| T100 | 1706-1714 | SP_10 | denotes | SARS-CoV |
| T99 | 1719-1727 | SP_9 | denotes | MERS-CoV |
| T98 | 1733-1744 | CHEBI:3638;DG_10;CHEBI:3638 | denotes | chloroquine |
| T97 | 1745-1754 | CHEBI:18367;CHEBI:18367 | denotes | phosphate |
| T96 | 1838-1847 | CHEBI:23888;CHEBI:23888 | denotes | Medicines |
| T95 | 1878-1886 | SP_7 | denotes | COVID-19 |
| T94 | 1895-1906 | CHEBI:7798;CHEBI:7798 | denotes | Oseltamivir |
| T92 | 1920-1929 | DG_30 | denotes | Ritonavir |
| T91 | 1931-1940 | CHEBI:63580;CHEBI:63580;DG_29 | denotes | Ribavirin |
| T90 | 1946-1957 | CHEBI:3638;CHEBI:3638;DG_10 | denotes | Chloroquine |
| T89 | 1971-1978 | CHEBI:43176;CHEBI:43176 | denotes | Hydroxy |
| T88 | 1979-1990 | DG_10;CHEBI:50178;CHEBI:50178 | denotes | Chloroquine |
| T87 | 1991-1998 | CHEBI:50178;CHEBI:50178 | denotes | Sulfate |
| T86 | 2027-2038 | GO:0008152 | denotes | metabolized |
| T85 | 2046-2051 | UBERON:0002107 | denotes | liver |
| T84 | 2065-2076 | CHEBI:25212;CHEBI:25212 | denotes | metabolites |
| T83 | 2090-2101 | CHEBI:7798;CHEBI:7798 | denotes | Oseltamivir |
| T82 | 2103-2112 | CHEBI:85129;CHEBI:85129;DG_29 | denotes | Ribavirin |
| T81 | 2129-2140 | CHEBI:25212;CHEBI:25212 | denotes | metabolites |
| T80 | 2144-2153 | DG_23 | denotes | Lopinavir |
| T79 | 2156-2165 | DG_30 | denotes | Ritonavir |
| T78 | 2167-2178 | CHEBI:3638;CHEBI:3638;DG_10 | denotes | Chloroquine |
| T77 | 2193-2200 | CHEBI:43176;CHEBI:43176 | denotes | Hydroxy |
| T76 | 2201-2212 | DG_10;CHEBI:50178;CHEBI:50178 | denotes | Chloroquine |
| T75 | 2213-2220 | CHEBI:50178;CHEBI:50178 | denotes | Sulfate |
| T74 | 2238-2243 | UBERON:0001088 | denotes | urine |
| T73 | 2251-2256 | UBERON:0002113 | denotes | renal |
| T72 | 2257-2266 | GO:0007588 | denotes | excretion |
| T71 | 2293-2298 | UBERON:0002107 | denotes | liver |
| T70 | 2303-2310 | UBERON:0002113 | denotes | kidneys |
| T69 | 2322-2332 | GO:0008152 | denotes | metabolism |
| T68 | 2334-2343 | GO:0007588 | denotes | excretion |
| T67 | 2387-2398 | CHEBI:23888;CHEBI:23888 | denotes | medications |
| T66 | 2504-2509 | UBERON:0002107 | denotes | liver |
| T65 | 2514-2521 | UBERON:0002113 | denotes | kidneys |
| T64 | 2554-2562 | SP_7 | denotes | COVID-19 |
| T63 | 2616-2625 | CHEBI:23888;CHEBI:23888 | denotes | medicines |
| T62 | 2669-2673 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T61 | 2745-2750 | UBERON:0002107 | denotes | liver |
| T60 | 2755-2761 | UBERON:0002113 | denotes | kidney |
| T59 | 2789-2797 | SP_7 | denotes | COVID-19 |
| T58 | 2829-2834 | UBERON:0002107 | denotes | liver |
| T57 | 2839-2845 | UBERON:0002113 | denotes | kidney |
| T56 | 2956-2960 | CHEBI:23888;CHEBI:23888 | denotes | drug |
| T3 | 59-63 | CHEBI:23888;CHEBI:23888 | denotes | Drug |
| T4 | 29-37 | SP_7 | denotes | COVID-19 |
| T5 | 10-16 | UBERON:0002113 | denotes | Kidney |
| T6 | 0-5 | UBERON:0002107 | denotes | Liver |
| T93 | 1908-1917 | DG_23 | denotes | Lopinavir |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 0-5 | Body_part | denotes | Liver | http://purl.org/sig/ont/fma/fma7197 |
| T2 | 10-16 | Body_part | denotes | Kidney | http://purl.org/sig/ont/fma/fma7203 |
| T3 | 505-510 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T4 | 523-528 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T5 | 637-642 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T6 | 647-654 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T7 | 957-962 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T8 | 1064-1069 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T9 | 1084-1089 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T10 | 1144-1149 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T11 | 1384-1391 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T12 | 2046-2051 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T13 | 2238-2243 | Body_part | denotes | urine | http://purl.org/sig/ont/fma/fma12274 |
| T14 | 2293-2298 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T15 | 2303-2310 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T16 | 2504-2509 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T17 | 2514-2521 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T18 | 2745-2750 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T19 | 2755-2761 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T20 | 2829-2834 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T21 | 2839-2845 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 0-5 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T2 | 10-16 | Body_part | denotes | Kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T3 | 523-528 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T4 | 619-625 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T5 | 637-642 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T6 | 957-962 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T7 | 1064-1069 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T8 | 1084-1089 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T9 | 1144-1149 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T10 | 2046-2051 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T11 | 2238-2243 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T12 | 2293-2298 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T13 | 2504-2509 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T14 | 2745-2750 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T15 | 2755-2761 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T16 | 2829-2834 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T17 | 2839-2845 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid_AGAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p19006s9 | 2315-2321 | NegReg | denotes | impair |
| p19006s10 | 2322-2332 | MPA | denotes | metabolism |
| p19006s12 | 2334-2343 | MPA | denotes | excretion |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 29-37 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T2 | 106-114 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 141-159 | Disease | denotes | infectious disease | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T4 | 163-171 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T5 | 232-240 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 433-441 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T7 | 479-487 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T8 | 587-595 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T9 | 844-853 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T10 | 859-867 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T11 | 939-947 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T12 | 1050-1069 | Disease | denotes | steatosis and liver | http://purl.obolibrary.org/obo/MONDO_0004790|http://purl.obolibrary.org/obo/MONDO_0009220 |
| T14 | 1070-1076 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T15 | 1115-1123 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T16 | 1231-1237 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T17 | 1248-1256 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T18 | 1296-1304 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T19 | 1312-1324 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T20 | 1472-1478 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T21 | 1582-1590 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T22 | 1706-1714 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T23 | 1878-1886 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T24 | 2279-2285 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T25 | 2554-2562 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T26 | 2789-2797 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T27 | 2839-2855 | Disease | denotes | kidney disorders | http://purl.obolibrary.org/obo/MONDO_0005240 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-5 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | Liver |
| T2 | 0-5 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | Liver |
| T3 | 10-16 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | Kidney |
| T4 | 10-16 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | Kidney |
| T5 | 10-16 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | Kidney |
| T6 | 73-74 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T7 | 118-119 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 135-140 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T9 | 186-189 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T10 | 324-336 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | Organization |
| T11 | 343-346 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T12 | 356-357 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T13 | 411-412 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 505-510 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T15 | 523-528 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T16 | 619-625 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organs |
| T17 | 637-642 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T18 | 637-642 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T19 | 647-654 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T20 | 647-654 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T21 | 647-654 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T22 | 957-962 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T23 | 957-962 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T24 | 1064-1069 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T25 | 1064-1069 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T26 | 1084-1089 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T27 | 1084-1089 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T28 | 1100-1101 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T29 | 1144-1149 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T30 | 1144-1149 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T31 | 1352-1353 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T32 | 1384-1391 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T33 | 1384-1391 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T34 | 1384-1391 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T35 | 1393-1397 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 3, 4 |
| T36 | 1484-1485 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T37 | 1801-1804 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T38 | 1820-1821 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T39 | 2046-2051 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T40 | 2046-2051 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T41 | 2293-2298 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T42 | 2293-2298 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T43 | 2303-2310 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T44 | 2303-2310 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T45 | 2303-2310 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T46 | 2504-2509 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T47 | 2504-2509 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T48 | 2514-2521 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T49 | 2514-2521 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T50 | 2514-2521 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T51 | 2700-2701 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T52 | 2745-2750 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T53 | 2745-2750 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T54 | 2755-2761 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T55 | 2755-2761 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T56 | 2755-2761 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T57 | 2829-2834 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T58 | 2829-2834 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T59 | 2839-2845 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T60 | 2839-2845 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T61 | 2839-2845 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 75-81 | Chemical | denotes | Letter | http://purl.obolibrary.org/obo/CHEBI_6446 |
| T2 | 1733-1744 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T3 | 1745-1754 | Chemical | denotes | phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474 |
| T7 | 1767-1775 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T8 | 1895-1906 | Chemical | denotes | Oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
| T9 | 1908-1917 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T10 | 1946-1957 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T11 | 1958-1967 | Chemical | denotes | Phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26078 |
| T13 | 1979-1990 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T14 | 1991-1998 | Chemical | denotes | Sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T15 | 2065-2076 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T16 | 2090-2101 | Chemical | denotes | Oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
| T17 | 2129-2140 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T18 | 2144-2153 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T19 | 2167-2178 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T20 | 2179-2188 | Chemical | denotes | Phosphate | http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26078 |
| T22 | 2201-2212 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T23 | 2213-2220 | Chemical | denotes | Sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T24 | 2669-2673 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T25 | 2956-2960 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 677-687 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T2 | 692-701 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
| T3 | 1312-1324 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T4 | 2257-2266 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
| T5 | 2322-2332 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T6 | 2334-2343 | http://purl.obolibrary.org/obo/GO_0007588 | denotes | excretion |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-91 | Sentence | denotes | Liver and Kidney Injuries in COVID-19 and Their Effects on Drug Therapy; a Letter to Editor |
| T2 | 93-105 | Sentence | denotes | Dear Editor, |
| T3 | 106-231 | Sentence | denotes | COVID-19 is a newly emerging human infectious disease of SARS-CoV-2 origin that has affected many countries around the world. |
| T4 | 232-444 | Sentence | denotes | COVID-19 is now rapidly spreading worldwide, and this letter is written as the World Health Organization (WHO) has declared a global emergency on January 31st amid concerns about a growing outbreak of SARS-CoV-2. |
| T5 | 445-748 | Sentence | denotes | Most of the published articles on COVID-19 have highlighted lungs as the main organ involved in the disease, while few articles have reported SARS-CoV-2 involvement in other organs, including liver and kidneys, which can impair the metabolism and excretion of the medications taken to treat the disease. |
| T6 | 749-1019 | Sentence | denotes | According to Zhang et al. the incidence of hepatic abnormalities significantly increases after infection with COVID-19 and during the course of the disease, which may indicate the effect of SARS-CoV-2 on the liver or side effects of the medications used by patients (1). |
| T7 | 1020-1128 | Sentence | denotes | Also, Xu et al. have reported steatosis and liver injury in the liver biopsy of a patient with COVID-19 (2). |
| T8 | 1129-1399 | Sentence | denotes | In addition to liver injuries, some articles have also reported an increased incidence of acute renal injury following COVID-19, which could be due to the presence of SARS-CoV-2, the inflammation induced by the disease, or a synergistic effect of both on kidneys (3, 4). |
| T9 | 1400-1539 | Sentence | denotes | Additionally, Cheng et al. have reported that patients with acute renal injury have a higher mortality rate compared to other patients (3). |
| T10 | 1540-1837 | Sentence | denotes | There is currently no definitive cure for COVID-19, and the treatment regimens prescribed for patients are the main treatments that have previously been effective in SARS-CoV and MERS-CoV, and chloroquine phosphate is the only medicine whose therapeutic effect has been proven by a clinical trial. |
| T11 | 1838-1999 | Sentence | denotes | Medicines currently prescribed to treat COVID-19 include Oseltamivir, Lopinavir / Ritonavir, Ribavirin, and Chloroquine Phosphate or Hydroxy Chloroquine Sulfate. |
| T12 | 2000-2052 | Sentence | denotes | All of these medicines are metabolized in the liver. |
| T13 | 2053-2267 | Sentence | denotes | Most of the metabolites derived from Oseltamivir, Ribavirin and some of the metabolites of Lopinavir / Ritonavir, Chloroquine Phosphate and Hydroxy Chloroquine Sulfate are found in the urine due to renal excretion. |
| T14 | 2268-2477 | Sentence | denotes | Therefore, injury to the liver and kidneys can impair metabolism, excretion, dosing and expected concentrations of the medications, which can increase the risk of toxicity using the aforementioned medications. |
| T15 | 2478-2696 | Sentence | denotes | According to the reports, liver and kidneys can be damaged in patients with COVID-19, which may make reaching the therapeutic dose of the medicines difficult and increase the risk of adverse drug reactions in patients. |
| T16 | 2697-2971 | Sentence | denotes | As a result, frequent and careful monitoring of liver and kidney functions in patients with COVID-19 can lead to early diagnosis of liver and kidney disorders, and also help in achieving the optimal therapeutic concentrations and reducing the risk of adverse drug reactions. |
| T17 | 2973-2994 | Sentence | denotes | Authors’ contribution |
| T18 | 2995-3131 | Sentence | denotes | All authors met the criteria for authorship contribution based on recommendations of international committee of medical journal editors. |
| T19 | 3133-3153 | Sentence | denotes | Conflict of interest |
| T20 | 3154-3158 | Sentence | denotes | None |
| T21 | 3160-3179 | Sentence | denotes | Funding and support |
| T22 | 3180-3184 | Sentence | denotes | None |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1050-1059 | Phenotype | denotes | steatosis | http://purl.obolibrary.org/obo/HP_0001397 |
| T2 | 2661-2683 | Phenotype | denotes | adverse drug reactions | http://purl.obolibrary.org/obo/HP_0020172 |
| T3 | 2948-2970 | Phenotype | denotes | adverse drug reactions | http://purl.obolibrary.org/obo/HP_0020172 |