PMC:7074453 / 15928-17128 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"481","span":{"begin":125,"end":144},"obj":"Disease"},{"id":"486","span":{"begin":305,"end":312},"obj":"Species"},{"id":"487","span":{"begin":449,"end":456},"obj":"Species"},{"id":"488","span":{"begin":409,"end":417},"obj":"Disease"},{"id":"489","span":{"begin":673,"end":684},"obj":"Disease"},{"id":"492","span":{"begin":1167,"end":1185},"obj":"Chemical"},{"id":"493","span":{"begin":1001,"end":1008},"obj":"Disease"}],"attributes":[{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"MESH:D060085"},{"id":"A486","pred":"tao:has_database_id","subj":"486","obj":"Tax:9606"},{"id":"A487","pred":"tao:has_database_id","subj":"487","obj":"Tax:9606"},{"id":"A488","pred":"tao:has_database_id","subj":"488","obj":"MESH:D003371"},{"id":"A489","pred":"tao:has_database_id","subj":"489","obj":"MESH:D055370"},{"id":"A492","pred":"tao:has_database_id","subj":"492","obj":"MESH:D008775"},{"id":"A493","pred":"tao:has_database_id","subj":"493","obj":"MESH:D004417"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T59","span":{"begin":163,"end":168},"obj":"Body_part"},{"id":"T60","span":{"begin":528,"end":532},"obj":"Body_part"},{"id":"T61","span":{"begin":673,"end":677},"obj":"Body_part"},{"id":"T62","span":{"begin":1029,"end":1034},"obj":"Body_part"}],"attributes":[{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma9576"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T38","span":{"begin":163,"end":168},"obj":"Body_part"},{"id":"T39","span":{"begin":528,"end":532},"obj":"Body_part"},{"id":"T40","span":{"begin":673,"end":677},"obj":"Body_part"},{"id":"T41","span":{"begin":1029,"end":1034},"obj":"Body_part"}],"attributes":[{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T108","span":{"begin":135,"end":144},"obj":"Disease"},{"id":"T109","span":{"begin":678,"end":684},"obj":"Disease"}],"attributes":[{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T163","span":{"begin":53,"end":61},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T164","span":{"begin":163,"end":168},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T165","span":{"begin":383,"end":389},"obj":"http://purl.obolibrary.org/obo/UBERON_0001005"},{"id":"T166","span":{"begin":528,"end":532},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T167","span":{"begin":528,"end":532},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T168","span":{"begin":673,"end":677},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T169","span":{"begin":673,"end":677},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T170","span":{"begin":775,"end":783},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T171","span":{"begin":1029,"end":1034},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"},{"id":"T172","span":{"begin":1082,"end":1083},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T173","span":{"begin":1096,"end":1099},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T38","span":{"begin":912,"end":917},"obj":"Chemical"},{"id":"T39","span":{"begin":1048,"end":1063},"obj":"Chemical"},{"id":"T40","span":{"begin":1167,"end":1185},"obj":"Chemical"}],"attributes":[{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_24261"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_6888"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T6","span":{"begin":390,"end":400},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-sentences","denotations":[{"id":"T130","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"T131","span":{"begin":187,"end":522},"obj":"Sentence"},{"id":"T132","span":{"begin":523,"end":685},"obj":"Sentence"},{"id":"T133","span":{"begin":686,"end":815},"obj":"Sentence"},{"id":"T134","span":{"begin":816,"end":965},"obj":"Sentence"},{"id":"T135","span":{"begin":966,"end":1200},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T77","span":{"begin":409,"end":417},"obj":"Phenotype"},{"id":"T78","span":{"begin":1001,"end":1008},"obj":"Phenotype"}],"attributes":[{"id":"A77","pred":"hp_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A78","pred":"hp_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/HP_0002094"}],"text":"Treatment principle: based on symptomatic treatment, actively prevent and treat complications, treat basic diseases, prevent secondary infection, and timely apply organ function support.\nRespiratory support: apply noninvasive mechanical ventilation for two hours, if the condition is not improved, or the patient is intolerable to noninvasive ventilation, accompanied with increased airway secretions, severe coughing, or unstable hemodynamics, the patient should be transferred to invasive mechanical ventilation in time. The “lung-protective ventilation strategy” with low tidal volume should be adopted in invasive mechanical ventilation to reduce ventilator-associated lung injury. If necessary, ventilation in the prone position, recruitment maneuver, or extracorporeal membrane oxygenation (ECMO) can be used.\nCirculation support: improve microcirculation based on full fluid resuscitation, use vasoactive drugs, and apply hemodynamic monitoring if necessary.\nOthers: according to the degree of dyspnea and the progress of chest imaging, use glucocorticoids appropriately for a short time (3–5 days) with the recommended dose no more than what is equivalent to methylprednisolone 1–2 mg/kg·day."}