PMC:7074432 / 93-889
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7074432","sourcedb":"PMC","sourceid":"7074432","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7074432","text":"In the 21st century, three coronaviruses (CoVs) caused three major epidemic of respiratory distress[1] syndrome, which include severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 with epicenter in Guangdong, China,[2] Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 in Saudi Arabia,[3] and the third epidemic of respiratory coronavirus the 2019-novel coronavirus (2019-nCoV) or coronavirus disease (COVID-19) mainly centered in Wuhan province, China.[4] The case fatalities vary from 2.5% (2019-nCoV),[5]10% (SARS), to 35% (MERS-CoV).[6] Till now, there is no approved antiviral or vaccine for the management of infection by CoV. However, from earlier experience of the management of SERS-CoV and MERS-CoV, many agents are being used in the treatment of 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