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PMC:7074432 / 93-14928 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
20 27-40 Species denotes coronaviruses Tax:11118
21 42-46 Species denotes CoVs Tax:11118
22 127-172 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
23 174-182 Species denotes SARS-CoV Tax:694009
24 231-286 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
25 353-364 Species denotes coronavirus Tax:11118
26 369-391 Species denotes 2019-novel coronavirus Tax:2697049
27 393-402 Species denotes 2019-nCoV Tax:2697049
28 519-528 Species denotes 2019-nCoV Tax:2697049
29 553-561 Species denotes MERS-CoV Tax:1335626
30 654-657 Species denotes CoV Tax:11118
31 718-721 Species denotes CoV Tax:11118
32 726-734 Species denotes MERS-CoV Tax:1335626
33 783-792 Species denotes 2019-nCoV Tax:2697049
34 79-111 Disease denotes respiratory distress[1] syndrome MESH:D012128
35 407-426 Disease denotes coronavirus disease MESH:D018352
36 428-436 Disease denotes COVID-19 MESH:C000657245
37 641-650 Disease denotes infection MESH:D007239
39 810-820 Chemical denotes Nucleoside MESH:D009705
60 905-909 Species denotes CoVs Tax:11118
61 922-930 Species denotes SARS-CoV Tax:694009
62 946-954 Species denotes patients Tax:9606
63 1061-1069 Species denotes SARS-CoV Tax:694009
64 1214-1222 Species denotes SARS-CoV Tax:694009
65 1385-1393 Species denotes patients Tax:9606
66 1650-1659 Species denotes 2019-nCoV Tax:2697049
67 828-837 Chemical denotes Ribavirin MESH:D012254
68 841-851 Chemical denotes nucleoside MESH:D009705
69 973-982 Chemical denotes ribavirin MESH:D012254
70 1196-1205 Chemical denotes ribavirin MESH:D012254
71 1224-1233 Chemical denotes Ribavirin MESH:D012254
72 1369-1378 Chemical denotes ribavirin MESH:D012254
73 1397-1406 Chemical denotes ribavirin MESH:D012254
74 1558-1568 Chemical denotes nucleoside MESH:D009705
75 1581-1592 Chemical denotes favipiravir MESH:C462182
76 1597-1608 Chemical denotes galidesivir MESH:C517546
77 1265-1281 Disease denotes hemolytic anemia MESH:D000743
78 1283-1295 Disease denotes hypocalcemia MESH:D006996
79 1301-1315 Disease denotes hypomagnesemia MESH:C537153
81 1662-1675 Gene denotes Neuraminidase Gene:4758
96 1687-1700 Gene denotes Neuraminidase Gene:4758
97 1784-1792 Species denotes MERS-CoV Tax:1335626
98 1841-1849 Species denotes patients Tax:9606
99 1883-1891 Species denotes patients Tax:9606
100 1905-1920 Species denotes influenza virus Tax:11309
101 2041-2049 Species denotes MERS-CoV Tax:1335626
102 2110-2118 Species denotes MERS-CoV Tax:1335626
103 2171-2180 Species denotes 2019-nCoV Tax:2697049
104 1747-1756 Species denotes influenza Tax:11309
105 1859-1870 Chemical denotes oseltamivir MESH:D053139
106 1953-1964 Chemical denotes oseltamivir MESH:D053139
107 2001-2012 Chemical denotes oseltamivir MESH:D053139
108 2095-2106 Chemical denotes oseltamivir MESH:D053139
109 2124-2135 Chemical denotes Oseltamivir MESH:D053139
126 2514-2521 Gene denotes NSP1–16 Gene:10045
127 2362-2370 Species denotes SARS-CoV Tax:694009
128 2567-2570 Species denotes CoV Tax:11118
129 2694-2697 Species denotes CoV Tax:11118
130 2803-2811 Species denotes SARS-CoV Tax:694009
131 3383-3392 Species denotes 2019-nCoV Tax:2697049
132 2878-2886 Species denotes SARS-CoV Tax:694009
133 2610-2619 Chemical denotes lopinavir MESH:D061466
134 2647-2657 Chemical denotes saquinavir MESH:D019258
135 2817-2820 Chemical denotes pro MESH:D011392
136 2897-2906 Chemical denotes lopinavir MESH:D061466
137 2956-2959 Chemical denotes HKU
138 2979-2988 Chemical denotes Ritonavir MESH:D019438
139 3009-3018 Chemical denotes lopinavir MESH:D061466
140 3223-3242 Chemical denotes lopinavir/ritonavir MESH:C558899
141 3302-3323 Chemical denotes lopinavir + ritonavir MESH:C558899
150 3514-3517 Species denotes CoV Tax:11118
151 3522-3530 Species denotes MERS-CoV Tax:1335626
152 3594-3603 Species denotes 2019-nCoV Tax:2697049
153 3849-3852 Species denotes CoV Tax:11118
154 3857-3865 Species denotes MERS-CoV Tax:1335626
155 3877-3884 Chemical denotes steroid MESH:D013256
156 3893-3906 Disease denotes complications MESH:D005117
157 3915-3924 Disease denotes psychosis MESH:D011605
169 4135-4140 Gene denotes IFN-α Gene:3439
170 4259-4264 Gene denotes IFN-α Gene:3439
171 4329-4334 Gene denotes IFN-α Gene:3439
172 4447-4452 Gene denotes IFN-α Gene:3439
173 4043-4051 Species denotes SARS-CoV Tax:694009
174 4052-4060 Species denotes patients Tax:9606
175 4432-4441 Species denotes 2019-nCoV Tax:2697049
176 4074-4083 Chemical denotes ribavirin MESH:D012254
177 4377-4383 Chemical denotes oxygen MESH:D010100
178 4501-4522 Chemical denotes lopinavir + ritonavir MESH:C558899
179 4027-4038 Disease denotes hepatitis B MESH:D006509
182 4735-4743 Species denotes Patients Tax:9606
183 4568-4582 Disease denotes critically ill MESH:D016638
190 5276-5284 Species denotes SARS-CoV Tax:694009
191 5288-5296 Species denotes MERS-CoV Tax:1335626
192 5087-5096 Chemical denotes metformin MESH:D008687
193 5098-5110 Chemical denotes atorvastatin MESH:D000069059
194 5178-5213 Disease denotes acute respiratory distress syndrome MESH:D012128
195 5215-5219 Disease denotes ARDS MESH:D012128
200 5631-5635 Gene denotes IL-6 Gene:3569
201 5384-5387 Species denotes CoV Tax:11118
202 5639-5650 Chemical denotes tocilizumab MESH:C502936
203 5522-5530 Disease denotes COVID-19 MESH:C000657245
206 5765-5792 Gene denotes tumor necrosis factor-alpha Gene:7124
207 5830-5844 Chemical denotes pentoxifylline MESH:D010431
210 5959-5981 Species denotes 2019-Novel Coronavirus Tax:2697049
211 5983-6005 Disease denotes Coronavirus Disease-19 MESH:C000657245
226 6034-6042 Species denotes patients Tax:9606
227 6048-6057 Species denotes 2019-nCoV Tax:2697049
228 6479-6486 Species denotes persons Tax:9606
229 6616-6624 Species denotes patients Tax:9606
230 6656-6663 Species denotes patient Tax:9606
231 7030-7036 Chemical denotes oxygen MESH:D010100
232 6161-6170 Disease denotes infection MESH:D007239
233 6352-6373 Disease denotes respiratory infection MESH:D012141
234 6385-6418 Disease denotes coronavirus (2019-nCoV) infection MESH:C000657245
235 6502-6530 Disease denotes acute respiratory infections MESH:D012120
236 6630-6650 Disease denotes respiratory distress MESH:D012128
237 6845-6866 Disease denotes respiratory infection MESH:D012141
238 6952-6971 Disease denotes respiratory failure MESH:D012131
239 7213-7225 Disease denotes septic shock MESH:D012772
241 7245-7267 Species denotes 2019-Novel Coronavirus Tax:2697049
254 7334-7343 Species denotes 2019-nCoV Tax:2697049
255 7427-7436 Species denotes 2019-nCoV Tax:2697049
258 7450-7459 Chemical denotes lopinavir MESH:D061466
259 7461-7470 Chemical denotes ritonavir MESH:D019438
260 7472-7479 Chemical denotes arbidol MESH:C086979
261 10688-10699 Chemical denotes oseltamivir MESH:D053139
262 10706-10717 Chemical denotes ganciclovir MESH:D015774
327 8451-8459 Species denotes patients Tax:9606
328 8465-8473 Species denotes patients Tax:9606
329 8530-8538 Species denotes patients Tax:9606
330 8676-8683 Species denotes patient Tax:9606
331 8718-8726 Species denotes patients Tax:9606
332 8773-8781 Species denotes patients Tax:9606
333 8797-8804 Species denotes patient Tax:9606
334 8928-8936 Species denotes patients Tax:9606
335 8969-8977 Species denotes patients Tax:9606
336 9385-9394 Species denotes 2019-nCoV Tax:2697049
337 9405-9413 Species denotes patients Tax:9606
338 9415-9423 Species denotes Patients Tax:9606
339 9516-9524 Species denotes patients Tax:9606
340 9870-9878 Species denotes Patients Tax:9606
341 10025-10033 Species denotes patients Tax:9606
342 10042-10050 Species denotes patients Tax:9606
343 10190-10198 Species denotes patients Tax:9606
344 10279-10287 Species denotes patients Tax:9606
345 10333-10341 Species denotes patients Tax:9606
346 10562-10570 Species denotes patients Tax:9606
347 10576-10584 Species denotes patients Tax:9606
348 10641-10649 Species denotes patients Tax:9606
349 11031-11039 Species denotes patients Tax:9606
350 11252-11260 Species denotes patients Tax:9606
351 11403-11411 Species denotes patients Tax:9606
352 11422-11430 Species denotes patients Tax:9606
353 11470-11475 Species denotes human Tax:9606
355 11622-11630 Species denotes patients Tax:9606
356 8849-8857 Species denotes patients Tax:9606
357 9127-9135 Species denotes patients Tax:9606
358 10812-10820 Species denotes patients Tax:9606
359 8483-8489 Chemical denotes oxygen MESH:D010100
360 8569-8578 Chemical denotes lopinavir MESH:D061466
361 8580-8589 Chemical denotes ritonavir MESH:D019438
362 8591-8598 Chemical denotes arbidol MESH:C086979
363 8604-8609 Chemical denotes SFJDC
364 8946-8957 Chemical denotes oseltamivir MESH:D053139
365 10060-10071 Chemical denotes oseltamivir MESH:D053139
366 10113-10124 Chemical denotes ceftriaxone MESH:D002443
367 10132-10144 Chemical denotes moxifloxacin MESH:D000077266
368 10156-10168 Chemical denotes azithromycin MESH:D017963
371 10722-10741 Chemical denotes lopinavir/ritonavir MESH:C558899
372 11505-11517 Chemical denotes moxifloxacin MESH:D000077266
373 11531-11542 Chemical denotes oseltamivir MESH:D053139
374 11547-11567 Chemical denotes abidol hydrochloride
375 9119-9124 Disease denotes Death MESH:D003643
376 9225-9230 Disease denotes Death MESH:D003643
377 9396-9404 Disease denotes infected MESH:D007239
378 9728-9733 Disease denotes death MESH:D003643
379 9861-9868 Disease denotes dyspnea MESH:D004417
380 9972-9991 Disease denotes respiratory failure MESH:D012131
381 10536-10541 Disease denotes Death MESH:D003643
382 10873-10892 Disease denotes bacterial infection MESH:D001424
383 11222-11226 Disease denotes Died MESH:D003643
384 11246-11251 Disease denotes death MESH:D003643
385 11266-11272 Disease denotes deaths MESH:D003643
386 11339-11357 Disease denotes outcomeLymphopenia
387 11369-11378 Disease denotes pneumonia MESH:D011014
389 8367-8386 Disease denotes 2019-nCoV infection MESH:C000657245
392 11846-11856 Chemical denotes Remdesivir MESH:C000606551
393 11861-11872 Chemical denotes chloroquine MESH:D002738
411 11904-11913 Species denotes 2019-nCoV Tax:2697049
412 12201-12210 Species denotes 2019-nCoV Tax:2697049
413 11973-11982 Chemical denotes ribavirin MESH:D012254
414 11984-11995 Chemical denotes penciclovir MESH:C053539
415 11997-12009 Chemical denotes nitazoxanide MESH:C041747
416 12011-12021 Chemical denotes nafamostat MESH:C032855
417 12023-12034 Chemical denotes chloroquine MESH:D002738
418 12036-12046 Chemical denotes remdesivir MESH:C000606551
419 12048-12054 Chemical denotes GS5734 MESH:C000606551
420 12061-12072 Chemical denotes favipiravir MESH:C462182
421 12074-12079 Chemical denotes T-705 MESH:C462182
422 12486-12497 Chemical denotes chloroquine MESH:D002738
423 12502-12512 Chemical denotes remdesivir MESH:C000606551
424 12106-12118 Disease denotes Cytotoxicity MESH:D064420
425 12173-12182 Disease denotes infection MESH:D007239
426 12523-12538 Disease denotes virus infection MESH:D001102
427 12141-12143 CellLine denotes E6 CVCL:4582
443 13242-13273 Gene denotes angiotensin-converting enzyme 2 Gene:59272
444 13275-13280 Gene denotes ACE-2 Gene:59272
445 12614-12623 Chemical denotes adenosine MESH:D000241
446 12632-12642 Chemical denotes remdesivir MESH:C000606551
447 12738-12749 Chemical denotes chloroquine MESH:D002738
448 12786-12797 Chemical denotes Chloroquine MESH:D002738
449 12902-12913 Chemical denotes chloroquine MESH:D002738
450 13024-13035 Chemical denotes chloroquine MESH:D002738
451 13083-13094 Chemical denotes Chloroquine MESH:D002738
452 13188-13199 Chemical denotes Chloroquine MESH:D002738
453 13429-13440 Chemical denotes chloroquine MESH:D002738
454 12849-12867 Disease denotes SARS-CoV infection MESH:C000657245
455 12950-12968 Disease denotes SARS CoV infection MESH:C000657245
456 13059-13077 Disease denotes SARS-CoV infection MESH:C000657245
457 12927-12929 CellLine denotes E6 CVCL:4582
459 13478-13489 Chemical denotes Baricitinib MESH:C000596027
473 13550-13554 Gene denotes ACE2 Gene:59272
474 13706-13737 Gene denotes AP2-associated protein kinase 1 Gene:22848
475 13739-13743 Gene denotes AAK1 Gene:22848
476 13787-13791 Gene denotes AAK1 Gene:22848
477 13969-13973 Gene denotes AAK1 Gene:22848
478 14124-14128 Gene denotes AAK1 Gene:22848
479 14195-14221 Gene denotes cyclin G-associated kinase Gene:2580
480 13510-13518 Species denotes 2019nCoV Tax:2697049
481 14357-14366 Species denotes 2019-nCoV Tax:2697049
482 13494-13501 Species denotes SARSCoV Tax:694009
483 14065-14076 Chemical denotes baricitinib MESH:C000596027
484 14130-14141 Chemical denotes baricitinib MESH:C000596027
485 14255-14266 Chemical denotes baricitinib MESH:C000596027
488 14532-14535 Species denotes CoV Tax:11118
489 14561-14564 Species denotes CoV Tax:11118

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T380 8367-8376 SP_7 denotes 2019-nCoV
T378 14577-14588 SO:0000704 denotes genetically
T375 13478-13489 DG_41 denotes Baricitinib
T374 13510-13518 SP_7 denotes 2019nCoV
T373 13550-13554 G_3;PG_10;PR:000003622 denotes ACE2
T372 13619-13624 UBERON:0000170 denotes lungs
T371 13681-13692 GO:0006897 denotes endocytosis
T370 13706-13737 PR:000003526 denotes AP2-associated protein kinase 1
T369 13739-13743 PR:000003526 denotes AAK1
T368 13787-13791 PR:000003526 denotes AAK1
T367 13969-13973 PR:000003526 denotes AAK1
T366 14055-14064 CHEBI:66921;CHEBI:66921 denotes inhibitor
T365 14065-14076 DG_41 denotes baricitinib
T364 14124-14128 PR:000003526 denotes AAK1
T363 14130-14141 DG_41 denotes baricitinib
T362 14164-14175 GO:0006897 denotes endocytosis
T361 14195-14221 PR:000007805 denotes cyclin G-associated kinase
T360 14255-14266 DG_41 denotes baricitinib
T359 14357-14366 SP_7 denotes 2019-nCoV
T344 11846-11856 DG_28 denotes Remdesivir
T343 11861-11872 DG_10;CHEBI:3638;CHEBI:3638 denotes chloroquine
T342 11904-11913 SP_7 denotes 2019-nCoV
T341 11973-11982 CHEBI:63580;DG_29;CHEBI:63580 denotes ribavirin
T340 11984-11995 CHEBI:7956;CHEBI:7956 denotes penciclovir
T339 11997-12009 CHEBI:17154;CHEBI:17154 denotes nitazoxanide
T338 12023-12034 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T337 12036-12046 DG_28 denotes remdesivir
T336 12048-12054 DG_28 denotes GS5734
T335 12061-12072 NCBITaxon:31032;CHEBI:119915;DG_17;CHEBI:119915 denotes favipiravir
T334 12074-12079 DG_17 denotes T-705
T333 12136-12140 CL_6 denotes vero
T332 12201-12210 SP_7 denotes 2019-nCoV
T331 12243-12247 CHEBI:23888;CHEBI:23888 denotes drug
T330 12282-12303 GO:0001171 denotes Reverse transcription
T329 12371-12376 NCBITaxon:10239 denotes viral
T328 12444-12456 GO:0000786;PG_4 denotes nucleocapsid
T327 12457-12464 PG_4 denotes protein
T326 12486-12497 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T325 12502-12512 DG_28 denotes remdesivir
T324 12523-12528 NCBITaxon:10239 denotes virus
T323 12614-12623 CHEBI:22260;CHEBI:22260 denotes adenosine
T322 12632-12642 DG_28 denotes remdesivir
T321 12666-12671 NCBITaxon:10239 denotes viral
T320 12738-12749 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T319 12786-12797 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T318 12849-12857 SP_10 denotes SARS-CoV
T317 12902-12913 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T316 12922-12926 CL_6 denotes vero
T315 12950-12958 SP_10 denotes SARS CoV
T314 12987-13000 GO:0009294 denotes postinfection
T313 13024-13035 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T312 13059-13067 SP_10 denotes SARS-CoV
T311 13083-13094 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T310 13105-13114 GO:0005768 denotes endosomal
T309 13169-13174 NCBITaxon:10239 denotes virus
T308 13175-13186 GO:0061025 denotes cell fusion
T307 13188-13199 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T306 13242-13273 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T305 13275-13280 G_3;PG_10;PR:000003622 denotes ACE-2
T304 13306-13311 NCBITaxon:10239 denotes viral
T303 13429-13440 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T268 7334-7343 SP_7 denotes 2019-nCoV
T267 7374-7390 CHEBI:22587;CHEBI:22587 denotes antiviral agents
T266 7427-7436 SP_7 denotes 2019-nCoV
T265 7450-7459 DG_23 denotes lopinavir
T264 7461-7470 DG_30 denotes ritonavir
T263 7472-7479 CHEBI:57472;CHEBI:57472;DG_49 denotes arbidol
T262 7485-7496 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T261 7507-7518 CHEBI:465284;CHEBI:465284 denotes ganciclovir
T260 7566-7572 CHEBI:38867;CHEBI:38867 denotes agents
T259 7588-7603 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T258 7620-7634 GO:0019814 denotes immunoglobulin
T257 8067-8075 SP_7 denotes 2019nCoV
T256 8112-8117 GO:0016265 denotes death
T243 6048-6057 SP_7 denotes 2019-nCoV
T242 6171-6178 GO:0065007 denotes control
T241 6352-6363 UBERON:0001004 denotes respiratory
T240 6385-6396 NCBITaxon:11118 denotes coronavirus
T239 6398-6407 SP_7 denotes 2019-nCoV
T238 6479-6486 NCBITaxon:9606 denotes persons
T237 6508-6519 UBERON:0001004 denotes respiratory
T236 6541-6545 UBERON:0002398 denotes hand
T235 6596-6603 NCBITaxon:33208 denotes animals
T234 6630-6641 UBERON:0001004 denotes respiratory
T233 6792-6801 NCBITaxon:1 denotes organisms
T232 6845-6856 UBERON:0001004 denotes respiratory
T231 6952-6963 UBERON:0001004 denotes respiratory
T230 7024-7029 UBERON:0000004 denotes nasal
T214 5758-5763 SO:0000646 denotes SiRNA
T213 5765-5792 PR:000000134 denotes tumor necrosis factor-alpha
T212 5793-5803 CHEBI:35222;CHEBI:35222 denotes inhibitors
T211 5818-5828 GO:0042571 denotes antibodies
T210 5830-5844 CHEBI:7986;CHEBI:7986 denotes pentoxifylline
T207 4962-4966 GO:0006955 denotes host
T206 4967-4973 UBERON:0002405;GO:0006955 denotes immune
T205 4974-4982 GO:0006955 denotes response
T204 5036-5041 NCBITaxon:10239 denotes viral
T203 5112-5120 NCBITaxon:4894 denotes fibrates
T202 5184-5195 UBERON:0001004 denotes respiratory
T201 5276-5284 SP_10 denotes SARS-CoV
T200 5288-5296 SP_9 denotes MERS-CoV
T199 5429-5440 GO:0006260 denotes replication
T198 5522-5530 SP_7 denotes COVID-19
T197 5631-5635 PR:000001393 denotes IL-6
T196 5639-5650 DG_35 denotes tocilizumab
T185 4541-4556 GO:0019814 denotes Immunoglobulins
T184 4583-4587 SP_10 denotes SARS
T183 4822-4836 GO:0019814 denotes immunoglobulin
T180 4043-4051 SP_10 denotes SARS-CoV
T179 4074-4083 DG_29 denotes ribavirin
T178 4153-4167 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T177 4269-4283 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T176 4285-4299 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T175 4312-4326 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T174 4432-4441 SP_7 denotes 2019-nCoV
T173 4501-4510 CHEBI:6426;DG_23;CHEBI:6426 denotes lopinavir
T172 4513-4522 CHEBI:85129;DG_30;CHEBI:85129 denotes ritonavir
T160 3439-3454 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T159 3455-3470 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T158 3522-3530 SP_9 denotes MERS-CoV
T157 3594-3603 SP_7 denotes 2019-nCoV
T156 3676-3691 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T155 3747-3761 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T154 3817-3822 NCBITaxon:10239 denotes viral
T153 3857-3865 SP_9 denotes MERS-CoV
T152 3877-3884 CHEBI:35341;CHEBI:35341 denotes steroid
T143 2362-2370 SP_10 denotes SARS-CoV
T142 2446-2454 MOP:0000780 denotes cleaving
T141 2514-2518 PR:000014815 denotes NSP1
T140 2571-2581 UBERON:0000104 denotes life cycle
T108 1676-1686 CHEBI:35222;CHEBI:35222 denotes inhibitors
T107 1701-1711 CHEBI:35222;CHEBI:35222 denotes inhibitors
T106 1784-1792 SP_9 denotes MERS-CoV
T105 1859-1870 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T104 1905-1914 NCBITaxon:7719 denotes influenza
T103 1915-1920 NCBITaxon:10239 denotes virus
T102 1953-1964 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T101 2001-2012 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T100 2041-2049 SP_9 denotes MERS-CoV
T99 2095-2106 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T98 2110-2118 SP_9 denotes MERS-CoV
T97 2124-2135 CHEBI:7798;CHEBI:7798 denotes Oseltamivir
T96 2171-2180 SP_7 denotes 2019-nCoV
T80 810-820 CHEBI:33838;CHEBI:33838 denotes Nucleoside
T79 828-837 DG_29 denotes Ribavirin
T78 898-904 NCBITaxon:33208 denotes animal
T77 922-930 SP_10 denotes SARS-CoV
T76 973-982 DG_29;CHEBI:28201;CHEBI:28201 denotes ribavirin
T75 994-1009 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T74 1061-1069 SP_10 denotes SARS-CoV
T73 1196-1205 CHEBI:28201;DG_29;CHEBI:28201 denotes ribavirin
T72 1214-1222 SP_10 denotes SARS-CoV
T71 1224-1233 CHEBI:85129;DG_29;CHEBI:85129 denotes Ribavirin
T70 1369-1378 DG_29 denotes ribavirin
T69 1397-1406 DG_29 denotes ribavirin
T68 1411-1425 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T67 1465-1470 NCBITaxon:10239 denotes viral
T66 1558-1568 CHEBI:23447;CHEBI:23447 denotes nucleoside
T65 1581-1592 CHEBI:119915;CHEBI:119915;DG_17;NCBITaxon:31032 denotes favipiravir
T64 1597-1608 DG_19;NCBITaxon:9031 denotes galidesivir
T63 1650-1659 SP_7 denotes 2019-nCoV
T41 27-40 NCBITaxon:11118 denotes coronaviruses
T40 79-90 UBERON:0001004 denotes respiratory
T39 127-139 SP_10 denotes severe acute
T38 140-151 SP_10;UBERON:0001004 denotes respiratory
T37 152-172 SP_10 denotes syndrome coronavirus
T36 174-182 SP_10 denotes SARS-CoV
T35 231-242 SP_9 denotes Middle East
T34 243-254 SP_9;UBERON:0001004 denotes respiratory
T33 255-275 SP_9 denotes syndrome coronavirus
T32 277-285 SP_9 denotes MERS-CoV
T31 353-364 NCBITaxon:11118 denotes coronavirus
T30 380-391 NCBITaxon:11118 denotes coronavirus
T29 393-402 SP_7 denotes 2019-nCoV
T28 407-418 NCBITaxon:11118 denotes coronavirus
T27 428-436 SP_7 denotes COVID-19
T26 519-528 SP_7 denotes 2019-nCoV
T25 538-542 SP_10 denotes SARS
T24 553-561 SP_9 denotes MERS-CoV
T23 726-734 SP_9 denotes MERS-CoV
T22 741-747 CHEBI:52217;CHEBI:52217 denotes agents
T21 783-792 SP_7 denotes 2019-nCoV
T131 2979-2988 DG_30 denotes Ritonavir
T130 3009-3018 DG_23 denotes lopinavir
T229 7070-7082 UBERON:0001852 denotes endotracheal
T139 2610-2619 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T138 2633-2642 CHEBI:35222;CHEBI:35222 denotes inhibitor
T137 2647-2657 CHEBI:63621;DG_32;CHEBI:63621 denotes saquinavir
T136 2681-2690 CHEBI:35222;CHEBI:35222 denotes inhibitor
T135 2779-2789 CHEBI:35222;CHEBI:35222 denotes inhibitors
T134 2803-2811 SP_10 denotes SARS-CoV
T133 2878-2886 SP_10 denotes SARS-CoV
T132 2897-2906 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T129 3223-3232 DG_23 denotes lopinavir
T128 3233-3242 DG_30 denotes ritonavir
T127 3302-3311 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T126 3314-3323 DG_30 denotes ritonavir
T125 3383-3392 SP_7 denotes 2019-nCoV

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 2504-2512 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T2 3048-3051 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T3 3823-3826 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T4 4300-4303 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T5 4335-4338 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T6 4541-4556 Body_part denotes Immunoglobulins http://purl.org/sig/ont/fma/fma62871
T7 4697-4711 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T8 4822-4836 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T9 5388-5391 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T10 5444-5448 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T11 5477-5485 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T12 5569-5578 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T13 6541-6545 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T14 7620-7634 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T15 7806-7813 Body_part denotes capsule http://purl.org/sig/ont/fma/fma85272
T16 8698-8712 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T17 9484-9498 Body_part denotes Immunoglobulin http://purl.org/sig/ont/fma/fma62871
T18 11661-11668 Body_part denotes Capsule http://purl.org/sig/ont/fma/fma85272
T19 12144-12149 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 12190-12195 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 12457-12464 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T22 12672-12675 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T23 12930-12935 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 13105-13114 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T25 13175-13179 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 13318-13325 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 13536-13541 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T28 13602-13607 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 13619-13624 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T30 13721-13728 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 14186-14193 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4300-4303 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T2 4335-4338 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T3 6541-6545 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T4 7806-7813 Body_part denotes capsule http://purl.obolibrary.org/obo/UBERON_0003893
T5 11661-11668 Body_part denotes Capsule http://purl.obolibrary.org/obo/UBERON_0003893

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p17514s10 1453-1461 PosReg denotes increase
p17514s12 1465-1475 MPA denotes viral load
p17549s21 5429-5440 MPA denotes replication
p17634s1 13095-13104 PosReg denotes increases
p17634s2 13105-13114 CPA denotes endosomal

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 127-160 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T2 174-182 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 428-436 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 538-542 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 641-650 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 922-930 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 1061-1069 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1214-1222 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1265-1281 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T10 1275-1281 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T11 1283-1295 Disease denotes hypocalcemia http://purl.obolibrary.org/obo/MONDO_0018543
T12 1301-1315 Disease denotes hypomagnesemia http://purl.obolibrary.org/obo/MONDO_0018100
T13 1747-1756 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T14 1905-1914 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T15 2362-2370 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 2803-2811 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 2878-2886 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 3915-3924 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T19 4027-4038 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T20 4027-4036 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T21 4043-4051 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 4583-4587 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 5178-5213 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T24 5184-5213 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T25 5215-5219 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T26 5276-5284 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 5522-5530 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T28 5765-5770 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T29 6161-6170 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 6352-6373 Disease denotes respiratory infection http://purl.obolibrary.org/obo/MONDO_0024355
T31 6364-6373 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T32 6397-6418 Disease denotes (2019-nCoV) infection http://purl.obolibrary.org/obo/MONDO_0100096
T33 6409-6418 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 6508-6530 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T35 6845-6866 Disease denotes respiratory infection http://purl.obolibrary.org/obo/MONDO_0024355
T36 6857-6866 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 6952-6971 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T38 8067-8085 Disease denotes 2019nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T39 8076-8085 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 8367-8386 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T41 8377-8386 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T42 9972-9991 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T43 10873-10892 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T44 10883-10892 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T45 11369-11378 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T46 12173-12182 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47 12523-12538 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T48 12529-12538 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 12849-12867 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T50 12858-12867 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 12950-12954 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 12959-12968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T53 13059-13077 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T54 13068-13077 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 548-550 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T2 839-840 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 876-884 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T4 898-904 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T5 1021-1022 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 1163-1170 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T7 1529-1530 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1764-1765 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 1827-1828 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1838-1840 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T11 1915-1920 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T12 1931-1933 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T13 2120-2122 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T14 2376-2378 http://purl.obolibrary.org/obo/CLO_0052906 denotes CL
T15 3057-3058 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T16 3180-3181 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 3736-3738 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T18 4037-4038 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T19 4300-4303 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arm
T20 4335-4338 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arm
T21 4731-4733 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T22 5403-5411 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T23 5444-5448 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T24 5495-5496 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 5765-5792 http://purl.obolibrary.org/obo/PR_000000134 denotes tumor necrosis factor-alpha
T26 6065-6070 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T27 6440-6447 http://purl.obolibrary.org/obo/CLO_0009985 denotes focuses
T28 6596-6603 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T29 6792-6801 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T30 6792-6801 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T31 7227-7229 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T32 7815-7816 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 7869-7872 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34 7975-7976 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 8087-8089 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T36 8611-8612 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 8846-8848 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T38 8912-8914 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T39 8959-8961 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T40 9164-9166 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T41 9242-9244 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T42 9303-9305 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T43 9351-9353 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T44 10170-10172 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T45 10183-10185 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T46 10389-10391 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T47 10931-10932 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 11094-11095 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 11227-11229 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T50 11231-11233 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T51 11263-11265 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T52 11470-11475 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T53 11733-11741 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T54 12136-12149 http://purl.obolibrary.org/obo/CLO_0051719 denotes vero E6 cells
T55 12190-12195 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T56 12238-12242 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T57 12523-12528 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T58 12716-12718 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T59 12822-12823 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 12880-12882 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T61 12922-12935 http://purl.obolibrary.org/obo/CLO_0051719 denotes vero E6 cells
T62 13079-13081 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T63 13169-13174 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T64 13175-13179 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T65 13378-13380 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T66 13454-13455 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 13536-13541 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T68 13602-13607 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T69 13619-13624 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T70 13626-13628 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T71 13641-13650 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T72 13751-13752 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 14623-14632 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T74 14664-14673 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 598-607 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T2 810-820 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T3 839-851 Chemical denotes a nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T4 866-875 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T5 973-982 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T6 994-1009 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T7 1096-1101 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T8 1196-1205 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T9 1369-1378 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T10 1397-1406 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T11 1411-1425 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T12 1558-1568 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T13 1581-1592 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T14 1662-1686 Chemical denotes Neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T15 1676-1686 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T16 1687-1711 Chemical denotes Neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T17 1701-1711 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T18 1859-1870 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T19 1953-1964 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T20 2001-2012 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T21 2095-2106 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T22 2124-2135 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T23 2273-2278 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T24 2309-2318 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T25 2504-2512 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26 2589-2608 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T28 2598-2608 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T29 2610-2619 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T30 2633-2642 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T31 2647-2657 Chemical denotes saquinavir http://purl.obolibrary.org/obo/CHEBI_63621
T32 2681-2690 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T33 2779-2789 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T34 2897-2906 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T35 3009-3018 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T36 3223-3242 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T37 3223-3232 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T38 3233-3242 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T39 3302-3311 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T40 3314-3323 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T41 3343-3361 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T43 3352-3361 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T44 3676-3691 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T45 3747-3761 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T46 3877-3884 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T47 3980-3990 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T48 4074-4083 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T49 4087-4097 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T50 4099-4102 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T51 4135-4138 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T52 4153-4167 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T53 4168-4173 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T54 4259-4262 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T55 4269-4283 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T56 4285-4299 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T57 4312-4326 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T58 4329-4332 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T59 4377-4383 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T60 4447-4450 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T61 4501-4510 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T62 4513-4522 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T63 5069-5085 Chemical denotes immunomodulators http://purl.obolibrary.org/obo/CHEBI_50846
T64 5087-5096 Chemical denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801
T65 5098-5110 Chemical denotes atorvastatin http://purl.obolibrary.org/obo/CHEBI_39548
T66 5346-5355 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T67 5631-5633 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T69 5639-5650 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T70 5787-5792 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T71 5793-5803 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T72 6720-6733 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T73 7030-7036 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T74 7374-7390 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T75 7450-7459 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T76 7461-7470 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T77 7472-7479 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T78 7485-7496 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T79 7507-7518 Chemical denotes ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T80 7530-7546 Chemical denotes immunomodulators http://purl.obolibrary.org/obo/CHEBI_50846
T81 7588-7603 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T82 7837-7845 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T83 7993-8008 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T84 8143-8148 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T85 8234-8239 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T86 8483-8489 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T87 8557-8567 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T88 8569-8578 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T89 8580-8589 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T90 8591-8598 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T91 8633-8641 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T92 8745-8755 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T93 8946-8957 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T94 8998-9013 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T95 9276-9290 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T96 9612-9626 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T97 10060-10071 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T98 10096-10107 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T99 10113-10124 Chemical denotes ceftriaxone http://purl.obolibrary.org/obo/CHEBI_29007
T100 10132-10144 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T101 10156-10168 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T102 10219-10233 Chemical denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T103 10452-10461 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T104 10466-10480 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T105 10662-10672 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T106 10688-10699 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T107 10706-10717 Chemical denotes ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T108 10722-10741 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T109 10722-10731 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T110 10732-10741 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T111 10767-10776 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T112 10830-10840 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T113 10943-10953 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T114 10979-10989 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T115 11074-11089 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T116 11454-11468 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T117 11476-11481 Chemical denotes gamma http://purl.obolibrary.org/obo/CHEBI_30212
T118 11492-11503 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T119 11505-11517 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T120 11520-11529 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T121 11531-11542 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T122 11554-11567 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T123 11588-11596 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T124 11861-11872 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T125 11973-11982 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T126 11984-11995 Chemical denotes penciclovir http://purl.obolibrary.org/obo/CHEBI_7956
T127 12011-12021 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T128 12023-12034 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T129 12036-12046 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T130 12048-12054 Chemical denotes GS5734 http://purl.obolibrary.org/obo/CHEBI_145994
T131 12061-12072 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T132 12074-12079 Chemical denotes T-705 http://purl.obolibrary.org/obo/CHEBI_134722
T133 12243-12247 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T134 12457-12464 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T135 12486-12497 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T136 12502-12512 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T137 12614-12623 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T138 12632-12642 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T139 12738-12749 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T140 12756-12771 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T141 12786-12797 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T142 12831-12840 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T143 12902-12913 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T144 13024-13035 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T145 13083-13094 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T146 13188-13199 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T147 13242-13253 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T148 13318-13325 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 13429-13440 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T150 13721-13728 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 13862-13869 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T152 13946-13953 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T153 14042-14064 Chemical denotes janus kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_76617
T154 14055-14064 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T155 14186-14193 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T156 14772-14777 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 4967-4982 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T2 5036-5053 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T3 5036-5053 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T4 5771-5779 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T5 5771-5779 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T6 5771-5779 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T7 5771-5779 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T8 12282-12303 http://purl.obolibrary.org/obo/GO_0001171 denotes Reverse transcription
T9 12290-12303 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10 13175-13186 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T11 13175-13186 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T12 13175-13186 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T13 13175-13186 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T14 13217-13230 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T15 13350-13375 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T16 13641-13650 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T17 13659-13692 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor mediates the endocytosis
T18 13681-13692 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T19 14048-14064 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitor
T20 14164-14175 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T21 14195-14201 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-658 Sentence denotes In the 21st century, three coronaviruses (CoVs) caused three major epidemic of respiratory distress[1] syndrome, which include severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 with epicenter in Guangdong, China,[2] Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 in Saudi Arabia,[3] and the third epidemic of respiratory coronavirus the 2019-novel coronavirus (2019-nCoV) or coronavirus disease (COVID-19) mainly centered in Wuhan province, China.[4] The case fatalities vary from 2.5% (2019-nCoV),[5]10% (SARS), to 35% (MERS-CoV).[6] Till now, there is no approved antiviral or vaccine for the management of infection by CoV.
T4 659-796 Sentence denotes However, from earlier experience of the management of SERS-CoV and MERS-CoV, many agents are being used in the treatment of 2019-nCoV.[7]
T5 798-808 Sentence denotes Antivirals
T6 810-827 Sentence denotes Nucleoside analog
T7 828-1070 Sentence denotes Ribavirin, a nucleoside analog, shows antiviral activity against some animal CoVs, and in the SARS-CoV epidemic, many patients were treated with ribavirin along with corticosteroids and became a standard regimen for the treatment of SARS-CoV.
T8 1071-1146 Sentence denotes However, lack of control group hindered the estimation of true effect size.
T9 1147-1223 Sentence denotes Again, in vitro testing did not show efficacy of ribavirin against SARS-CoV.
T10 1224-1317 Sentence denotes Ribavirin is known for its side effects (hemolytic anemia, hypocalcemia, and hypomagnesemia).
T11 1318-1379 Sentence denotes Many subsequent studies questioned the efficacy of ribavirin.
T12 1380-1500 Sentence denotes Many patients on ribavirin and corticosteroid combination even showed an increase in viral load following the treatment.
T13 1501-1660 Sentence denotes Thus, its use declined over a period.[8] Other important nucleoside analogs are favipiravir and galidesivir, but these are not evaluated till now in 2019-nCoV.
T14 1662-1686 Sentence denotes Neuraminidase inhibitors
T15 1687-1879 Sentence denotes Neuraminidase inhibitors are indicated in the management of influenza.[9] In a study on possible MERS-CoV cases in Paris from 2013 to 2016, a total of 35 patients received oseltamivir (37.6%).
T16 1880-2298 Sentence denotes In patients positive for influenza virus (n = 25), 52% (n = 13) received oseltamivir and it was concluded that empirical oseltamivir can be started in suspected MERS-CoV cases.[10] Many other studies also evaluated oseltamivir in MERS-CoV.[11] Oseltamivir was also used in the management of 2019-nCoV; however, definite evidence of efficacy is inconclusive because of lack of suitable control group in the studies.[12]
T17 2300-2318 Sentence denotes Protease inhibitor
T18 2319-2582 Sentence denotes There are two types of protease present in SARS-CoV, the CL-like protease and the papain-like protease, which is important for cleaving the polyproteins and releasing the nonstructural proteins (NSP1–16), which carry out important functions in the CoV life cycle.
T19 2583-3419 Sentence denotes Among protease inhibitors, lopinavir was the most inhibitor and saquinavir was the least powerful inhibitor of CoV protease.[13] In molecular dynamic studies, flap closing was observed when these inhibitors bound to the SARS-CoV 3CL (pro).[14] Hong Kong University researchers demonstrated anti-SARS-CoV action of lopinavir at concentration of 4 μg/ml in vitro against the HKU-39849 isolate.[15] Ritonavir boosting along with lopinavir is used in the management of HIV.[16] A clinical study at the same Hong Kong University suggests that even after adjustment for LDH level (possible confounder), a significant association was seen between lopinavir/ritonavir use and better outcome.[15] As per the current guidelines, lopinavir + ritonavir is the recommended protease inhibitor for the treatment of 2019-nCoV (weak recommendation).[17]
T20 3421-3437 Sentence denotes Immunomodulators
T21 3439-3454 Sentence denotes Corticosteroids
T22 3455-3604 Sentence denotes Corticosteroids were widely used for the treatment of SERS-CoV and MERS-CoV and are also used in the management of the current epidemic of 2019-nCoV.
T23 3605-3929 Sentence denotes However, the interim guidelines by the WHO prohibit the use of routine corticosteroids unless indicated for other clinical ground.[18] Use of corticosteroid is reported to be associated with delayed clearance of viral RNA (both in case of SERS-CoV and MERS-CoV) and other steroid-related complications such as psychosis.[19]
T24 3931-3941 Sentence denotes Interferon
T25 3942-4039 Sentence denotes Interferons (IFNs) are broad-spectrum antivirals, primarily used in the treatment of hepatitis B.
T26 4040-4539 Sentence denotes In SARS-CoV patients, compared to ribavirin or interferon (IFN) alone, the benefit was seen on IFN-α + high-dose corticosteroid group.[20] Other observational studies also support these findings and the combined use of IFN-α and corticosteroid (corticosteroid arm n = 13; corticosteroid + IFN-α arm n = 9) showed less disease-associated oxygen saturation impairment.[21] For the treatment of 2019-nCoV (7), IFN-α (5 million U bid inh) is recommended along with lopinavir + ritonavir combination.[17]
T27 4541-4556 Sentence denotes Immunoglobulins
T28 4557-4841 Sentence denotes In case of critically ill SARS, who show signs of deterioration, further escalation of immunomodulation is indicated and intravenous (i.v.) immunoglobulin may be considered.[22] Patients who show poor response to initial empirical therapy may get benefit from i.v. immunoglobulin.[23]
T29 4843-4866 Sentence denotes Host-Directed Therapies
T30 4867-5242 Sentence denotes Host-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity.
T31 5243-5320 Sentence denotes However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]
T32 5321-5656 Sentence denotes Zinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]
T33 5658-5673 Sentence denotes Other Therapies
T34 5674-5943 Sentence denotes Other treatment options, which are either used rarely or in experimental state, are SiRNA, tumor necrosis factor-alpha inhibitors, neutralizing antibodies, pentoxifylline, etc., However, the level of evidence is quite poor and hence not recommended for routine care.[8]
T35 5945-6006 Sentence denotes Management of 2019-Novel Coronavirus (Coronavirus Disease-19)
T36 6007-6604 Sentence denotes Clinical care of suspected patients with 2019-nCoV should focus on recognition of the disease condition at the earliest, isolation and adoption of proper infection control measures, and delivery of optimized supportive care toward the suspected/confirmed cases.[26] For preventive measure, the WHO guideline “Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected” mainly focuses on avoiding close contact with persons suffering from acute respiratory infections, frequent hand wash, and avoidance of unwanted contact with wild animals.
T37 6605-6709 Sentence denotes In case of patients with respiratory distress, the patient is to be evaluated for the presence of shock.
T38 6710-6868 Sentence denotes Empirical antimicrobial coverage is to be given (to cover up the likely causative organisms, which may be responsible for severe acute respiratory infection).
T39 6869-6930 Sentence denotes Special concern is to be given for other comorbid conditions.
T40 6931-7140 Sentence denotes In case of hypoxemic respiratory failure, it needs to be managed aggressively with high-flow nasal oxygen or noninvasive ventilation or by endotracheal intubation and positive pressure ventilation as required.
T41 7141-7230 Sentence denotes Special concern is to be taken for the identification and management of septic shock.[27]
T42 7232-7268 Sentence denotes Treatment of 2019-Novel Coronavirus:
T43 7269-7288 Sentence denotes Evidence from China
T44 7289-7369 Sentence denotes The details of treatment reported in case of 2019-nCoV are presented in Table 1.
T45 7370-8303 Sentence denotes The antiviral agents which are used in the management of 2019-nCoV episodes are lopinavir, ritonavir, arbidol,[28] oseltamivir,[12] i.v. ganciclovir.[29] Among immunomodulators, the commonly used agents are systematic corticosteroids,[1230] and i.v. immunoglobulin was used in more serious cases who were refractory to initial therapy.[28] Among herbal medicines, Chinese herbal medicinal products Tanreqing i.v. gtt,[31] shufeng jiedu capsule (a traditional Chinese medicine) was used.[28] The WHO has specified that at this present time there is no high level evidence is available, which favous use of a single specific antiviral agent for the treatment of patients with suspected or confirmed 2019nCoV infection.[27] Although many of the death cases were in higher age group[32] and many were smokers and had bilateral disease,[29] lack of appropriate control group is the main hindrance in interpreting these prognostic factors.
T46 8304-8386 Sentence denotes Table 1 Details of reported therapeutic strategies to counter 2019-nCoV infection
T47 8387-8442 Sentence denotes Study details Sample size Therapeutic agents Outcome
T48 8443-8525 Sentence denotes [28] 4 patients All patients received oxygen therapy and mechanical ventilation.
T49 8526-8643 Sentence denotes All patients were treated with antibiotic, lopinavir, ritonavir, arbidol, and SFJDC (a traditional Chinese medicine).
T50 8644-8713 Sentence denotes However, only one seriously ill patient received i.v. immunoglobulin.
T51 8714-8839 Sentence denotes All patients were treated with antivirals for 6-15 days 3 patients improved, last patient still on ventilator (but improved)
T52 8840-8916 Sentence denotes [12] 41 patients Antibiotic therapy was administered in 100% cases (n=41).
T53 8917-8958 Sentence denotes 93% (n=38) patients received oseltamivir.
T54 8959-9036 Sentence denotes 22% (n=9) patients received systematic corticosteroids Discharged=68% (n=28)
T55 9037-9055 Sentence denotes Antiviral therapy:
T56 9056-9135 Sentence denotes Overall 38 (93%), ICU setting 12 (92%), non-ICU care 26 (93%) Death=6 patients
T57 9136-9155 Sentence denotes Antibiotic therapy:
T58 9156-9231 Sentence denotes Overall 41 (100%), ICU setting 13 (100%), non-ICU setting 28 (100%) Death:
T59 9232-9268 Sentence denotes Overall 6/41, ICU 5/13, non-ICU 1/28
T60 9269-9291 Sentence denotes Use of corticosteroid:
T61 9292-9355 Sentence denotes Overall 9 (22%), ICU settings 6 (46%), non-ICU settings 3 (11%)
T62 9356-9483 Sentence denotes [32] Clinical data from 137 2019-nCoV- infected patients Patients were treated symptomatically and given respiratory support.
T63 9484-9571 Sentence denotes Immunoglobulin was given to few patients depending upon clinical severity and response.
T64 9572-9627 Sentence denotes No benefit was observed from systematic corticosteroid.
T65 9628-9715 Sentence denotes Notably, early respiratory support facilitated disease recovery and improved prognosis.
T66 9716-10014 Sentence denotes The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea Patients with higher age at presentation and concomitant disease were more likely to show features of respiratory failure and had poorer outcome
T67 10015-10072 Sentence denotes [30] 138 patients 90% of patients received oseltamivir.
T68 10073-10175 Sentence denotes The most commonly used antibiotics were ceftriaxone (25%), moxifloxacin (64%), and azithromycin (18%).
T69 10176-10270 Sentence denotes Around 45% of patients received additional glucocorticoid therapy Still admitted=61.6% (n=85)
T70 10271-10399 Sentence denotes 9.4% of patients required additional vasopressor and 1.44% of patients required renal replacement therapy Discharged=34% (n=47)
T71 10400-10489 Sentence denotes Severity of disease was an important determinant of antiviral and corticosteroid therapy.
T72 10490-10552 Sentence denotes However, no effective outcomes were observed Death=4.3% (n=6)
T73 10553-10657 Sentence denotes [29] 99 patients All patients were treated in isolationAntiviral therapy given to 76% patients (n=75).
T74 10658-10750 Sentence denotes The antivirals used were oral oseltamivir, i.v. ganciclovir and lopinavir/ritonavir tablets.
T75 10751-10851 Sentence denotes The duration of antiviral therapy ranged from 3 to 14 days70 patients received antibiotic treatment.
T76 10852-10962 Sentence denotes In case of secondary bacterial infection, culture and sensitivity were used as a guide for antibiotic therapy.
T77 10963-11394 Sentence denotes The duration of antibiotic therapy ranged from 3 to 17 days19 (19%) patients were also treated with additional corticosteroids for a duration of 3-15 daysNoninvasive ventilator=13, invasive ventilator=4, ECMO=3, and requirement of RRT=9 Discharged=31% (n=31)Died=11 (11%)Details of death patients:7/11 deaths age >60 yearsLong history of smoking=3MuLBSTA score could predict outcomeLymphopenia=8Bilateral pneumonia=7Hypertension=3
T78 11395-11640 Sentence denotes [31] 2 patients Both the patients were treated with i.v. corticosteroid, human gamma globulin, antibiotics (moxifloxacin), antiviral (oseltamivir and abidol hydrochloride) and Chinese herbal medicine Tanreqing i.v. gtt Both patients recovered
T79 11641-11784 Sentence denotes SFJDC=Shufeng Jiedu Capsule, ICU=Intensive care unit, i.v.=Intravenous, ECMO=Extracorporeal membrane oxygenation, RRT=Renal replacement therapy
T80 11786-11844 Sentence denotes Recent Advances in the Treatment of 2019-Novel Coronavirus
T81 11846-11876 Sentence denotes Remdesivir and chloroquine[33]
T82 11877-12105 Sentence denotes Using clinical isolates of 2019-nCoV, Wang et al., 2020 evaluated the efficacy of seven agents (ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine, remdesivir [GS5734], and favipiravir [T-705]) in in vitro conditions.
T83 12106-12281 Sentence denotes Cytotoxicity was evaluated in vero E6 cells, which was followed by infection of the cells with 2019-nCoV clinical isolates, and the test drug was evaluated at different doses.
T84 12282-12480 Sentence denotes Reverse transcription polymerase chain reaction-based quantification was done to get the viral yield, which was later confirmed by immunofluorescence microscopy (nucleocapsid protein visualization).
T85 12481-12604 Sentence denotes Both chloroquine and remdesivir inhibited virus infection at micromolar level (0.77–1.13 μM) and with high selectivity.[33]
T86 12605-12785 Sentence denotes Being an adenosine analog, remdesivir gets incorporated into viral RNA and causes premature chain termination.[34] The importance of chloroquine as an antiviral agent is coming up.
T87 12786-12969 Sentence denotes Chloroquine even showed efficacy as a potent antiviral against SARS-CoV infection and spread.[35] Pretreatment with chloroquine renders vero E6 cells refractory to SARS CoV infection.
T88 12970-13187 Sentence denotes Moreover, in the postinfection period, treatment with chloroquine prevents the spread of SARS-CoV infection.[35] Chloroquine increases endosomal pH and thus makes the environment unfavorable for the virus/cell fusion.
T89 13188-13476 Sentence denotes Chloroquine also affects the glycosylation process of angiotensin-converting enzyme 2 (ACE-2, receptor for binding of viral spike protein, which is essential for interaction with the host).[35] Being nonexpensive and easily available agent, chloroquine may prove as a promising candidate.
T90 13478-13489 Sentence denotes Baricitinib
T91 13490-13780 Sentence denotes The SARSCoV and the 2019nCoV both enters host cells through ACE2 receptormediated entry, especially through AT2 cells present in lungs.[36] Downstream signaling of this receptor mediates the endocytosis process, and AP2-associated protein kinase 1 (AAK1) plays a major role in this process.
T92 13781-13823 Sentence denotes Thus, AAK1 represents an important target.
T93 13824-13933 Sentence denotes Richardson et al., 2020 evaluated 378 ligands, of which 47 were already approved for use in other conditions.
T94 13934-13993 Sentence denotes Among these ligands, six inhibited AAK1 with high affinity.
T95 13994-14108 Sentence denotes Considering the side effect profile, they found janus kinase inhibitor baricitinib to be the most important agent.
T96 14109-14223 Sentence denotes In addition to AAK1, baricitinib also binds to another endocytosis regulator protein (cyclin G-associated kinase).
T97 14224-14371 Sentence denotes Thus, the authors suggest that baricitinib can be evaluated in the in vitro conditions as well as in the clinical trial settings for 2019-nCoV.[37]
T98 14373-14404 Sentence denotes Limitations of current research
T99 14405-14545 Sentence denotes Lack of high-quality evidence (especially randomized controlled trails [RCTs]) is the most important limitation of the current CoV research.
T100 14546-14835 Sentence denotes As most of the CoV strains are genetically different and the outbreaks occur extremely randomly, conducting an RCT is extremely difficult, and we have to rely on observational studies (most of which do not have proper control group), which hamper the estimation of proper treatment effect.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 79-99 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 1265-1281 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878
T3 1283-1295 Phenotype denotes hypocalcemia http://purl.obolibrary.org/obo/HP_0002901
T4 1301-1315 Phenotype denotes hypomagnesemia http://purl.obolibrary.org/obo/HP_0002917
T5 3915-3924 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T6 4027-4036 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T7 5184-5204 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T8 5477-5491 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T9 5765-5770 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T10 6352-6373 Phenotype denotes respiratory infection http://purl.obolibrary.org/obo/HP_0011947
T11 6508-6530 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T12 6630-6650 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T13 6703-6708 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T14 6845-6866 Phenotype denotes respiratory infection http://purl.obolibrary.org/obo/HP_0011947
T15 6952-6971 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T16 7220-7225 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T17 9861-9868 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T18 9972-9991 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T19 11369-11378 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32201439-17597972-47219406 1539-1540 17597972 denotes 8
32201439-30012113-47219407 2057-2059 30012113 denotes 10
32201439-30882305-47219408 2120-2122 30882305 denotes 11
32201439-31986264-47219409 2295-2297 31986264 denotes 12
32201439-18706430-47219410 2823-2825 18706430 denotes 14
32201439-14985565-47219411 2975-2977 14985565 denotes 15
32201439-16827606-47219412 3053-3055 16827606 denotes 16
32201439-14985565-47219413 3267-3269 14985565 denotes 15
32201439-32029004-47219414 3416-3418 32029004 denotes 17
32201439-32043983-47219415 3926-3928 32043983 denotes 19
32201439-12867568-47219416 4175-4177 12867568 denotes 20
32201439-14693875-47219417 4407-4409 14693875 denotes 21
32201439-32029004-47219418 4536-4538 32029004 denotes 17
32201439-15912185-47219419 4731-4733 15912185 denotes 22
32201439-15018130-47219420 4838-4840 15018130 denotes 23
32201439-26868298-47219421 5055-5056 26868298 denotes 6
32201439-32035018-47219422 5317-5319 32035018 denotes 24
32201439-32035018-47219423 5364-5366 32035018 denotes 24
32201439-21079686-47219424 5470-5472 21079686 denotes 25
32201439-32035018-47219425 5653-5655 32035018 denotes 24
32201439-17597972-47219426 5941-5942 17597972 denotes 8
32201439-31986264-47219427 7498-7500 31986264 denotes 12
32201439-32007143-47219428 7520-7522 32007143 denotes 29
32201439-31986264-47219429 7605-7607 31986264 denotes 12
32201439-32007143-47219430 8202-8204 32007143 denotes 29
32201439-31986264-47219431 8841-8843 31986264 denotes 12
32201439-32007143-47219432 10554-10556 32007143 denotes 29
32201439-32020029-47219433 11873-11875 32020029 denotes 33
32201439-32020029-47219434 12601-12603 32020029 denotes 33
32201439-26934220-47219435 12716-12718 26934220 denotes 34
32201439-16115318-47219436 12880-12882 16115318 denotes 35
32201439-16115318-47219437 13079-13081 16115318 denotes 35
32201439-16115318-47219438 13378-13380 16115318 denotes 35
32201439-32032529-47219439 14368-14370 32032529 denotes 37
T83959 1539-1540 17597972 denotes 8
T19064 2057-2059 30012113 denotes 10
T33497 2120-2122 30882305 denotes 11
T42850 2295-2297 31986264 denotes 12
T5394 2823-2825 18706430 denotes 14
T51142 2975-2977 14985565 denotes 15
T94741 3053-3055 16827606 denotes 16
T99431 3267-3269 14985565 denotes 15
T46519 3416-3418 32029004 denotes 17
T87822 3926-3928 32043983 denotes 19
T43328 4175-4177 12867568 denotes 20
T72085 4407-4409 14693875 denotes 21
T4398 4536-4538 32029004 denotes 17
T78101 4731-4733 15912185 denotes 22
T89577 4838-4840 15018130 denotes 23
T10426 5055-5056 26868298 denotes 6
T92752 5317-5319 32035018 denotes 24
T75307 5364-5366 32035018 denotes 24
T32309 5470-5472 21079686 denotes 25
T13267 5653-5655 32035018 denotes 24
T4899 5941-5942 17597972 denotes 8
T85215 7498-7500 31986264 denotes 12
T15501 7520-7522 32007143 denotes 29
T97145 7605-7607 31986264 denotes 12
T54773 8202-8204 32007143 denotes 29
T29858 8841-8843 31986264 denotes 12
T34227 10554-10556 32007143 denotes 29
T41189 11873-11875 32020029 denotes 33
T4625 12601-12603 32020029 denotes 33
T49263 12716-12718 26934220 denotes 34
T96382 12880-12882 16115318 denotes 35
T21534 13079-13081 16115318 denotes 35
T99419 13378-13380 16115318 denotes 35
T4041 14368-14370 32032529 denotes 37