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PMC:7074432 / 891-3512 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
39 12-22 Chemical denotes Nucleoside MESH:D009705
60 107-111 Species denotes CoVs Tax:11118
61 124-132 Species denotes SARS-CoV Tax:694009
62 148-156 Species denotes patients Tax:9606
63 263-271 Species denotes SARS-CoV Tax:694009
64 416-424 Species denotes SARS-CoV Tax:694009
65 587-595 Species denotes patients Tax:9606
66 852-861 Species denotes 2019-nCoV Tax:2697049
67 30-39 Chemical denotes Ribavirin MESH:D012254
68 43-53 Chemical denotes nucleoside MESH:D009705
69 175-184 Chemical denotes ribavirin MESH:D012254
70 398-407 Chemical denotes ribavirin MESH:D012254
71 426-435 Chemical denotes Ribavirin MESH:D012254
72 571-580 Chemical denotes ribavirin MESH:D012254
73 599-608 Chemical denotes ribavirin MESH:D012254
74 760-770 Chemical denotes nucleoside MESH:D009705
75 783-794 Chemical denotes favipiravir MESH:C462182
76 799-810 Chemical denotes galidesivir MESH:C517546
77 467-483 Disease denotes hemolytic anemia MESH:D000743
78 485-497 Disease denotes hypocalcemia MESH:D006996
79 503-517 Disease denotes hypomagnesemia MESH:C537153
81 864-877 Gene denotes Neuraminidase Gene:4758
96 889-902 Gene denotes Neuraminidase Gene:4758
97 986-994 Species denotes MERS-CoV Tax:1335626
98 1043-1051 Species denotes patients Tax:9606
99 1085-1093 Species denotes patients Tax:9606
100 1107-1122 Species denotes influenza virus Tax:11309
101 1243-1251 Species denotes MERS-CoV Tax:1335626
102 1312-1320 Species denotes MERS-CoV Tax:1335626
103 1373-1382 Species denotes 2019-nCoV Tax:2697049
104 949-958 Species denotes influenza Tax:11309
105 1061-1072 Chemical denotes oseltamivir MESH:D053139
106 1155-1166 Chemical denotes oseltamivir MESH:D053139
107 1203-1214 Chemical denotes oseltamivir MESH:D053139
108 1297-1308 Chemical denotes oseltamivir MESH:D053139
109 1326-1337 Chemical denotes Oseltamivir MESH:D053139
126 1716-1723 Gene denotes NSP1–16 Gene:10045
127 1564-1572 Species denotes SARS-CoV Tax:694009
128 1769-1772 Species denotes CoV Tax:11118
129 1896-1899 Species denotes CoV Tax:11118
130 2005-2013 Species denotes SARS-CoV Tax:694009
131 2585-2594 Species denotes 2019-nCoV Tax:2697049
132 2080-2088 Species denotes SARS-CoV Tax:694009
133 1812-1821 Chemical denotes lopinavir MESH:D061466
134 1849-1859 Chemical denotes saquinavir MESH:D019258
135 2019-2022 Chemical denotes pro MESH:D011392
136 2099-2108 Chemical denotes lopinavir MESH:D061466
137 2158-2161 Chemical denotes HKU
138 2181-2190 Chemical denotes Ritonavir MESH:D019438
139 2211-2220 Chemical denotes lopinavir MESH:D061466
140 2425-2444 Chemical denotes lopinavir/ritonavir MESH:C558899
141 2504-2525 Chemical denotes lopinavir + ritonavir MESH:C558899

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T143 1564-1572 SP_10 denotes SARS-CoV
T142 1648-1656 MOP:0000780 denotes cleaving
T141 1716-1720 PR:000014815 denotes NSP1
T140 1773-1783 UBERON:0000104 denotes life cycle
T108 878-888 CHEBI:35222;CHEBI:35222 denotes inhibitors
T107 903-913 CHEBI:35222;CHEBI:35222 denotes inhibitors
T106 986-994 SP_9 denotes MERS-CoV
T105 1061-1072 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T104 1107-1116 NCBITaxon:7719 denotes influenza
T103 1117-1122 NCBITaxon:10239 denotes virus
T102 1155-1166 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T101 1203-1214 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T100 1243-1251 SP_9 denotes MERS-CoV
T99 1297-1308 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T98 1312-1320 SP_9 denotes MERS-CoV
T97 1326-1337 CHEBI:7798;CHEBI:7798 denotes Oseltamivir
T96 1373-1382 SP_7 denotes 2019-nCoV
T80 12-22 CHEBI:33838;CHEBI:33838 denotes Nucleoside
T79 30-39 DG_29 denotes Ribavirin
T78 100-106 NCBITaxon:33208 denotes animal
T77 124-132 SP_10 denotes SARS-CoV
T76 175-184 DG_29;CHEBI:28201;CHEBI:28201 denotes ribavirin
T75 196-211 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T74 263-271 SP_10 denotes SARS-CoV
T73 398-407 CHEBI:28201;DG_29;CHEBI:28201 denotes ribavirin
T72 416-424 SP_10 denotes SARS-CoV
T71 426-435 CHEBI:85129;DG_29;CHEBI:85129 denotes Ribavirin
T70 571-580 DG_29 denotes ribavirin
T69 599-608 DG_29 denotes ribavirin
T68 613-627 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T67 667-672 NCBITaxon:10239 denotes viral
T66 760-770 CHEBI:23447;CHEBI:23447 denotes nucleoside
T65 783-794 CHEBI:119915;CHEBI:119915;DG_17;NCBITaxon:31032 denotes favipiravir
T64 799-810 DG_19;NCBITaxon:9031 denotes galidesivir
T63 852-861 SP_7 denotes 2019-nCoV
T131 2181-2190 DG_30 denotes Ritonavir
T130 2211-2220 DG_23 denotes lopinavir
T139 1812-1821 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T138 1835-1844 CHEBI:35222;CHEBI:35222 denotes inhibitor
T137 1849-1859 CHEBI:63621;DG_32;CHEBI:63621 denotes saquinavir
T136 1883-1892 CHEBI:35222;CHEBI:35222 denotes inhibitor
T135 1981-1991 CHEBI:35222;CHEBI:35222 denotes inhibitors
T134 2005-2013 SP_10 denotes SARS-CoV
T133 2080-2088 SP_10 denotes SARS-CoV
T132 2099-2108 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T129 2425-2434 DG_23 denotes lopinavir
T128 2435-2444 DG_30 denotes ritonavir
T127 2504-2513 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T126 2516-2525 DG_30 denotes ritonavir
T125 2585-2594 SP_7 denotes 2019-nCoV

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1706-1714 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T2 2250-2253 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p17514s10 655-663 PosReg denotes increase
p17514s12 667-677 MPA denotes viral load

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T6 124-132 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 263-271 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 416-424 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 467-483 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T10 477-483 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T11 485-497 Disease denotes hypocalcemia http://purl.obolibrary.org/obo/MONDO_0018543
T12 503-517 Disease denotes hypomagnesemia http://purl.obolibrary.org/obo/MONDO_0018100
T13 949-958 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T14 1107-1116 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T15 1564-1572 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 2005-2013 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 2080-2088 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T2 41-42 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 78-86 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T4 100-106 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T5 223-224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 365-372 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T7 731-732 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 966-967 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 1029-1030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1040-1042 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T11 1117-1122 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T12 1133-1135 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T13 1322-1324 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T14 1578-1580 http://purl.obolibrary.org/obo/CLO_0052906 denotes CL
T15 2259-2260 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T16 2382-2383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T2 12-22 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T3 41-53 Chemical denotes a nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T4 68-77 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T5 175-184 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T6 196-211 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T7 298-303 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T8 398-407 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T9 571-580 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T10 599-608 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T11 613-627 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T12 760-770 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T13 783-794 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T14 864-888 Chemical denotes Neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T15 878-888 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T16 889-913 Chemical denotes Neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T17 903-913 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T18 1061-1072 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T19 1155-1166 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T20 1203-1214 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T21 1297-1308 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T22 1326-1337 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T23 1475-1480 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T24 1511-1520 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T25 1706-1714 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26 1791-1810 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T28 1800-1810 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T29 1812-1821 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T30 1835-1844 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T31 1849-1859 Chemical denotes saquinavir http://purl.obolibrary.org/obo/CHEBI_63621
T32 1883-1892 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T33 1981-1991 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T34 2099-2108 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T35 2211-2220 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T36 2425-2444 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T37 2425-2434 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T38 2435-2444 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T39 2504-2513 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T40 2516-2525 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T41 2545-2563 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T43 2554-2563 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T5 0-10 Sentence denotes Antivirals
T6 12-29 Sentence denotes Nucleoside analog
T7 30-272 Sentence denotes Ribavirin, a nucleoside analog, shows antiviral activity against some animal CoVs, and in the SARS-CoV epidemic, many patients were treated with ribavirin along with corticosteroids and became a standard regimen for the treatment of SARS-CoV.
T8 273-348 Sentence denotes However, lack of control group hindered the estimation of true effect size.
T9 349-425 Sentence denotes Again, in vitro testing did not show efficacy of ribavirin against SARS-CoV.
T10 426-519 Sentence denotes Ribavirin is known for its side effects (hemolytic anemia, hypocalcemia, and hypomagnesemia).
T11 520-581 Sentence denotes Many subsequent studies questioned the efficacy of ribavirin.
T12 582-702 Sentence denotes Many patients on ribavirin and corticosteroid combination even showed an increase in viral load following the treatment.
T13 703-862 Sentence denotes Thus, its use declined over a period.[8] Other important nucleoside analogs are favipiravir and galidesivir, but these are not evaluated till now in 2019-nCoV.
T14 864-888 Sentence denotes Neuraminidase inhibitors
T15 889-1081 Sentence denotes Neuraminidase inhibitors are indicated in the management of influenza.[9] In a study on possible MERS-CoV cases in Paris from 2013 to 2016, a total of 35 patients received oseltamivir (37.6%).
T16 1082-1500 Sentence denotes In patients positive for influenza virus (n = 25), 52% (n = 13) received oseltamivir and it was concluded that empirical oseltamivir can be started in suspected MERS-CoV cases.[10] Many other studies also evaluated oseltamivir in MERS-CoV.[11] Oseltamivir was also used in the management of 2019-nCoV; however, definite evidence of efficacy is inconclusive because of lack of suitable control group in the studies.[12]
T17 1502-1520 Sentence denotes Protease inhibitor
T18 1521-1784 Sentence denotes There are two types of protease present in SARS-CoV, the CL-like protease and the papain-like protease, which is important for cleaving the polyproteins and releasing the nonstructural proteins (NSP1–16), which carry out important functions in the CoV life cycle.
T19 1785-2621 Sentence denotes Among protease inhibitors, lopinavir was the most inhibitor and saquinavir was the least powerful inhibitor of CoV protease.[13] In molecular dynamic studies, flap closing was observed when these inhibitors bound to the SARS-CoV 3CL (pro).[14] Hong Kong University researchers demonstrated anti-SARS-CoV action of lopinavir at concentration of 4 μg/ml in vitro against the HKU-39849 isolate.[15] Ritonavir boosting along with lopinavir is used in the management of HIV.[16] A clinical study at the same Hong Kong University suggests that even after adjustment for LDH level (possible confounder), a significant association was seen between lopinavir/ritonavir use and better outcome.[15] As per the current guidelines, lopinavir + ritonavir is the recommended protease inhibitor for the treatment of 2019-nCoV (weak recommendation).[17]

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 467-483 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878
T3 485-497 Phenotype denotes hypocalcemia http://purl.obolibrary.org/obo/HP_0002901
T4 503-517 Phenotype denotes hypomagnesemia http://purl.obolibrary.org/obo/HP_0002917

2_test

Id Subject Object Predicate Lexical cue
32201439-17597972-47219406 741-742 17597972 denotes 8
32201439-30012113-47219407 1259-1261 30012113 denotes 10
32201439-30882305-47219408 1322-1324 30882305 denotes 11
32201439-31986264-47219409 1497-1499 31986264 denotes 12
32201439-18706430-47219410 2025-2027 18706430 denotes 14
32201439-14985565-47219411 2177-2179 14985565 denotes 15
32201439-16827606-47219412 2255-2257 16827606 denotes 16
32201439-14985565-47219413 2469-2471 14985565 denotes 15
32201439-32029004-47219414 2618-2620 32029004 denotes 17
T83959 741-742 17597972 denotes 8
T19064 1259-1261 30012113 denotes 10
T33497 1322-1324 30882305 denotes 11
T42850 1497-1499 31986264 denotes 12
T5394 2025-2027 18706430 denotes 14
T51142 2177-2179 14985565 denotes 15
T94741 2255-2257 16827606 denotes 16
T99431 2469-2471 14985565 denotes 15
T46519 2618-2620 32029004 denotes 17