PMC:7074432 / 4936-5749 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"190","span":{"begin":433,"end":441},"obj":"Species"},{"id":"191","span":{"begin":445,"end":453},"obj":"Species"},{"id":"192","span":{"begin":244,"end":253},"obj":"Chemical"},{"id":"193","span":{"begin":255,"end":267},"obj":"Chemical"},{"id":"194","span":{"begin":335,"end":370},"obj":"Disease"},{"id":"195","span":{"begin":372,"end":376},"obj":"Disease"},{"id":"200","span":{"begin":788,"end":792},"obj":"Gene"},{"id":"201","span":{"begin":541,"end":544},"obj":"Species"},{"id":"202","span":{"begin":796,"end":807},"obj":"Chemical"},{"id":"203","span":{"begin":679,"end":687},"obj":"Disease"}],"attributes":[{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"Tax:694009"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"Tax:1335626"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"MESH:D008687"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"MESH:D000069059"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"MESH:D012128"},{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"MESH:D012128"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Gene:3569"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Tax:11118"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"MESH:C502936"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T207","span":{"begin":119,"end":123},"obj":"GO:0006955"},{"id":"T206","span":{"begin":124,"end":130},"obj":"UBERON:0002405;GO:0006955"},{"id":"T205","span":{"begin":131,"end":139},"obj":"GO:0006955"},{"id":"T204","span":{"begin":193,"end":198},"obj":"NCBITaxon:10239"},{"id":"T203","span":{"begin":269,"end":277},"obj":"NCBITaxon:4894"},{"id":"T202","span":{"begin":341,"end":352},"obj":"UBERON:0001004"},{"id":"T201","span":{"begin":433,"end":441},"obj":"SP_10"},{"id":"T200","span":{"begin":445,"end":453},"obj":"SP_9"},{"id":"T199","span":{"begin":586,"end":597},"obj":"GO:0006260"},{"id":"T198","span":{"begin":679,"end":687},"obj":"SP_7"},{"id":"T197","span":{"begin":788,"end":792},"obj":"PR:000001393"},{"id":"T196","span":{"begin":796,"end":807},"obj":"DG_35"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T9","span":{"begin":545,"end":548},"obj":"Body_part"},{"id":"T10","span":{"begin":601,"end":605},"obj":"Body_part"},{"id":"T11","span":{"begin":634,"end":642},"obj":"Body_part"},{"id":"T12","span":{"begin":726,"end":735},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid_AGAC","denotations":[{"id":"p17549s21","span":{"begin":586,"end":597},"obj":"MPA"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T23","span":{"begin":335,"end":370},"obj":"Disease"},{"id":"T24","span":{"begin":341,"end":370},"obj":"Disease"},{"id":"T25","span":{"begin":372,"end":376},"obj":"Disease"},{"id":"T26","span":{"begin":433,"end":441},"obj":"Disease"},{"id":"T27","span":{"begin":679,"end":687},"obj":"Disease"}],"attributes":[{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T22","span":{"begin":560,"end":568},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T23","span":{"begin":601,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T24","span":{"begin":652,"end":653},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T63","span":{"begin":226,"end":242},"obj":"Chemical"},{"id":"T64","span":{"begin":244,"end":253},"obj":"Chemical"},{"id":"T65","span":{"begin":255,"end":267},"obj":"Chemical"},{"id":"T66","span":{"begin":503,"end":512},"obj":"Chemical"},{"id":"T67","span":{"begin":788,"end":790},"obj":"Chemical"},{"id":"T69","span":{"begin":796,"end":807},"obj":"Chemical"}],"attributes":[{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_50846"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_6801"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_39548"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A67","pred":"chebi_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A68","pred":"chebi_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_64360"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":124,"end":139},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T2","span":{"begin":193,"end":210},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T3","span":{"begin":193,"end":210},"obj":"http://purl.obolibrary.org/obo/GO_0019058"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T29","span":{"begin":0,"end":23},"obj":"Sentence"},{"id":"T30","span":{"begin":24,"end":399},"obj":"Sentence"},{"id":"T31","span":{"begin":400,"end":477},"obj":"Sentence"},{"id":"T32","span":{"begin":478,"end":813},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":341,"end":361},"obj":"Phenotype"},{"id":"T8","span":{"begin":634,"end":648},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}

{"project":"2_test","denotations":[{"id":"32201439-26868298-47219421","span":{"begin":212,"end":213},"obj":"26868298"},{"id":"32201439-32035018-47219422","span":{"begin":474,"end":476},"obj":"32035018"},{"id":"32201439-32035018-47219423","span":{"begin":521,"end":523},"obj":"32035018"},{"id":"32201439-21079686-47219424","span":{"begin":627,"end":629},"obj":"21079686"},{"id":"32201439-32035018-47219425","span":{"begin":810,"end":812},"obj":"32035018"},{"id":"T10426","span":{"begin":212,"end":213},"obj":"26868298"},{"id":"T92752","span":{"begin":474,"end":476},"obj":"32035018"},{"id":"T75307","span":{"begin":521,"end":523},"obj":"32035018"},{"id":"T32309","span":{"begin":627,"end":629},"obj":"21079686"},{"id":"T13267","span":{"begin":810,"end":812},"obj":"32035018"}],"text":"Host-Directed Therapies\nHost-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity. However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]\nZinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]"}