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PMC:7074432 / 2393-3512 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
126 214-221 Gene denotes NSP1–16 Gene:10045
127 62-70 Species denotes SARS-CoV Tax:694009
128 267-270 Species denotes CoV Tax:11118
129 394-397 Species denotes CoV Tax:11118
130 503-511 Species denotes SARS-CoV Tax:694009
131 1083-1092 Species denotes 2019-nCoV Tax:2697049
132 578-586 Species denotes SARS-CoV Tax:694009
133 310-319 Chemical denotes lopinavir MESH:D061466
134 347-357 Chemical denotes saquinavir MESH:D019258
135 517-520 Chemical denotes pro MESH:D011392
136 597-606 Chemical denotes lopinavir MESH:D061466
137 656-659 Chemical denotes HKU
138 679-688 Chemical denotes Ritonavir MESH:D019438
139 709-718 Chemical denotes lopinavir MESH:D061466
140 923-942 Chemical denotes lopinavir/ritonavir MESH:C558899
141 1002-1023 Chemical denotes lopinavir + ritonavir MESH:C558899

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T143 62-70 SP_10 denotes SARS-CoV
T142 146-154 MOP:0000780 denotes cleaving
T141 214-218 PR:000014815 denotes NSP1
T140 271-281 UBERON:0000104 denotes life cycle
T131 679-688 DG_30 denotes Ritonavir
T130 709-718 DG_23 denotes lopinavir
T139 310-319 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T138 333-342 CHEBI:35222;CHEBI:35222 denotes inhibitor
T137 347-357 CHEBI:63621;DG_32;CHEBI:63621 denotes saquinavir
T136 381-390 CHEBI:35222;CHEBI:35222 denotes inhibitor
T135 479-489 CHEBI:35222;CHEBI:35222 denotes inhibitors
T134 503-511 SP_10 denotes SARS-CoV
T133 578-586 SP_10 denotes SARS-CoV
T132 597-606 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T129 923-932 DG_23 denotes lopinavir
T128 933-942 DG_30 denotes ritonavir
T127 1002-1011 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T126 1014-1023 DG_30 denotes ritonavir
T125 1083-1092 SP_7 denotes 2019-nCoV

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 204-212 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T2 748-751 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T15 62-70 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 503-511 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 578-586 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T14 76-78 http://purl.obolibrary.org/obo/CLO_0052906 denotes CL
T15 757-758 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T16 880-881 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T24 9-18 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T25 204-212 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26 289-308 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T28 298-308 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T29 310-319 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T30 333-342 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T31 347-357 Chemical denotes saquinavir http://purl.obolibrary.org/obo/CHEBI_63621
T32 381-390 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T33 479-489 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T34 597-606 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T35 709-718 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T36 923-942 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T37 923-932 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T38 933-942 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T39 1002-1011 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T40 1014-1023 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T41 1043-1061 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T43 1052-1061 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T17 0-18 Sentence denotes Protease inhibitor
T18 19-282 Sentence denotes There are two types of protease present in SARS-CoV, the CL-like protease and the papain-like protease, which is important for cleaving the polyproteins and releasing the nonstructural proteins (NSP1–16), which carry out important functions in the CoV life cycle.
T19 283-1119 Sentence denotes Among protease inhibitors, lopinavir was the most inhibitor and saquinavir was the least powerful inhibitor of CoV protease.[13] In molecular dynamic studies, flap closing was observed when these inhibitors bound to the SARS-CoV 3CL (pro).[14] Hong Kong University researchers demonstrated anti-SARS-CoV action of lopinavir at concentration of 4 μg/ml in vitro against the HKU-39849 isolate.[15] Ritonavir boosting along with lopinavir is used in the management of HIV.[16] A clinical study at the same Hong Kong University suggests that even after adjustment for LDH level (possible confounder), a significant association was seen between lopinavir/ritonavir use and better outcome.[15] As per the current guidelines, lopinavir + ritonavir is the recommended protease inhibitor for the treatment of 2019-nCoV (weak recommendation).[17]

2_test

Id Subject Object Predicate Lexical cue
32201439-18706430-47219410 523-525 18706430 denotes 14
32201439-14985565-47219411 675-677 14985565 denotes 15
32201439-16827606-47219412 753-755 16827606 denotes 16
32201439-14985565-47219413 967-969 14985565 denotes 15
32201439-32029004-47219414 1116-1118 32029004 denotes 17
T5394 523-525 18706430 denotes 14
T51142 675-677 14985565 denotes 15
T94741 753-755 16827606 denotes 16
T99431 967-969 14985565 denotes 15
T46519 1116-1118 32029004 denotes 17