PMC:7074432 / 13583-14464
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 473 | 60-64 | Gene | denotes | ACE2 | Gene:59272 |
| 474 | 216-247 | Gene | denotes | AP2-associated protein kinase 1 | Gene:22848 |
| 475 | 249-253 | Gene | denotes | AAK1 | Gene:22848 |
| 476 | 297-301 | Gene | denotes | AAK1 | Gene:22848 |
| 477 | 479-483 | Gene | denotes | AAK1 | Gene:22848 |
| 478 | 634-638 | Gene | denotes | AAK1 | Gene:22848 |
| 479 | 705-731 | Gene | denotes | cyclin G-associated kinase | Gene:2580 |
| 480 | 20-28 | Species | denotes | 2019nCoV | Tax:2697049 |
| 481 | 867-876 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 482 | 4-11 | Species | denotes | SARSCoV | Tax:694009 |
| 483 | 575-586 | Chemical | denotes | baricitinib | MESH:C000596027 |
| 484 | 640-651 | Chemical | denotes | baricitinib | MESH:C000596027 |
| 485 | 765-776 | Chemical | denotes | baricitinib | MESH:C000596027 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T374 | 20-28 | SP_7 | denotes | 2019nCoV |
| T373 | 60-64 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T372 | 129-134 | UBERON:0000170 | denotes | lungs |
| T371 | 191-202 | GO:0006897 | denotes | endocytosis |
| T370 | 216-247 | PR:000003526 | denotes | AP2-associated protein kinase 1 |
| T369 | 249-253 | PR:000003526 | denotes | AAK1 |
| T368 | 297-301 | PR:000003526 | denotes | AAK1 |
| T367 | 479-483 | PR:000003526 | denotes | AAK1 |
| T366 | 565-574 | CHEBI:66921;CHEBI:66921 | denotes | inhibitor |
| T365 | 575-586 | DG_41 | denotes | baricitinib |
| T364 | 634-638 | PR:000003526 | denotes | AAK1 |
| T363 | 640-651 | DG_41 | denotes | baricitinib |
| T362 | 674-685 | GO:0006897 | denotes | endocytosis |
| T361 | 705-731 | PR:000007805 | denotes | cyclin G-associated kinase |
| T360 | 765-776 | DG_41 | denotes | baricitinib |
| T359 | 867-876 | SP_7 | denotes | 2019-nCoV |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T27 | 46-51 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T28 | 112-117 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T29 | 129-134 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T30 | 231-238 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T31 | 696-703 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T67 | 46-51 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T68 | 112-117 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T69 | 129-134 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T70 | 136-138 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T71 | 151-160 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T72 | 261-262 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T150 | 231-238 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T151 | 372-379 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T152 | 456-463 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T153 | 552-574 | Chemical | denotes | janus kinase inhibitor | http://purl.obolibrary.org/obo/CHEBI_76617 |
| T154 | 565-574 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T155 | 696-703 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T16 | 151-160 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T17 | 169-202 | http://purl.obolibrary.org/obo/GO_0006898 | denotes | receptor mediates the endocytosis |
| T18 | 191-202 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T19 | 558-574 | http://purl.obolibrary.org/obo/GO_0033673 | denotes | kinase inhibitor |
| T20 | 674-685 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T21 | 705-711 | http://purl.obolibrary.org/obo/GO_0016538 | denotes | cyclin |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T91 | 0-290 | Sentence | denotes | The SARSCoV and the 2019nCoV both enters host cells through ACE2 receptormediated entry, especially through AT2 cells present in lungs.[36] Downstream signaling of this receptor mediates the endocytosis process, and AP2-associated protein kinase 1 (AAK1) plays a major role in this process. |
| T92 | 291-333 | Sentence | denotes | Thus, AAK1 represents an important target. |
| T93 | 334-443 | Sentence | denotes | Richardson et al., 2020 evaluated 378 ligands, of which 47 were already approved for use in other conditions. |
| T94 | 444-503 | Sentence | denotes | Among these ligands, six inhibited AAK1 with high affinity. |
| T95 | 504-618 | Sentence | denotes | Considering the side effect profile, they found janus kinase inhibitor baricitinib to be the most important agent. |
| T96 | 619-733 | Sentence | denotes | In addition to AAK1, baricitinib also binds to another endocytosis regulator protein (cyclin G-associated kinase). |
| T97 | 734-881 | Sentence | denotes | Thus, the authors suggest that baricitinib can be evaluated in the in vitro conditions as well as in the clinical trial settings for 2019-nCoV.[37] |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32201439-32032529-47219439 | 878-880 | 32032529 | denotes | 37 |
| T4041 | 878-880 | 32032529 | denotes | 37 |