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PMC:7074432 / 11879-14928 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
392 60-70 Chemical denotes Remdesivir MESH:C000606551
393 75-86 Chemical denotes chloroquine MESH:D002738
411 118-127 Species denotes 2019-nCoV Tax:2697049
412 415-424 Species denotes 2019-nCoV Tax:2697049
413 187-196 Chemical denotes ribavirin MESH:D012254
414 198-209 Chemical denotes penciclovir MESH:C053539
415 211-223 Chemical denotes nitazoxanide MESH:C041747
416 225-235 Chemical denotes nafamostat MESH:C032855
417 237-248 Chemical denotes chloroquine MESH:D002738
418 250-260 Chemical denotes remdesivir MESH:C000606551
419 262-268 Chemical denotes GS5734 MESH:C000606551
420 275-286 Chemical denotes favipiravir MESH:C462182
421 288-293 Chemical denotes T-705 MESH:C462182
422 700-711 Chemical denotes chloroquine MESH:D002738
423 716-726 Chemical denotes remdesivir MESH:C000606551
424 320-332 Disease denotes Cytotoxicity MESH:D064420
425 387-396 Disease denotes infection MESH:D007239
426 737-752 Disease denotes virus infection MESH:D001102
427 355-357 CellLine denotes E6 CVCL:4582
443 1456-1487 Gene denotes angiotensin-converting enzyme 2 Gene:59272
444 1489-1494 Gene denotes ACE-2 Gene:59272
445 828-837 Chemical denotes adenosine MESH:D000241
446 846-856 Chemical denotes remdesivir MESH:C000606551
447 952-963 Chemical denotes chloroquine MESH:D002738
448 1000-1011 Chemical denotes Chloroquine MESH:D002738
449 1116-1127 Chemical denotes chloroquine MESH:D002738
450 1238-1249 Chemical denotes chloroquine MESH:D002738
451 1297-1308 Chemical denotes Chloroquine MESH:D002738
452 1402-1413 Chemical denotes Chloroquine MESH:D002738
453 1643-1654 Chemical denotes chloroquine MESH:D002738
454 1063-1081 Disease denotes SARS-CoV infection MESH:C000657245
455 1164-1182 Disease denotes SARS CoV infection MESH:C000657245
456 1273-1291 Disease denotes SARS-CoV infection MESH:C000657245
457 1141-1143 CellLine denotes E6 CVCL:4582
459 1692-1703 Chemical denotes Baricitinib MESH:C000596027
473 1764-1768 Gene denotes ACE2 Gene:59272
474 1920-1951 Gene denotes AP2-associated protein kinase 1 Gene:22848
475 1953-1957 Gene denotes AAK1 Gene:22848
476 2001-2005 Gene denotes AAK1 Gene:22848
477 2183-2187 Gene denotes AAK1 Gene:22848
478 2338-2342 Gene denotes AAK1 Gene:22848
479 2409-2435 Gene denotes cyclin G-associated kinase Gene:2580
480 1724-1732 Species denotes 2019nCoV Tax:2697049
481 2571-2580 Species denotes 2019-nCoV Tax:2697049
482 1708-1715 Species denotes SARSCoV Tax:694009
483 2279-2290 Chemical denotes baricitinib MESH:C000596027
484 2344-2355 Chemical denotes baricitinib MESH:C000596027
485 2469-2480 Chemical denotes baricitinib MESH:C000596027
488 2746-2749 Species denotes CoV Tax:11118
489 2775-2778 Species denotes CoV Tax:11118

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T378 2791-2802 SO:0000704 denotes genetically
T375 1692-1703 DG_41 denotes Baricitinib
T374 1724-1732 SP_7 denotes 2019nCoV
T373 1764-1768 G_3;PG_10;PR:000003622 denotes ACE2
T372 1833-1838 UBERON:0000170 denotes lungs
T371 1895-1906 GO:0006897 denotes endocytosis
T370 1920-1951 PR:000003526 denotes AP2-associated protein kinase 1
T369 1953-1957 PR:000003526 denotes AAK1
T368 2001-2005 PR:000003526 denotes AAK1
T367 2183-2187 PR:000003526 denotes AAK1
T366 2269-2278 CHEBI:66921;CHEBI:66921 denotes inhibitor
T365 2279-2290 DG_41 denotes baricitinib
T364 2338-2342 PR:000003526 denotes AAK1
T363 2344-2355 DG_41 denotes baricitinib
T362 2378-2389 GO:0006897 denotes endocytosis
T361 2409-2435 PR:000007805 denotes cyclin G-associated kinase
T360 2469-2480 DG_41 denotes baricitinib
T359 2571-2580 SP_7 denotes 2019-nCoV
T344 60-70 DG_28 denotes Remdesivir
T343 75-86 DG_10;CHEBI:3638;CHEBI:3638 denotes chloroquine
T342 118-127 SP_7 denotes 2019-nCoV
T341 187-196 CHEBI:63580;DG_29;CHEBI:63580 denotes ribavirin
T340 198-209 CHEBI:7956;CHEBI:7956 denotes penciclovir
T339 211-223 CHEBI:17154;CHEBI:17154 denotes nitazoxanide
T338 237-248 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T337 250-260 DG_28 denotes remdesivir
T336 262-268 DG_28 denotes GS5734
T335 275-286 NCBITaxon:31032;CHEBI:119915;DG_17;CHEBI:119915 denotes favipiravir
T334 288-293 DG_17 denotes T-705
T333 350-354 CL_6 denotes vero
T332 415-424 SP_7 denotes 2019-nCoV
T331 457-461 CHEBI:23888;CHEBI:23888 denotes drug
T330 496-517 GO:0001171 denotes Reverse transcription
T329 585-590 NCBITaxon:10239 denotes viral
T328 658-670 GO:0000786;PG_4 denotes nucleocapsid
T327 671-678 PG_4 denotes protein
T326 700-711 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T325 716-726 DG_28 denotes remdesivir
T324 737-742 NCBITaxon:10239 denotes virus
T323 828-837 CHEBI:22260;CHEBI:22260 denotes adenosine
T322 846-856 DG_28 denotes remdesivir
T321 880-885 NCBITaxon:10239 denotes viral
T320 952-963 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T319 1000-1011 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T318 1063-1071 SP_10 denotes SARS-CoV
T317 1116-1127 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T316 1136-1140 CL_6 denotes vero
T315 1164-1172 SP_10 denotes SARS CoV
T314 1201-1214 GO:0009294 denotes postinfection
T313 1238-1249 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T312 1273-1281 SP_10 denotes SARS-CoV
T311 1297-1308 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T310 1319-1328 GO:0005768 denotes endosomal
T309 1383-1388 NCBITaxon:10239 denotes virus
T308 1389-1400 GO:0061025 denotes cell fusion
T307 1402-1413 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T306 1456-1487 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T305 1489-1494 G_3;PG_10;PR:000003622 denotes ACE-2
T304 1520-1525 NCBITaxon:10239 denotes viral
T303 1643-1654 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T19 358-363 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 404-409 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 671-678 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T22 886-889 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T23 1144-1149 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 1319-1328 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T25 1389-1393 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 1532-1539 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 1750-1755 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T28 1816-1821 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 1833-1838 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T30 1935-1942 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 2400-2407 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p17634s1 1309-1318 PosReg denotes increases
p17634s2 1319-1328 CPA denotes endosomal

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T46 387-396 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47 737-752 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T48 743-752 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 1063-1081 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T50 1072-1081 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 1164-1168 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 1173-1182 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T53 1273-1291 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T54 1282-1291 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T54 350-363 http://purl.obolibrary.org/obo/CLO_0051719 denotes vero E6 cells
T55 404-409 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T56 452-456 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T57 737-742 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T58 930-932 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T59 1036-1037 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 1094-1096 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T61 1136-1149 http://purl.obolibrary.org/obo/CLO_0051719 denotes vero E6 cells
T62 1293-1295 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T63 1383-1388 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T64 1389-1393 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T65 1592-1594 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T66 1668-1669 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 1750-1755 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T68 1816-1821 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T69 1833-1838 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T70 1840-1842 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T71 1855-1864 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T72 1965-1966 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 2837-2846 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T74 2878-2887 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T124 75-86 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T125 187-196 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T126 198-209 Chemical denotes penciclovir http://purl.obolibrary.org/obo/CHEBI_7956
T127 225-235 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T128 237-248 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T129 250-260 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T130 262-268 Chemical denotes GS5734 http://purl.obolibrary.org/obo/CHEBI_145994
T131 275-286 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T132 288-293 Chemical denotes T-705 http://purl.obolibrary.org/obo/CHEBI_134722
T133 457-461 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T134 671-678 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T135 700-711 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T136 716-726 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T137 828-837 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T138 846-856 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T139 952-963 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T140 970-985 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T141 1000-1011 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T142 1045-1054 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T143 1116-1127 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T144 1238-1249 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T145 1297-1308 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T146 1402-1413 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T147 1456-1467 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T148 1532-1539 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 1643-1654 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T150 1935-1942 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 2076-2083 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T152 2160-2167 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T153 2256-2278 Chemical denotes janus kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_76617
T154 2269-2278 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T155 2400-2407 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T156 2986-2991 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T8 496-517 http://purl.obolibrary.org/obo/GO_0001171 denotes Reverse transcription
T9 504-517 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10 1389-1400 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T11 1389-1400 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T12 1389-1400 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T13 1389-1400 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T14 1431-1444 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T15 1564-1589 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T16 1855-1864 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T17 1873-1906 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor mediates the endocytosis
T18 1895-1906 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T19 2262-2278 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitor
T20 2378-2389 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T21 2409-2415 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T80 0-58 Sentence denotes Recent Advances in the Treatment of 2019-Novel Coronavirus
T81 60-90 Sentence denotes Remdesivir and chloroquine[33]
T82 91-319 Sentence denotes Using clinical isolates of 2019-nCoV, Wang et al., 2020 evaluated the efficacy of seven agents (ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine, remdesivir [GS5734], and favipiravir [T-705]) in in vitro conditions.
T83 320-495 Sentence denotes Cytotoxicity was evaluated in vero E6 cells, which was followed by infection of the cells with 2019-nCoV clinical isolates, and the test drug was evaluated at different doses.
T84 496-694 Sentence denotes Reverse transcription polymerase chain reaction-based quantification was done to get the viral yield, which was later confirmed by immunofluorescence microscopy (nucleocapsid protein visualization).
T85 695-818 Sentence denotes Both chloroquine and remdesivir inhibited virus infection at micromolar level (0.77–1.13 μM) and with high selectivity.[33]
T86 819-999 Sentence denotes Being an adenosine analog, remdesivir gets incorporated into viral RNA and causes premature chain termination.[34] The importance of chloroquine as an antiviral agent is coming up.
T87 1000-1183 Sentence denotes Chloroquine even showed efficacy as a potent antiviral against SARS-CoV infection and spread.[35] Pretreatment with chloroquine renders vero E6 cells refractory to SARS CoV infection.
T88 1184-1401 Sentence denotes Moreover, in the postinfection period, treatment with chloroquine prevents the spread of SARS-CoV infection.[35] Chloroquine increases endosomal pH and thus makes the environment unfavorable for the virus/cell fusion.
T89 1402-1690 Sentence denotes Chloroquine also affects the glycosylation process of angiotensin-converting enzyme 2 (ACE-2, receptor for binding of viral spike protein, which is essential for interaction with the host).[35] Being nonexpensive and easily available agent, chloroquine may prove as a promising candidate.
T90 1692-1703 Sentence denotes Baricitinib
T91 1704-1994 Sentence denotes The SARSCoV and the 2019nCoV both enters host cells through ACE2 receptormediated entry, especially through AT2 cells present in lungs.[36] Downstream signaling of this receptor mediates the endocytosis process, and AP2-associated protein kinase 1 (AAK1) plays a major role in this process.
T92 1995-2037 Sentence denotes Thus, AAK1 represents an important target.
T93 2038-2147 Sentence denotes Richardson et al., 2020 evaluated 378 ligands, of which 47 were already approved for use in other conditions.
T94 2148-2207 Sentence denotes Among these ligands, six inhibited AAK1 with high affinity.
T95 2208-2322 Sentence denotes Considering the side effect profile, they found janus kinase inhibitor baricitinib to be the most important agent.
T96 2323-2437 Sentence denotes In addition to AAK1, baricitinib also binds to another endocytosis regulator protein (cyclin G-associated kinase).
T97 2438-2585 Sentence denotes Thus, the authors suggest that baricitinib can be evaluated in the in vitro conditions as well as in the clinical trial settings for 2019-nCoV.[37]
T98 2587-2618 Sentence denotes Limitations of current research
T99 2619-2759 Sentence denotes Lack of high-quality evidence (especially randomized controlled trails [RCTs]) is the most important limitation of the current CoV research.
T100 2760-3049 Sentence denotes As most of the CoV strains are genetically different and the outbreaks occur extremely randomly, conducting an RCT is extremely difficult, and we have to rely on observational studies (most of which do not have proper control group), which hamper the estimation of proper treatment effect.

2_test

Id Subject Object Predicate Lexical cue
32201439-32020029-47219433 87-89 32020029 denotes 33
32201439-32020029-47219434 815-817 32020029 denotes 33
32201439-26934220-47219435 930-932 26934220 denotes 34
32201439-16115318-47219436 1094-1096 16115318 denotes 35
32201439-16115318-47219437 1293-1295 16115318 denotes 35
32201439-16115318-47219438 1592-1594 16115318 denotes 35
32201439-32032529-47219439 2582-2584 32032529 denotes 37
T41189 87-89 32020029 denotes 33
T4625 815-817 32020029 denotes 33
T49263 930-932 26934220 denotes 34
T96382 1094-1096 16115318 denotes 35
T21534 1293-1295 16115318 denotes 35
T99419 1592-1594 16115318 denotes 35
T4041 2582-2584 32032529 denotes 37