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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 41-63 Species denotes 2019-novel coronavirus Tax:2697049
20 120-133 Species denotes coronaviruses Tax:11118
21 135-139 Species denotes CoVs Tax:11118
22 220-265 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
23 267-275 Species denotes SARS-CoV Tax:694009
24 324-379 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
25 446-457 Species denotes coronavirus Tax:11118
26 462-484 Species denotes 2019-novel coronavirus Tax:2697049
27 486-495 Species denotes 2019-nCoV Tax:2697049
28 612-621 Species denotes 2019-nCoV Tax:2697049
29 646-654 Species denotes MERS-CoV Tax:1335626
30 747-750 Species denotes CoV Tax:11118
31 811-814 Species denotes CoV Tax:11118
32 819-827 Species denotes MERS-CoV Tax:1335626
33 876-885 Species denotes 2019-nCoV Tax:2697049
34 172-204 Disease denotes respiratory distress[1] syndrome MESH:D012128
35 500-519 Disease denotes coronavirus disease MESH:D018352
36 521-529 Disease denotes COVID-19 MESH:C000657245
37 734-743 Disease denotes infection MESH:D007239
39 903-913 Chemical denotes Nucleoside MESH:D009705
60 998-1002 Species denotes CoVs Tax:11118
61 1015-1023 Species denotes SARS-CoV Tax:694009
62 1039-1047 Species denotes patients Tax:9606
63 1154-1162 Species denotes SARS-CoV Tax:694009
64 1307-1315 Species denotes SARS-CoV Tax:694009
65 1478-1486 Species denotes patients Tax:9606
66 1743-1752 Species denotes 2019-nCoV Tax:2697049
67 921-930 Chemical denotes Ribavirin MESH:D012254
68 934-944 Chemical denotes nucleoside MESH:D009705
69 1066-1075 Chemical denotes ribavirin MESH:D012254
70 1289-1298 Chemical denotes ribavirin MESH:D012254
71 1317-1326 Chemical denotes Ribavirin MESH:D012254
72 1462-1471 Chemical denotes ribavirin MESH:D012254
73 1490-1499 Chemical denotes ribavirin MESH:D012254
74 1651-1661 Chemical denotes nucleoside MESH:D009705
75 1674-1685 Chemical denotes favipiravir MESH:C462182
76 1690-1701 Chemical denotes galidesivir MESH:C517546
77 1358-1374 Disease denotes hemolytic anemia MESH:D000743
78 1376-1388 Disease denotes hypocalcemia MESH:D006996
79 1394-1408 Disease denotes hypomagnesemia MESH:C537153
81 1755-1768 Gene denotes Neuraminidase Gene:4758
96 1780-1793 Gene denotes Neuraminidase Gene:4758
97 1877-1885 Species denotes MERS-CoV Tax:1335626
98 1934-1942 Species denotes patients Tax:9606
99 1976-1984 Species denotes patients Tax:9606
100 1998-2013 Species denotes influenza virus Tax:11309
101 2134-2142 Species denotes MERS-CoV Tax:1335626
102 2203-2211 Species denotes MERS-CoV Tax:1335626
103 2264-2273 Species denotes 2019-nCoV Tax:2697049
104 1840-1849 Species denotes influenza Tax:11309
105 1952-1963 Chemical denotes oseltamivir MESH:D053139
106 2046-2057 Chemical denotes oseltamivir MESH:D053139
107 2094-2105 Chemical denotes oseltamivir MESH:D053139
108 2188-2199 Chemical denotes oseltamivir MESH:D053139
109 2217-2228 Chemical denotes Oseltamivir MESH:D053139
126 2607-2614 Gene denotes NSP1–16 Gene:10045
127 2455-2463 Species denotes SARS-CoV Tax:694009
128 2660-2663 Species denotes CoV Tax:11118
129 2787-2790 Species denotes CoV Tax:11118
130 2896-2904 Species denotes SARS-CoV Tax:694009
131 3476-3485 Species denotes 2019-nCoV Tax:2697049
132 2971-2979 Species denotes SARS-CoV Tax:694009
133 2703-2712 Chemical denotes lopinavir MESH:D061466
134 2740-2750 Chemical denotes saquinavir MESH:D019258
135 2910-2913 Chemical denotes pro MESH:D011392
136 2990-2999 Chemical denotes lopinavir MESH:D061466
137 3049-3052 Chemical denotes HKU
138 3072-3081 Chemical denotes Ritonavir MESH:D019438
139 3102-3111 Chemical denotes lopinavir MESH:D061466
140 3316-3335 Chemical denotes lopinavir/ritonavir MESH:C558899
141 3395-3416 Chemical denotes lopinavir + ritonavir MESH:C558899
150 3607-3610 Species denotes CoV Tax:11118
151 3615-3623 Species denotes MERS-CoV Tax:1335626
152 3687-3696 Species denotes 2019-nCoV Tax:2697049
153 3942-3945 Species denotes CoV Tax:11118
154 3950-3958 Species denotes MERS-CoV Tax:1335626
155 3970-3977 Chemical denotes steroid MESH:D013256
156 3986-3999 Disease denotes complications MESH:D005117
157 4008-4017 Disease denotes psychosis MESH:D011605
169 4228-4233 Gene denotes IFN-α Gene:3439
170 4352-4357 Gene denotes IFN-α Gene:3439
171 4422-4427 Gene denotes IFN-α Gene:3439
172 4540-4545 Gene denotes IFN-α Gene:3439
173 4136-4144 Species denotes SARS-CoV Tax:694009
174 4145-4153 Species denotes patients Tax:9606
175 4525-4534 Species denotes 2019-nCoV Tax:2697049
176 4167-4176 Chemical denotes ribavirin MESH:D012254
177 4470-4476 Chemical denotes oxygen MESH:D010100
178 4594-4615 Chemical denotes lopinavir + ritonavir MESH:C558899
179 4120-4131 Disease denotes hepatitis B MESH:D006509
182 4828-4836 Species denotes Patients Tax:9606
183 4661-4675 Disease denotes critically ill MESH:D016638
190 5369-5377 Species denotes SARS-CoV Tax:694009
191 5381-5389 Species denotes MERS-CoV Tax:1335626
192 5180-5189 Chemical denotes metformin MESH:D008687
193 5191-5203 Chemical denotes atorvastatin MESH:D000069059
194 5271-5306 Disease denotes acute respiratory distress syndrome MESH:D012128
195 5308-5312 Disease denotes ARDS MESH:D012128
200 5724-5728 Gene denotes IL-6 Gene:3569
201 5477-5480 Species denotes CoV Tax:11118
202 5732-5743 Chemical denotes tocilizumab MESH:C502936
203 5615-5623 Disease denotes COVID-19 MESH:C000657245
206 5858-5885 Gene denotes tumor necrosis factor-alpha Gene:7124
207 5923-5937 Chemical denotes pentoxifylline MESH:D010431
210 6052-6074 Species denotes 2019-Novel Coronavirus Tax:2697049
211 6076-6098 Disease denotes Coronavirus Disease-19 MESH:C000657245
226 6127-6135 Species denotes patients Tax:9606
227 6141-6150 Species denotes 2019-nCoV Tax:2697049
228 6572-6579 Species denotes persons Tax:9606
229 6709-6717 Species denotes patients Tax:9606
230 6749-6756 Species denotes patient Tax:9606
231 7123-7129 Chemical denotes oxygen MESH:D010100
232 6254-6263 Disease denotes infection MESH:D007239
233 6445-6466 Disease denotes respiratory infection MESH:D012141
234 6478-6511 Disease denotes coronavirus (2019-nCoV) infection MESH:C000657245
235 6595-6623 Disease denotes acute respiratory infections MESH:D012120
236 6723-6743 Disease denotes respiratory distress MESH:D012128
237 6938-6959 Disease denotes respiratory infection MESH:D012141
238 7045-7064 Disease denotes respiratory failure MESH:D012131
239 7306-7318 Disease denotes septic shock MESH:D012772
241 7338-7360 Species denotes 2019-Novel Coronavirus Tax:2697049
254 7427-7436 Species denotes 2019-nCoV Tax:2697049
255 7520-7529 Species denotes 2019-nCoV Tax:2697049
258 7543-7552 Chemical denotes lopinavir MESH:D061466
259 7554-7563 Chemical denotes ritonavir MESH:D019438
260 7565-7572 Chemical denotes arbidol MESH:C086979
261 10781-10792 Chemical denotes oseltamivir MESH:D053139
262 10799-10810 Chemical denotes ganciclovir MESH:D015774
327 8544-8552 Species denotes patients Tax:9606
328 8558-8566 Species denotes patients Tax:9606
329 8623-8631 Species denotes patients Tax:9606
330 8769-8776 Species denotes patient Tax:9606
331 8811-8819 Species denotes patients Tax:9606
332 8866-8874 Species denotes patients Tax:9606
333 8890-8897 Species denotes patient Tax:9606
334 9021-9029 Species denotes patients Tax:9606
335 9062-9070 Species denotes patients Tax:9606
336 9478-9487 Species denotes 2019-nCoV Tax:2697049
337 9498-9506 Species denotes patients Tax:9606
338 9508-9516 Species denotes Patients Tax:9606
339 9609-9617 Species denotes patients Tax:9606
340 9963-9971 Species denotes Patients Tax:9606
341 10118-10126 Species denotes patients Tax:9606
342 10135-10143 Species denotes patients Tax:9606
343 10283-10291 Species denotes patients Tax:9606
344 10372-10380 Species denotes patients Tax:9606
345 10426-10434 Species denotes patients Tax:9606
346 10655-10663 Species denotes patients Tax:9606
347 10669-10677 Species denotes patients Tax:9606
348 10734-10742 Species denotes patients Tax:9606
349 11124-11132 Species denotes patients Tax:9606
350 11345-11353 Species denotes patients Tax:9606
351 11496-11504 Species denotes patients Tax:9606
352 11515-11523 Species denotes patients Tax:9606
353 11563-11568 Species denotes human Tax:9606
355 11715-11723 Species denotes patients Tax:9606
356 8942-8950 Species denotes patients Tax:9606
357 9220-9228 Species denotes patients Tax:9606
358 10905-10913 Species denotes patients Tax:9606
359 8576-8582 Chemical denotes oxygen MESH:D010100
360 8662-8671 Chemical denotes lopinavir MESH:D061466
361 8673-8682 Chemical denotes ritonavir MESH:D019438
362 8684-8691 Chemical denotes arbidol MESH:C086979
363 8697-8702 Chemical denotes SFJDC
364 9039-9050 Chemical denotes oseltamivir MESH:D053139
365 10153-10164 Chemical denotes oseltamivir MESH:D053139
366 10206-10217 Chemical denotes ceftriaxone MESH:D002443
367 10225-10237 Chemical denotes moxifloxacin MESH:D000077266
368 10249-10261 Chemical denotes azithromycin MESH:D017963
371 10815-10834 Chemical denotes lopinavir/ritonavir MESH:C558899
372 11598-11610 Chemical denotes moxifloxacin MESH:D000077266
373 11624-11635 Chemical denotes oseltamivir MESH:D053139
374 11640-11660 Chemical denotes abidol hydrochloride
375 9212-9217 Disease denotes Death MESH:D003643
376 9318-9323 Disease denotes Death MESH:D003643
377 9489-9497 Disease denotes infected MESH:D007239
378 9821-9826 Disease denotes death MESH:D003643
379 9954-9961 Disease denotes dyspnea MESH:D004417
380 10065-10084 Disease denotes respiratory failure MESH:D012131
381 10629-10634 Disease denotes Death MESH:D003643
382 10966-10985 Disease denotes bacterial infection MESH:D001424
383 11315-11319 Disease denotes Died MESH:D003643
384 11339-11344 Disease denotes death MESH:D003643
385 11359-11365 Disease denotes deaths MESH:D003643
386 11432-11450 Disease denotes outcomeLymphopenia
387 11462-11471 Disease denotes pneumonia MESH:D011014
389 8460-8479 Disease denotes 2019-nCoV infection MESH:C000657245
392 11939-11949 Chemical denotes Remdesivir MESH:C000606551
393 11954-11965 Chemical denotes chloroquine MESH:D002738
411 11997-12006 Species denotes 2019-nCoV Tax:2697049
412 12294-12303 Species denotes 2019-nCoV Tax:2697049
413 12066-12075 Chemical denotes ribavirin MESH:D012254
414 12077-12088 Chemical denotes penciclovir MESH:C053539
415 12090-12102 Chemical denotes nitazoxanide MESH:C041747
416 12104-12114 Chemical denotes nafamostat MESH:C032855
417 12116-12127 Chemical denotes chloroquine MESH:D002738
418 12129-12139 Chemical denotes remdesivir MESH:C000606551
419 12141-12147 Chemical denotes GS5734 MESH:C000606551
420 12154-12165 Chemical denotes favipiravir MESH:C462182
421 12167-12172 Chemical denotes T-705 MESH:C462182
422 12579-12590 Chemical denotes chloroquine MESH:D002738
423 12595-12605 Chemical denotes remdesivir MESH:C000606551
424 12199-12211 Disease denotes Cytotoxicity MESH:D064420
425 12266-12275 Disease denotes infection MESH:D007239
426 12616-12631 Disease denotes virus infection MESH:D001102
427 12234-12236 CellLine denotes E6 CVCL:4582
443 13335-13366 Gene denotes angiotensin-converting enzyme 2 Gene:59272
444 13368-13373 Gene denotes ACE-2 Gene:59272
445 12707-12716 Chemical denotes adenosine MESH:D000241
446 12725-12735 Chemical denotes remdesivir MESH:C000606551
447 12831-12842 Chemical denotes chloroquine MESH:D002738
448 12879-12890 Chemical denotes Chloroquine MESH:D002738
449 12995-13006 Chemical denotes chloroquine MESH:D002738
450 13117-13128 Chemical denotes chloroquine MESH:D002738
451 13176-13187 Chemical denotes Chloroquine MESH:D002738
452 13281-13292 Chemical denotes Chloroquine MESH:D002738
453 13522-13533 Chemical denotes chloroquine MESH:D002738
454 12942-12960 Disease denotes SARS-CoV infection MESH:C000657245
455 13043-13061 Disease denotes SARS CoV infection MESH:C000657245
456 13152-13170 Disease denotes SARS-CoV infection MESH:C000657245
457 13020-13022 CellLine denotes E6 CVCL:4582
459 13571-13582 Chemical denotes Baricitinib MESH:C000596027
473 13643-13647 Gene denotes ACE2 Gene:59272
474 13799-13830 Gene denotes AP2-associated protein kinase 1 Gene:22848
475 13832-13836 Gene denotes AAK1 Gene:22848
476 13880-13884 Gene denotes AAK1 Gene:22848
477 14062-14066 Gene denotes AAK1 Gene:22848
478 14217-14221 Gene denotes AAK1 Gene:22848
479 14288-14314 Gene denotes cyclin G-associated kinase Gene:2580
480 13603-13611 Species denotes 2019nCoV Tax:2697049
481 14450-14459 Species denotes 2019-nCoV Tax:2697049
482 13587-13594 Species denotes SARSCoV Tax:694009
483 14158-14169 Chemical denotes baricitinib MESH:C000596027
484 14223-14234 Chemical denotes baricitinib MESH:C000596027
485 14348-14359 Chemical denotes baricitinib MESH:C000596027
488 14625-14628 Species denotes CoV Tax:11118
489 14654-14657 Species denotes CoV Tax:11118

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T380 8460-8469 SP_7 denotes 2019-nCoV
T378 14670-14681 SO:0000704 denotes genetically
T375 13571-13582 DG_41 denotes Baricitinib
T374 13603-13611 SP_7 denotes 2019nCoV
T373 13643-13647 G_3;PG_10;PR:000003622 denotes ACE2
T372 13712-13717 UBERON:0000170 denotes lungs
T371 13774-13785 GO:0006897 denotes endocytosis
T370 13799-13830 PR:000003526 denotes AP2-associated protein kinase 1
T369 13832-13836 PR:000003526 denotes AAK1
T368 13880-13884 PR:000003526 denotes AAK1
T367 14062-14066 PR:000003526 denotes AAK1
T366 14148-14157 CHEBI:66921;CHEBI:66921 denotes inhibitor
T365 14158-14169 DG_41 denotes baricitinib
T364 14217-14221 PR:000003526 denotes AAK1
T363 14223-14234 DG_41 denotes baricitinib
T362 14257-14268 GO:0006897 denotes endocytosis
T361 14288-14314 PR:000007805 denotes cyclin G-associated kinase
T360 14348-14359 DG_41 denotes baricitinib
T359 14450-14459 SP_7 denotes 2019-nCoV
T344 11939-11949 DG_28 denotes Remdesivir
T343 11954-11965 DG_10;CHEBI:3638;CHEBI:3638 denotes chloroquine
T342 11997-12006 SP_7 denotes 2019-nCoV
T341 12066-12075 CHEBI:63580;DG_29;CHEBI:63580 denotes ribavirin
T340 12077-12088 CHEBI:7956;CHEBI:7956 denotes penciclovir
T339 12090-12102 CHEBI:17154;CHEBI:17154 denotes nitazoxanide
T338 12116-12127 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T337 12129-12139 DG_28 denotes remdesivir
T336 12141-12147 DG_28 denotes GS5734
T335 12154-12165 NCBITaxon:31032;CHEBI:119915;DG_17;CHEBI:119915 denotes favipiravir
T334 12167-12172 DG_17 denotes T-705
T333 12229-12233 CL_6 denotes vero
T332 12294-12303 SP_7 denotes 2019-nCoV
T331 12336-12340 CHEBI:23888;CHEBI:23888 denotes drug
T330 12375-12396 GO:0001171 denotes Reverse transcription
T329 12464-12469 NCBITaxon:10239 denotes viral
T328 12537-12549 GO:0000786;PG_4 denotes nucleocapsid
T327 12550-12557 PG_4 denotes protein
T326 12579-12590 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T325 12595-12605 DG_28 denotes remdesivir
T324 12616-12621 NCBITaxon:10239 denotes virus
T323 12707-12716 CHEBI:22260;CHEBI:22260 denotes adenosine
T322 12725-12735 DG_28 denotes remdesivir
T321 12759-12764 NCBITaxon:10239 denotes viral
T320 12831-12842 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T319 12879-12890 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T318 12942-12950 SP_10 denotes SARS-CoV
T317 12995-13006 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T316 13015-13019 CL_6 denotes vero
T315 13043-13051 SP_10 denotes SARS CoV
T314 13080-13093 GO:0009294 denotes postinfection
T313 13117-13128 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T312 13152-13160 SP_10 denotes SARS-CoV
T311 13176-13187 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T310 13198-13207 GO:0005768 denotes endosomal
T309 13262-13267 NCBITaxon:10239 denotes virus
T308 13268-13279 GO:0061025 denotes cell fusion
T307 13281-13292 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T306 13335-13366 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T305 13368-13373 G_3;PG_10;PR:000003622 denotes ACE-2
T304 13399-13404 NCBITaxon:10239 denotes viral
T303 13522-13533 CHEBI:3638;DG_10;CHEBI:3638 denotes chloroquine
T268 7427-7436 SP_7 denotes 2019-nCoV
T267 7467-7483 CHEBI:22587;CHEBI:22587 denotes antiviral agents
T266 7520-7529 SP_7 denotes 2019-nCoV
T265 7543-7552 DG_23 denotes lopinavir
T264 7554-7563 DG_30 denotes ritonavir
T263 7565-7572 CHEBI:57472;CHEBI:57472;DG_49 denotes arbidol
T262 7578-7589 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T261 7600-7611 CHEBI:465284;CHEBI:465284 denotes ganciclovir
T260 7659-7665 CHEBI:38867;CHEBI:38867 denotes agents
T259 7681-7696 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T258 7713-7727 GO:0019814 denotes immunoglobulin
T257 8160-8168 SP_7 denotes 2019nCoV
T256 8205-8210 GO:0016265 denotes death
T243 6141-6150 SP_7 denotes 2019-nCoV
T242 6264-6271 GO:0065007 denotes control
T241 6445-6456 UBERON:0001004 denotes respiratory
T240 6478-6489 NCBITaxon:11118 denotes coronavirus
T239 6491-6500 SP_7 denotes 2019-nCoV
T238 6572-6579 NCBITaxon:9606 denotes persons
T237 6601-6612 UBERON:0001004 denotes respiratory
T236 6634-6638 UBERON:0002398 denotes hand
T235 6689-6696 NCBITaxon:33208 denotes animals
T234 6723-6734 UBERON:0001004 denotes respiratory
T233 6885-6894 NCBITaxon:1 denotes organisms
T232 6938-6949 UBERON:0001004 denotes respiratory
T231 7045-7056 UBERON:0001004 denotes respiratory
T230 7117-7122 UBERON:0000004 denotes nasal
T214 5851-5856 SO:0000646 denotes SiRNA
T213 5858-5885 PR:000000134 denotes tumor necrosis factor-alpha
T212 5886-5896 CHEBI:35222;CHEBI:35222 denotes inhibitors
T211 5911-5921 GO:0042571 denotes antibodies
T210 5923-5937 CHEBI:7986;CHEBI:7986 denotes pentoxifylline
T207 5055-5059 GO:0006955 denotes host
T206 5060-5066 UBERON:0002405;GO:0006955 denotes immune
T205 5067-5075 GO:0006955 denotes response
T204 5129-5134 NCBITaxon:10239 denotes viral
T203 5205-5213 NCBITaxon:4894 denotes fibrates
T202 5277-5288 UBERON:0001004 denotes respiratory
T201 5369-5377 SP_10 denotes SARS-CoV
T200 5381-5389 SP_9 denotes MERS-CoV
T199 5522-5533 GO:0006260 denotes replication
T198 5615-5623 SP_7 denotes COVID-19
T197 5724-5728 PR:000001393 denotes IL-6
T196 5732-5743 DG_35 denotes tocilizumab
T185 4634-4649 GO:0019814 denotes Immunoglobulins
T184 4676-4680 SP_10 denotes SARS
T183 4915-4929 GO:0019814 denotes immunoglobulin
T180 4136-4144 SP_10 denotes SARS-CoV
T179 4167-4176 DG_29 denotes ribavirin
T178 4246-4260 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T177 4362-4376 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T176 4378-4392 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T175 4405-4419 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T174 4525-4534 SP_7 denotes 2019-nCoV
T173 4594-4603 CHEBI:6426;DG_23;CHEBI:6426 denotes lopinavir
T172 4606-4615 CHEBI:85129;DG_30;CHEBI:85129 denotes ritonavir
T160 3532-3547 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T159 3548-3563 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T158 3615-3623 SP_9 denotes MERS-CoV
T157 3687-3696 SP_7 denotes 2019-nCoV
T156 3769-3784 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T155 3840-3854 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T154 3910-3915 NCBITaxon:10239 denotes viral
T153 3950-3958 SP_9 denotes MERS-CoV
T152 3970-3977 CHEBI:35341;CHEBI:35341 denotes steroid
T143 2455-2463 SP_10 denotes SARS-CoV
T142 2539-2547 MOP:0000780 denotes cleaving
T141 2607-2611 PR:000014815 denotes NSP1
T140 2664-2674 UBERON:0000104 denotes life cycle
T108 1769-1779 CHEBI:35222;CHEBI:35222 denotes inhibitors
T107 1794-1804 CHEBI:35222;CHEBI:35222 denotes inhibitors
T106 1877-1885 SP_9 denotes MERS-CoV
T105 1952-1963 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T104 1998-2007 NCBITaxon:7719 denotes influenza
T103 2008-2013 NCBITaxon:10239 denotes virus
T102 2046-2057 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T101 2094-2105 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T100 2134-2142 SP_9 denotes MERS-CoV
T99 2188-2199 CHEBI:7798;CHEBI:7798 denotes oseltamivir
T98 2203-2211 SP_9 denotes MERS-CoV
T97 2217-2228 CHEBI:7798;CHEBI:7798 denotes Oseltamivir
T96 2264-2273 SP_7 denotes 2019-nCoV
T80 903-913 CHEBI:33838;CHEBI:33838 denotes Nucleoside
T79 921-930 DG_29 denotes Ribavirin
T78 991-997 NCBITaxon:33208 denotes animal
T77 1015-1023 SP_10 denotes SARS-CoV
T76 1066-1075 DG_29;CHEBI:28201;CHEBI:28201 denotes ribavirin
T75 1087-1102 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T74 1154-1162 SP_10 denotes SARS-CoV
T73 1289-1298 CHEBI:28201;DG_29;CHEBI:28201 denotes ribavirin
T72 1307-1315 SP_10 denotes SARS-CoV
T71 1317-1326 CHEBI:85129;DG_29;CHEBI:85129 denotes Ribavirin
T70 1462-1471 DG_29 denotes ribavirin
T69 1490-1499 DG_29 denotes ribavirin
T68 1504-1518 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T67 1558-1563 NCBITaxon:10239 denotes viral
T66 1651-1661 CHEBI:23447;CHEBI:23447 denotes nucleoside
T65 1674-1685 CHEBI:119915;CHEBI:119915;DG_17;NCBITaxon:31032 denotes favipiravir
T64 1690-1701 DG_19;NCBITaxon:9031 denotes galidesivir
T63 1743-1752 SP_7 denotes 2019-nCoV
T41 120-133 NCBITaxon:11118 denotes coronaviruses
T40 172-183 UBERON:0001004 denotes respiratory
T39 220-232 SP_10 denotes severe acute
T38 233-244 SP_10;UBERON:0001004 denotes respiratory
T37 245-265 SP_10 denotes syndrome coronavirus
T36 267-275 SP_10 denotes SARS-CoV
T35 324-335 SP_9 denotes Middle East
T34 336-347 SP_9;UBERON:0001004 denotes respiratory
T33 348-368 SP_9 denotes syndrome coronavirus
T32 370-378 SP_9 denotes MERS-CoV
T31 446-457 NCBITaxon:11118 denotes coronavirus
T30 473-484 NCBITaxon:11118 denotes coronavirus
T29 486-495 SP_7 denotes 2019-nCoV
T28 500-511 NCBITaxon:11118 denotes coronavirus
T27 521-529 SP_7 denotes COVID-19
T26 612-621 SP_7 denotes 2019-nCoV
T25 631-635 SP_10 denotes SARS
T24 646-654 SP_9 denotes MERS-CoV
T23 819-827 SP_9 denotes MERS-CoV
T22 834-840 CHEBI:52217;CHEBI:52217 denotes agents
T21 876-885 SP_7 denotes 2019-nCoV
T2 52-63 NCBITaxon:11118 denotes coronavirus
T131 3072-3081 DG_30 denotes Ritonavir
T130 3102-3111 DG_23 denotes lopinavir
T229 7163-7175 UBERON:0001852 denotes endotracheal
T139 2703-2712 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T138 2726-2735 CHEBI:35222;CHEBI:35222 denotes inhibitor
T137 2740-2750 CHEBI:63621;DG_32;CHEBI:63621 denotes saquinavir
T136 2774-2783 CHEBI:35222;CHEBI:35222 denotes inhibitor
T135 2872-2882 CHEBI:35222;CHEBI:35222 denotes inhibitors
T134 2896-2904 SP_10 denotes SARS-CoV
T133 2971-2979 SP_10 denotes SARS-CoV
T132 2990-2999 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T129 3316-3325 DG_23 denotes lopinavir
T128 3326-3335 DG_30 denotes ritonavir
T127 3395-3404 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T126 3407-3416 DG_30 denotes ritonavir
T125 3476-3485 SP_7 denotes 2019-nCoV

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 2597-2605 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T2 3141-3144 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T3 3916-3919 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T4 4393-4396 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T5 4428-4431 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T6 4634-4649 Body_part denotes Immunoglobulins http://purl.org/sig/ont/fma/fma62871
T7 4790-4804 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T8 4915-4929 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T9 5481-5484 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T10 5537-5541 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T11 5570-5578 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T12 5662-5671 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T13 6634-6638 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T14 7713-7727 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T15 7899-7906 Body_part denotes capsule http://purl.org/sig/ont/fma/fma85272
T16 8791-8805 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T17 9577-9591 Body_part denotes Immunoglobulin http://purl.org/sig/ont/fma/fma62871
T18 11754-11761 Body_part denotes Capsule http://purl.org/sig/ont/fma/fma85272
T19 12237-12242 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T20 12283-12288 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T21 12550-12557 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T22 12765-12768 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T23 13023-13028 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 13198-13207 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T25 13268-13272 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 13411-13418 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 13629-13634 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T28 13695-13700 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 13712-13717 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T30 13814-13821 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 14279-14286 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4393-4396 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T2 4428-4431 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T3 6634-6638 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T4 7899-7906 Body_part denotes capsule http://purl.obolibrary.org/obo/UBERON_0003893
T5 11754-11761 Body_part denotes Capsule http://purl.obolibrary.org/obo/UBERON_0003893

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p17514s10 1546-1554 PosReg denotes increase
p17514s12 1558-1568 MPA denotes viral load
p17549s21 5522-5533 MPA denotes replication
p17634s1 13188-13197 PosReg denotes increases
p17634s2 13198-13207 CPA denotes endosomal

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 220-253 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T2 267-275 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 521-529 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 631-635 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 734-743 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 1015-1023 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 1154-1162 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1307-1315 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1358-1374 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T10 1368-1374 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T11 1376-1388 Disease denotes hypocalcemia http://purl.obolibrary.org/obo/MONDO_0018543
T12 1394-1408 Disease denotes hypomagnesemia http://purl.obolibrary.org/obo/MONDO_0018100
T13 1840-1849 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T14 1998-2007 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T15 2455-2463 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 2896-2904 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 2971-2979 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 4008-4017 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T19 4120-4131 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T20 4120-4129 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T21 4136-4144 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 4676-4680 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 5271-5306 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T24 5277-5306 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T25 5308-5312 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T26 5369-5377 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 5615-5623 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T28 5858-5863 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T29 6254-6263 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 6445-6466 Disease denotes respiratory infection http://purl.obolibrary.org/obo/MONDO_0024355
T31 6457-6466 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T32 6490-6511 Disease denotes (2019-nCoV) infection http://purl.obolibrary.org/obo/MONDO_0100096
T33 6502-6511 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T34 6601-6623 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T35 6938-6959 Disease denotes respiratory infection http://purl.obolibrary.org/obo/MONDO_0024355
T36 6950-6959 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 7045-7064 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T38 8160-8178 Disease denotes 2019nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T39 8169-8178 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 8460-8479 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T41 8470-8479 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T42 10065-10084 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T43 10966-10985 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T44 10976-10985 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T45 11462-11471 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T46 12266-12275 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47 12616-12631 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T48 12622-12631 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49 12942-12960 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T50 12951-12960 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 13043-13047 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 13052-13061 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T53 13152-13170 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T54 13161-13170 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 641-643 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T2 932-933 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 969-977 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T4 991-997 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T5 1114-1115 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 1256-1263 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T7 1622-1623 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1857-1858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 1920-1921 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1931-1933 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T11 2008-2013 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T12 2024-2026 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T13 2213-2215 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T14 2469-2471 http://purl.obolibrary.org/obo/CLO_0052906 denotes CL
T15 3150-3151 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T16 3273-3274 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 3829-3831 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T18 4130-4131 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T19 4393-4396 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arm
T20 4428-4431 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arm
T21 4824-4826 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T22 5496-5504 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T23 5537-5541 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T24 5588-5589 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 5858-5885 http://purl.obolibrary.org/obo/PR_000000134 denotes tumor necrosis factor-alpha
T26 6158-6163 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T27 6533-6540 http://purl.obolibrary.org/obo/CLO_0009985 denotes focuses
T28 6689-6696 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T29 6885-6894 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T30 6885-6894 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T31 7320-7322 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T32 7908-7909 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 7962-7965 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34 8068-8069 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 8180-8182 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T36 8704-8705 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 8939-8941 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T38 9005-9007 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T39 9052-9054 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T40 9257-9259 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T41 9335-9337 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T42 9396-9398 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T43 9444-9446 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T44 10263-10265 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T45 10276-10278 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T46 10482-10484 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T47 11024-11025 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 11187-11188 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 11320-11322 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T50 11324-11326 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T51 11356-11358 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T52 11563-11568 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T53 11826-11834 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T54 12229-12242 http://purl.obolibrary.org/obo/CLO_0051719 denotes vero E6 cells
T55 12283-12288 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T56 12331-12335 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T57 12616-12621 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T58 12809-12811 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T59 12915-12916 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 12973-12975 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T61 13015-13028 http://purl.obolibrary.org/obo/CLO_0051719 denotes vero E6 cells
T62 13172-13174 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T63 13262-13267 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T64 13268-13272 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T65 13471-13473 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T66 13547-13548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 13629-13634 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T68 13695-13700 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T69 13712-13717 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T70 13719-13721 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T71 13734-13743 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T72 13844-13845 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 14716-14725 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely
T74 14757-14766 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extremely

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 691-700 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T2 903-913 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T3 932-944 Chemical denotes a nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T4 959-968 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T5 1066-1075 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T6 1087-1102 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T7 1189-1194 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T8 1289-1298 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T9 1462-1471 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T10 1490-1499 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T11 1504-1518 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T12 1651-1661 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T13 1674-1685 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T14 1755-1779 Chemical denotes Neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T15 1769-1779 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T16 1780-1804 Chemical denotes Neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T17 1794-1804 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T18 1952-1963 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T19 2046-2057 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T20 2094-2105 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T21 2188-2199 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T22 2217-2228 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T23 2366-2371 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T24 2402-2411 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T25 2597-2605 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T26 2682-2701 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T28 2691-2701 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T29 2703-2712 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T30 2726-2735 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T31 2740-2750 Chemical denotes saquinavir http://purl.obolibrary.org/obo/CHEBI_63621
T32 2774-2783 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T33 2872-2882 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T34 2990-2999 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T35 3102-3111 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T36 3316-3335 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T37 3316-3325 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T38 3326-3335 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T39 3395-3404 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T40 3407-3416 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T41 3436-3454 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T43 3445-3454 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T44 3769-3784 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T45 3840-3854 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T46 3970-3977 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T47 4073-4083 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T48 4167-4176 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T49 4180-4190 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T50 4192-4195 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T51 4228-4231 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T52 4246-4260 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T53 4261-4266 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T54 4352-4355 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T55 4362-4376 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T56 4378-4392 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T57 4405-4419 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T58 4422-4425 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T59 4470-4476 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T60 4540-4543 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T61 4594-4603 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T62 4606-4615 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T63 5162-5178 Chemical denotes immunomodulators http://purl.obolibrary.org/obo/CHEBI_50846
T64 5180-5189 Chemical denotes metformin http://purl.obolibrary.org/obo/CHEBI_6801
T65 5191-5203 Chemical denotes atorvastatin http://purl.obolibrary.org/obo/CHEBI_39548
T66 5439-5448 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T67 5724-5726 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T69 5732-5743 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T70 5880-5885 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T71 5886-5896 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T72 6813-6826 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T73 7123-7129 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T74 7467-7483 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T75 7543-7552 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T76 7554-7563 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T77 7565-7572 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T78 7578-7589 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T79 7600-7611 Chemical denotes ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T80 7623-7639 Chemical denotes immunomodulators http://purl.obolibrary.org/obo/CHEBI_50846
T81 7681-7696 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T82 7930-7938 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T83 8086-8101 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T84 8236-8241 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T85 8327-8332 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T86 8576-8582 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T87 8650-8660 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T88 8662-8671 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T89 8673-8682 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T90 8684-8691 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T91 8726-8734 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T92 8838-8848 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T93 9039-9050 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T94 9091-9106 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T95 9369-9383 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T96 9705-9719 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T97 10153-10164 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T98 10189-10200 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T99 10206-10217 Chemical denotes ceftriaxone http://purl.obolibrary.org/obo/CHEBI_29007
T100 10225-10237 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T101 10249-10261 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T102 10312-10326 Chemical denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T103 10545-10554 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T104 10559-10573 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T105 10755-10765 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T106 10781-10792 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T107 10799-10810 Chemical denotes ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T108 10815-10834 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T109 10815-10824 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T110 10825-10834 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T111 10860-10869 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T112 10923-10933 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T113 11036-11046 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T114 11072-11082 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T115 11167-11182 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T116 11547-11561 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T117 11569-11574 Chemical denotes gamma http://purl.obolibrary.org/obo/CHEBI_30212
T118 11585-11596 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T119 11598-11610 Chemical denotes moxifloxacin http://purl.obolibrary.org/obo/CHEBI_63611
T120 11613-11622 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T121 11624-11635 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T122 11647-11660 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T123 11681-11689 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T124 11954-11965 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T125 12066-12075 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T126 12077-12088 Chemical denotes penciclovir http://purl.obolibrary.org/obo/CHEBI_7956
T127 12104-12114 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T128 12116-12127 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T129 12129-12139 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T130 12141-12147 Chemical denotes GS5734 http://purl.obolibrary.org/obo/CHEBI_145994
T131 12154-12165 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T132 12167-12172 Chemical denotes T-705 http://purl.obolibrary.org/obo/CHEBI_134722
T133 12336-12340 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T134 12550-12557 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T135 12579-12590 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T136 12595-12605 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T137 12707-12716 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T138 12725-12735 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T139 12831-12842 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T140 12849-12864 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T141 12879-12890 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T142 12924-12933 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T143 12995-13006 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T144 13117-13128 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T145 13176-13187 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T146 13281-13292 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T147 13335-13346 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T148 13411-13418 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 13522-13533 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T150 13814-13821 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 13955-13962 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T152 14039-14046 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T153 14135-14157 Chemical denotes janus kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_76617
T154 14148-14157 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T155 14279-14286 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T156 14865-14870 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 5060-5075 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T2 5129-5146 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T3 5129-5146 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T4 5864-5872 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T5 5864-5872 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T6 5864-5872 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T7 5864-5872 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T8 12375-12396 http://purl.obolibrary.org/obo/GO_0001171 denotes Reverse transcription
T9 12383-12396 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10 13268-13279 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T11 13268-13279 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T12 13268-13279 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T13 13268-13279 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T14 13310-13323 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T15 13443-13468 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T16 13734-13743 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T17 13752-13785 http://purl.obolibrary.org/obo/GO_0006898 denotes receptor mediates the endocytosis
T18 13774-13785 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T19 14141-14157 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitor
T20 14257-14268 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T21 14288-14294 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-64 Sentence denotes Therapeutic options for the treatment of 2019-novel coronavirus:
T2 65-91 Sentence denotes An evidence-based approach
T3 93-751 Sentence denotes In the 21st century, three coronaviruses (CoVs) caused three major epidemic of respiratory distress[1] syndrome, which include severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 with epicenter in Guangdong, China,[2] Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 in Saudi Arabia,[3] and the third epidemic of respiratory coronavirus the 2019-novel coronavirus (2019-nCoV) or coronavirus disease (COVID-19) mainly centered in Wuhan province, China.[4] The case fatalities vary from 2.5% (2019-nCoV),[5]10% (SARS), to 35% (MERS-CoV).[6] Till now, there is no approved antiviral or vaccine for the management of infection by CoV.
T4 752-889 Sentence denotes However, from earlier experience of the management of SERS-CoV and MERS-CoV, many agents are being used in the treatment of 2019-nCoV.[7]
T5 891-901 Sentence denotes Antivirals
T6 903-920 Sentence denotes Nucleoside analog
T7 921-1163 Sentence denotes Ribavirin, a nucleoside analog, shows antiviral activity against some animal CoVs, and in the SARS-CoV epidemic, many patients were treated with ribavirin along with corticosteroids and became a standard regimen for the treatment of SARS-CoV.
T8 1164-1239 Sentence denotes However, lack of control group hindered the estimation of true effect size.
T9 1240-1316 Sentence denotes Again, in vitro testing did not show efficacy of ribavirin against SARS-CoV.
T10 1317-1410 Sentence denotes Ribavirin is known for its side effects (hemolytic anemia, hypocalcemia, and hypomagnesemia).
T11 1411-1472 Sentence denotes Many subsequent studies questioned the efficacy of ribavirin.
T12 1473-1593 Sentence denotes Many patients on ribavirin and corticosteroid combination even showed an increase in viral load following the treatment.
T13 1594-1753 Sentence denotes Thus, its use declined over a period.[8] Other important nucleoside analogs are favipiravir and galidesivir, but these are not evaluated till now in 2019-nCoV.
T14 1755-1779 Sentence denotes Neuraminidase inhibitors
T15 1780-1972 Sentence denotes Neuraminidase inhibitors are indicated in the management of influenza.[9] In a study on possible MERS-CoV cases in Paris from 2013 to 2016, a total of 35 patients received oseltamivir (37.6%).
T16 1973-2391 Sentence denotes In patients positive for influenza virus (n = 25), 52% (n = 13) received oseltamivir and it was concluded that empirical oseltamivir can be started in suspected MERS-CoV cases.[10] Many other studies also evaluated oseltamivir in MERS-CoV.[11] Oseltamivir was also used in the management of 2019-nCoV; however, definite evidence of efficacy is inconclusive because of lack of suitable control group in the studies.[12]
T17 2393-2411 Sentence denotes Protease inhibitor
T18 2412-2675 Sentence denotes There are two types of protease present in SARS-CoV, the CL-like protease and the papain-like protease, which is important for cleaving the polyproteins and releasing the nonstructural proteins (NSP1–16), which carry out important functions in the CoV life cycle.
T19 2676-3512 Sentence denotes Among protease inhibitors, lopinavir was the most inhibitor and saquinavir was the least powerful inhibitor of CoV protease.[13] In molecular dynamic studies, flap closing was observed when these inhibitors bound to the SARS-CoV 3CL (pro).[14] Hong Kong University researchers demonstrated anti-SARS-CoV action of lopinavir at concentration of 4 μg/ml in vitro against the HKU-39849 isolate.[15] Ritonavir boosting along with lopinavir is used in the management of HIV.[16] A clinical study at the same Hong Kong University suggests that even after adjustment for LDH level (possible confounder), a significant association was seen between lopinavir/ritonavir use and better outcome.[15] As per the current guidelines, lopinavir + ritonavir is the recommended protease inhibitor for the treatment of 2019-nCoV (weak recommendation).[17]
T20 3514-3530 Sentence denotes Immunomodulators
T21 3532-3547 Sentence denotes Corticosteroids
T22 3548-3697 Sentence denotes Corticosteroids were widely used for the treatment of SERS-CoV and MERS-CoV and are also used in the management of the current epidemic of 2019-nCoV.
T23 3698-4022 Sentence denotes However, the interim guidelines by the WHO prohibit the use of routine corticosteroids unless indicated for other clinical ground.[18] Use of corticosteroid is reported to be associated with delayed clearance of viral RNA (both in case of SERS-CoV and MERS-CoV) and other steroid-related complications such as psychosis.[19]
T24 4024-4034 Sentence denotes Interferon
T25 4035-4132 Sentence denotes Interferons (IFNs) are broad-spectrum antivirals, primarily used in the treatment of hepatitis B.
T26 4133-4632 Sentence denotes In SARS-CoV patients, compared to ribavirin or interferon (IFN) alone, the benefit was seen on IFN-α + high-dose corticosteroid group.[20] Other observational studies also support these findings and the combined use of IFN-α and corticosteroid (corticosteroid arm n = 13; corticosteroid + IFN-α arm n = 9) showed less disease-associated oxygen saturation impairment.[21] For the treatment of 2019-nCoV (7), IFN-α (5 million U bid inh) is recommended along with lopinavir + ritonavir combination.[17]
T27 4634-4649 Sentence denotes Immunoglobulins
T28 4650-4934 Sentence denotes In case of critically ill SARS, who show signs of deterioration, further escalation of immunomodulation is indicated and intravenous (i.v.) immunoglobulin may be considered.[22] Patients who show poor response to initial empirical therapy may get benefit from i.v. immunoglobulin.[23]
T29 4936-4959 Sentence denotes Host-Directed Therapies
T30 4960-5335 Sentence denotes Host-directed therapies basically target improvement of the status of the host, improvement of host immune response, or handling of host-related factors associated with viral replication.[6] Apart from immunomodulators, metformin, atorvastatin, fibrates, as well as nutritional supplements may help in treating acute respiratory distress syndrome (ARDS) by boosting immunity.
T31 5336-5413 Sentence denotes However, evidence of efficacy in SARS-CoV or MERS-CoV is poorly reported.[24]
T32 5414-5749 Sentence denotes Zinc is reported to have antiviral effect,[24] and it inhibits CoV RNA polymerase activity and thus hampers replication in cell culture experiments.[25] As cytokine storm is a pathognomonic feature of COVID-19, inhibition of these pro-inflammatory cytokines may theoretically prove useful (e.g., inhibition of IL-6 by tocilizumab).[24]
T33 5751-5766 Sentence denotes Other Therapies
T34 5767-6036 Sentence denotes Other treatment options, which are either used rarely or in experimental state, are SiRNA, tumor necrosis factor-alpha inhibitors, neutralizing antibodies, pentoxifylline, etc., However, the level of evidence is quite poor and hence not recommended for routine care.[8]
T35 6038-6099 Sentence denotes Management of 2019-Novel Coronavirus (Coronavirus Disease-19)
T36 6100-6697 Sentence denotes Clinical care of suspected patients with 2019-nCoV should focus on recognition of the disease condition at the earliest, isolation and adoption of proper infection control measures, and delivery of optimized supportive care toward the suspected/confirmed cases.[26] For preventive measure, the WHO guideline “Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected” mainly focuses on avoiding close contact with persons suffering from acute respiratory infections, frequent hand wash, and avoidance of unwanted contact with wild animals.
T37 6698-6802 Sentence denotes In case of patients with respiratory distress, the patient is to be evaluated for the presence of shock.
T38 6803-6961 Sentence denotes Empirical antimicrobial coverage is to be given (to cover up the likely causative organisms, which may be responsible for severe acute respiratory infection).
T39 6962-7023 Sentence denotes Special concern is to be given for other comorbid conditions.
T40 7024-7233 Sentence denotes In case of hypoxemic respiratory failure, it needs to be managed aggressively with high-flow nasal oxygen or noninvasive ventilation or by endotracheal intubation and positive pressure ventilation as required.
T41 7234-7323 Sentence denotes Special concern is to be taken for the identification and management of septic shock.[27]
T42 7325-7361 Sentence denotes Treatment of 2019-Novel Coronavirus:
T43 7362-7381 Sentence denotes Evidence from China
T44 7382-7462 Sentence denotes The details of treatment reported in case of 2019-nCoV are presented in Table 1.
T45 7463-8396 Sentence denotes The antiviral agents which are used in the management of 2019-nCoV episodes are lopinavir, ritonavir, arbidol,[28] oseltamivir,[12] i.v. ganciclovir.[29] Among immunomodulators, the commonly used agents are systematic corticosteroids,[1230] and i.v. immunoglobulin was used in more serious cases who were refractory to initial therapy.[28] Among herbal medicines, Chinese herbal medicinal products Tanreqing i.v. gtt,[31] shufeng jiedu capsule (a traditional Chinese medicine) was used.[28] The WHO has specified that at this present time there is no high level evidence is available, which favous use of a single specific antiviral agent for the treatment of patients with suspected or confirmed 2019nCoV infection.[27] Although many of the death cases were in higher age group[32] and many were smokers and had bilateral disease,[29] lack of appropriate control group is the main hindrance in interpreting these prognostic factors.
T46 8397-8479 Sentence denotes Table 1 Details of reported therapeutic strategies to counter 2019-nCoV infection
T47 8480-8535 Sentence denotes Study details Sample size Therapeutic agents Outcome
T48 8536-8618 Sentence denotes [28] 4 patients All patients received oxygen therapy and mechanical ventilation.
T49 8619-8736 Sentence denotes All patients were treated with antibiotic, lopinavir, ritonavir, arbidol, and SFJDC (a traditional Chinese medicine).
T50 8737-8806 Sentence denotes However, only one seriously ill patient received i.v. immunoglobulin.
T51 8807-8932 Sentence denotes All patients were treated with antivirals for 6-15 days 3 patients improved, last patient still on ventilator (but improved)
T52 8933-9009 Sentence denotes [12] 41 patients Antibiotic therapy was administered in 100% cases (n=41).
T53 9010-9051 Sentence denotes 93% (n=38) patients received oseltamivir.
T54 9052-9129 Sentence denotes 22% (n=9) patients received systematic corticosteroids Discharged=68% (n=28)
T55 9130-9148 Sentence denotes Antiviral therapy:
T56 9149-9228 Sentence denotes Overall 38 (93%), ICU setting 12 (92%), non-ICU care 26 (93%) Death=6 patients
T57 9229-9248 Sentence denotes Antibiotic therapy:
T58 9249-9324 Sentence denotes Overall 41 (100%), ICU setting 13 (100%), non-ICU setting 28 (100%) Death:
T59 9325-9361 Sentence denotes Overall 6/41, ICU 5/13, non-ICU 1/28
T60 9362-9384 Sentence denotes Use of corticosteroid:
T61 9385-9448 Sentence denotes Overall 9 (22%), ICU settings 6 (46%), non-ICU settings 3 (11%)
T62 9449-9576 Sentence denotes [32] Clinical data from 137 2019-nCoV- infected patients Patients were treated symptomatically and given respiratory support.
T63 9577-9664 Sentence denotes Immunoglobulin was given to few patients depending upon clinical severity and response.
T64 9665-9720 Sentence denotes No benefit was observed from systematic corticosteroid.
T65 9721-9808 Sentence denotes Notably, early respiratory support facilitated disease recovery and improved prognosis.
T66 9809-10107 Sentence denotes The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea Patients with higher age at presentation and concomitant disease were more likely to show features of respiratory failure and had poorer outcome
T67 10108-10165 Sentence denotes [30] 138 patients 90% of patients received oseltamivir.
T68 10166-10268 Sentence denotes The most commonly used antibiotics were ceftriaxone (25%), moxifloxacin (64%), and azithromycin (18%).
T69 10269-10363 Sentence denotes Around 45% of patients received additional glucocorticoid therapy Still admitted=61.6% (n=85)
T70 10364-10492 Sentence denotes 9.4% of patients required additional vasopressor and 1.44% of patients required renal replacement therapy Discharged=34% (n=47)
T71 10493-10582 Sentence denotes Severity of disease was an important determinant of antiviral and corticosteroid therapy.
T72 10583-10645 Sentence denotes However, no effective outcomes were observed Death=4.3% (n=6)
T73 10646-10750 Sentence denotes [29] 99 patients All patients were treated in isolationAntiviral therapy given to 76% patients (n=75).
T74 10751-10843 Sentence denotes The antivirals used were oral oseltamivir, i.v. ganciclovir and lopinavir/ritonavir tablets.
T75 10844-10944 Sentence denotes The duration of antiviral therapy ranged from 3 to 14 days70 patients received antibiotic treatment.
T76 10945-11055 Sentence denotes In case of secondary bacterial infection, culture and sensitivity were used as a guide for antibiotic therapy.
T77 11056-11487 Sentence denotes The duration of antibiotic therapy ranged from 3 to 17 days19 (19%) patients were also treated with additional corticosteroids for a duration of 3-15 daysNoninvasive ventilator=13, invasive ventilator=4, ECMO=3, and requirement of RRT=9 Discharged=31% (n=31)Died=11 (11%)Details of death patients:7/11 deaths age >60 yearsLong history of smoking=3MuLBSTA score could predict outcomeLymphopenia=8Bilateral pneumonia=7Hypertension=3
T78 11488-11733 Sentence denotes [31] 2 patients Both the patients were treated with i.v. corticosteroid, human gamma globulin, antibiotics (moxifloxacin), antiviral (oseltamivir and abidol hydrochloride) and Chinese herbal medicine Tanreqing i.v. gtt Both patients recovered
T79 11734-11877 Sentence denotes SFJDC=Shufeng Jiedu Capsule, ICU=Intensive care unit, i.v.=Intravenous, ECMO=Extracorporeal membrane oxygenation, RRT=Renal replacement therapy
T80 11879-11937 Sentence denotes Recent Advances in the Treatment of 2019-Novel Coronavirus
T81 11939-11969 Sentence denotes Remdesivir and chloroquine[33]
T82 11970-12198 Sentence denotes Using clinical isolates of 2019-nCoV, Wang et al., 2020 evaluated the efficacy of seven agents (ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine, remdesivir [GS5734], and favipiravir [T-705]) in in vitro conditions.
T83 12199-12374 Sentence denotes Cytotoxicity was evaluated in vero E6 cells, which was followed by infection of the cells with 2019-nCoV clinical isolates, and the test drug was evaluated at different doses.
T84 12375-12573 Sentence denotes Reverse transcription polymerase chain reaction-based quantification was done to get the viral yield, which was later confirmed by immunofluorescence microscopy (nucleocapsid protein visualization).
T85 12574-12697 Sentence denotes Both chloroquine and remdesivir inhibited virus infection at micromolar level (0.77–1.13 μM) and with high selectivity.[33]
T86 12698-12878 Sentence denotes Being an adenosine analog, remdesivir gets incorporated into viral RNA and causes premature chain termination.[34] The importance of chloroquine as an antiviral agent is coming up.
T87 12879-13062 Sentence denotes Chloroquine even showed efficacy as a potent antiviral against SARS-CoV infection and spread.[35] Pretreatment with chloroquine renders vero E6 cells refractory to SARS CoV infection.
T88 13063-13280 Sentence denotes Moreover, in the postinfection period, treatment with chloroquine prevents the spread of SARS-CoV infection.[35] Chloroquine increases endosomal pH and thus makes the environment unfavorable for the virus/cell fusion.
T89 13281-13569 Sentence denotes Chloroquine also affects the glycosylation process of angiotensin-converting enzyme 2 (ACE-2, receptor for binding of viral spike protein, which is essential for interaction with the host).[35] Being nonexpensive and easily available agent, chloroquine may prove as a promising candidate.
T90 13571-13582 Sentence denotes Baricitinib
T91 13583-13873 Sentence denotes The SARSCoV and the 2019nCoV both enters host cells through ACE2 receptormediated entry, especially through AT2 cells present in lungs.[36] Downstream signaling of this receptor mediates the endocytosis process, and AP2-associated protein kinase 1 (AAK1) plays a major role in this process.
T92 13874-13916 Sentence denotes Thus, AAK1 represents an important target.
T93 13917-14026 Sentence denotes Richardson et al., 2020 evaluated 378 ligands, of which 47 were already approved for use in other conditions.
T94 14027-14086 Sentence denotes Among these ligands, six inhibited AAK1 with high affinity.
T95 14087-14201 Sentence denotes Considering the side effect profile, they found janus kinase inhibitor baricitinib to be the most important agent.
T96 14202-14316 Sentence denotes In addition to AAK1, baricitinib also binds to another endocytosis regulator protein (cyclin G-associated kinase).
T97 14317-14464 Sentence denotes Thus, the authors suggest that baricitinib can be evaluated in the in vitro conditions as well as in the clinical trial settings for 2019-nCoV.[37]
T98 14466-14497 Sentence denotes Limitations of current research
T99 14498-14638 Sentence denotes Lack of high-quality evidence (especially randomized controlled trails [RCTs]) is the most important limitation of the current CoV research.
T100 14639-14928 Sentence denotes As most of the CoV strains are genetically different and the outbreaks occur extremely randomly, conducting an RCT is extremely difficult, and we have to rely on observational studies (most of which do not have proper control group), which hamper the estimation of proper treatment effect.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 172-192 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 1358-1374 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878
T3 1376-1388 Phenotype denotes hypocalcemia http://purl.obolibrary.org/obo/HP_0002901
T4 1394-1408 Phenotype denotes hypomagnesemia http://purl.obolibrary.org/obo/HP_0002917
T5 4008-4017 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T6 4120-4129 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T7 5277-5297 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T8 5570-5584 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T9 5858-5863 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T10 6445-6466 Phenotype denotes respiratory infection http://purl.obolibrary.org/obo/HP_0011947
T11 6601-6623 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T12 6723-6743 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T13 6796-6801 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T14 6938-6959 Phenotype denotes respiratory infection http://purl.obolibrary.org/obo/HP_0011947
T15 7045-7064 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T16 7313-7318 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T17 9954-9961 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T18 10065-10084 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T19 11462-11471 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
32201439-17597972-47219406 1632-1633 17597972 denotes 8
32201439-30012113-47219407 2150-2152 30012113 denotes 10
32201439-30882305-47219408 2213-2215 30882305 denotes 11
32201439-31986264-47219409 2388-2390 31986264 denotes 12
32201439-18706430-47219410 2916-2918 18706430 denotes 14
32201439-14985565-47219411 3068-3070 14985565 denotes 15
32201439-16827606-47219412 3146-3148 16827606 denotes 16
32201439-14985565-47219413 3360-3362 14985565 denotes 15
32201439-32029004-47219414 3509-3511 32029004 denotes 17
32201439-32043983-47219415 4019-4021 32043983 denotes 19
32201439-12867568-47219416 4268-4270 12867568 denotes 20
32201439-14693875-47219417 4500-4502 14693875 denotes 21
32201439-32029004-47219418 4629-4631 32029004 denotes 17
32201439-15912185-47219419 4824-4826 15912185 denotes 22
32201439-15018130-47219420 4931-4933 15018130 denotes 23
32201439-26868298-47219421 5148-5149 26868298 denotes 6
32201439-32035018-47219422 5410-5412 32035018 denotes 24
32201439-32035018-47219423 5457-5459 32035018 denotes 24
32201439-21079686-47219424 5563-5565 21079686 denotes 25
32201439-32035018-47219425 5746-5748 32035018 denotes 24
32201439-17597972-47219426 6034-6035 17597972 denotes 8
32201439-31986264-47219427 7591-7593 31986264 denotes 12
32201439-32007143-47219428 7613-7615 32007143 denotes 29
32201439-31986264-47219429 7698-7700 31986264 denotes 12
32201439-32007143-47219430 8295-8297 32007143 denotes 29
32201439-31986264-47219431 8934-8936 31986264 denotes 12
32201439-32007143-47219432 10647-10649 32007143 denotes 29
32201439-32020029-47219433 11966-11968 32020029 denotes 33
32201439-32020029-47219434 12694-12696 32020029 denotes 33
32201439-26934220-47219435 12809-12811 26934220 denotes 34
32201439-16115318-47219436 12973-12975 16115318 denotes 35
32201439-16115318-47219437 13172-13174 16115318 denotes 35
32201439-16115318-47219438 13471-13473 16115318 denotes 35
32201439-32032529-47219439 14461-14463 32032529 denotes 37
T83959 1632-1633 17597972 denotes 8
T19064 2150-2152 30012113 denotes 10
T33497 2213-2215 30882305 denotes 11
T42850 2388-2390 31986264 denotes 12
T5394 2916-2918 18706430 denotes 14
T51142 3068-3070 14985565 denotes 15
T94741 3146-3148 16827606 denotes 16
T99431 3360-3362 14985565 denotes 15
T46519 3509-3511 32029004 denotes 17
T87822 4019-4021 32043983 denotes 19
T43328 4268-4270 12867568 denotes 20
T72085 4500-4502 14693875 denotes 21
T4398 4629-4631 32029004 denotes 17
T78101 4824-4826 15912185 denotes 22
T89577 4931-4933 15018130 denotes 23
T10426 5148-5149 26868298 denotes 6
T92752 5410-5412 32035018 denotes 24
T75307 5457-5459 32035018 denotes 24
T32309 5563-5565 21079686 denotes 25
T13267 5746-5748 32035018 denotes 24
T4899 6034-6035 17597972 denotes 8
T85215 7591-7593 31986264 denotes 12
T15501 7613-7615 32007143 denotes 29
T97145 7698-7700 31986264 denotes 12
T54773 8295-8297 32007143 denotes 29
T29858 8934-8936 31986264 denotes 12
T34227 10647-10649 32007143 denotes 29
T41189 11966-11968 32020029 denotes 33
T4625 12694-12696 32020029 denotes 33
T49263 12809-12811 26934220 denotes 34
T96382 12973-12975 16115318 denotes 35
T21534 13172-13174 16115318 denotes 35
T99419 13471-13473 16115318 denotes 35
T4041 14461-14463 32032529 denotes 37