PMC:7074424 / 24386-24893 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"562","span":{"begin":30,"end":35},"obj":"Chemical"},{"id":"563","span":{"begin":111,"end":117},"obj":"Chemical"},{"id":"564","span":{"begin":184,"end":201},"obj":"Chemical"},{"id":"565","span":{"begin":203,"end":223},"obj":"Chemical"},{"id":"566","span":{"begin":237,"end":257},"obj":"Chemical"},{"id":"567","span":{"begin":263,"end":278},"obj":"Chemical"},{"id":"568","span":{"begin":291,"end":304},"obj":"Chemical"},{"id":"569","span":{"begin":323,"end":333},"obj":"Chemical"}],"attributes":[{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"MESH:D008670"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"MESH:D005419"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"6.2 μM) is reported.[79] Some metal-conjugated and peptidomimetic compounds showed inhibitory activity against 3CLpro.[77] Some of the small molecules also act as an inhibitor that is arylboronic acids, quinolinecarboxylate derivatives, thiophenecarboxylate, and phthalhydrazide-substituted ketoglutamine analogs.[77] Some flavonoids are also reported to inhibit Mpro.[75] GC376 also has protease inhibitor activity.[81] A crystal structure of Mpro with small molecule inhibitor N3 is also reported (PDB ID:"}

{"project":"2_test","denotations":[{"id":"32201449-24080461-47217125","span":{"begin":21,"end":23},"obj":"24080461"},{"id":"32201449-15788388-47217126","span":{"begin":119,"end":121},"obj":"15788388"},{"id":"32201449-15788388-47217127","span":{"begin":314,"end":316},"obj":"15788388"},{"id":"32201449-31724441-47217128","span":{"begin":369,"end":371},"obj":"31724441"},{"id":"32201449-31585653-47217129","span":{"begin":417,"end":419},"obj":"31585653"},{"id":"T645","span":{"begin":21,"end":23},"obj":"24080461"},{"id":"T37277","span":{"begin":119,"end":121},"obj":"15788388"},{"id":"T90937","span":{"begin":314,"end":316},"obj":"15788388"},{"id":"T96138","span":{"begin":369,"end":371},"obj":"31724441"},{"id":"T58881","span":{"begin":417,"end":419},"obj":"31585653"}],"text":"6.2 μM) is reported.[79] Some metal-conjugated and peptidomimetic compounds showed inhibitory activity against 3CLpro.[77] Some of the small molecules also act as an inhibitor that is arylboronic acids, quinolinecarboxylate derivatives, thiophenecarboxylate, and phthalhydrazide-substituted ketoglutamine analogs.[77] Some flavonoids are also reported to inhibit Mpro.[75] GC376 also has protease inhibitor activity.[81] A crystal structure of Mpro with small molecule inhibitor N3 is also reported (PDB ID:"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T754","span":{"begin":36,"end":46},"obj":"MOP:0000779"},{"id":"T753","span":{"begin":66,"end":75},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T752","span":{"begin":141,"end":150},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T751","span":{"begin":166,"end":175},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T750","span":{"begin":184,"end":195},"obj":"CHEBI:28619;CHEBI:28619"},{"id":"T749","span":{"begin":196,"end":201},"obj":"CHEBI:30956;CHEBI:30956"},{"id":"T748","span":{"begin":203,"end":223},"obj":"CHEBI:15854;CHEBI:15854"},{"id":"T747","span":{"begin":237,"end":257},"obj":"CHEBI:18022;CHEBI:18022"},{"id":"T746","span":{"begin":323,"end":333},"obj":"CHEBI:47916;CHEBI:47916"},{"id":"T745","span":{"begin":460,"end":468},"obj":"CHEBI:36357;CHEBI:36357"},{"id":"T744","span":{"begin":469,"end":478},"obj":"CHEBI:35222;CHEBI:35222"}],"text":"6.2 μM) is reported.[79] Some metal-conjugated and peptidomimetic compounds showed inhibitory activity against 3CLpro.[77] Some of the small molecules also act as an inhibitor that is arylboronic acids, quinolinecarboxylate derivatives, thiophenecarboxylate, and phthalhydrazide-substituted ketoglutamine analogs.[77] Some flavonoids are also reported to inhibit Mpro.[75] GC376 also has protease inhibitor activity.[81] A crystal structure of Mpro with small molecule inhibitor N3 is also reported (PDB ID:"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T259","span":{"begin":94,"end":102},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T260","span":{"begin":384,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T261","span":{"begin":407,"end":415},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T262","span":{"begin":421,"end":422},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"6.2 μM) is reported.[79] Some metal-conjugated and peptidomimetic compounds showed inhibitory activity against 3CLpro.[77] Some of the small molecules also act as an inhibitor that is arylboronic acids, quinolinecarboxylate derivatives, thiophenecarboxylate, and phthalhydrazide-substituted ketoglutamine analogs.[77] Some flavonoids are also reported to inhibit Mpro.[75] GC376 also has protease inhibitor activity.[81] A crystal structure of Mpro with small molecule inhibitor N3 is also reported (PDB ID:"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T290","span":{"begin":51,"end":65},"obj":"Chemical"},{"id":"T291","span":{"begin":141,"end":150},"obj":"Chemical"},{"id":"T292","span":{"begin":166,"end":175},"obj":"Chemical"},{"id":"T293","span":{"begin":196,"end":201},"obj":"Chemical"},{"id":"T294","span":{"begin":323,"end":333},"obj":"Chemical"},{"id":"T296","span":{"begin":388,"end":406},"obj":"Chemical"},{"id":"T298","span":{"begin":397,"end":406},"obj":"Chemical"},{"id":"T299","span":{"begin":460,"end":468},"obj":"Chemical"},{"id":"T300","span":{"begin":469,"end":478},"obj":"Chemical"},{"id":"T301","span":{"begin":504,"end":506},"obj":"Chemical"}],"attributes":[{"id":"A290","pred":"chebi_id","subj":"T290","obj":"http://purl.obolibrary.org/obo/CHEBI_63175"},{"id":"A291","pred":"chebi_id","subj":"T291","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A292","pred":"chebi_id","subj":"T292","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A293","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A294","pred":"chebi_id","subj":"T294","obj":"http://purl.obolibrary.org/obo/CHEBI_47916"},{"id":"A295","pred":"chebi_id","subj":"T294","obj":"http://purl.obolibrary.org/obo/CHEBI_72544"},{"id":"A296","pred":"chebi_id","subj":"T296","obj":"http://purl.obolibrary.org/obo/CHEBI_37670"},{"id":"A297","pred":"chebi_id","subj":"T296","obj":"http://purl.obolibrary.org/obo/CHEBI_60258"},{"id":"A298","pred":"chebi_id","subj":"T298","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_141439"}],"text":"6.2 μM) is reported.[79] Some metal-conjugated and peptidomimetic compounds showed inhibitory activity against 3CLpro.[77] Some of the small molecules also act as an inhibitor that is arylboronic acids, quinolinecarboxylate derivatives, thiophenecarboxylate, and phthalhydrazide-substituted ketoglutamine analogs.[77] Some flavonoids are also reported to inhibit Mpro.[75] GC376 also has protease inhibitor activity.[81] A crystal structure of Mpro with small molecule inhibitor N3 is also reported (PDB ID:"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T62","span":{"begin":388,"end":415},"obj":"http://purl.obolibrary.org/obo/GO_0030414"}],"text":"6.2 μM) is reported.[79] Some metal-conjugated and peptidomimetic compounds showed inhibitory activity against 3CLpro.[77] Some of the small molecules also act as an inhibitor that is arylboronic acids, quinolinecarboxylate derivatives, thiophenecarboxylate, and phthalhydrazide-substituted ketoglutamine analogs.[77] Some flavonoids are also reported to inhibit Mpro.[75] GC376 also has protease inhibitor activity.[81] A crystal structure of Mpro with small molecule inhibitor N3 is also reported (PDB ID:"}

{"project":"LitCovid-sentences","denotations":[{"id":"T146","span":{"begin":0,"end":507},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"6.2 μM) is reported.[79] Some metal-conjugated and peptidomimetic compounds showed inhibitory activity against 3CLpro.[77] Some of the small molecules also act as an inhibitor that is arylboronic acids, quinolinecarboxylate derivatives, thiophenecarboxylate, and phthalhydrazide-substituted ketoglutamine analogs.[77] Some flavonoids are also reported to inhibit Mpro.[75] GC376 also has protease inhibitor activity.[81] A crystal structure of Mpro with small molecule inhibitor N3 is also reported (PDB ID:"}