PMC:7074424 / 23006-23650 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"517","span":{"begin":4,"end":8},"obj":"Gene"},{"id":"518","span":{"begin":9,"end":12},"obj":"Species"},{"id":"519","span":{"begin":104,"end":107},"obj":"Species"},{"id":"520","span":{"begin":231,"end":234},"obj":"Chemical"},{"id":"521","span":{"begin":284,"end":287},"obj":"Chemical"},{"id":"522","span":{"begin":526,"end":529},"obj":"Chemical"},{"id":"523","span":{"begin":585,"end":590},"obj":"Chemical"}],"attributes":[{"id":"A517","pred":"tao:has_database_id","subj":"517","obj":"Gene:54938"},{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"Tax:11118"},{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"Tax:11118"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The SERS-CoV genome encodes a number of proteins. The replicase gene, which is a major component of the CoV genome encoded for 16 NSPs in the form of two large PPs (PP1a and PP1ab).[74] Two types of cysteine proteases act on these PPs to release the NSPs. The C-terminal end of these PPs is cleaved by chymotrypsin-like cysteine protease (main protease [Mpro] or 3C-like protease [3CLpro]) and the N-terminal end is processed by the Mpro (also known as papain-like protease [PLpro]).[74] The first three cleavage sites of the PPs is cut by PLpro while the rest 11 sites are cleaved by CLpro, and this cleavage results in release of 16 NSPs.[75]"}

{"project":"2_test","denotations":[{"id":"32201449-16306591-47217115","span":{"begin":182,"end":184},"obj":"16306591"},{"id":"32201449-16306591-47217116","span":{"begin":484,"end":486},"obj":"16306591"},{"id":"32201449-31724441-47217117","span":{"begin":641,"end":643},"obj":"31724441"},{"id":"T36550","span":{"begin":182,"end":184},"obj":"16306591"},{"id":"T90942","span":{"begin":484,"end":486},"obj":"16306591"},{"id":"T76544","span":{"begin":641,"end":643},"obj":"31724441"}],"text":"The SERS-CoV genome encodes a number of proteins. The replicase gene, which is a major component of the CoV genome encoded for 16 NSPs in the form of two large PPs (PP1a and PP1ab).[74] Two types of cysteine proteases act on these PPs to release the NSPs. The C-terminal end of these PPs is cleaved by chymotrypsin-like cysteine protease (main protease [Mpro] or 3C-like protease [3CLpro]) and the N-terminal end is processed by the Mpro (also known as papain-like protease [PLpro]).[74] The first three cleavage sites of the PPs is cut by PLpro while the rest 11 sites are cleaved by CLpro, and this cleavage results in release of 16 NSPs.[75]"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T790","span":{"begin":13,"end":19},"obj":"SO:0001026"},{"id":"T789","span":{"begin":64,"end":68},"obj":"SO:0000704"},{"id":"T788","span":{"begin":108,"end":114},"obj":"SO:0001026"},{"id":"T787","span":{"begin":165,"end":169},"obj":"PG_16;PR:000003209"},{"id":"T786","span":{"begin":174,"end":179},"obj":"PG_15;PR:000001623"},{"id":"T785","span":{"begin":250,"end":254},"obj":"GO:0005643"},{"id":"T784","span":{"begin":291,"end":298},"obj":"MOP:0000780"},{"id":"T783","span":{"begin":504,"end":512},"obj":"MOP:0000780"},{"id":"T782","span":{"begin":533,"end":536},"obj":"MOP:0000780"},{"id":"T781","span":{"begin":574,"end":581},"obj":"MOP:0000780"},{"id":"T780","span":{"begin":601,"end":609},"obj":"MOP:0000780"}],"text":"The SERS-CoV genome encodes a number of proteins. The replicase gene, which is a major component of the CoV genome encoded for 16 NSPs in the form of two large PPs (PP1a and PP1ab).[74] Two types of cysteine proteases act on these PPs to release the NSPs. The C-terminal end of these PPs is cleaved by chymotrypsin-like cysteine protease (main protease [Mpro] or 3C-like protease [3CLpro]) and the N-terminal end is processed by the Mpro (also known as papain-like protease [PLpro]).[74] The first three cleavage sites of the PPs is cut by PLpro while the rest 11 sites are cleaved by CLpro, and this cleavage results in release of 16 NSPs.[75]"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T250","span":{"begin":13,"end":19},"obj":"Body_part"},{"id":"T251","span":{"begin":40,"end":48},"obj":"Body_part"},{"id":"T252","span":{"begin":64,"end":68},"obj":"Body_part"},{"id":"T253","span":{"begin":108,"end":114},"obj":"Body_part"},{"id":"T254","span":{"begin":199,"end":207},"obj":"Body_part"},{"id":"T255","span":{"begin":320,"end":328},"obj":"Body_part"}],"attributes":[{"id":"A250","pred":"fma_id","subj":"T250","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A251","pred":"fma_id","subj":"T251","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A252","pred":"fma_id","subj":"T252","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A253","pred":"fma_id","subj":"T253","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma82751"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma82751"}],"text":"The SERS-CoV genome encodes a number of proteins. The replicase gene, which is a major component of the CoV genome encoded for 16 NSPs in the form of two large PPs (PP1a and PP1ab).[74] Two types of cysteine proteases act on these PPs to release the NSPs. The C-terminal end of these PPs is cleaved by chymotrypsin-like cysteine protease (main protease [Mpro] or 3C-like protease [3CLpro]) and the N-terminal end is processed by the Mpro (also known as papain-like protease [PLpro]).[74] The first three cleavage sites of the PPs is cut by PLpro while the rest 11 sites are cleaved by CLpro, and this cleavage results in release of 16 NSPs.[75]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T247","span":{"begin":28,"end":29},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T248","span":{"begin":64,"end":68},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T249","span":{"begin":79,"end":80},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T250","span":{"begin":561,"end":563},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"}],"text":"The SERS-CoV genome encodes a number of proteins. The replicase gene, which is a major component of the CoV genome encoded for 16 NSPs in the form of two large PPs (PP1a and PP1ab).[74] Two types of cysteine proteases act on these PPs to release the NSPs. The C-terminal end of these PPs is cleaved by chymotrypsin-like cysteine protease (main protease [Mpro] or 3C-like protease [3CLpro]) and the N-terminal end is processed by the Mpro (also known as papain-like protease [PLpro]).[74] The first three cleavage sites of the PPs is cut by PLpro while the rest 11 sites are cleaved by CLpro, and this cleavage results in release of 16 NSPs.[75]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T276","span":{"begin":40,"end":48},"obj":"Chemical"},{"id":"T277","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T278","span":{"begin":320,"end":328},"obj":"Chemical"}],"attributes":[{"id":"A276","pred":"chebi_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"},{"id":"A278","pred":"chebi_id","subj":"T278","obj":"http://purl.obolibrary.org/obo/CHEBI_15356"}],"text":"The SERS-CoV genome encodes a number of proteins. The replicase gene, which is a major component of the CoV genome encoded for 16 NSPs in the form of two large PPs (PP1a and PP1ab).[74] Two types of cysteine proteases act on these PPs to release the NSPs. The C-terminal end of these PPs is cleaved by chymotrypsin-like cysteine protease (main protease [Mpro] or 3C-like protease [3CLpro]) and the N-terminal end is processed by the Mpro (also known as papain-like protease [PLpro]).[74] The first three cleavage sites of the PPs is cut by PLpro while the rest 11 sites are cleaved by CLpro, and this cleavage results in release of 16 NSPs.[75]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T135","span":{"begin":0,"end":49},"obj":"Sentence"},{"id":"T136","span":{"begin":50,"end":255},"obj":"Sentence"},{"id":"T137","span":{"begin":256,"end":644},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The SERS-CoV genome encodes a number of proteins. The replicase gene, which is a major component of the CoV genome encoded for 16 NSPs in the form of two large PPs (PP1a and PP1ab).[74] Two types of cysteine proteases act on these PPs to release the NSPs. The C-terminal end of these PPs is cleaved by chymotrypsin-like cysteine protease (main protease [Mpro] or 3C-like protease [3CLpro]) and the N-terminal end is processed by the Mpro (also known as papain-like protease [PLpro]).[74] The first three cleavage sites of the PPs is cut by PLpro while the rest 11 sites are cleaved by CLpro, and this cleavage results in release of 16 NSPs.[75]"}