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PMC:7074424 / 21031-22301 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
474 878-898 Gene denotes nucleocapsid protein Gene:918763
475 282-302 Gene denotes nucleocapsid protein Gene:918763
476 620-629 Species denotes HCoV-OC43 Tax:31631
477 718-721 Species denotes CoV Tax:11118
478 752-755 Species denotes COV Tax:11118
479 1257-1265 Species denotes SARS-CoV Tax:694009
480 756-760 Species denotes OC43 Tax:31631
481 137-169 Chemical denotes ribonucleoside 5'-monophosphates
482 171-174 Chemical denotes AMP MESH:D000249
483 176-179 Chemical denotes UMP MESH:D014542
484 181-184 Chemical denotes CMP MESH:D003568
485 190-193 Chemical denotes GMP MESH:C066524
486 248-251 Chemical denotes AMP MESH:D000249
487 256-259 Chemical denotes UMP MESH:D014542
488 520-582 Chemical denotes N-(6-oxo-5,6-dihydrophenanthridine-2-yl) (N, N dimethyl amino)
489 584-588 Chemical denotes PJ34 MESH:C434926
490 652-656 Chemical denotes PJ34 MESH:C434926
491 782-786 Chemical denotes PJ34 MESH:C434926
492 862-866 Chemical denotes PJ34 MESH:C434926
493 939-941 Chemical denotes H3 MESH:C012616
494 943-1005 Chemical denotes 6-chloro-7-(2-morpholin-4-yl-ethylamino) quinoxaline-5,8-dione
495 1138-1154 Chemical denotes catechin gallate MESH:C417939
496 1159-1180 Chemical denotes gallocatechin gallate MESH:C417940
497 1191-1213 Chemical denotes polyphenolic compounds
498 422-425 CellLine denotes LM9 CVCL:5998
499 428-431 CellLine denotes LM7 CVCL:0515

2_test

Id Subject Object Predicate Lexical cue
32201449-24564608-47217103 196-198 24564608 denotes 26
32201449-24564608-47217104 457-459 24564608 denotes 26
32201449-24564608-47217105 637-639 24564608 denotes 26
32201449-24564608-47217106 723-725 24564608 denotes 26
32201449-24564608-47217107 821-823 24564608 denotes 26
32201449-24564608-47217108 1041-1043 24564608 denotes 26
32201449-26542199-47217109 1041-1045 26542199 denotes 2669
32201449-22619553-47217110 1267-1269 22619553 denotes 70
T31743 196-198 24564608 denotes 26
T60843 457-459 24564608 denotes 26
T45276 637-639 24564608 denotes 26
T26983 723-725 24564608 denotes 26
T31768 821-823 24564608 denotes 26
T96844 1041-1043 24564608 denotes 26
T90388 1041-1045 26542199 denotes 2669
T27065 1267-1269 22619553 denotes 70

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T648 878-898 PG_4 denotes nucleocapsid protein
T647 908-917 CHEBI:35222;CHEBI:35222 denotes inhibitor
T646 957-966 CHEBI:34856;CHEBI:34856 denotes morpholin
T645 966-972 CHEBI:53233;CHEBI:53233 denotes -4-yl-
T644 972-982 CHEBI:27750;CHEBI:27750 denotes ethylamino
T643 982-983 CHEBI:53233;CHEBI:53233 denotes )
T642 984-995 CHEBI:36616;CHEBI:36616 denotes quinoxaline
T641 995-1005 CHEBI:53233;CHEBI:53233 denotes -5,8-dione
T640 1138-1146 CHEBI:23053;CHEBI:23053 denotes catechin
T639 1147-1154 CHEBI:16918;CHEBI:16918 denotes gallate
T638 1159-1172 CHEBI:68330;CHEBI:68330 denotes gallocatechin
T637 1173-1180 CHEBI:16918;CHEBI:16918 denotes gallate
T636 1191-1203 CHEBI:26195;CHEBI:26195 denotes polyphenolic
T635 1204-1213 CHEBI:36357;CHEBI:36357 denotes compounds
T634 1257-1265 SP_10 denotes SARS-CoV
T668 17-22 SO:0000410 denotes sites
T667 23-26 SO:0000235 denotes for
T666 48-61 SO:0000409 denotes binding sites
T665 76-85 PG_4 denotes N protein
T664 282-302 PG_4 denotes nucleocapsid protein
T663 304-314 CHEBI:35222;CHEBI:35222 denotes inhibitors
T662 382-389 GO:0032991 denotes complex
T661 470-478 CHEBI:36357;CHEBI:36357 denotes molecule
T660 520-521 CHEBI:7586;CHEBI:7586 denotes N
T659 521-522 CHEBI:82321;CHEBI:82321 denotes -
T658 522-525 CHEBI:75508;CHEBI:75508 denotes (6-
T657 525-528 CHEBI:46629;CHEBI:46629 denotes oxo
T656 528-531 CHEBI:75508;CHEBI:75508 denotes -5,
T655 531-554 CHEBI:53233;CHEBI:53233 denotes 6-dihydrophenanthridine
T654 554-555 CHEBI:75508;CHEBI:75508 denotes -
T653 555-559 CHEBI:53233;CHEBI:53233 denotes 2-yl
T652 676-682 SO:0001026 denotes genome
T651 695-706 GO:0006260 denotes replication
T650 772-781 CHEBI:35222;CHEBI:35222 denotes inhibitor
T649 787-794 GO:0032991 denotes complex

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T231 27-30 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T232 44-47 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T233 78-85 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T234 295-302 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T235 318-321 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T236 676-682 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T237 891-898 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T238 939-941 Body_part denotes H3 http://purl.org/sig/ont/fma/fma84131
T239 1028-1031 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T240 1088-1091 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T108 4-7 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T110 69-72 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T112 275-278 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T114 660-663 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T116 763-766 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T118 871-874 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T120 1081-1084 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T122 1257-1265 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 1257-1261 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T229 78-85 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T230 137-169 Chemical denotes ribonucleoside 5'-monophosphates http://purl.obolibrary.org/obo/CHEBI_37010
T231 137-151 Chemical denotes ribonucleoside http://purl.obolibrary.org/obo/CHEBI_18254
T232 171-174 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T235 176-179 Chemical denotes UMP http://purl.obolibrary.org/obo/CHEBI_16695|http://purl.obolibrary.org/obo/CHEBI_57865
T237 181-184 Chemical denotes CMP http://purl.obolibrary.org/obo/CHEBI_17361|http://purl.obolibrary.org/obo/CHEBI_60377
T239 190-193 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T241 248-251 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T244 256-259 Chemical denotes UMP http://purl.obolibrary.org/obo/CHEBI_16695|http://purl.obolibrary.org/obo/CHEBI_57865
T246 295-302 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T247 304-314 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T248 470-478 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T249 525-528 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T250 567-575 Chemical denotes dimethyl http://purl.obolibrary.org/obo/CHEBI_33601|http://purl.obolibrary.org/obo/CHEBI_42266
T252 576-581 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T253 772-781 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T254 811-813 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T255 891-898 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T256 908-917 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T257 945-951 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T258 984-995 Chemical denotes quinoxaline http://purl.obolibrary.org/obo/CHEBI_36616
T259 1138-1146 Chemical denotes catechin http://purl.obolibrary.org/obo/CHEBI_23053
T260 1147-1154 Chemical denotes gallate http://purl.obolibrary.org/obo/CHEBI_16918
T261 1159-1172 Chemical denotes gallocatechin http://purl.obolibrary.org/obo/CHEBI_31018|http://purl.obolibrary.org/obo/CHEBI_68330
T263 1173-1180 Chemical denotes gallate http://purl.obolibrary.org/obo/CHEBI_16918

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T59 1019-1039 http://purl.obolibrary.org/obo/GO_1905215 denotes inhibits RNA binding

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T125 0-39 Sentence denotes The NTD contains sites for RNA binding.
T126 40-344 Sentence denotes The RNA-binding sites on the NTD of N protein were identified by observing its interactions with ribonucleoside 5'-monophosphates (AMP, UMP, CMP, and GMP).[26] Using the information about interaction between AMP and UMP binding to the NTD of nucleocapsid protein, inhibitors of RNA binding were designed.
T127 345-814 Sentence denotes Three-dimensional structure with all complex can see from PDB that is 4LMC, 4LM9, 4LM7, and 4LI4, respectively.[26] One such molecule which was designed with this strategy is N-(6-oxo-5,6-dihydrophenanthridine-2-yl) (N, N dimethyl amino) (PJ34), which was designed using the HCoV-OC43 model.[26] Binding of PJ34 on NTD affects the genome binding and replication process of CoV.[26] The crystal structure of COV-OC43 N-NTD with inhibitor PJ34 complex is given in PDB ID:
T128 815-1100 Sentence denotes 4KXJ.[26] On the basis of interactions between PJ34 and NTD of nucleocapsid protein, another inhibitor was designed that is H3 (6-chloro-7-(2-morpholin-4-yl-ethylamino) quinoxaline-5,8-dione), which also inhibits RNA binding.[2669] This highlights the importance of NTD in RNA binding.
T129 1101-1270 Sentence denotes Some of the herbal products, such as catechin gallate and gallocatechin gallate (both are polyphenolic compounds), have shown the inhibitory action against SARS-CoV.[70]