PMC:7074424 / 14751-15258 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"324","span":{"begin":33,"end":41},"obj":"Species"},{"id":"328","span":{"begin":89,"end":97},"obj":"Species"},{"id":"329","span":{"begin":162,"end":171},"obj":"Disease"},{"id":"333","span":{"begin":251,"end":260},"obj":"Species"},{"id":"334","span":{"begin":300,"end":303},"obj":"Species"},{"id":"335","span":{"begin":177,"end":181},"obj":"Species"},{"id":"343","span":{"begin":477,"end":488},"obj":"Chemical"}],"attributes":[{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Tax:694009"},{"id":"A328","pred":"tao:has_database_id","subj":"328","obj":"Tax:694009"},{"id":"A329","pred":"tao:has_database_id","subj":"329","obj":"MESH:D007239"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"Tax:31631"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"Tax:11118"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"Tax:31631"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"MESH:D002738"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"2_test","denotations":[{"id":"32201449-19198616-47217060","span":{"begin":79,"end":81},"obj":"19198616"},{"id":"32201449-16153058-47217061","span":{"begin":79,"end":83},"obj":"16153058"},{"id":"32201449-16510163-47217062","span":{"begin":79,"end":85},"obj":"16510163"},{"id":"32201449-30989115-47217063","span":{"begin":173,"end":175},"obj":"30989115"},{"id":"32201449-30989115-47217064","span":{"begin":332,"end":334},"obj":"30989115"},{"id":"32201449-30989115-47217065","span":{"begin":473,"end":475},"obj":"30989115"},{"id":"T12042","span":{"begin":79,"end":81},"obj":"19198616"},{"id":"T73573","span":{"begin":79,"end":83},"obj":"16153058"},{"id":"T58379","span":{"begin":79,"end":85},"obj":"16510163"},{"id":"T34405","span":{"begin":173,"end":175},"obj":"30989115"},{"id":"T24383","span":{"begin":332,"end":334},"obj":"30989115"},{"id":"T42014","span":{"begin":473,"end":475},"obj":"30989115"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T427","span":{"begin":33,"end":41},"obj":"SP_10"},{"id":"T426","span":{"begin":47,"end":51},"obj":"CL_6"},{"id":"T425","span":{"begin":89,"end":97},"obj":"SP_10"},{"id":"T424","span":{"begin":111,"end":119},"obj":"GO:0042571"},{"id":"T423","span":{"begin":241,"end":247},"obj":"SO:0000417"},{"id":"T422","span":{"begin":410,"end":415},"obj":"SO:0001114"},{"id":"T421","span":{"begin":465,"end":471},"obj":"SO:0000417"},{"id":"T420","span":{"begin":477,"end":488},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T419","span":{"begin":493,"end":505},"obj":"CHEBI:67079;CHEBI:67079"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T136","span":{"begin":52,"end":57},"obj":"Body_part"},{"id":"T137","span":{"begin":111,"end":119},"obj":"Body_part"},{"id":"T138","span":{"begin":351,"end":358},"obj":"Body_part"},{"id":"T139","span":{"begin":410,"end":415},"obj":"Body_part"}],"attributes":[{"id":"A136","pred":"fma_id","subj":"T136","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma60992"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T18","span":{"begin":410,"end":415},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0002488"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T74","span":{"begin":33,"end":41},"obj":"Disease"},{"id":"T75","span":{"begin":33,"end":37},"obj":"Disease"},{"id":"T76","span":{"begin":89,"end":97},"obj":"Disease"},{"id":"T77","span":{"begin":89,"end":93},"obj":"Disease"},{"id":"T78","span":{"begin":162,"end":171},"obj":"Disease"}],"attributes":[{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A77","pred":"mondo_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A78","pred":"mondo_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T159","span":{"begin":47,"end":51},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T160","span":{"begin":47,"end":51},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T161","span":{"begin":52,"end":57},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T162","span":{"begin":87,"end":88},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T163","span":{"begin":188,"end":189},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T164","span":{"begin":190,"end":197},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T165","span":{"begin":238,"end":240},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T166","span":{"begin":238,"end":240},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T167","span":{"begin":296,"end":299},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9596"},{"id":"T168","span":{"begin":399,"end":400},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T141","span":{"begin":190,"end":197},"obj":"Chemical"},{"id":"T142","span":{"begin":238,"end":240},"obj":"Chemical"},{"id":"T143","span":{"begin":351,"end":358},"obj":"Chemical"},{"id":"T144","span":{"begin":375,"end":377},"obj":"Chemical"},{"id":"T145","span":{"begin":477,"end":488},"obj":"Chemical"},{"id":"T146","span":{"begin":493,"end":505},"obj":"Chemical"}],"attributes":[{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_141439"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_38068"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}

{"project":"LitCovid-sentences","denotations":[{"id":"T99","span":{"begin":87,"end":176},"obj":"Sentence"},{"id":"T100","span":{"begin":177,"end":476},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"teraction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]\nA SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]\nOC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]\nChloroquine, an antimalarial a"}