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PMC:7074424 / 12349-17019 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
285 666-670 Gene denotes ACE2 Gene:59272
286 37-42 Species denotes clove Tax:219868
287 516-519 Species denotes CoV Tax:11118
288 682-690 Species denotes SARS-CoV Tax:694009
289 711-719 Species denotes MERS-CoV Tax:1335626
290 805-808 Species denotes CoV Tax:11118
291 1015-1018 Species denotes CoV Tax:11118
305 1271-1276 Gene denotes ACE-2 Gene:59272
306 1385-1390 Gene denotes ACE-2 Gene:59272
307 1528-1533 Gene denotes ACE-2 Gene:59272
308 1572-1577 Gene denotes ACE-2 Gene:59272
309 1581-1586 Gene denotes DPP-4 Gene:1803
310 1615-1620 Gene denotes ACE-2 Gene:103231639
311 1857-1863 Gene denotes L-SIGN Gene:10332
312 2023-2029 Gene denotes L-SIGN Gene:10332
313 2034-2041 Gene denotes DC-SIGN Gene:30835
314 1327-1335 Species denotes SARS-CoV Tax:694009
315 1898-1907 Gene denotes S protein Gene:43740568
316 1972-1982 Chemical denotes asparagine MESH:D001216
317 1674-1676 CellLine denotes E6 CVCL:4582
319 2222-2231 Gene denotes S protein Gene:43740568
323 2394-2399 Gene denotes ACE-2 Gene:59272
324 2435-2443 Species denotes SARS-CoV Tax:694009
325 2367-2376 Gene denotes S protein Gene:43740568
328 2491-2499 Species denotes SARS-CoV Tax:694009
329 2564-2573 Disease denotes infection MESH:D007239
333 2653-2662 Species denotes HCoV-OC43 Tax:31631
334 2702-2705 Species denotes CoV Tax:11118
335 2579-2583 Species denotes OC43 Tax:31631
340 3003-3008 Gene denotes ACE-2 Gene:59272
341 2924-2928 Gene denotes SERS Gene:54938
342 2929-2932 Species denotes CoV Tax:11118
343 2879-2890 Chemical denotes Chloroquine MESH:D002738
346 3113-3117 Gene denotes ACE2 Gene:59272
347 3167-3178 Gene denotes cathepsin L Gene:1514
359 3344-3349 Gene denotes ACE-2 Gene:59272
360 3420-3425 Gene denotes ACE-2 Gene:59272
361 3379-3384 Species denotes human Tax:9606
362 3728-3736 Species denotes SARS-CoV Tax:694009
363 3747-3755 Species denotes SARS-CoV Tax:694009
364 3579-3586 Chemical denotes glucose MESH:D005947
365 3636-3654 Disease denotes SARS-CoV infection MESH:C000657245
366 3663-3677 Disease denotes virus-infected MESH:D001102
367 3398-3402 CellLine denotes 293T CVCL:0063
368 3526-3528 CellLine denotes E6 CVCL:4582
369 3683-3685 CellLine denotes E6 CVCL:4582
375 3916-3919 Gene denotes Fab Gene:2187
376 3838-3845 Species denotes persons Tax:9606
377 3942-3950 Species denotes SARS-CoV Tax:694009
378 3888-3896 Species denotes SARS-CoV Tax:694009
379 3820-3837 Disease denotes SARS-CoV-infected MESH:C000657245
389 4354-4359 Gene denotes ACE-2 Gene:59272
390 4215-4219 Gene denotes SERS Gene:54938
391 4220-4223 Species denotes CoV Tax:11118
392 4225-4240 Species denotes transgenic mice Tax:10090
393 4278-4285 Species denotes persons Tax:9606
394 4406-4411 Species denotes human Tax:9606
395 4412-4420 Species denotes SARS-CoV Tax:694009
396 4265-4277 Disease denotes CoV-infected MESH:D018352
397 4393-4402 Disease denotes infection MESH:D007239
400 4474-4478 Species denotes Mice Tax:10090
401 4495-4501 Chemical denotes SARS-n

2_test

Id Subject Object Predicate Lexical cue
32201449-22816037-47217043 70-71 22816037 denotes 2
32201449-22816037-47217044 231-232 22816037 denotes 2
32201449-22816037-47217045 521-522 22816037 denotes 2
32201449-27578435-47217046 596-598 27578435 denotes 10
32201449-27578435-47217047 934-936 27578435 denotes 10
32201449-27578435-47217048 1020-1022 27578435 denotes 10
32201449-28393837-47217049 1203-1205 28393837 denotes 40
32201449-19198616-47217050 1248-1250 19198616 denotes 25
32201449-14715271-47217051 1351-1353 14715271 denotes 45
32201449-19198616-47217052 1535-1537 19198616 denotes 25
32201449-14647384-47217053 1684-1686 14647384 denotes 14
32201449-14715271-47217054 1684-1688 14715271 denotes 1445
32201449-15496474-47217055 1892-1894 15496474 denotes 46
32201449-15140961-47217056 1892-1896 15140961 denotes 4647
32201449-17715238-47217057 2075-2077 17715238 denotes 48
32201449-19198616-47217058 2181-2183 19198616 denotes 25
32201449-19198616-47217059 2305-2307 19198616 denotes 25
32201449-19198616-47217060 2481-2483 19198616 denotes 25
32201449-16153058-47217061 2481-2485 16153058 denotes 2549
32201449-16510163-47217062 2481-2487 16510163 denotes 254950
32201449-30989115-47217063 2575-2577 30989115 denotes 39
32201449-30989115-47217064 2734-2736 30989115 denotes 39
32201449-30989115-47217065 2875-2877 30989115 denotes 39
32201449-16115318-47217066 3071-3073 16115318 denotes 51
32201449-23678171-47217067 3279-3281 23678171 denotes 52
32201449-15380189-47217068 3391-3393 15380189 denotes 53
32201449-15380189-47217069 3514-3516 15380189 denotes 53
32201449-15380189-47217070 3656-3658 15380189 denotes 53
32201449-19198616-47217071 3769-3771 19198616 denotes 25
32201449-15652970-47217072 3769-3773 15652970 denotes 2554
32201449-30712865-47217073 3898-3900 30712865 denotes 55
32201449-30712865-47217074 4049-4051 30712865 denotes 55
32201449-16597622-47217075 4139-4141 16597622 denotes 56
32201449-19198616-47217076 4287-4289 19198616 denotes 25
32201449-19198616-47217077 4470-4472 19198616 denotes 25
32201449-15755609-47217078 4572-4574 15755609 denotes 57
T60572 70-71 22816037 denotes 2
T55396 231-232 22816037 denotes 2
T90917 521-522 22816037 denotes 2
T51025 596-598 27578435 denotes 10
T33030 934-936 27578435 denotes 10
T44754 1020-1022 27578435 denotes 10
T34407 1203-1205 28393837 denotes 40
T94307 1248-1250 19198616 denotes 25
T78902 1351-1353 14715271 denotes 45
T49316 1535-1537 19198616 denotes 25
T22941 1684-1686 14647384 denotes 14
T71142 1684-1688 14715271 denotes 1445
T39791 1892-1894 15496474 denotes 46
T81241 1892-1896 15140961 denotes 4647
T3268 2075-2077 17715238 denotes 48
T15470 2181-2183 19198616 denotes 25
T48939 2305-2307 19198616 denotes 25
T12042 2481-2483 19198616 denotes 25
T73573 2481-2485 16153058 denotes 2549
T58379 2481-2487 16510163 denotes 254950
T34405 2575-2577 30989115 denotes 39
T24383 2734-2736 30989115 denotes 39
T42014 2875-2877 30989115 denotes 39
T95658 3071-3073 16115318 denotes 51
T99909 3279-3281 23678171 denotes 52
T73009 3391-3393 15380189 denotes 53
T80388 3514-3516 15380189 denotes 53
T87331 3656-3658 15380189 denotes 53
T19561 3769-3771 19198616 denotes 25
T66480 3769-3773 15652970 denotes 2554
T71434 3898-3900 30712865 denotes 55
T4831 4049-4051 30712865 denotes 55
T48540 4139-4141 16597622 denotes 56
T79542 4287-4289 19198616 denotes 25
T11089 4470-4472 19198616 denotes 25
T96562 4572-4574 15755609 denotes 57

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T487 158-171 GO:0005622 denotes intracellular
T486 172-178 SO:0000417 denotes domain
T485 200-213 GO:0005622 denotes intracellular
T484 258-264 SO:0000417 denotes domain
T483 290-298 GO:0016020;GO:0061025 denotes membrane
T482 299-305 GO:0061025 denotes fusion
T481 569-574 NCBITaxon:10239;GO:0035376 denotes virus
T480 575-580 GO:0035376 denotes entry
T479 636-642 SO:0000417 denotes domain
T478 666-670 G_3;PG_10;PR:000003622 denotes ACE2
T477 682-690 SP_10 denotes SARS-CoV
T476 711-719 SP_9 denotes MERS-CoV
T475 756-765 GO:0061025 denotes fusion of
T474 770-774 GO:0018995 denotes host
T473 779-784 NCBITaxon:10239;GO:0036338 denotes viral
T472 785-794 GO:0036338 denotes membranes
T471 805-808 NCBITaxon:11886 denotes CoV
T470 814-820 SO:0001026 denotes genome
T469 913-917 CHEBI:23888;CHEBI:23888 denotes drug
T468 975-981 UBERON:0002405;GO:0006955 denotes immune
T467 982-993 GO:0006955 denotes response of
T466 1028-1034 SO:0000417 denotes domain
T465 1065-1071 SO:0000417 denotes domain
T464 1091-1097 SO:0000417 denotes domain
T463 1123-1129 SO:0000417 denotes domain
T462 1144-1150 SO:0000417 denotes domain
T461 1167-1174 CHEBI:59132;CHEBI:59132 denotes antigen
T460 1182-1189 GO:0009986 denotes surface
T459 1197-1202 NCBITaxon:10239 denotes virus
T458 1203-1205 NCBITaxon:10633 denotes 40
T457 1234-1240 SO:0000417 denotes domain
T456 1271-1276 G_3;PG_10;PR:000003622 denotes ACE-2
T455 1327-1335 SP_10 denotes SARS-CoV
T454 1385-1390 G_3;PG_10;PR:000003622 denotes ACE-2
T453 1528-1533 G_3;PG_10;PR:000003622 denotes ACE-2
T452 1546-1552 SO:0000417 denotes domain
T451 1572-1577 G_3;PG_10;PR:000003622 denotes ACE-2
T450 1581-1586 PG_7;PR:000001341 denotes DPP-4
T449 1615-1620 G_3;PG_10;PR:000003622 denotes ACE-2
T448 1621-1629 GO:0042571 denotes antibody
T447 1638-1643 NCBITaxon:10239;GO:0035376 denotes viral
T446 1644-1649 GO:0035376 denotes entry
T445 1654-1665 GO:0006260 denotes replication
T444 1669-1673 CL_6 denotes Vero
T443 1715-1720 NCBITaxon:10239 denotes virus
T442 1755-1764 GO:0030425 denotes dendritic
T441 1779-1801 PR:000001468 denotes intercellular adhesion
T440 1802-1810 PR:000001468;CHEBI:36357;CHEBI:36357 denotes molecule
T439 1810-1812 PR:000001468 denotes -3
T438 1857-1863 PR:000001294 denotes L-SIGN
T437 1867-1878 UBERON:0000029 denotes lymph nodes
T436 1885-1890 UBERON:0002107 denotes liver
T435 1898-1907 PG_1 denotes S protein
T434 2023-2029 PR:000001294 denotes L-SIGN
T433 2048-2053 NCBITaxon:10239 denotes virus
T432 2186-2190 CHEBI:23888;CHEBI:23888 denotes Drug
T431 2222-2231 PG_1 denotes S protein
T430 2281-2285 CHEBI:23888;CHEBI:23888 denotes drug
T429 2367-2376 PG_1 denotes S protein
T428 2394-2399 G_3;PG_10;PR:000003622 denotes ACE-2
T427 2435-2443 SP_10 denotes SARS-CoV
T426 2449-2453 CL_6 denotes Vero
T425 2491-2499 SP_10 denotes SARS-CoV
T424 2513-2521 GO:0042571 denotes antibody
T423 2643-2649 SO:0000417 denotes domain
T422 2812-2817 SO:0001114 denotes helix
T421 2867-2873 SO:0000417 denotes domain
T420 2879-2890 CHEBI:3638;DG_10;CHEBI:3638 denotes Chloroquine
T419 2895-2907 CHEBI:67079;CHEBI:67079 denotes antimalarial
T418 2949-2958 GO:0005768 denotes endosomal
T417 3003-3008 G_3;PG_10;PR:000003622 denotes ACE-2
T416 3047-3052 NCBITaxon:10239 denotes virus
T415 3081-3091 CHEBI:35222;CHEBI:35222 denotes inhibitors
T414 3092-3100 PG_1 denotes SSAA09E2
T413 3113-3117 G_3;PG_10;PR:000003622 denotes ACE2
T412 3153-3157 GO:0018995 denotes host
T411 3203-3208 NCBITaxon:10239;GO:0035376 denotes viral
T410 3209-3214 GO:0035376 denotes entry
T409 3249-3253 GO:0018995 denotes host
T408 3258-3263 NCBITaxon:10239 denotes viral
T407 3264-3277 GO:0005886 denotes cell membrane
T406 3314-3323 CHEBI:36357;CHEBI:36357 denotes molecules
T405 3344-3349 G_3;PG_10;PR:000003622 denotes ACE-2
T404 3368-3373 NCBITaxon:10239 denotes virus
T403 3379-3384 SP_6;NCBITaxon:9606 denotes human
T402 3398-3402 CL_4 denotes 293T
T401 3409-3419 GO:0010467 denotes expressing
T400 3420-3425 G_3;PG_10;PR:000003622 denotes ACE-2
T399 3490-3494 SP_10 denotes SARS
T398 3495-3506 NCBITaxon:11886 denotes pseudovirus
T397 3521-3525 CL_6 denotes Vero
T396 3546-3555 CHEBI:36357;CHEBI:36357 denotes molecules
T395 3556-3561 CHEBI:75055;CHEBI:75055 denotes tetra
T394 3561-3564 CHEBI:17634;CHEBI:17634 denotes -O-
T393 3564-3586 CHEBI:24183;CHEBI:24183 denotes galloyl beta-D-glucose
T392 3591-3599 CHEBI:15864;CHEBI:15864 denotes luteolin
T391 3615-3619 SP_10 denotes SARS
T390 3620-3631 NCBITaxon:11886;SO:0000336 denotes pseudovirus
T389 3636-3644 SP_10 denotes SARS-CoV
T388 3663-3668 NCBITaxon:10239 denotes virus
T387 3678-3682 CL_6 denotes Vero
T386 3695-3700 SO:0000646 denotes siRNA
T385 3728-3736 SP_10 denotes SARS-CoV
T384 3747-3755 SP_10 denotes SARS-CoV
T383 3756-3767 GO:0006260 denotes replication
T382 3784-3792 GO:0042571 denotes antibody
T381 3802-3808 GO:0007613 denotes memory
T380 3809-3816 CL:0000787 denotes B-cells
T379 3820-3828 SP_10 denotes SARS-CoV
T378 3838-3845 NCBITaxon:1 denotes persons
T377 3888-3896 SP_10 denotes SARS-CoV
T376 3907-3915 GO:0042571 denotes antibody
T375 3942-3950 SP_10 denotes SARS-CoV
T374 3951-3958 GO:0032991 denotes complex
T373 4068-4076 GO:0042571 denotes antibody
T372 4154-4162 GO:0042571 denotes antibody
T371 4236-4240 NCBITaxon:10088 denotes mice
T370 4254-4261 CL:0000236 denotes B-cells
T369 4265-4268 NCBITaxon:11118 denotes CoV
T368 4317-4327 GO:0042571 denotes antibodies
T367 4354-4359 G_3;PG_10;PR:000003622 denotes ACE-2
T366 4406-4411 SP_6;NCBITaxon:9606 denotes human
T365 4412-4420 SP_10 denotes SARS-CoV
T364 4445-4455 SP_5 denotes palm civet
T363 4474-4478 NCBITaxon:10088 denotes Mice
T362 4495-4499 SP_10 denotes SARS
T361 4513-4519 GO:0042110;CL:0000084 denotes T-cell
T360 4520-4526 UBERON:0002405;GO:0006955 denotes immune
T359 4527-4535 GO:0006955 denotes response
T358 4580-4589 CL:0000910 denotes cytotoxic
T357 4590-4596 GO:0042110;CL:0000910 denotes T-cell
T356 4623-4627 SP_10 denotes SARS
T355 4632-4643 GO:0009294 denotes transfected
T354 4644-4652 UBERON:0003215;CL:0000322 denotes alveolar
T353 4653-4663 CL:0000322;UBERON:0000483 denotes epithelial
T352 4664-4669 CL:0000322 denotes cells

LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 3579-3586 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T109 6-13 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T110 24-31 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T111 61-68 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T112 83-90 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T113 380-388 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T114 534-541 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T115 736-746 Body_part denotes S2 segment http://purl.org/sig/ont/fma/fma256627
T116 810-813 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T117 814-820 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T118 846-851 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T119 868-876 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T120 948-955 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T121 1003-1007 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T122 1311-1322 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T123 1342-1349 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T124 1621-1629 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T125 1677-1682 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T126 1741-1745 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T127 1755-1769 Body_part denotes dendritic cell http://purl.org/sig/ont/fma/fma273565
T128 1765-1769 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T129 1826-1834 Body_part denotes integrin http://purl.org/sig/ont/fma/fma67222
T130 1867-1878 Body_part denotes lymph nodes http://purl.org/sig/ont/fma/fma5034
T131 1867-1872 Body_part denotes lymph http://purl.org/sig/ont/fma/fma9671
T132 1885-1890 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T133 1900-1907 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 2224-2231 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T135 2369-2376 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T136 2454-2459 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T137 2513-2521 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T138 2753-2760 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T139 2812-2817 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T140 2949-2958 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T141 3264-3277 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T142 3264-3268 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T143 3385-3389 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T144 3403-3408 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 3529-3534 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T146 3579-3586 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T147 3686-3691 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T148 3784-3792 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T149 3811-3816 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T150 3907-3915 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T151 4068-4076 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T152 4154-4162 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T153 4204-4211 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T154 4256-4261 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T155 4445-4449 Body_part denotes palm http://purl.org/sig/ont/fma/fma24920
T156 4502-4505 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T157 4515-4519 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T158 4580-4596 Body_part denotes cytotoxic T-cell http://purl.org/sig/ont/fma/fma70573
T159 4592-4596 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T160 4628-4631 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T161 4644-4669 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T162 4664-4669 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T14 220-224 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T15 1867-1878 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/UBERON_0000029
T16 1867-1872 Body_part denotes lymph http://purl.obolibrary.org/obo/UBERON_0002391
T17 1885-1890 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T18 2812-2817 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p17313s14 1506-1522 MPA denotes binding activity
p17329s18 2977-2999 MPA denotes terminal glycosylation

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T68 682-690 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 682-686 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T70 1099-1102 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T72 1327-1335 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 1327-1331 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T74 2435-2443 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T75 2435-2439 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T76 2491-2499 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 2491-2495 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T78 2564-2573 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T79 3490-3494 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T80 3615-3619 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T81 3636-3654 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T82 3636-3640 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T83 3645-3654 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 3713-3724 Disease denotes S sequences http://purl.obolibrary.org/obo/MONDO_0007821
T85 3728-3736 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 3728-3732 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T87 3747-3755 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T88 3747-3751 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T89 3820-3828 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T90 3820-3824 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T91 3888-3896 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 3888-3892 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T93 3942-3950 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 3942-3946 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T95 4393-4402 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 4412-4420 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T97 4412-4416 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T98 4495-4499 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 4623-4627 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T107 35-36 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 91-94 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T109 220-224 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T110 255-257 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T111 272-274 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T112 275-280 http://purl.obolibrary.org/obo/UBERON_0000033 denotes heads
T113 275-280 http://www.ebi.ac.uk/efo/EFO_0000964 denotes heads
T114 290-298 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T115 314-316 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T116 314-316 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T117 481-482 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T118 569-574 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T119 633-635 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T120 736-738 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T121 736-738 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T122 785-794 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T123 846-851 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T124 961-970 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T125 1003-1007 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T126 1025-1027 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T127 1062-1064 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T128 1141-1143 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T129 1159-1160 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 1197-1202 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T131 1211-1214 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T132 1215-1216 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T133 1256-1258 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T134 1351-1353 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T135 1514-1522 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T136 1532-1537 http://purl.obolibrary.org/obo/CLO_0001196 denotes 2.[25
T137 1543-1545 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T138 1669-1682 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T139 1715-1720 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T140 1741-1745 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T141 1755-1769 http://purl.obolibrary.org/obo/CL_0000451 denotes dendritic cell
T142 1867-1878 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
T143 1885-1890 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T144 1885-1890 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T145 1892-1896 http://purl.obolibrary.org/obo/CLO_0001013 denotes 4647
T146 1892-1896 http://purl.obolibrary.org/obo/CLO_0052464 denotes 4647
T147 1908-1911 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T148 2048-2053 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T149 2075-2077 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T150 2080-2082 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T151 2080-2082 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T152 2095-2097 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T153 2095-2097 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T154 2106-2109 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T155 2172-2179 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T156 2309-2310 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T157 2311-2318 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T158 2386-2388 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T159 2449-2453 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T160 2449-2453 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T161 2454-2459 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T162 2489-2490 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T163 2590-2591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 2592-2599 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T165 2640-2642 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T166 2640-2642 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T167 2698-2701 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T168 2801-2802 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T169 3047-3052 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T170 3264-3268 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T171 3269-3277 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T172 3279-3281 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T173 3305-3307 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T174 3368-3373 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T175 3379-3389 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cell
T176 3398-3402 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T177 3398-3402 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T178 3398-3402 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T179 3403-3408 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T180 3462-3463 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T181 3521-3534 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T182 3663-3668 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T183 3678-3691 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T184 3693-3694 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 3809-3816 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cells
T186 4084-4087 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T187 4088-4089 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 4254-4261 http://purl.obolibrary.org/obo/CL_0000236 denotes B-cells
T189 4403-4411 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes by human
T190 4513-4519 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T191 4590-4596 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T192 4653-4663 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T193 4664-4669 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T104 6-13 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 24-31 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T106 58-60 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T108 61-68 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T109 83-90 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T110 131-133 Chemical denotes ED http://purl.obolibrary.org/obo/CHEBI_73503
T111 143-145 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T113 314-316 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T114 370-372 Chemical denotes ED http://purl.obolibrary.org/obo/CHEBI_73503
T115 380-388 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T116 483-488 Chemical denotes crown http://purl.obolibrary.org/obo/CHEBI_37409
T117 534-541 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T118 695-697 Chemical denotes PP http://purl.obolibrary.org/obo/CHEBI_53550|http://purl.obolibrary.org/obo/CHEBI_73646
T120 736-738 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T121 868-876 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T122 913-917 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T123 948-955 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T124 1167-1174 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T125 1311-1322 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T126 1311-1316 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T127 1317-1322 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T128 1342-1349 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T129 1581-1584 Chemical denotes DPP http://purl.obolibrary.org/obo/CHEBI_34680|http://purl.obolibrary.org/obo/CHEBI_60069
T131 1802-1810 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T132 1900-1907 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T133 1972-1982 Chemical denotes asparagine http://purl.obolibrary.org/obo/CHEBI_22653
T134 2080-2082 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T135 2095-2097 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T136 2172-2179 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T137 2224-2231 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 2281-2285 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T139 2311-2318 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T140 2369-2376 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T141 2592-2599 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T142 2640-2642 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T143 2753-2760 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T144 2777-2779 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T145 2879-2890 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T146 2895-2907 Chemical denotes antimalarial http://purl.obolibrary.org/obo/CHEBI_38068
T147 3081-3091 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T148 3314-3323 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T149 3546-3555 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T150 3564-3586 Chemical denotes galloyl beta-D-glucose http://purl.obolibrary.org/obo/CHEBI_24183
T151 3572-3586 Chemical denotes beta-D-glucose http://purl.obolibrary.org/obo/CHEBI_15903
T152 3572-3576 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T153 3577-3586 Chemical denotes D-glucose http://purl.obolibrary.org/obo/CHEBI_17634|http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_42758
T156 3579-3586 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234
T157 3591-3599 Chemical denotes luteolin http://purl.obolibrary.org/obo/CHEBI_15864|http://purl.obolibrary.org/obo/CHEBI_57545
T159 4128-4130 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T160 4204-4211 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 4502-4505 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T162 4628-4631 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T21 290-305 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T22 575-594 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T23 961-990 http://purl.obolibrary.org/obo/GO_0002253 denotes activates the immune response
T24 975-990 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T25 1958-1971 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T26 2054-2073 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T27 2977-2999 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T28 2986-2999 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T29 3802-3808 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T30 4520-4535 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T87 0-13 Sentence denotes Spike protein
T88 14-373 Sentence denotes The spike protein is a clove-shaped, type I-TM protein.[2] The spike protein has three segments that are ectodomain (ED) region, TM region, and intracellular domain, which comprises the intracellular short tail part.[2] The receptor-binding S1 domain (three S1 heads) and the membrane fusion subunit S2 (trimeric stalk) on C-terminal together comprise the ED.
T89 374-1023 Sentence denotes Spike proteins gather in the trimeric form on the outer surface of the virion, giving it the appearance of a crown, due to which it is called CoV.[2] The spike protein plays an important role in virus entry into the host.[10] Initial interactions between the S1 domain and its host receptor (ACE2 in case of SARS-CoV and PP 4 In case of MERS-CoV) and subsequent S2 segment mediated fusion of the host and viral membranes allow the CoV- RNA genome to enter inside the host cells and thus, these proteins represent as important targets from drug discovery side.[10] The spike protein also activates the immune response of the host cell toward CoV.[10]
T90 1025-1034 Sentence denotes S1 domain
T91 1035-1136 Sentence denotes The main components of the S1 domain are the N-terminal domain (NTD) and the C-terminal domain (CTD).
T92 1137-1444 Sentence denotes The S1 domain acts as a major antigen on the surface of the virus[40] and has a receptor-binding domain (RBD).[25] The 18 residues of ACE-2 interact with the RBD (contain 14 amino acids) of SARS-CoV spike protein,[45] and for this contact, K341 of ACE-2 and R453 residue of RBD play the most important role.
T93 1445-1609 Sentence denotes If point mutated on the D454 or R441 of RBD, it disturbs the binding activity with ACE-2.[25] The S1 domain interacts with the ACE-2 or DPP-4 receptors of the host.
T94 1610-2078 Sentence denotes Anti-ACE-2 antibody blocked viral entry and replication in Vero E6 cells.[1445] One another mechanism of virus for binding to host cell is using dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN receptor) or L-SIGN in lymph nodes or in liver.[4647] S protein has seven (109, 118, 119, 158, 227, 589, and 699) glycosylation asparagine-linked sites, which is pivotal for both L-SIGN- or DC-SIGN-based virus entry into the host.[48]
T95 2080-2090 Sentence denotes S2 subunit
T96 2091-2184 Sentence denotes The S2 subunit has two heptad repeat regions (HR 1 and 2) and hydrophobic fusion peptide.[25]
T97 2186-2252 Sentence denotes Drug designing strategies targeting S protein and its interactions
T98 2253-2488 Sentence denotes The RBD is targeted in many drug designing studies.[25] A peptide sequence with sequence similarity to the RBD of S protein hampered S1-RBD: ACE-2 interaction and prevented entry of SARS-CoV into Vero cells (IC50 around 40 μM).[254950]
T99 2489-2578 Sentence denotes A SARS-CoV RBD-specific antibody (FM6) failed to inhibit the occurrence of infection.[39]
T100 2579-2878 Sentence denotes OC43-HR2P, a peptide derived from heptad repeat 2 regions of S2 domain of HCoV-OC43 and its optimized form EK1, showed pan-CoV fusion inhibition property.[39] The structure (protein data bank [PDB] ID 5ZUV and 5ZVM) shows a stable 6-helix bundle structure with α-HCoV and long β-HCoV-HR1 domain.[39]
T101 2879-3074 Sentence denotes Chloroquine, an antimalarial agent, inhibits SERS-CoV by elevation of endosomal pH and alters the terminal glycosylation of ACE-2, which ultimately interferes with the virus receptor binding.[51]
T102 3075-3282 Sentence denotes Other inhibitors SSAA09E2 block the S-ACE2 interaction, SSAA09E1 inhibits the host protease cathepsin L (which is important for viral entry), and SSAA09E3 prevents fusion of host and viral cell membrane.[52]
T103 3283-3774 Sentence denotes Kao et al. identified 18 small molecules that targeted the S-ACE-2-mediated entry of virus into human cell.[53] In 293T cells expressing ACE-2, one of these agents (VE607) showed a significant inhibition of SARS-pseudovirus entry.[53] In Vero E6 cells, two other molecules tetra-O-galloyl beta-D-glucose and luteolin also inhibited SARS-pseudovirus and SARS-CoV infection.[53] In virus-infected Vero E6 cells, a siRNA against the S sequences of SARS-CoV inhibited SARS-CoV replication.[2554]
T104 3775-4026 Sentence denotes The S230 antibody (origin: memory B-cells of SARS-CoV-infected persons) neutralizes wide spectrum of isolates of SARS-CoV.[55] S230 antibody Fab fragment binds to the SARS-CoV complex to neutralize it, and their structures are also available (PDB IDs:
T105 4027-4131 Sentence denotes 6NB6, 6NB7, and 6NB8.[55] The monoclonal antibody, m396, has a competitive role for RBD binding (PDB ID:
T106 4132-4142 Sentence denotes 2DD8).[56]
T107 4143-4473 Sentence denotes Monoclonal antibody can be generated by immunizing the spike protein of SERS-CoV (transgenic mice) or from the B-cells of CoV-infected persons.[25] Spike-specific monoclonal antibodies 80R and CR301 block the S-ACE-2 interactions and thus neutralize infection by human SARS-CoV (HKu39849 and Tor2) and palm civet strain (SZ3).[25]
T108 4474-4670 Sentence denotes Mice vaccinated with SARS-n DNA showed T-cell immune response (both induction and proliferation),[57] and cytotoxic T-cell response was seen against SARS-DNA-transfected alveolar epithelial cells.