PMC:7073332 / 44215-45821
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1129 | 493-506 | Gene | denotes | drugs A and B | |
1130 | 292-296 | Species | denotes | HCoV | Tax:694448 |
1131 | 333-337 | Species | denotes | HCoV | Tax:694448 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T210 | 313-321 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T307 | 499-500 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T308 | 505-506 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T309 | 873-875 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | AA |
T310 | 911-913 | http://purl.obolibrary.org/obo/CLO_0001869 | denotes | BB |
T311 | 1372-1373 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T312 | 1439-1440 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T470 | 36-40 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T471 | 136-140 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T472 | 275-279 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T473 | 313-321 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T474 | 323-327 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T475 | 328-332 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T476 | 375-379 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T477 | 423-428 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T478 | 493-498 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T479 | 873-875 | Chemical | denotes | AA | http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816 |
T481 | 911-913 | Chemical | denotes | BB | http://purl.obolibrary.org/obo/CHEBI_53109 |
T482 | 1374-1378 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T483 | 1561-1566 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T267 | 0-352 | Sentence | denotes | For this network-based approach for drug combinations to be effective, we need to establish if the topological relationship between two drug–target modules reflects biological and pharmacological relationships, while also quantifying their network-based relationship between drug targets and HCoV-associated host proteins (drug–drug–HCoV combinations). |
T268 | 353-429 | Sentence | denotes | To identify potential drug combinations, we combined the top lists of drugs. |
T269 | 430-1343 | Sentence | denotes | Then, “separation” measure SAB was calculated for each pair of drugs A and B using the following method:3 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$S_{AB} = \left\langle {d_{AB}} \right\rangle - \frac{{\left\langle {d_{AA}} \right\rangle + \left\langle {d_{BB}} \right\rangle }}{2},$$\end{document}SAB=dAB−dAA+dBB2,where \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left\langle {d_ \cdot } \right\rangle$$\end{document}d⋅ was calculated based on the “closest” method. |
T270 | 1344-1606 | Sentence | denotes | Our key methodology is that a drug combination is therapeutically effective only if it follows a specific relationship to the disease module, as captured by Complementary Exposure patterns in targets’ modules of both drugs without overlapping toxic mechanisms28. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32194980-30867426-19614266 | 1603-1605 | 30867426 | denotes | 28 |