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PMC:7073332 / 44215-45821 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1129 493-506 Gene denotes drugs A and B
1130 292-296 Species denotes HCoV Tax:694448
1131 333-337 Species denotes HCoV Tax:694448

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T210 313-321 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T307 499-500 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T308 505-506 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T309 873-875 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T310 911-913 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T311 1372-1373 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 1439-1440 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T470 36-40 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T471 136-140 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T472 275-279 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T473 313-321 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T474 323-327 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T475 328-332 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T476 375-379 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T477 423-428 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T478 493-498 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T479 873-875 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T481 911-913 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109
T482 1374-1378 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T483 1561-1566 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T267 0-352 Sentence denotes For this network-based approach for drug combinations to be effective, we need to establish if the topological relationship between two drug–target modules reflects biological and pharmacological relationships, while also quantifying their network-based relationship between drug targets and HCoV-associated host proteins (drug–drug–HCoV combinations).
T268 353-429 Sentence denotes To identify potential drug combinations, we combined the top lists of drugs.
T269 430-1343 Sentence denotes Then, “separation” measure SAB was calculated for each pair of drugs A and B using the following method:3 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$S_{AB} = \left\langle {d_{AB}} \right\rangle - \frac{{\left\langle {d_{AA}} \right\rangle + \left\langle {d_{BB}} \right\rangle }}{2},$$\end{document}SAB=dAB−dAA+dBB2,where \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left\langle {d_ \cdot } \right\rangle$$\end{document}d⋅ was calculated based on the “closest” method.
T270 1344-1606 Sentence denotes Our key methodology is that a drug combination is therapeutically effective only if it follows a specific relationship to the disease module, as captured by Complementary Exposure patterns in targets’ modules of both drugs without overlapping toxic mechanisms28.

2_test

Id Subject Object Predicate Lexical cue
32194980-30867426-19614266 1603-1605 30867426 denotes 28