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PMC:7073332 / 35790-37513 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1060 585-594 Species denotes 2019-nCoV Tax:2697049
1061 595-605 Species denotes SARS-CoV-2 Tax:2697049
1062 1190-1195 Species denotes human Tax:9606
1063 1299-1303 Species denotes nCoV Tax:2697049
1064 1162-1166 Species denotes HCoV Tax:694448
1065 263-273 Chemical denotes Mesalazine MESH:D019804
1066 512-522 Chemical denotes mesalazine MESH:D019804
1067 1519-1529 Chemical denotes remdesivir MESH:C000606551
1068 131-139 Disease denotes toxicity MESH:D064420
1069 296-322 Disease denotes inflammatory bowel disease MESH:D015212
1070 453-473 Disease denotes pulmonary toxicities MESH:D008171
1071 485-494 Disease denotes pneumonia MESH:D011014

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T174 309-314 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T175 550-554 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T176 564-568 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T177 611-619 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T178 1309-1317 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T179 1444-1452 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T10 550-554 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T151 296-322 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T152 485-494 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T153 595-603 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T256 9-10 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 327-328 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 550-554 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T259 550-554 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T260 564-568 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T261 1016-1017 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 1190-1195 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T263 1414-1419 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T264 1438-1443 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T265 1498-1503 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T407 32-36 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T408 96-101 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T409 170-175 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T410 180-184 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T411 263-273 Chemical denotes Mesalazine http://purl.obolibrary.org/obo/CHEBI_6775
T412 287-291 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T413 364-368 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T414 512-522 Chemical denotes mesalazine http://purl.obolibrary.org/obo/CHEBI_6775
T415 611-619 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T416 713-718 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T417 722-726 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T418 896-900 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T419 1081-1086 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T420 1138-1143 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T421 1267-1272 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T422 1309-1317 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T423 1385-1390 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T424 1420-1425 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T425 1444-1452 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T426 1504-1509 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T427 1573-1578 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T428 1591-1595 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T25 296-322 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T26 485-494 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T221 0-249 Sentence denotes Owing to a lack of the complete drug-target information (such as the molecular “promiscuity” of drugs), the dose–response and dose–toxicity effects for both repurposable drugs and drug combinations cannot be identified in the current network models.
T222 250-401 Sentence denotes For example, Mesalazine, an approved drug for inflammatory bowel disease, is a top network-predicted repurposable drug associated with HCoVs (Fig. 5a).
T223 402-534 Sentence denotes Yet, several clinical studies showed the potential pulmonary toxicities (including pneumonia) associated with mesalazine usage81,82.
T224 535-740 Sentence denotes Integration of lung-specific gene expression23 of 2019-nCoV/SARS-CoV-2 host proteins and physiologically based pharmacokinetic modeling83 may reduce side effects of repurposable drugs or drug combinations.
T225 741-846 Sentence denotes Preclinical studies are warranted to evaluate in vivo efficiency and side effects before clinical trials.
T226 847-962 Sentence denotes Furthermore, we only limited to predict pairwise drug combinations based on our previous network-based framework28.
T227 963-1208 Sentence denotes However, we expect that our methodology remain to be a useful network-based tool for prediction of combining multiple drugs toward exploring network relationships of multiple drugs’ targets with the HCoV–host subnetwork in the human interactome.
T228 1209-1323 Sentence denotes Finally, we aimed to systematically identify repurposable drugs by specifically targeting nCoV host proteins only.
T229 1324-1458 Sentence denotes Thus, our current network models cannot predict repurposable drugs from the existing anti-virus drugs that target virus proteins only.
T230 1459-1723 Sentence denotes Thus, combination of the existing anti-virus drugs (such as remdesivir64) with the network-predicted repurposable drugs (Fig. 5) or drug combinations (Fig. 6) may improve coverage of current network-based methodologies by utilizing multi-layer network framework16.

2_test

Id Subject Object Predicate Lexical cue
32194980-23667838-19614242 528-530 23667838 denotes 81
32194980-28458997-19614243 531-533 28458997 denotes 82
32194980-31375661-19614244 579-581 31375661 denotes 23
32194980-29052226-19614245 670-672 29052226 denotes 83
32194980-30867426-19614246 959-961 30867426 denotes 28
32194980-32020029-19614247 1529-1531 32020029 denotes 64