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PMC:7073332 / 31237-32587 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
956 467-471 Gene denotes ACE2 Gene:59272
957 633-643 Gene denotes calmodulin Gene:801
958 648-658 Gene denotes calmodulin Gene:801
959 674-678 Gene denotes ACE2 Gene:59272
960 783-788 Gene denotes c-Jun Gene:3725
961 937-942 Gene denotes c-Jun Gene:3725
962 1167-1171 Gene denotes ACE2 Gene:59272
963 1173-1178 Gene denotes c-Jun Gene:3725
964 1278-1282 Gene denotes ACE2 Gene:59272
965 140-145 Species denotes human Tax:9606
966 262-270 Species denotes SARS-CoV Tax:694009
967 275-283 Species denotes MERS-CoV Tax:1335626
968 553-562 Species denotes 2019-nCoV Tax:2697049
969 563-573 Species denotes SARS-CoV-2 Tax:2697049
970 749-757 Species denotes SARS-CoV Tax:694009
971 830-857 Species denotes infectious bronchitis virus Tax:11120
972 1095-1104 Species denotes 2019-nCoV Tax:2697049
973 1105-1115 Species denotes SARS-CoV-2 Tax:2697049
974 1308-1317 Species denotes 2019-nCoV Tax:2697049
975 1318-1328 Species denotes SARS-CoV-2 Tax:2697049
976 727-737 Species denotes infectious Tax:11120
977 103-107 Species denotes HCoV Tax:694448
978 825-829 Species denotes HCoV Tax:694448
979 37-51 Chemical denotes mercaptopurine MESH:D015122
980 56-65 Chemical denotes melatonin MESH:D008550
981 214-228 Chemical denotes mercaptopurine MESH:D015122
982 324-333 Chemical denotes Melatonin MESH:D008550
983 436-445 Chemical denotes Melatonin MESH:D008550
984 599-608 Chemical denotes melatonin MESH:D008550
985 882-896 Chemical denotes mercaptopurine MESH:D015122
986 901-910 Chemical denotes melatonin MESH:D008550
987 1020-1034 Chemical denotes mercaptopurine MESH:D015122
988 1039-1048 Chemical denotes melatonin MESH:D008550
989 1295-1304 Chemical denotes melatonin MESH:D008550
990 370-379 Disease denotes infection MESH:D007239
991 517-532 Disease denotes viral infection MESH:D001102

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T155 56-65 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T156 124-132 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T157 324-333 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T158 436-445 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T159 599-608 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T160 633-643 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T161 648-658 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T162 804-811 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T163 901-910 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T164 1039-1048 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T165 1295-1304 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T132 262-270 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 370-379 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T134 517-532 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T135 523-532 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T136 563-571 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 727-737 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T138 749-753 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T139 830-840 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T140 841-851 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T141 1105-1113 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 1318-1326 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T230 140-145 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T231 232-233 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T232 484-485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 721-722 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 793-794 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 943-952 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T236 1059-1060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 1179-1188 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T364 37-51 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T365 56-65 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T366 124-132 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T367 214-228 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T368 244-253 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T369 324-333 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T370 360-369 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T371 410-421 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T372 436-445 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T373 599-608 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T374 804-811 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T375 882-896 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T376 901-910 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T377 1020-1034 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T378 1039-1048 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T379 1295-1304 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T52 517-532 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T53 943-952 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T54 1179-1188 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T24 841-851 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T193 0-166 Sentence denotes As shown in Fig. 5a, targets of both mercaptopurine and melatonin showed strong network proximity with HCoV-associated host proteins in the human interactome network.
T194 167-323 Sentence denotes Recent in vitro and in vivo studies identified mercaptopurine as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease53,54.
T195 324-435 Sentence denotes Melatonin was reported in potential antiviral infection via its anti-inflammatory and antioxidant effects58–62.
T196 436-579 Sentence denotes Melatonin indirectly regulates ACE2 expression, a key entry receptor involved in viral infection of HCoVs, including 2019-nCoV/SARS-CoV-2 (ref.
T197 580-584 Sentence denotes 33).
T198 585-763 Sentence denotes Specifically, melatonin was reported to inhibit calmodulin and calmodulin interacts with ACE2 by inhibiting shedding of its ectodomain, a key infectious process of SARS-CoV72,73.
T199 764-860 Sentence denotes JUN, also known as c-Jun, is a key host protein involving in HCoV infectious bronchitis virus74.
T200 861-992 Sentence denotes As shown in Fig. 6d, mercaptopurine and melatonin may synergistically block c-Jun signaling by targeting multiple cellular targets.
T201 993-1231 Sentence denotes In summary, combination of mercaptopurine and melatonin may offer a potential combination therapy for 2019-nCoV/SARS-CoV-2 by synergistically targeting papain-like protease, ACE2, c-Jun signaling, and anti-inflammatory pathways (Fig. 6d).
T202 1232-1350 Sentence denotes However, further experimental observations on ACE2 pathways by melatonin in 2019-nCoV/SARS-CoV-2 are highly warranted.

2_test

Id Subject Object Predicate Lexical cue
32194980-19374142-19614228 317-319 19374142 denotes 53
32194980-25542975-19614229 320-322 25542975 denotes 54
32194980-24090288-19614230 429-431 24090288 denotes 58
32194980-22264213-19614230 429-431 22264213 denotes 58
32194980-25262626-19614230 429-431 25262626 denotes 58
32194980-17198536-19614230 429-431 17198536 denotes 58
32194980-22998574-19614230 429-431 22998574 denotes 58
32194980-32015507-19614231 580-582 32015507 denotes 33
32194980-18070603-19614232 757-759 18070603 denotes 72
32194980-12071468-19614233 760-762 12071468 denotes 73
32194980-29238080-19614234 857-859 29238080 denotes 74