PMC:7073332 / 30354-31205
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
874 | 0-10 | Chemical | denotes | Toremifene | MESH:D017312 |
875 | 16-22 | Chemical | denotes | Emodin | MESH:D004642 |
896 | 651-655 | Gene | denotes | ACE2 | Gene:59272 |
897 | 633-638 | Gene | denotes | spike | Gene:43740568 |
898 | 246-257 | Species | denotes | Ebola virus | Tax:1570291 |
899 | 344-352 | Species | denotes | MERS-CoV | Tax:1335626 |
900 | 367-370 | Species | denotes | CoV | Tax:11118 |
901 | 448-464 | Species | denotes | rheum tanguticum | Tax:137226 |
902 | 551-559 | Species | denotes | SARS-CoV | Tax:694009 |
903 | 624-632 | Species | denotes | SARS-CoV | Tax:694009 |
904 | 820-829 | Species | denotes | 2019-nCoV | Tax:2697049 |
905 | 830-840 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
906 | 23-33 | Chemical | denotes | Toremifene | MESH:D017312 |
907 | 158-168 | Chemical | denotes | toremifene | MESH:D017312 |
908 | 313-323 | Chemical | denotes | toremifene | MESH:D017312 |
909 | 384-390 | Chemical | denotes | Emodin | MESH:D004642 |
910 | 395-408 | Chemical | denotes | anthraquinone | MESH:D000880 |
911 | 534-540 | Chemical | denotes | emdoin | |
912 | 753-763 | Chemical | denotes | toremifene | MESH:D017312 |
913 | 768-774 | Chemical | denotes | emdoin | |
914 | 124-137 | Disease | denotes | breast cancer | MESH:D001943 |
915 | 186-201 | Disease | denotes | virus infection | MESH:D001102 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T152 | 124-130 | Body_part | denotes | breast | http://purl.org/sig/ont/fma/fma9601 |
T153 | 639-646 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T8 | 124-130 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T127 | 180-185 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
T128 | 246-251 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
T129 | 551-559 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T130 | 624-632 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T131 | 830-838 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T223 | 124-130 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
T224 | 186-191 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T225 | 252-257 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T226 | 466-469 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T227 | 505-510 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T228 | 662-664 | http://purl.obolibrary.org/obo/CLO_0054055 | denotes | 71 |
T229 | 783-784 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T354 | 16-22 | Chemical | denotes | Emodin | http://purl.obolibrary.org/obo/CHEBI_42223 |
T355 | 158-168 | Chemical | denotes | toremifene | http://purl.obolibrary.org/obo/CHEBI_9635 |
T356 | 313-323 | Chemical | denotes | toremifene | http://purl.obolibrary.org/obo/CHEBI_9635 |
T357 | 384-390 | Chemical | denotes | Emodin | http://purl.obolibrary.org/obo/CHEBI_42223 |
T358 | 395-408 | Chemical | denotes | anthraquinone | http://purl.obolibrary.org/obo/CHEBI_22580|http://purl.obolibrary.org/obo/CHEBI_40448 |
T360 | 639-646 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T361 | 753-763 | Chemical | denotes | toremifene | http://purl.obolibrary.org/obo/CHEBI_9635 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T51 | 334-340 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T184 | 0-22 | Sentence | denotes | Toremifene plus Emodin |
T185 | 23-140 | Sentence | denotes | Toremifene is among the approved first-generation nonsteroidal SERMs for the treatment of metastatic breast cancer68. |
T186 | 141-273 | Sentence | denotes | SERMs (including toremifene) inhibited Ebola virus infection18 by interacting with and destabilizing the Ebola virus glycoprotein39. |
T187 | 274-383 | Sentence | denotes | In vitro assays have demonstrated that toremifene inhibited growth of MERS-CoV17,69 and SARA-CoV38 (Table 1). |
T188 | 384-519 | Sentence | denotes | Emodin, an anthraquinone derivative extracted from the roots of rheum tanguticum, has been reported to have various anti-virus effects. |
T189 | 520-661 | Sentence | denotes | Specifically, emdoin inhibited SARS-CoV-associated 3a protein70, and blocked an interaction between the SARS-CoV spike protein and ACE2 (ref. |
T190 | 662-666 | Sentence | denotes | 71). |
T191 | 667-851 | Sentence | denotes | Altogether, network analyses and published experimental data suggested that combining toremifene and emdoin offered a potential therapeutic approach for 2019-nCoV/SARS-CoV-2 (Fig. 6c). |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32194980-21553116-19614221 | 137-139 | 21553116 | denotes | 68 |
32194980-27362232-19614222 | 270-272 | 27362232 | denotes | 39 |
32194980-24841273-19614223 | 352-354 | 24841273 | denotes | 17 |
32194980-29566060-19614224 | 355-357 | 29566060 | denotes | 69 |
32194980-24841269-19614225 | 370-372 | 24841269 | denotes | 38 |
32194980-21356245-19614226 | 581-583 | 21356245 | denotes | 70 |
32194980-16730806-19614227 | 662-664 | 16730806 | denotes | 71 |