PMC:7073332 / 28698-29388
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 803 | 410-427 | Gene | denotes | estrogen receptor | Gene:2099 |
| 809 | 347-353 | Disease | denotes | tumors | MESH:D009369 |
| 810 | 494-511 | Disease | denotes | polycystic kidney | MESH:D007690 |
| 811 | 571-593 | Disease | denotes | rhythm sleep disorders | MESH:D012893 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T141 | 298-301 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T142 | 410-418 | Body_part | denotes | estrogen | http://purl.org/sig/ont/fma/fma83376 |
| T143 | 505-511 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T144 | 520-529 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
| T145 | 533-547 | Body_part | denotes | biogenic amine | http://purl.org/sig/ont/fma/fma67161 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T7 | 505-511 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T122 | 347-353 | Disease | denotes | tumors | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T123 | 561-593 | Disease | denotes | circadian rhythm sleep disorders | http://purl.obolibrary.org/obo/MONDO_0024361 |
| T124 | 578-593 | Disease | denotes | sleep disorders | http://purl.obolibrary.org/obo/MONDO_0003406 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T210 | 81-82 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T211 | 92-96 | http://purl.obolibrary.org/obo/CLO_0001869 | denotes | B. b |
| T212 | 184-185 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T213 | 197-198 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T214 | 410-427 | http://purl.obolibrary.org/obo/PR_000007204 | denotes | estrogen receptor |
| T215 | 505-511 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T216 | 505-511 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T217 | 505-511 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T218 | 531-532 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T318 | 165-169 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T319 | 186-195 | Chemical | denotes | sirolimus | http://purl.obolibrary.org/obo/CHEBI_9168 |
| T320 | 206-223 | Chemical | denotes | immunosuppressant | http://purl.obolibrary.org/obo/CHEBI_35705 |
| T321 | 234-244 | Chemical | denotes | antifungal | http://purl.obolibrary.org/obo/CHEBI_35718 |
| T322 | 249-263 | Chemical | denotes | antineoplastic | http://purl.obolibrary.org/obo/CHEBI_35610 |
| T323 | 312-321 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T324 | 358-368 | Chemical | denotes | toremifene | http://purl.obolibrary.org/obo/CHEBI_9635 |
| T325 | 410-437 | Chemical | denotes | estrogen receptor modulator | http://purl.obolibrary.org/obo/CHEBI_50739 |
| T326 | 410-418 | Chemical | denotes | estrogen | http://purl.obolibrary.org/obo/CHEBI_50114 |
| T327 | 419-437 | Chemical | denotes | receptor modulator | http://purl.obolibrary.org/obo/CHEBI_90710 |
| T328 | 444-450 | Chemical | denotes | emodin | http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659 |
| T330 | 468-472 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T331 | 520-529 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
| T332 | 542-547 | Chemical | denotes | amine | http://purl.obolibrary.org/obo/CHEBI_32952 |
| T333 | 600-614 | Chemical | denotes | mercaptopurine | http://purl.obolibrary.org/obo/CHEBI_50667 |
| T334 | 619-633 | Chemical | denotes | antimetabolite | http://purl.obolibrary.org/obo/CHEBI_35221 |
| T335 | 634-654 | Chemical | denotes | antineoplastic agent | http://purl.obolibrary.org/obo/CHEBI_35610 |
| T336 | 660-677 | Chemical | denotes | immunosuppressant | http://purl.obolibrary.org/obo/CHEBI_35705 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T39 | 298-311 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T40 | 302-311 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T41 | 561-577 | http://purl.obolibrary.org/obo/GO_0007623 | denotes | circadian rhythm |
| T42 | 571-577 | http://purl.obolibrary.org/obo/GO_0048511 | denotes | rhythm |
| T43 | 578-583 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T21 | 494-511 | Phenotype | denotes | polycystic kidney | http://purl.obolibrary.org/obo/HP_0000113 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T176 | 0-690 | Sentence | denotes | SAB denotes separation score (see Materials and methods) of targets between Drug A and Drug B. b–d Inferred mechanism-of-action networks for three selected pairwise drug combinations: b sirolimus (a potent immunosuppressant with both antifungal and antineoplastic properties) plus dactinomycin (an RNA synthesis inhibitor for treatment of various tumors), c toremifene (first-generation nonsteroidal-selective estrogen receptor modulator) plus emodin (an experimental drug for the treatment of polycystic kidney), and d melatonin (a biogenic amine for treating circadian rhythm sleep disorders) plus mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties). |