PMC:7073332 / 25289-26593
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
758 | 992-996 | Gene | denotes | ACE2 | Gene:59272 |
759 | 998-1004 | Gene | denotes | BCL2L1 | Gene:598 |
760 | 1015-1020 | Gene | denotes | IKBKB | Gene:3551 |
761 | 570-578 | Species | denotes | patients | Tax:9606 |
762 | 773-781 | Species | denotes | patients | Tax:9606 |
763 | 829-837 | Species | denotes | patients | Tax:9606 |
764 | 1256-1260 | Species | denotes | mice | Tax:10090 |
765 | 1275-1301 | Species | denotes | encephalomyocarditis virus | Tax:12104 |
766 | 959-963 | Species | denotes | HCoV | Tax:694448 |
767 | 83-88 | Chemical | denotes | amine | MESH:D000588 |
768 | 90-99 | Chemical | denotes | melatonin | MESH:D008550 |
769 | 101-129 | Chemical | denotes | N-acetyl-5-methoxytryptamine | |
770 | 146-150 | Chemical | denotes | GSEA | |
771 | 514-523 | Chemical | denotes | melatonin | MESH:D008550 |
772 | 634-643 | Chemical | denotes | melatonin | MESH:D008550 |
773 | 751-760 | Chemical | denotes | melatonin | MESH:D008550 |
774 | 922-931 | Chemical | denotes | melatonin | MESH:D008550 |
775 | 1022-1032 | Chemical | denotes | Eplerenone | MESH:D000077545 |
776 | 1049-1060 | Chemical | denotes | aldosterone | MESH:D000450 |
777 | 1140-1149 | Chemical | denotes | melatonin | MESH:D008550 |
778 | 1221-1231 | Chemical | denotes | eplerenone | MESH:D000077545 |
779 | 46-62 | Disease | denotes | viral infections | MESH:D001102 |
780 | 265-281 | Disease | denotes | viral infections | MESH:D001102 |
781 | 288-304 | Disease | denotes | Viral infections | MESH:D001102 |
782 | 1211-1219 | Disease | denotes | fibrosis | MESH:D005355 |
783 | 1261-1269 | Disease | denotes | infected | MESH:D007239 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T130 | 74-88 | Body_part | denotes | biogenic amine | http://purl.org/sig/ont/fma/fma67161 |
T131 | 90-99 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T132 | 514-523 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T133 | 634-643 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T134 | 751-760 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T135 | 839-853 | Body_part | denotes | immune systems | http://purl.org/sig/ont/fma/fma9825 |
T136 | 922-931 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T137 | 1140-1149 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T138 | 1165-1174 | Body_part | denotes | mast-cell | http://purl.org/sig/ont/fma/fma66784 |
T139 | 1170-1174 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T6 | 839-853 | Body_part | denotes | immune systems | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid_AGAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
p14966s22 | 433-441 | NegReg | denotes | negative |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T113 | 288-304 | Disease | denotes | Viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
T114 | 351-357 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T192 | 72-73 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T193 | 168-169 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T194 | 223-224 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T195 | 533-534 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T196 | 816-817 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T197 | 839-853 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune systems |
T198 | 894-899 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T199 | 1102-1103 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T200 | 1170-1174 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T284 | 83-88 | Chemical | denotes | amine | http://purl.obolibrary.org/obo/CHEBI_32952 |
T285 | 90-99 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T286 | 101-129 | Chemical | denotes | N-acetyl-5-methoxytryptamine | http://purl.obolibrary.org/obo/CHEBI_16796 |
T287 | 103-109 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
T289 | 492-503 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
T290 | 514-523 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T291 | 554-558 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T292 | 601-610 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T293 | 634-643 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T294 | 736-747 | Chemical | denotes | application | http://purl.obolibrary.org/obo/CHEBI_33232 |
T295 | 751-760 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T296 | 922-931 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T297 | 1022-1032 | Chemical | denotes | Eplerenone | http://purl.obolibrary.org/obo/CHEBI_31547 |
T298 | 1049-1060 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
T300 | 1070-1080 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
T301 | 1140-1149 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T302 | 1221-1231 | Chemical | denotes | eplerenone | http://purl.obolibrary.org/obo/CHEBI_31547 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T34 | 288-304 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | Viral infections |
T35 | 678-695 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T36 | 678-695 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T37 | 1015-1020 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKBKB |
T38 | 1183-1194 | http://purl.obolibrary.org/obo/GO_0004175 | denotes | proteinases |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T18 | 381-397 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T154 | 0-68 | Sentence | denotes | Inflammatory pathways play essential roles in viral infections56,57. |
T155 | 69-287 | Sentence | denotes | As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59. |
T156 | 288-487 | Sentence | denotes | Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60. |
T157 | 488-718 | Sentence | denotes | The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients’ clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62. |
T158 | 719-900 | Sentence | denotes | In addition, the application of melatonin may prolong patients’ survival time, which may provide a chance for patients’ immune systems to recover and eventually eradicate the virus. |
T159 | 901-1021 | Sentence | denotes | As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB. |
T160 | 1022-1150 | Sentence | denotes | Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin. |
T161 | 1151-1304 | Sentence | denotes | By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32194980-16835706-19614207 | 62-64 | 16835706 | denotes | 56 |
32194980-21189219-19614208 | 65-67 | 21189219 | denotes | 57 |
32194980-24090288-19614209 | 281-283 | 24090288 | denotes | 58 |
32194980-22264213-19614210 | 284-286 | 22264213 | denotes | 59 |
32194980-25262626-19614211 | 484-486 | 25262626 | denotes | 60 |
32194980-17198536-19614212 | 712-714 | 17198536 | denotes | 61 |
32194980-22998574-19614213 | 715-717 | 22998574 | denotes | 62 |
32194980-19213804-19614214 | 1301-1303 | 19213804 | denotes | 63 |