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PMC:7073332 / 25289-26593 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
758 992-996 Gene denotes ACE2 Gene:59272
759 998-1004 Gene denotes BCL2L1 Gene:598
760 1015-1020 Gene denotes IKBKB Gene:3551
761 570-578 Species denotes patients Tax:9606
762 773-781 Species denotes patients Tax:9606
763 829-837 Species denotes patients Tax:9606
764 1256-1260 Species denotes mice Tax:10090
765 1275-1301 Species denotes encephalomyocarditis virus Tax:12104
766 959-963 Species denotes HCoV Tax:694448
767 83-88 Chemical denotes amine MESH:D000588
768 90-99 Chemical denotes melatonin MESH:D008550
769 101-129 Chemical denotes N-acetyl-5-methoxytryptamine
770 146-150 Chemical denotes GSEA
771 514-523 Chemical denotes melatonin MESH:D008550
772 634-643 Chemical denotes melatonin MESH:D008550
773 751-760 Chemical denotes melatonin MESH:D008550
774 922-931 Chemical denotes melatonin MESH:D008550
775 1022-1032 Chemical denotes Eplerenone MESH:D000077545
776 1049-1060 Chemical denotes aldosterone MESH:D000450
777 1140-1149 Chemical denotes melatonin MESH:D008550
778 1221-1231 Chemical denotes eplerenone MESH:D000077545
779 46-62 Disease denotes viral infections MESH:D001102
780 265-281 Disease denotes viral infections MESH:D001102
781 288-304 Disease denotes Viral infections MESH:D001102
782 1211-1219 Disease denotes fibrosis MESH:D005355
783 1261-1269 Disease denotes infected MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T130 74-88 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T131 90-99 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T132 514-523 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T133 634-643 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T134 751-760 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T135 839-853 Body_part denotes immune systems http://purl.org/sig/ont/fma/fma9825
T136 922-931 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T137 1140-1149 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T138 1165-1174 Body_part denotes mast-cell http://purl.org/sig/ont/fma/fma66784
T139 1170-1174 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 839-853 Body_part denotes immune systems http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p14966s22 433-441 NegReg denotes negative

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T113 288-304 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T114 351-357 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T192 72-73 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 168-169 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 223-224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 533-534 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 816-817 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 839-853 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune systems
T198 894-899 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 1102-1103 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 1170-1174 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T284 83-88 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T285 90-99 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T286 101-129 Chemical denotes N-acetyl-5-methoxytryptamine http://purl.obolibrary.org/obo/CHEBI_16796
T287 103-109 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T289 492-503 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T290 514-523 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T291 554-558 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T292 601-610 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T293 634-643 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T294 736-747 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T295 751-760 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T296 922-931 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T297 1022-1032 Chemical denotes Eplerenone http://purl.obolibrary.org/obo/CHEBI_31547
T298 1049-1060 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T300 1070-1080 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T301 1140-1149 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T302 1221-1231 Chemical denotes eplerenone http://purl.obolibrary.org/obo/CHEBI_31547

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T34 288-304 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T35 678-695 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T36 678-695 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T37 1015-1020 http://purl.obolibrary.org/obo/GO_0008384 denotes IKBKB
T38 1183-1194 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T18 381-397 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T154 0-68 Sentence denotes Inflammatory pathways play essential roles in viral infections56,57.
T155 69-287 Sentence denotes As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59.
T156 288-487 Sentence denotes Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60.
T157 488-718 Sentence denotes The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients’ clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62.
T158 719-900 Sentence denotes In addition, the application of melatonin may prolong patients’ survival time, which may provide a chance for patients’ immune systems to recover and eventually eradicate the virus.
T159 901-1021 Sentence denotes As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB.
T160 1022-1150 Sentence denotes Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin.
T161 1151-1304 Sentence denotes By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63.

2_test

Id Subject Object Predicate Lexical cue
32194980-16835706-19614207 62-64 16835706 denotes 56
32194980-21189219-19614208 65-67 21189219 denotes 57
32194980-24090288-19614209 281-283 24090288 denotes 58
32194980-22264213-19614210 284-286 22264213 denotes 59
32194980-25262626-19614211 484-486 25262626 denotes 60
32194980-17198536-19614212 712-714 17198536 denotes 61
32194980-22998574-19614213 715-717 22998574 denotes 62
32194980-19213804-19614214 1301-1303 19213804 denotes 63