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PMC:7073332 / 25264-26949 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
758 1017-1021 Gene denotes ACE2 Gene:59272
759 1023-1029 Gene denotes BCL2L1 Gene:598
760 1040-1045 Gene denotes IKBKB Gene:3551
761 595-603 Species denotes patients Tax:9606
762 798-806 Species denotes patients Tax:9606
763 854-862 Species denotes patients Tax:9606
764 1281-1285 Species denotes mice Tax:10090
765 1300-1326 Species denotes encephalomyocarditis virus Tax:12104
766 984-988 Species denotes HCoV Tax:694448
767 108-113 Chemical denotes amine MESH:D000588
768 115-124 Chemical denotes melatonin MESH:D008550
769 126-154 Chemical denotes N-acetyl-5-methoxytryptamine
770 171-175 Chemical denotes GSEA
771 539-548 Chemical denotes melatonin MESH:D008550
772 659-668 Chemical denotes melatonin MESH:D008550
773 776-785 Chemical denotes melatonin MESH:D008550
774 947-956 Chemical denotes melatonin MESH:D008550
775 1047-1057 Chemical denotes Eplerenone MESH:D000077545
776 1074-1085 Chemical denotes aldosterone MESH:D000450
777 1165-1174 Chemical denotes melatonin MESH:D008550
778 1246-1256 Chemical denotes eplerenone MESH:D000077545
779 71-87 Disease denotes viral infections MESH:D001102
780 290-306 Disease denotes viral infections MESH:D001102
781 313-329 Disease denotes Viral infections MESH:D001102
782 1236-1244 Disease denotes fibrosis MESH:D005355
783 1286-1294 Disease denotes infected MESH:D007239
786 1497-1506 Species denotes 2019-nCoV Tax:2697049
787 1507-1517 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T130 99-113 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T131 115-124 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T132 539-548 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T133 659-668 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T134 776-785 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T135 864-878 Body_part denotes immune systems http://purl.org/sig/ont/fma/fma9825
T136 947-956 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T137 1165-1174 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T138 1190-1199 Body_part denotes mast-cell http://purl.org/sig/ont/fma/fma66784
T139 1195-1199 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 864-878 Body_part denotes immune systems http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p14966s22 458-466 NegReg denotes negative

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T113 313-329 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T114 376-382 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T115 1507-1515 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T192 97-98 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 193-194 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 248-249 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 558-559 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 841-842 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 864-878 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune systems
T198 919-924 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 1127-1128 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 1195-1199 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T283 0-24 Chemical denotes Anti-inflammatory agents http://purl.obolibrary.org/obo/CHEBI_67079
T284 108-113 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T285 115-124 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T286 126-154 Chemical denotes N-acetyl-5-methoxytryptamine http://purl.obolibrary.org/obo/CHEBI_16796
T287 128-134 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T289 517-528 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T290 539-548 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T291 579-583 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T292 626-635 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T293 659-668 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T294 761-772 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T295 776-785 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T296 947-956 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T297 1047-1057 Chemical denotes Eplerenone http://purl.obolibrary.org/obo/CHEBI_31547
T298 1074-1085 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T300 1095-1105 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T301 1165-1174 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T302 1246-1256 Chemical denotes eplerenone http://purl.obolibrary.org/obo/CHEBI_31547
T303 1411-1416 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T34 313-329 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T35 703-720 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T36 703-720 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T37 1040-1045 http://purl.obolibrary.org/obo/GO_0008384 denotes IKBKB
T38 1208-1219 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T18 406-422 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T153 0-24 Sentence denotes Anti-inflammatory agents
T154 25-93 Sentence denotes Inflammatory pathways play essential roles in viral infections56,57.
T155 94-312 Sentence denotes As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59.
T156 313-512 Sentence denotes Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60.
T157 513-743 Sentence denotes The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients’ clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62.
T158 744-925 Sentence denotes In addition, the application of melatonin may prolong patients’ survival time, which may provide a chance for patients’ immune systems to recover and eventually eradicate the virus.
T159 926-1046 Sentence denotes As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB.
T160 1047-1175 Sentence denotes Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin.
T161 1176-1329 Sentence denotes By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63.
T162 1330-1518 Sentence denotes In summary, our network proximity analyses offer multiple candidate repurposable drugs that target diverse cellular pathways for potential prevention and treatment of 2019-nCoV/SARS-CoV-2.
T163 1519-1685 Sentence denotes However, further preclinical experiments64 and clinical trials are required to verify the clinical benefits of these network-predicted candidates before clinical use.

2_test

Id Subject Object Predicate Lexical cue
32194980-16835706-19614207 87-89 16835706 denotes 56
32194980-21189219-19614208 90-92 21189219 denotes 57
32194980-24090288-19614209 306-308 24090288 denotes 58
32194980-22264213-19614210 309-311 22264213 denotes 59
32194980-25262626-19614211 509-511 25262626 denotes 60
32194980-17198536-19614212 737-739 17198536 denotes 61
32194980-22998574-19614213 740-742 22998574 denotes 62
32194980-19213804-19614214 1326-1328 19213804 denotes 63
32194980-32020029-19614215 1559-1561 32020029 denotes 64