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PMC:7073332 / 23959-25262 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
703 77-83 Gene denotes mTORC1 Gene:382056
704 260-289 Gene denotes mammalian target of rapamycin Gene:2475
705 291-295 Gene denotes mTOR Gene:2475
706 1266-1272 Gene denotes PABPC1 Gene:26986
707 1274-1278 Gene denotes NPM1 Gene:4869
708 1284-1287 Gene denotes NCL Gene:4691
709 158-179 Species denotes Andes orthohantavirus Tax:1980456
710 184-195 Species denotes coronavirus Tax:11118
711 541-549 Species denotes patients Tax:9606
712 562-566 Species denotes H1N1 Tax:114727
713 625-633 Species denotes patients Tax:9606
714 1025-1033 Species denotes SARS-CoV Tax:694009
715 1038-1046 Species denotes MERS-CoV Tax:1335626
716 56-65 Chemical denotes rapamycin MESH:D020123
717 202-211 Chemical denotes Sirolimus MESH:D020123
718 227-231 Chemical denotes GSEA
719 451-460 Chemical denotes sirolimus MESH:D020123
720 513-522 Chemical denotes sirolimus MESH:D020123
721 662-676 Chemical denotes Mercaptopurine MESH:D015122
722 692-696 Chemical denotes GSEA
723 959-973 Chemical denotes Mercaptopurine MESH:D015122
724 1187-1201 Chemical denotes mercaptopurine MESH:D015122
725 469-487 Disease denotes MERS-CoV infection MESH:D018352
726 567-576 Disease denotes pneumonia MESH:D011014
727 587-606 Disease denotes respiratory failure MESH:D012131
728 789-795 Disease denotes cancer MESH:D009369
729 884-904 Disease denotes rheumatoid arthritis MESH:D001172
730 906-934 Disease denotes systemic lupus erythematosus MESH:D008180
731 940-955 Disease denotes Crohn’s disease MESH:D003424

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T128 338-345 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T129 1234-1242 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T102 478-487 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 567-576 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T104 581-606 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T106 789-795 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T107 852-872 Disease denotes auto-immune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T108 884-904 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T109 895-904 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T110 906-934 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T111 915-934 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T112 1025-1033 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T188 125-132 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T189 766-769 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T190 974-977 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T191 995-996 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T266 56-65 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T267 202-211 Chemical denotes Sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T268 247-256 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T269 280-289 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T270 338-345 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T271 438-449 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T272 451-460 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T273 513-522 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T274 662-676 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T275 712-732 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T276 738-755 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T277 829-840 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T278 959-973 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T279 1007-1016 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T280 1141-1151 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T281 1187-1201 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T282 1234-1242 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T33 1106-1122 http://purl.obolibrary.org/obo/GO_0019075 denotes viral maturation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 567-576 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 587-606 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T14 789-795 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T15 852-872 Phenotype denotes auto-immune diseases http://purl.obolibrary.org/obo/HP_0002960
T16 884-904 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T17 906-934 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T146 0-201 Sentence denotes Previous studies have confirmed the mammalian target of rapamycin complex 1 (mTORC1) as the key factor in regulating various viruses’ replications, including Andes orthohantavirus and coronavirus48,49.
T147 202-390 Sentence denotes Sirolimus (Z = –2.35 and GSEA score = 3), an inhibitor of mammalian target of rapamycin (mTOR), was reported to effectively block viral protein expression and virion release effectively50.
T148 391-502 Sentence denotes Indeed, the latest study revealed the clinical application: sirolimus reduced MERS-CoV infection by over 60%51.
T149 503-661 Sentence denotes Moreover, sirolimus usage in managing patients with severe H1N1 pneumonia and acute respiratory failure can improve those patients’ prognosis significantly50.
T150 662-958 Sentence denotes Mercaptopurine (Z = –2.44 and GSEA score = 1), an antineoplastic agent with immunosuppressant property, has been used to treat cancer since the 1950s and expanded its application to several auto-immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Crohn’s disease52.
T151 959-1169 Sentence denotes Mercaptopurine has been reported as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease which plays key roles in viral maturation and antagonism to interferon stimulation53,54.
T152 1170-1303 Sentence denotes Mechanistically, mercaptopurine potentially target several host proteins in HCoVs, such as JUN, PABPC1, NPM1, and NCL40,55 (Fig. 5d).

2_test

Id Subject Object Predicate Lexical cue
32194980-23135723-19614197 195-197 23135723 denotes 48
32194980-26276683-19614198 198-200 26276683 denotes 49
32194980-24105455-19614199 387-389 24105455 denotes 50
32194980-29143192-19614200 499-501 29143192 denotes 51
32194980-24105455-19614201 658-660 24105455 denotes 50
32194980-18097462-19614202 955-957 18097462 denotes 52
32194980-19374142-19614203 1163-1165 19374142 denotes 53
32194980-25542975-19614204 1166-1168 25542975 denotes 54
32194980-23637410-19614205 1287-1289 23637410 denotes 40
32194980-11967337-19614206 1290-1292 11967337 denotes 55