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PMC:7073332 / 23916-25262 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
703 120-126 Gene denotes mTORC1 Gene:382056
704 303-332 Gene denotes mammalian target of rapamycin Gene:2475
705 334-338 Gene denotes mTOR Gene:2475
706 1309-1315 Gene denotes PABPC1 Gene:26986
707 1317-1321 Gene denotes NPM1 Gene:4869
708 1327-1330 Gene denotes NCL Gene:4691
709 201-222 Species denotes Andes orthohantavirus Tax:1980456
710 227-238 Species denotes coronavirus Tax:11118
711 584-592 Species denotes patients Tax:9606
712 605-609 Species denotes H1N1 Tax:114727
713 668-676 Species denotes patients Tax:9606
714 1068-1076 Species denotes SARS-CoV Tax:694009
715 1081-1089 Species denotes MERS-CoV Tax:1335626
716 99-108 Chemical denotes rapamycin MESH:D020123
717 245-254 Chemical denotes Sirolimus MESH:D020123
718 270-274 Chemical denotes GSEA
719 494-503 Chemical denotes sirolimus MESH:D020123
720 556-565 Chemical denotes sirolimus MESH:D020123
721 705-719 Chemical denotes Mercaptopurine MESH:D015122
722 735-739 Chemical denotes GSEA
723 1002-1016 Chemical denotes Mercaptopurine MESH:D015122
724 1230-1244 Chemical denotes mercaptopurine MESH:D015122
725 512-530 Disease denotes MERS-CoV infection MESH:D018352
726 610-619 Disease denotes pneumonia MESH:D011014
727 630-649 Disease denotes respiratory failure MESH:D012131
728 832-838 Disease denotes cancer MESH:D009369
729 927-947 Disease denotes rheumatoid arthritis MESH:D001172
730 949-977 Disease denotes systemic lupus erythematosus MESH:D008180
731 983-998 Disease denotes Crohn’s disease MESH:D003424

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T128 381-388 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T129 1277-1285 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T102 521-530 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 610-619 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T104 624-649 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T106 832-838 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T107 895-915 Disease denotes auto-immune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T108 927-947 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T109 938-947 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T110 949-977 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T111 958-977 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T112 1068-1076 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T188 168-175 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T189 809-812 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T190 1017-1020 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T191 1038-1039 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T265 21-42 Chemical denotes antineoplastic agents http://purl.obolibrary.org/obo/CHEBI_35610
T266 99-108 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T267 245-254 Chemical denotes Sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T268 290-299 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T269 323-332 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T270 381-388 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T271 481-492 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T272 494-503 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T273 556-565 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T274 705-719 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T275 755-775 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T276 781-798 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T277 872-883 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T278 1002-1016 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T279 1050-1059 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T280 1184-1194 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T281 1230-1244 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T282 1277-1285 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T33 1149-1165 http://purl.obolibrary.org/obo/GO_0019075 denotes viral maturation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 610-619 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 630-649 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T14 832-838 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T15 895-915 Phenotype denotes auto-immune diseases http://purl.obolibrary.org/obo/HP_0002960
T16 927-947 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T17 949-977 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T145 0-42 Sentence denotes Immunosuppressant or antineoplastic agents
T146 43-244 Sentence denotes Previous studies have confirmed the mammalian target of rapamycin complex 1 (mTORC1) as the key factor in regulating various viruses’ replications, including Andes orthohantavirus and coronavirus48,49.
T147 245-433 Sentence denotes Sirolimus (Z = –2.35 and GSEA score = 3), an inhibitor of mammalian target of rapamycin (mTOR), was reported to effectively block viral protein expression and virion release effectively50.
T148 434-545 Sentence denotes Indeed, the latest study revealed the clinical application: sirolimus reduced MERS-CoV infection by over 60%51.
T149 546-704 Sentence denotes Moreover, sirolimus usage in managing patients with severe H1N1 pneumonia and acute respiratory failure can improve those patients’ prognosis significantly50.
T150 705-1001 Sentence denotes Mercaptopurine (Z = –2.44 and GSEA score = 1), an antineoplastic agent with immunosuppressant property, has been used to treat cancer since the 1950s and expanded its application to several auto-immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Crohn’s disease52.
T151 1002-1212 Sentence denotes Mercaptopurine has been reported as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease which plays key roles in viral maturation and antagonism to interferon stimulation53,54.
T152 1213-1346 Sentence denotes Mechanistically, mercaptopurine potentially target several host proteins in HCoVs, such as JUN, PABPC1, NPM1, and NCL40,55 (Fig. 5d).

2_test

Id Subject Object Predicate Lexical cue
32194980-23135723-19614197 238-240 23135723 denotes 48
32194980-26276683-19614198 241-243 26276683 denotes 49
32194980-24105455-19614199 430-432 24105455 denotes 50
32194980-29143192-19614200 542-544 29143192 denotes 51
32194980-24105455-19614201 701-703 24105455 denotes 50
32194980-18097462-19614202 998-1000 18097462 denotes 52
32194980-19374142-19614203 1206-1208 19374142 denotes 53
32194980-25542975-19614204 1209-1211 25542975 denotes 54
32194980-23637410-19614205 1330-1332 23637410 denotes 40
32194980-11967337-19614206 1333-1335 11967337 denotes 55