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PMC:7073332 / 21354-22886 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
555 10-27 Gene denotes estrogen receptor Gene:2099
588 60-77 Gene denotes estrogen receptor Gene:2099
589 323-340 Gene denotes estrogen receptor Gene:2099
590 510-527 Gene denotes estrogen receptor Gene:2099
591 787-791 Gene denotes ESR1 Gene:2099
592 1113-1118 Gene denotes RPL19 Gene:6143
593 1120-1127 Gene denotes HNRNPA1 Gene:3178
594 1129-1133 Gene denotes NPM1 Gene:4869
595 1135-1140 Gene denotes EIF3I Gene:8668
596 1142-1147 Gene denotes EIF3F Gene:8665
597 1153-1158 Gene denotes EIF3E Gene:3646
598 935-943 Gene denotes membrane Gene:43740571
599 878-886 Gene denotes membrane Gene:43740571
600 693-701 Species denotes MERS-CoV Tax:1335626
601 703-711 Species denotes SARS-CoV Tax:694009
602 717-728 Species denotes Ebola virus Tax:1570291
603 1321-1338 Species denotes Zaire Ebola virus Tax:186538
604 1356-1384 Species denotes human immunodeficiency virus Tax:12721
605 1386-1391 Species denotes ZEBOV Tax:186538
608 1099-1103 Species denotes HCoV Tax:694448
609 161-178 Gene denotes estrogen receptor Gene:2099
610 542-552 Chemical denotes Toremifene MESH:D017312
611 819-829 Chemical denotes toremifene MESH:D017312
612 1026-1036 Chemical denotes toremifene MESH:D017312
613 1188-1192 Chemical denotes GSEA
614 1219-1226 Chemical denotes steroid MESH:D013256
615 1448-1458 Chemical denotes toremifene MESH:D017312
616 1463-1470 Chemical denotes equilin MESH:D004857
617 665-681 Disease denotes viral infections MESH:D001102
618 1239-1245 Disease denotes horses MESH:D006734
619 1395-1398 Disease denotes HIV MESH:D015658

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T112 10-18 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T113 60-68 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T114 161-169 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T115 323-331 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T116 510-518 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T117 744-748 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T118 868-877 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T119 944-956 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T120 1074-1082 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T121 1208-1218 Body_part denotes estrogenic http://purl.org/sig/ont/fma/fma83376
T122 1339-1351 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T123 1395-1398 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T84 665-681 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T85 703-711 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 717-722 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T87 1327-1332 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T88 1362-1378 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T89 1521-1529 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T158 10-27 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T159 60-77 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T160 78-81 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T161 101-102 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 161-178 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T163 225-226 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 450-458 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T165 510-527 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T166 723-728 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T167 744-748 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T168 878-886 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 929-934 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T170 935-943 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T171 1239-1245 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes horses
T172 1252-1255 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T173 1285-1293 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T174 1333-1338 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T175 1356-1361 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T176 1379-1384 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T177 1399-1401 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T230 10-18 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T231 19-38 Chemical denotes receptor modulators http://purl.obolibrary.org/obo/CHEBI_90710
T232 60-68 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T233 161-169 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T234 170-189 Chemical denotes receptor modulators http://purl.obolibrary.org/obo/CHEBI_90710
T235 323-331 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T236 440-449 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T237 510-518 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T238 800-809 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T239 819-829 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T240 944-956 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T241 1026-1036 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T242 1074-1082 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T243 1165-1172 Chemical denotes Equilin http://purl.obolibrary.org/obo/CHEBI_42309
T244 1219-1226 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T245 1339-1351 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T246 1392-1394 Chemical denotes GP http://purl.obolibrary.org/obo/CHEBI_70744
T247 1448-1458 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T248 1463-1470 Chemical denotes equilin http://purl.obolibrary.org/obo/CHEBI_42309
T249 1501-1506 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T27 243-271 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T28 254-271 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T29 254-271 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T30 665-681 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T7 1362-1378 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T128 0-38 Sentence denotes Selective estrogen receptor modulators
T129 39-150 Sentence denotes An overexpression of estrogen receptor has been shown to play a crucial role in inhibiting viral replication37.
T130 151-343 Sentence denotes Selective estrogen receptor modulators (SERMs) have been reported to play a broader role in inhibiting viral replication through the non-classical pathways associated with estrogen receptor37.
T131 344-541 Sentence denotes SERMs interfere at the post viral entry step and affect the triggering of fusion, as the SERMs’ antiviral activity still can be observed in the absence of detectable estrogen receptor expression18.
T132 542-760 Sentence denotes Toremifene (Z = –3.23, Fig. 5a), the first generation of nonsteroidal SERM, exhibits potential effects in blocking various viral infections, including MERS-CoV, SARS-CoV, and Ebola virus in established cell lines17,38.
T133 761-1004 Sentence denotes Compared to the classical ESR1-related antiviral pathway, toremifene prevents fusion between the viral and endosomal membrane by interacting with and destabilizing the virus membrane glycoprotein, and eventually inhibiting viral replication39.
T134 1005-1164 Sentence denotes As shown in Fig. 5b, toremifene potentially affects several key host proteins associated with HCoV, such as RPL19, HNRNPA1, NPM1, EIF3I, EIF3F, and EIF3E40,41.
T135 1165-1402 Sentence denotes Equilin (Z = –2.52 and GSEA score = 3), an estrogenic steroid produced by horses, also has been proven to have moderate activity in inhibiting the entry of Zaire Ebola virus glycoprotein and human immunodeficiency virus (ZEBOV-GP/HIV)18.
T136 1403-1532 Sentence denotes Altogether, network-predicted SERMs (such as toremifene and equilin) offer candidate repurposable drugs for 2019-nCoV/SARS-CoV-2.

2_test

Id Subject Object Predicate Lexical cue
32194980-31474372-19614186 147-149 31474372 denotes 37
32194980-31474372-19614187 340-342 31474372 denotes 37
32194980-24841273-19614188 754-756 24841273 denotes 17
32194980-24841269-19614189 757-759 24841269 denotes 38
32194980-27362232-19614190 1001-1003 27362232 denotes 39
32194980-23637410-19614191 1158-1160 23637410 denotes 40
32194980-30632963-19614192 1161-1163 30632963 denotes 41