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PMC:7073332 / 2042-49300 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
104 13-26 Species denotes Coronaviruses Tax:11118
105 28-32 Species denotes CoVs Tax:11118
106 95-101 Species denotes humans Tax:9606
107 208-213 Species denotes human Tax:9606
108 214-218 Species denotes CoVs Tax:11118
109 238-283 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
110 285-293 Species denotes SARS-CoV Tax:694009
111 299-354 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
112 518-526 Species denotes SARS-CoV Tax:694009
113 680-688 Species denotes MERS-CoV Tax:1335626
114 831-853 Species denotes 2019 novel coronavirus Tax:2697049
115 855-864 Species denotes 2019-nCoV Tax:2697049
116 865-875 Species denotes SARS-CoV-2 Tax:2697049
117 1062-1071 Species denotes 2019-nCoV Tax:2697049
118 1072-1082 Species denotes SARS-CoV-2 Tax:2697049
119 1116-1121 Species denotes human Tax:9606
120 1125-1130 Species denotes human Tax:9606
121 1242-1251 Species denotes 2019-nCoV Tax:2697049
122 1252-1262 Species denotes SARS-CoV-2 Tax:2697049
123 1383-1392 Species denotes 2019-nCoV Tax:2697049
124 1393-1403 Species denotes SARS-CoV-2 Tax:2697049
125 1548-1557 Species denotes 2019-nCoV Tax:2697049
126 1558-1568 Species denotes SARS-CoV-2 Tax:2697049
127 55-66 Species denotes respiratory Tax:12814
128 819-823 Species denotes HCoV Tax:694448
129 130-158 Disease denotes respiratory tract infections MESH:D012141
130 442-451 Disease denotes mortality MESH:D003643
131 489-497 Disease denotes infected MESH:D007239
132 741-747 Disease denotes deaths MESH:D003643
133 894-918 Disease denotes coronavirus disease 2019 MESH:C000657245
134 935-943 Disease denotes COVID-19 MESH:C000657245
135 1047-1053 Disease denotes deaths MESH:D003643
138 1766-1767 Gene denotes S Gene:43740568
139 2615-2620 Species denotes human Tax:9606
152 14721-14729 Species denotes SARS-CoV Tax:694009
153 14731-14739 Species denotes MERS-CoV Tax:1335626
158 2785-2789 Species denotes HCoV Tax:694448
159 2855-2864 Disease denotes infection MESH:D007239
160 3004-3019 Disease denotes viral infection MESH:D001102
161 3185-3201 Disease denotes viral infections MESH:D001102
173 5343-5348 Species denotes human Tax:9606
174 5364-5381 Species denotes Human coronavirus Tax:694448
175 5648-5653 Species denotes human Tax:9606
176 6012-6017 Species denotes human Tax:9606
177 6221-6226 Species denotes human Tax:9606
178 6447-6452 Species denotes human Tax:9606
179 5383-5387 Species denotes HCoV Tax:694448
180 5475-5479 Species denotes HCoV Tax:694448
181 5545-5549 Species denotes HCoV Tax:694448
182 5949-5953 Species denotes HCoV Tax:694448
183 6374-6383 Disease denotes infection MESH:D007239
193 4397-4402 Species denotes human Tax:9606
194 4628-4633 Species denotes human Tax:9606
195 4845-4850 Species denotes human Tax:9606
196 4996-5001 Species denotes human Tax:9606
197 4551-4555 Species denotes HCoV Tax:694448
198 4964-4968 Species denotes HCoV Tax:694448
199 5073-5077 Species denotes HCoV Tax:694448
200 4524-4539 Disease denotes viral infection MESH:D001102
201 4772-4781 Disease denotes infection MESH:D007239
203 6501-6510 Species denotes 2019-nCoV Tax:2697049
205 7318-7331 Species denotes coronaviruses Tax:11118
214 7941-7946 Gene denotes spike Gene:43740568
215 7356-7367 Species denotes coronavirus Tax:11118
216 7369-7372 Species denotes CoV Tax:11118
217 7459-7472 Species denotes coronaviruses Tax:11118
218 7515-7537 Species denotes coronavirus, 2019-nCoV Tax:2697049
219 7538-7548 Species denotes SARS-CoV-2 Tax:2697049
220 7906-7914 Species denotes SARS-CoV Tax:694009
221 7710-7714 Species denotes HCoV Tax:694448
241 6592-6601 Species denotes 2019-nCoV Tax:2697049
242 6602-6612 Species denotes SARS-CoV-2 Tax:2697049
243 6614-6622 Species denotes SARS-CoV Tax:694009
244 6624-6632 Species denotes MERS-CoV Tax:1335626
245 6634-6643 Species denotes HCoV-OC43 Tax:31631
246 6649-6658 Species denotes HCoV-HKU1 Tax:290028
247 6682-6691 Species denotes HCoV-NL63 Tax:277944
248 6696-6705 Species denotes HCoV-229E Tax:11137
249 6854-6863 Species denotes 2019-nCoV Tax:2697049
250 6864-6874 Species denotes SARS-CoV-2 Tax:2697049
251 6928-6937 Species denotes 2019-nCoV Tax:2697049
252 6938-6948 Species denotes SARS-CoV-2 Tax:2697049
253 7013-7021 Species denotes patients Tax:9606
254 7052-7061 Species denotes 2019-nCoV Tax:2697049
255 7062-7072 Species denotes SARS-CoV-2 Tax:2697049
256 7134-7142 Species denotes SARS-CoV Tax:694009
257 7241-7250 Species denotes 2019-nCoV Tax:2697049
258 7251-7261 Species denotes SARS-CoV-2 Tax:2697049
259 7266-7274 Species denotes SARS-CoV Tax:694009
287 8265-8271 Gene denotes ORF1ab Gene:43740578
288 8274-8279 Gene denotes spike Gene:43740568
289 8281-8282 Gene denotes S Gene:43740568
290 8295-8296 Gene denotes E Gene:43740570
291 8299-8307 Gene denotes membrane Gene:43740571
292 8309-8310 Gene denotes M Gene:43740571
293 8358-8364 Gene denotes ORF1ab Gene:43740578
294 8553-8557 Gene denotes nsp7 Gene:43740578
295 8562-8566 Gene denotes nsp8 Gene:43740578
296 8716-8720 Gene denotes nsp7 Gene:43740578
297 8725-8729 Gene denotes nsp8 Gene:43740578
298 8768-8773 Gene denotes spike Gene:43740568
299 8941-8946 Gene denotes spike Gene:43740568
300 9017-9021 Gene denotes ACE2 Gene:59272
301 9118-9122 Gene denotes ACE2 Gene:59272
302 9147-9151 Gene denotes ACE2 Gene:59272
303 9339-9344 Gene denotes spike Gene:43740568
304 9351-9355 Gene denotes ACE2 Gene:59272
305 9273-9278 Gene denotes spike Gene:43740568
306 8642-8650 Species denotes SARS-CoV Tax:694009
307 9026-9034 Species denotes SARS-CoV Tax:694009
308 9078-9087 Species denotes 2019-nCoV Tax:2697049
309 9088-9098 Species denotes SARS-CoV-2 Tax:2697049
310 9318-9327 Species denotes 2019-nCoV Tax:2697049
311 9328-9338 Species denotes SARS-CoV-2 Tax:2697049
312 9382-9390 Species denotes SARS-CoV Tax:694009
313 8845-8860 Disease denotes viral infection MESH:D001102
328 9964-9969 Gene denotes spike Gene:43740568
329 10106-10111 Gene denotes spike Gene:43740568
330 9633-9642 Species denotes 2019-nCoV Tax:2697049
331 9643-9653 Species denotes SARS-CoV-2 Tax:2697049
332 9693-9701 Species denotes SARS-CoV Tax:694009
333 9784-9793 Species denotes 2019-nCoV Tax:2697049
334 9794-9804 Species denotes SARS-CoV-2 Tax:2697049
335 9916-9924 Species denotes SARS-CoV Tax:694009
336 10056-10065 Species denotes 2019-nCoV Tax:2697049
337 10066-10076 Species denotes SARS-CoV-2 Tax:2697049
338 10081-10089 Species denotes SARS-CoV Tax:694009
339 10123-10132 Species denotes 2019-nCoV Tax:2697049
340 10133-10143 Species denotes SARS-CoV-2 Tax:2697049
341 10189-10197 Species denotes MERS-CoV Tax:1335626
343 10200-10204 Species denotes HCoV Tax:694448
345 12100-12104 Species denotes HCoV Tax:694448
350 12600-12605 Species denotes human Tax:9606
351 12155-12159 Species denotes HCoV Tax:694448
352 12209-12213 Species denotes HCoV Tax:694448
353 12668-12672 Species denotes HCoV Tax:694448
380 10800-10804 Gene denotes XPO1 Gene:7514
381 10806-10810 Gene denotes NPM1 Gene:4869
382 10816-10823 Gene denotes HNRNPA1 Gene:3178
383 11772-11777 Gene denotes GSK3B Gene:2932
384 11779-11783 Gene denotes DPP4 Gene:1803
385 11785-11790 Gene denotes SMAD3 Gene:4088
386 11792-11797 Gene denotes PARP1 Gene:142
387 11803-11808 Gene denotes IKBKB Gene:3551
388 10292-10295 Species denotes CoV Tax:11118
389 10344-10352 Species denotes SARS-CoV Tax:694009
390 10354-10362 Species denotes MERS-CoV Tax:1335626
391 10364-10373 Species denotes HCoV-229E Tax:11137
392 10379-10388 Species denotes HCoV-NL63 Tax:277944
393 10395-10400 Species denotes mouse Tax:10090
394 10518-10522 Species denotes CoVs Tax:11118
395 11625-11630 Species denotes human Tax:9606
396 12035-12044 Species denotes 2019-nCoV Tax:2697049
397 12045-12055 Species denotes SARS-CoV-2 Tax:2697049
398 10244-10248 Species denotes HCoV Tax:694448
399 10626-10630 Species denotes HCoV Tax:694448
400 10699-10703 Species denotes HCoV Tax:694448
401 11543-11547 Species denotes HCoV Tax:694448
402 11868-11872 Species denotes HCoV Tax:694448
403 10679-10693 Disease denotes HCoV infection MESH:D007239
404 11055-11083 Disease denotes Epstein-Barr virus infection MESH:D020031
405 11195-11210 Disease denotes viral infection MESH:D001102
414 12988-12993 Species denotes human Tax:9606
415 13186-13191 Species denotes human Tax:9606
416 13465-13470 Species denotes human Tax:9606
417 13684-13689 Species denotes human Tax:9606
418 14237-14242 Species denotes human Tax:9606
419 13075-13079 Species denotes HCoV Tax:694448
420 13406-13410 Species denotes HCoV Tax:694448
421 12891-12906 Disease denotes viral infection MESH:D001102
423 15282-15286 Species denotes HCoV Tax:694448
431 15531-15536 Species denotes human Tax:9606
432 15724-15732 Species denotes SARS-CoV Tax:694009
433 15734-15742 Species denotes MERS-CoV Tax:1335626
434 15879-15884 Species denotes human Tax:9606
435 15347-15351 Species denotes HCoV Tax:694448
436 15499-15503 Species denotes HCoV Tax:694448
437 15847-15851 Species denotes HCoV Tax:694448
449 14516-14524 Gene denotes S4 and 5 Gene:6192
450 14585-14589 Species denotes CoVs Tax:11118
451 14663-14667 Species denotes CoVs Tax:11118
452 37034-37042 Species denotes SARS-CoV Tax:694009
453 37044-37052 Species denotes MERS-CoV Tax:1335626
457 14463-14467 Species denotes HCoV Tax:694448
458 37738-37742 Species denotes HCoV Tax:694448
461 17744-17748 Species denotes HCoV Tax:694448
474 18561-18578 Gene denotes estrogen receptor Gene:2099
475 18086-18091 Species denotes human Tax:9606
476 17976-17980 Species denotes HCoV Tax:694448
477 18053-18057 Species denotes HCoV Tax:694448
478 18150-18154 Species denotes HCoV Tax:694448
479 18331-18335 Chemical denotes GSEA
480 18509-18519 Chemical denotes toremifene MESH:D017312
481 18593-18603 Chemical denotes irbesartan MESH:D000077405
482 18641-18655 Chemical denotes mercaptopurine MESH:D015122
483 18738-18747 Chemical denotes melatonin MESH:D008550
484 18760-18765 Chemical denotes amine MESH:D000588
485 18789-18811 Disease denotes rhythm sleep disorders MESH:D012893
504 19250-19262 Gene denotes HSV-1 and -2
505 18960-18981 Species denotes hepatitis delta virus Tax:12475
506 18983-18987 Species denotes EBOV Tax:1570291
507 18988-18993 Species denotes Ebola Tax:1570291
508 19003-19008 Species denotes ZEBOV Tax:186538
509 19012-19029 Species denotes Zaire Ebola virus Tax:186538
510 19082-19100 Species denotes Epstein-Barr virus Tax:10376
511 19107-19128 Species denotes Andes orthohantavirus Tax:1980456
512 19130-19134 Species denotes EMCV Tax:12104
513 19135-19161 Species denotes encephalomyocarditis virus Tax:12104
514 19163-19167 Species denotes FECV Tax:12663
515 19168-19194 Species denotes feline enteric coronavirus Tax:12663
516 19200-19227 Species denotes respiratory syncytial virus Tax:12814
517 19229-19233 Species denotes EV71 Tax:39054
518 19234-19248 Species denotes enterovirus 71 Tax:39054
519 19287-19291 Species denotes CVB4 Tax:12073
520 19292-19309 Species denotes Coxsackievirus B4 Tax:12073
521 19044-19076 Disease denotes HIV human immunodeficiency virus MESH:D015658
538 17052-17069 Gene denotes estrogen receptor Gene:2099
539 16135-16143 Species denotes MERS-CoV Tax:1335626
540 16326-16331 Species denotes human Tax:9606
541 16621-16625 Species denotes HCoV Tax:694448
542 16778-16782 Species denotes HCoV Tax:694448
543 16435-16439 Chemical denotes GSEA
544 16797-16801 Chemical denotes GSEA
545 16902-16912 Chemical denotes Mesalazine MESH:D019804
546 16964-16973 Chemical denotes sirolimus MESH:D020123
547 17016-17023 Chemical denotes equilin MESH:D004857
548 17116-17120 Chemical denotes GSEA
549 17146-17156 Chemical denotes paroxetine MESH:D017374
550 17161-17170 Chemical denotes melatonin MESH:D008550
551 17484-17488 Chemical denotes GSEA
552 16148-16165 Disease denotes SARS-CoV infected MESH:C000657245
553 16935-16961 Disease denotes inflammatory bowel disease MESH:D015212
555 19322-19339 Gene denotes estrogen receptor Gene:2099
588 19372-19389 Gene denotes estrogen receptor Gene:2099
589 19635-19652 Gene denotes estrogen receptor Gene:2099
590 19822-19839 Gene denotes estrogen receptor Gene:2099
591 20099-20103 Gene denotes ESR1 Gene:2099
592 20425-20430 Gene denotes RPL19 Gene:6143
593 20432-20439 Gene denotes HNRNPA1 Gene:3178
594 20441-20445 Gene denotes NPM1 Gene:4869
595 20447-20452 Gene denotes EIF3I Gene:8668
596 20454-20459 Gene denotes EIF3F Gene:8665
597 20465-20470 Gene denotes EIF3E Gene:3646
598 20247-20255 Gene denotes membrane Gene:43740571
599 20190-20198 Gene denotes membrane Gene:43740571
600 20005-20013 Species denotes MERS-CoV Tax:1335626
601 20015-20023 Species denotes SARS-CoV Tax:694009
602 20029-20040 Species denotes Ebola virus Tax:1570291
603 20633-20650 Species denotes Zaire Ebola virus Tax:186538
604 20668-20696 Species denotes human immunodeficiency virus Tax:12721
605 20698-20703 Species denotes ZEBOV Tax:186538
608 20411-20415 Species denotes HCoV Tax:694448
609 19473-19490 Gene denotes estrogen receptor Gene:2099
610 19854-19864 Chemical denotes Toremifene MESH:D017312
611 20131-20141 Chemical denotes toremifene MESH:D017312
612 20338-20348 Chemical denotes toremifene MESH:D017312
613 20500-20504 Chemical denotes GSEA
614 20531-20538 Chemical denotes steroid MESH:D013256
615 20760-20770 Chemical denotes toremifene MESH:D017312
616 20775-20782 Chemical denotes equilin MESH:D004857
617 19977-19993 Disease denotes viral infections MESH:D001102
618 20551-20557 Disease denotes horses MESH:D006734
619 20707-20710 Disease denotes HIV MESH:D015658
647 21302-21309 Gene denotes SLC10A1 Gene:6554
648 21356-21360 Gene denotes NTCP Gene:6554
649 21411-21416 Gene denotes preS1 Gene:944569
650 21527-21531 Gene denotes NTCP Gene:6554
651 21567-21574 Gene denotes SLC10A1 Gene:6554
652 21590-21598 Gene denotes C11orf74 Gene:119710
653 21243-21248 Species denotes human Tax:9606
654 21443-21460 Species denotes hepatitis B virus Tax:10407
655 21475-21496 Species denotes hepatitis delta virus Tax:12475
656 21668-21676 Species denotes SARS-CoV Tax:694009
657 21854-21859 Species denotes human Tax:9606
658 21206-21210 Species denotes HCoV Tax:694448
659 21462-21465 Species denotes HBV Tax:10407
660 21498-21501 Species denotes HDV Tax:12475
661 21817-21821 Species denotes HCoV Tax:694448
662 20989-20999 Chemical denotes Irbesartan MESH:D000077405
663 21181-21191 Chemical denotes irbesartan MESH:D000077405
664 21283-21293 Chemical denotes irbesartan MESH:D000077405
665 21324-21330 Chemical denotes sodium MESH:D012964
666 21331-21340 Chemical denotes bile acid MESH:D001647
667 21504-21514 Chemical denotes Irbesartan MESH:D000077405
668 21718-21728 Chemical denotes eletriptan MESH:C115647
669 21730-21742 Chemical denotes frovatriptan MESH:C108128
670 21748-21760 Chemical denotes zolmitriptan MESH:C089750
671 20950-20965 Disease denotes viral infection MESH:D001102
672 21069-21081 Disease denotes hypertension MESH:D006973
673 21086-21106 Disease denotes diabetic nephropathy MESH:D003928
703 21994-22000 Gene denotes mTORC1 Gene:382056
704 22177-22206 Gene denotes mammalian target of rapamycin Gene:2475
705 22208-22212 Gene denotes mTOR Gene:2475
706 23183-23189 Gene denotes PABPC1 Gene:26986
707 23191-23195 Gene denotes NPM1 Gene:4869
708 23201-23204 Gene denotes NCL Gene:4691
709 22075-22096 Species denotes Andes orthohantavirus Tax:1980456
710 22101-22112 Species denotes coronavirus Tax:11118
711 22458-22466 Species denotes patients Tax:9606
712 22479-22483 Species denotes H1N1 Tax:114727
713 22542-22550 Species denotes patients Tax:9606
714 22942-22950 Species denotes SARS-CoV Tax:694009
715 22955-22963 Species denotes MERS-CoV Tax:1335626
716 21973-21982 Chemical denotes rapamycin MESH:D020123
717 22119-22128 Chemical denotes Sirolimus MESH:D020123
718 22144-22148 Chemical denotes GSEA
719 22368-22377 Chemical denotes sirolimus MESH:D020123
720 22430-22439 Chemical denotes sirolimus MESH:D020123
721 22579-22593 Chemical denotes Mercaptopurine MESH:D015122
722 22609-22613 Chemical denotes GSEA
723 22876-22890 Chemical denotes Mercaptopurine MESH:D015122
724 23104-23118 Chemical denotes mercaptopurine MESH:D015122
725 22386-22404 Disease denotes MERS-CoV infection MESH:D018352
726 22484-22493 Disease denotes pneumonia MESH:D011014
727 22504-22523 Disease denotes respiratory failure MESH:D012131
728 22706-22712 Disease denotes cancer MESH:D009369
729 22801-22821 Disease denotes rheumatoid arthritis MESH:D001172
730 22823-22851 Disease denotes systemic lupus erythematosus MESH:D008180
731 22857-22872 Disease denotes Crohn’s disease MESH:D003424
758 24239-24243 Gene denotes ACE2 Gene:59272
759 24245-24251 Gene denotes BCL2L1 Gene:598
760 24262-24267 Gene denotes IKBKB Gene:3551
761 23817-23825 Species denotes patients Tax:9606
762 24020-24028 Species denotes patients Tax:9606
763 24076-24084 Species denotes patients Tax:9606
764 24503-24507 Species denotes mice Tax:10090
765 24522-24548 Species denotes encephalomyocarditis virus Tax:12104
766 24206-24210 Species denotes HCoV Tax:694448
767 23330-23335 Chemical denotes amine MESH:D000588
768 23337-23346 Chemical denotes melatonin MESH:D008550
769 23348-23376 Chemical denotes N-acetyl-5-methoxytryptamine
770 23393-23397 Chemical denotes GSEA
771 23761-23770 Chemical denotes melatonin MESH:D008550
772 23881-23890 Chemical denotes melatonin MESH:D008550
773 23998-24007 Chemical denotes melatonin MESH:D008550
774 24169-24178 Chemical denotes melatonin MESH:D008550
775 24269-24279 Chemical denotes Eplerenone MESH:D000077545
776 24296-24307 Chemical denotes aldosterone MESH:D000450
777 24387-24396 Chemical denotes melatonin MESH:D008550
778 24468-24478 Chemical denotes eplerenone MESH:D000077545
779 23293-23309 Disease denotes viral infections MESH:D001102
780 23512-23528 Disease denotes viral infections MESH:D001102
781 23535-23551 Disease denotes Viral infections MESH:D001102
782 24458-24466 Disease denotes fibrosis MESH:D005355
783 24508-24516 Disease denotes infected MESH:D007239
786 24719-24728 Species denotes 2019-nCoV Tax:2697049
787 24729-24739 Species denotes SARS-CoV-2 Tax:2697049
789 24973-24982 Species denotes 2019-nCoV Tax:2697049
792 26212-26221 Species denotes 2019-nCoV Tax:2697049
793 26222-26232 Species denotes SARS-CoV-2 Tax:2697049
803 27066-27083 Gene denotes estrogen receptor Gene:2099
804 26620-26633 Gene denotes Drugs A and B
805 26525-26530 Species denotes human Tax:9606
806 26270-26274 Species denotes HCoV Tax:694448
807 26462-26466 Species denotes HCoV Tax:694448
808 26650-26654 Species denotes HCoV Tax:694448
809 27003-27009 Disease denotes tumors MESH:D009369
810 27150-27167 Disease denotes polycystic kidney MESH:D007690
811 27227-27249 Disease denotes rhythm sleep disorders MESH:D012893
820 25843-25852 Species denotes 2019-nCoV Tax:2697049
821 25853-25863 Species denotes SARS-CoV-2 Tax:2697049
822 26052-26061 Species denotes 2019-nCoV Tax:2697049
823 26062-26072 Species denotes SARS-CoV-2 Tax:2697049
824 25065-25073 Disease denotes toxicity MESH:D064420
825 25118-25134 Disease denotes viral infections MESH:D001102
826 25484-25496 Disease denotes hypertension MESH:D006973
827 25501-25507 Disease denotes cancer MESH:D009369
830 27348-27357 Chemical denotes Sirolimus MESH:D020123
831 27363-27375 Chemical denotes Dactinomycin MESH:D003609
852 27403-27407 Gene denotes mTOR Gene:2475
853 27573-27577 Gene denotes mTOR Gene:2475
854 28153-28157 Gene denotes mTOR Gene:2475
855 28205-28230 Gene denotes DNA topoisomerase 2-alpha Gene:7153
856 28232-28237 Gene denotes TOP2A Gene:7153
857 28243-28267 Gene denotes DNA topoisomerase 2-beta Gene:7155
858 28269-28274 Gene denotes TOP2B Gene:7155
859 27500-27508 Species denotes patients Tax:9606
860 27521-27525 Species denotes H1N1 Tax:114727
861 27845-27848 Species denotes CoV Tax:11118
862 27955-27959 Species denotes HCoV Tax:694448
863 28089-28093 Species denotes HCoV Tax:694448
864 27376-27385 Chemical denotes Sirolimus MESH:D020123
865 27638-27650 Chemical denotes Dactinomycin MESH:D003609
866 27663-27676 Chemical denotes actinomycin D MESH:D003609
867 27526-27535 Disease denotes pneumonia MESH:D011014
868 27546-27565 Disease denotes respiratory failure MESH:D012131
869 27621-27634 Disease denotes CoV infection MESH:D018352
870 27742-27748 Disease denotes cancer MESH:D009369
871 28280-28293 Disease denotes HCoV-infected MESH:D007239
874 28312-28322 Chemical denotes Toremifene MESH:D017312
875 28328-28334 Chemical denotes Emodin MESH:D004642
896 28963-28967 Gene denotes ACE2 Gene:59272
897 28945-28950 Gene denotes spike Gene:43740568
898 28558-28569 Species denotes Ebola virus Tax:1570291
899 28656-28664 Species denotes MERS-CoV Tax:1335626
900 28679-28682 Species denotes CoV Tax:11118
901 28760-28776 Species denotes rheum tanguticum Tax:137226
902 28863-28871 Species denotes SARS-CoV Tax:694009
903 28936-28944 Species denotes SARS-CoV Tax:694009
904 29132-29141 Species denotes 2019-nCoV Tax:2697049
905 29142-29152 Species denotes SARS-CoV-2 Tax:2697049
906 28335-28345 Chemical denotes Toremifene MESH:D017312
907 28470-28480 Chemical denotes toremifene MESH:D017312
908 28625-28635 Chemical denotes toremifene MESH:D017312
909 28696-28702 Chemical denotes Emodin MESH:D004642
910 28707-28720 Chemical denotes anthraquinone MESH:D000880
911 28846-28852 Chemical denotes emdoin
912 29065-29075 Chemical denotes toremifene MESH:D017312
913 29080-29086 Chemical denotes emdoin
914 28436-28449 Disease denotes breast cancer MESH:D001943
915 28498-28513 Disease denotes virus infection MESH:D001102
918 29165-29179 Chemical denotes Mercaptopurine MESH:D015122
919 29185-29194 Chemical denotes Melatonin MESH:D008550
956 29662-29666 Gene denotes ACE2 Gene:59272
957 29828-29838 Gene denotes calmodulin Gene:801
958 29843-29853 Gene denotes calmodulin Gene:801
959 29869-29873 Gene denotes ACE2 Gene:59272
960 29978-29983 Gene denotes c-Jun Gene:3725
961 30132-30137 Gene denotes c-Jun Gene:3725
962 30362-30366 Gene denotes ACE2 Gene:59272
963 30368-30373 Gene denotes c-Jun Gene:3725
964 30473-30477 Gene denotes ACE2 Gene:59272
965 29335-29340 Species denotes human Tax:9606
966 29457-29465 Species denotes SARS-CoV Tax:694009
967 29470-29478 Species denotes MERS-CoV Tax:1335626
968 29748-29757 Species denotes 2019-nCoV Tax:2697049
969 29758-29768 Species denotes SARS-CoV-2 Tax:2697049
970 29944-29952 Species denotes SARS-CoV Tax:694009
971 30025-30052 Species denotes infectious bronchitis virus Tax:11120
972 30290-30299 Species denotes 2019-nCoV Tax:2697049
973 30300-30310 Species denotes SARS-CoV-2 Tax:2697049
974 30503-30512 Species denotes 2019-nCoV Tax:2697049
975 30513-30523 Species denotes SARS-CoV-2 Tax:2697049
976 29922-29932 Species denotes infectious Tax:11120
977 29298-29302 Species denotes HCoV Tax:694448
978 30020-30024 Species denotes HCoV Tax:694448
979 29232-29246 Chemical denotes mercaptopurine MESH:D015122
980 29251-29260 Chemical denotes melatonin MESH:D008550
981 29409-29423 Chemical denotes mercaptopurine MESH:D015122
982 29519-29528 Chemical denotes Melatonin MESH:D008550
983 29631-29640 Chemical denotes Melatonin MESH:D008550
984 29794-29803 Chemical denotes melatonin MESH:D008550
985 30077-30091 Chemical denotes mercaptopurine MESH:D015122
986 30096-30105 Chemical denotes melatonin MESH:D008550
987 30215-30229 Chemical denotes mercaptopurine MESH:D015122
988 30234-30243 Chemical denotes melatonin MESH:D008550
989 30490-30499 Chemical denotes melatonin MESH:D008550
990 29565-29574 Disease denotes infection MESH:D007239
991 29712-29727 Disease denotes viral infection MESH:D001102
1003 35676-35685 Species denotes 2019-nCoV Tax:2697049
1004 35686-35696 Species denotes SARS-CoV-2 Tax:2697049
1031 32415-32420 Gene denotes EIF4A Gene:1974
1032 31477-31486 Species denotes 2019-nCoV Tax:2697049
1033 31487-31497 Species denotes SARS-CoV-2 Tax:2697049
1034 31590-31599 Species denotes 2019-nCoV Tax:2697049
1035 31600-31610 Species denotes SARS-CoV-2 Tax:2697049
1036 31658-31667 Species denotes 2019-nCoV Tax:2697049
1037 31668-31678 Species denotes SARS-CoV-2 Tax:2697049
1038 32338-32343 Species denotes Ebola Tax:1570291
1039 32350-32363 Species denotes Coronaviruses Tax:11118
1040 32872-32877 Species denotes human Tax:9606
1041 32960-32969 Species denotes 2019-nCoV Tax:2697049
1042 32970-32980 Species denotes SARS-CoV-2 Tax:2697049
1043 33561-33570 Species denotes 2019-nCoV Tax:2697049
1044 33571-33581 Species denotes SARS-CoV-2 Tax:2697049
1045 32242-32252 Chemical denotes Silvestrol MESH:C489897
1046 32281-32291 Chemical denotes flavagline
1047 32424-32434 Chemical denotes silvestrol MESH:C489897
1060 34333-34342 Species denotes 2019-nCoV Tax:2697049
1061 34343-34353 Species denotes SARS-CoV-2 Tax:2697049
1062 34938-34943 Species denotes human Tax:9606
1063 35047-35051 Species denotes nCoV Tax:2697049
1064 34910-34914 Species denotes HCoV Tax:694448
1065 34011-34021 Chemical denotes Mesalazine MESH:D019804
1066 34260-34270 Chemical denotes mesalazine MESH:D019804
1067 35267-35277 Chemical denotes remdesivir MESH:C000606551
1068 33879-33887 Disease denotes toxicity MESH:D064420
1069 34044-34070 Disease denotes inflammatory bowel disease MESH:D015212
1070 34201-34221 Disease denotes pulmonary toxicities MESH:D008171
1071 34233-34242 Disease denotes pneumonia MESH:D011014
1087 36577-36580 Gene denotes ebi Gene:6907
1088 36328-36337 Species denotes 2019-nCoV Tax:2697049
1089 36338-36348 Species denotes SARS-CoV-2 Tax:2697049
1100 37064-37073 Species denotes HCoV-229E Tax:11137
1101 37079-37088 Species denotes HCoV-NL63 Tax:277944
1102 36885-36889 Species denotes HCoV Tax:694448
1103 36976-36980 Species denotes HCoV Tax:694448
1104 37151-37155 Species denotes HCoV Tax:694448
1105 37206-37220 Disease denotes HCoV infection MESH:D007239
1109 38387-38392 Species denotes human Tax:9606
1111 38586-38591 Species denotes human Tax:9606
1115 38653-38658 Species denotes human Tax:9606
1116 39560-39565 Species denotes human Tax:9606
1117 39813-39818 Species denotes human Tax:9606
1122 39941-39946 Species denotes human Tax:9606
1123 40917-40922 Species denotes human Tax:9606
1124 40147-40151 Species denotes HCoV Tax:694448
1125 42029-42033 Species denotes HCoV Tax:694448
1129 42666-42679 Gene denotes drugs A and B
1130 42465-42469 Species denotes HCoV Tax:694448
1131 42506-42510 Species denotes HCoV Tax:694448
1145 44108-44115 Species denotes patient Tax:9606
1146 44377-44381 Species denotes HCoV Tax:694448
1147 44739-44743 Species denotes HCoV Tax:694448
1148 45512-45516 Species denotes HCoV Tax:694448
1149 46452-46456 Species denotes HCoV Tax:694448
1150 46932-46936 Species denotes HCoV Tax:694448
1151 47121-47125 Species denotes HCoV Tax:694448
1152 47169-47173 Chemical denotes GSEA
1153 43969-43977 Disease denotes infected MESH:D007239
1154 44077-44094 Disease denotes SARS-CoV-infected MESH:C000657245
1155 44228-44240 Disease denotes CoV-infected MESH:D018352
1156 44151-44157 CellLine denotes Calu-3 CVCL:0609
1157 44241-44247 CellLine denotes Calu-3 CVCL:0609

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T10 55-72 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T11 130-147 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T12 2535-2543 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T13 2676-2684 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T14 2907-2914 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 2915-2922 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 3365-3369 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T17 3422-3426 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T18 4482-4490 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T19 4655-4663 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T20 4944-4948 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T21 5002-5006 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 5405-5413 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T23 5480-5487 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T24 5561-5569 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T25 5654-5661 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 5686-5690 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T27 6102-6110 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T28 6257-6265 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T29 6400-6407 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 6408-6415 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 6775-6781 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T32 6917-6924 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T33 6961-6971 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T34 7092-7102 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T35 7445-7452 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T36 7715-7722 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T37 8042-8048 Body_part denotes Genome http://purl.org/sig/ont/fma/fma84116
T38 8165-8172 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T39 8334-8342 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T40 8365-8369 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T41 8397-8405 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T42 8421-8424 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T43 8498-8501 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T44 8512-8515 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T45 8613-8620 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 8793-8805 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T47 8947-8954 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 9477-9483 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T49 9492-9499 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T50 9578-9585 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T51 9772-9780 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T52 9970-9977 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53 10112-10119 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54 10312-10320 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T55 10427-10434 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 10493-10501 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T57 10584-10592 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T58 10631-10639 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T59 10776-10784 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T60 10879-10887 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T61 11018-11021 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T62 11110-11114 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T63 11445-11449 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T64 11631-11639 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 11833-11841 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T66 11977-11985 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T67 12230-12238 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T68 12253-12261 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T69 12345-12353 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T70 12397-12404 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T71 12405-12412 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 12500-12507 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T73 12508-12515 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 12622-12626 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T75 12684-12692 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T76 12838-12846 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T77 13092-13100 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T78 13192-13199 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T79 13200-13207 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T80 13690-13697 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T81 13800-13807 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T82 14567-14575 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T83 14701-14709 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T84 14850-14858 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T85 15515-15523 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T86 15863-15871 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T87 16071-16075 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T88 16171-16176 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T89 16230-16234 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T90 16289-16293 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T91 16332-16336 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T92 16365-16368 Body_part denotes Map http://purl.org/sig/ont/fma/fma67847
T93 16402-16406 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T94 16732-16736 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T95 16948-16953 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T96 17052-17060 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T97 17161-17170 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T98 17736-17743 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T99 17827-17831 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T100 17992-18000 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 18069-18077 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T102 18092-18099 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T103 18100-18107 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T104 18166-18173 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T105 18211-18219 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T106 18286-18294 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T107 18561-18569 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T108 18738-18747 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T109 18751-18765 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T110 19030-19042 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T111 19044-19047 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T112 19322-19330 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T113 19372-19380 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T114 19473-19481 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T115 19635-19643 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T116 19822-19830 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T117 20056-20060 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T118 20180-20189 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T119 20256-20268 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T120 20386-20394 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T121 20520-20530 Body_part denotes estrogenic http://purl.org/sig/ont/fma/fma83376
T122 20651-20663 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T123 20707-20710 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T124 21227-21235 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T125 21331-21335 Body_part denotes bile http://purl.org/sig/ont/fma/fma62971
T126 21362-21369 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T127 21838-21846 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T128 22255-22262 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T129 23151-23159 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T130 23321-23335 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T131 23337-23346 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T132 23761-23770 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T133 23881-23890 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T134 23998-24007 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T135 24086-24100 Body_part denotes immune systems http://purl.org/sig/ont/fma/fma9825
T136 24169-24178 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T137 24387-24396 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T138 24412-24421 Body_part denotes mast-cell http://purl.org/sig/ont/fma/fma66784
T139 24417-24421 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T140 26286-26293 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T141 26954-26957 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T142 27066-27074 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T143 27161-27167 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T144 27176-27185 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T145 27189-27203 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T146 27693-27696 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T147 27976-27983 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T148 28172-28175 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T149 28205-28208 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T150 28243-28246 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T151 28294-28299 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T152 28436-28442 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T153 28951-28958 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T154 29185-29194 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T155 29251-29260 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T156 29319-29327 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T157 29519-29528 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T158 29631-29640 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T159 29794-29803 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T160 29828-29838 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T161 29843-29853 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T162 29999-30006 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T163 30096-30105 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T164 30234-30243 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T165 30490-30499 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T166 30843-30847 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T167 30865-30872 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T168 30873-30880 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 31510-31520 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T170 31646-31654 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T171 32395-32398 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T172 32878-32882 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T173 33204-33211 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 34057-34062 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T175 34298-34302 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T176 34312-34316 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T177 34359-34367 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T178 35057-35065 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T179 35192-35200 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T180 36182-36188 Body_part denotes Genome http://purl.org/sig/ont/fma/fma84116
T181 36250-36253 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T182 36268-36275 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 36349-36356 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T184 36438-36444 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T185 36459-36466 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 36756-36763 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T187 36895-36902 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T188 36997-37005 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T189 37108-37116 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T190 37156-37164 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T191 37330-37337 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T192 37391-37394 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T193 37494-37502 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T194 37612-37619 Body_part denotes Genomes http://purl.org/sig/ont/fma/fma84116
T195 37631-37635 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T196 37754-37762 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T197 38592-38599 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T198 38600-38607 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T199 38895-38902 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T200 39313-39317 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T201 39474-39478 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T202 39566-39573 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T203 39574-39581 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T204 39677-39685 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T205 39819-39826 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T206 39827-39834 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T207 40897-40901 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T208 40923-40930 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T209 41811-41815 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T210 42486-42494 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T211 43781-43785 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T212 43827-43831 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T213 43934-43938 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T214 44001-44005 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T215 44455-44459 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T216 44474-44479 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T217 44544-44547 Body_part denotes Map http://purl.org/sig/ont/fma/fma67847
T218 44584-44588 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T219 45904-45908 Body_part denotes le s http://purl.org/sig/ont/fma/fma63048
T220 46306-46310 Body_part denotes le s http://purl.org/sig/ont/fma/fma63048
T221 46523-46527 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T222 46578-46582 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T223 46861-46865 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 55-72 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T2 130-147 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T3 7613-7618 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T4 8690-8699 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T5 21331-21335 Body_part denotes bile http://purl.obolibrary.org/obo/UBERON_0001970
T6 24086-24100 Body_part denotes immune systems http://purl.obolibrary.org/obo/UBERON_0002405
T7 27161-27167 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T8 28436-28442 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T9 32011-32016 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T10 34298-34302 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p14966s22 23680-23688 NegReg denotes negative

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 238-271 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T12 285-293 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 518-526 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 865-873 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 894-918 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T16 935-943 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1072-1080 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 1252-1260 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 1393-1401 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 1558-1566 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 3214-3218 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T22 3238-3243 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T23 3257-3261 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661
T24 3544-3549 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T25 4524-4539 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T26 4530-4539 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 4772-4781 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T28 6374-6383 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 6511-6519 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 6602-6610 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 6614-6622 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 6864-6872 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 6938-6946 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 7062-7070 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 7134-7142 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 7251-7259 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 7266-7274 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 7538-7546 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 7906-7914 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 8642-8650 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 8845-8860 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T42 8851-8860 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T43 9026-9034 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 9088-9096 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 9328-9336 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 9382-9386 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T47 9643-9651 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 9693-9701 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 9794-9802 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 9916-9924 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 10066-10074 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 10081-10089 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 10133-10141 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 10344-10352 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 10684-10693 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T56 11009-11016 Disease denotes measles http://purl.obolibrary.org/obo/MONDO_0004619
T57 11055-11083 Disease denotes Epstein-Barr virus infection http://purl.obolibrary.org/obo/MONDO_0005111
T58 11068-11083 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T59 11074-11083 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 11089-11098 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T61 11195-11210 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T62 11201-11210 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T63 12045-12053 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 12891-12906 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T65 12897-12906 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 14721-14729 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 15008-15016 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 15724-15732 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 16148-16156 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 16935-16961 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T71 18779-18811 Disease denotes circadian rhythm sleep disorders http://purl.obolibrary.org/obo/MONDO_0024361
T72 18796-18811 Disease denotes sleep disorders http://purl.obolibrary.org/obo/MONDO_0003406
T73 18914-18925 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T74 18914-18923 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T75 18937-18948 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T76 18937-18946 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T77 18956-18959 Disease denotes HDV http://purl.obolibrary.org/obo/MONDO_0005789
T78 18960-18975 Disease denotes hepatitis delta http://purl.obolibrary.org/obo/MONDO_0005789
T79 18960-18969 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T80 18988-18993 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T81 19018-19023 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T82 19054-19070 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T83 19263-19277 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T84 19977-19993 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T85 20015-20023 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 20029-20034 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T87 20639-20644 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T88 20674-20690 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T89 20833-20841 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T90 20950-20965 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T91 20956-20965 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T92 21023-21026 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T93 21069-21081 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T94 21086-21106 Disease denotes diabetic nephropathy http://purl.obolibrary.org/obo/MONDO_0005016
T95 21095-21106 Disease denotes nephropathy http://purl.obolibrary.org/obo/MONDO_0005240
T96 21443-21454 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T97 21443-21452 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T98 21475-21490 Disease denotes hepatitis delta http://purl.obolibrary.org/obo/MONDO_0005789
T99 21475-21484 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T100 21498-21501 Disease denotes HDV http://purl.obolibrary.org/obo/MONDO_0005789
T101 21668-21672 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T102 22395-22404 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 22484-22493 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T104 22498-22523 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T106 22706-22712 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T107 22769-22789 Disease denotes auto-immune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T108 22801-22821 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T109 22812-22821 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T110 22823-22851 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T111 22832-22851 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T112 22942-22950 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T113 23535-23551 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T114 23598-23604 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T115 24729-24737 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T116 24983-24991 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 25484-25496 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T118 25501-25507 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T119 25853-25861 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T120 26062-26070 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T121 26222-26230 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T122 27003-27009 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T123 27217-27249 Disease denotes circadian rhythm sleep disorders http://purl.obolibrary.org/obo/MONDO_0024361
T124 27234-27249 Disease denotes sleep disorders http://purl.obolibrary.org/obo/MONDO_0003406
T125 27526-27535 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T126 27742-27748 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T127 28492-28497 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T128 28558-28563 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T129 28863-28871 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T130 28936-28944 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T131 29142-29150 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T132 29457-29465 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 29565-29574 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T134 29712-29727 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T135 29718-29727 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T136 29758-29766 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 29922-29932 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T138 29944-29948 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T139 30025-30035 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T140 30036-30046 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T141 30300-30308 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 30513-30521 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 30734-30742 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 31098-31106 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 31316-31324 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 31487-31495 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T147 31600-31608 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T148 31668-31676 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T149 32970-32978 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T150 33571-33579 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 34044-34070 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T152 34233-34242 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T153 34343-34351 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T154 35686-35694 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 35922-35930 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T156 36099-36115 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T157 36338-36346 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T158 37034-37042 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 37211-37220 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T160 38042-38045 Disease denotes BPS http://purl.obolibrary.org/obo/MONDO_0009901
T161 44077-44085 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T8 95-101 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T9 208-213 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T10 370-376 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T11 639-651 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T12 689-692 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T13 697-698 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1116-1121 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T15 1125-1130 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T16 1144-1147 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T17 1657-1660 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T18 1804-1807 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T19 1851-1852 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T20 2006-2021 http://purl.obolibrary.org/obo/CHEBI_24431 denotes chemical entity
T21 2244-2246 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T22 2615-2620 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T23 2670-2675 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T24 2691-2694 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T25 2750-2755 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 2766-2773 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Viruses
T27 2896-2901 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T28 3086-3091 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T29 3120-3121 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 3365-3369 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T31 3422-3426 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T32 3592-3595 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T33 3704-3706 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T34 3744-3749 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T35 3988-3989 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 4253-4254 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 4350-4355 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 4397-4402 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T39 4628-4633 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T40 4695-4696 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 4845-4850 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T42 4944-4948 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T43 4996-5012 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T44 5062-5063 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 5199-5200 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 5296-5301 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T47 5343-5348 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T48 5362-5363 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 5364-5369 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T50 5469-5470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 5471-5474 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T52 5500-5501 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T53 5648-5661 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T54 5686-5690 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T55 6012-6017 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T56 6221-6226 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T57 6297-6298 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 6447-6452 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T59 6560-6562 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2a
T60 6564-6565 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T61 7043-7045 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T62 7281-7283 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2a
T63 7333-7334 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T64 7689-7690 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T65 7758-7765 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T66 7770-7777 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T67 8132-8134 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T68 8139-8141 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T69 8139-8141 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T70 8185-8190 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T71 8299-8307 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T72 8365-8369 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T73 8490-8491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 8594-8602 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T75 8670-8671 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 8777-8778 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 8817-8818 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 9051-9052 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T79 9723-9725 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T80 9723-9725 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T81 9946-9948 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T82 9946-9948 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T83 10149-10152 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T84 10395-10400 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T85 11042-11043 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T86 11044-11053 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T87 11068-11073 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T88 11110-11114 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T89 11299-11304 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T90 11408-11413 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T91 11445-11449 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T92 11625-11639 http://purl.obolibrary.org/obo/PR_000029067 denotes human proteins
T93 11914-11915 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 12123-12126 http://purl.obolibrary.org/obo/CLO_0001627 denotes a A
T95 12590-12591 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T96 12600-12605 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T97 12615-12616 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T98 12622-12626 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T99 12988-12993 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T100 13019-13020 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 13186-13199 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T102 13324-13325 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 13465-13470 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T104 13499-13500 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T105 13684-13697 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T106 13956-13965 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T107 14111-14112 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 14149-14153 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T109 14237-14242 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T110 14448-14452 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T111 14673-14674 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 15264-15265 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T113 15296-15299 http://purl.obolibrary.org/obo/CLO_0001627 denotes a A
T114 15531-15536 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T115 15670-15671 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T116 15672-15673 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T117 15879-15884 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T118 15942-15946 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T119 16071-16075 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T120 16171-16176 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T121 16230-16234 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T122 16289-16293 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T123 16326-16342 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T124 16402-16406 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T125 16433-16434 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T126 16593-16595 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T127 16640-16642 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T128 16673-16677 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T129 16703-16704 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 16732-16736 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T131 16756-16757 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 16767-16768 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T133 16885-16886 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 17052-17069 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T135 17325-17326 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 17403-17404 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 17718-17719 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T138 17794-17795 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 17827-17831 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T140 18086-18099 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T141 18440-18441 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T142 18507-18508 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T143 18561-18578 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T144 18749-18750 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T145 18924-18925 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T146 18926-18931 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T147 18949-18954 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T148 18976-18981 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T149 18994-19001 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T150 19024-19029 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T151 19048-19053 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T152 19071-19076 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T153 19095-19100 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 19156-19161 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T155 19222-19227 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T156 19246-19248 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T157 19278-19285 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T158 19322-19339 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T159 19372-19389 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T160 19390-19393 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T161 19413-19414 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 19473-19490 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T163 19537-19538 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 19762-19770 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T165 19822-19839 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T166 20035-20040 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T167 20056-20060 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T168 20190-20198 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 20241-20246 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T170 20247-20255 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T171 20551-20557 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes horses
T172 20564-20567 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T173 20597-20605 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T174 20645-20650 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T175 20668-20673 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T176 20691-20696 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T177 20711-20713 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T178 21013-21014 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T179 21147-21148 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T180 21243-21248 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T181 21375-21378 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T182 21398-21399 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 21453-21454 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T184 21455-21460 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T185 21491-21496 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T186 21600-21601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 21854-21859 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T188 22042-22049 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T189 22683-22686 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T190 22891-22894 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T191 22912-22913 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 23319-23320 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 23415-23416 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 23470-23471 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 23780-23781 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 24063-24064 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 24086-24100 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune systems
T198 24141-24146 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 24349-24350 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 24417-24421 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T201 25221-25222 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 25352-25353 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T203 25523-25524 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T204 25798-25799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 26234-26235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T206 26525-26530 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T207 26626-26627 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T208 26632-26633 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T209 26639-26640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 26737-26738 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T211 26748-26752 http://purl.obolibrary.org/obo/CLO_0001869 denotes B. b
T212 26840-26841 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T213 26853-26854 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T214 27066-27083 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T215 27161-27167 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T216 27161-27167 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T217 27161-27167 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T218 27187-27188 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 27460-27463 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T220 27578-27587 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T221 28158-28167 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T222 28294-28299 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T223 28436-28442 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T224 28498-28503 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T225 28564-28569 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T226 28778-28781 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T227 28817-28822 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T228 28974-28976 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T229 29095-29096 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 29335-29340 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T231 29427-29428 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T232 29679-29680 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 29916-29917 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 29988-29989 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 30138-30147 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T236 30254-30255 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 30374-30383 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T238 30586-30587 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 30837-30853 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T240 30859-30872 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T241 31688-31689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 31729-31730 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 31751-31752 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T244 31796-31797 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 31854-31855 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 31923-31924 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 32254-32255 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 32321-32329 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T249 32723-32728 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T250 32872-32887 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell line
T251 32927-32928 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T252 32933-32938 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T253 33195-33203 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T254 33473-33478 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T255 33534-33539 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T256 33757-33758 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 34075-34076 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 34298-34302 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T259 34298-34302 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T260 34312-34316 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T261 34764-34765 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 34938-34943 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T263 35162-35167 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T264 35186-35191 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T265 35246-35251 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T266 35505-35506 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T267 35766-35773 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T268 35814-35815 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T269 35948-35949 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 36126-36131 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T271 36427-36429 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T272 36849-36854 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T273 37432-37437 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T274 37602-37607 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Genes
T275 37631-37635 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T276 38387-38392 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T277 38419-38420 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 38586-38599 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T279 38629-38630 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 38653-38658 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T281 38688-38689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 38699-38701 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T283 38805-38811 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T284 39028-39037 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T285 39195-39197 http://purl.obolibrary.org/obo/CLO_0001547 denotes AP
T286 39198-39200 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T287 39313-39317 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T288 39382-39387 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T289 39474-39478 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T290 39560-39573 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T291 39708-39709 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T292 39813-39826 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T293 39941-39946 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T294 40114-40119 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T295 40136-40137 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T296 40833-40837 http://purl.obolibrary.org/obo/CLO_0009421 denotes t+∑t
T297 40833-40837 http://purl.obolibrary.org/obo/CLO_0009935 denotes t+∑t
T298 40833-40837 http://purl.obolibrary.org/obo/CLO_0052184 denotes t+∑t
T299 40833-40837 http://purl.obolibrary.org/obo/CLO_0052185 denotes t+∑t
T300 40844-40847 http://purl.obolibrary.org/obo/CL_0000990 denotes Cdc
T301 40897-40901 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T302 40917-40930 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T303 41012-41017 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T304 41748-41752 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T305 41811-41815 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T306 41943-41947 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T307 42672-42673 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T308 42678-42679 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T309 43046-43048 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T310 43084-43086 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T311 43545-43546 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 43612-43613 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T313 43781-43785 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T314 43827-43831 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T315 43934-43938 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T316 44001-44005 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T317 44151-44157 http://purl.obolibrary.org/obo/CLO_0002192 denotes Calu-3
T318 44241-44247 http://purl.obolibrary.org/obo/CLO_0002192 denotes Calu-3
T319 44341-44346 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T320 44455-44459 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T321 44474-44479 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T322 44584-44588 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T323 44726-44728 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T324 45092-45094 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T325 45142-45144 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T326 45173-45175 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T327 45227-45229 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T328 45258-45260 http://purl.obolibrary.org/obo/CLO_0008149 denotes ne
T329 45296-45298 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T330 45385-45387 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T331 45497-45502 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T332 45869-45870 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T333 45986-45987 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T334 46271-46272 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T335 46358-46363 http://purl.obolibrary.org/obo/CLO_0006985 denotes j - 1
T336 46358-46363 http://purl.obolibrary.org/obo/CLO_0006987 denotes j - 1
T337 46394-46395 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T338 46419-46424 http://purl.obolibrary.org/obo/CLO_0006985 denotes j = 1
T339 46419-46424 http://purl.obolibrary.org/obo/CLO_0006987 denotes j = 1
T340 46443-46448 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T341 46523-46527 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T342 46578-46582 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T343 46652-46657 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T344 46811-46816 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T345 46861-46865 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T346 46919-46924 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T347 47006-47008 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T348 47077-47079 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T349 47253-47255 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T31 1617-1631 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T32 1881-1895 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T33 2006-2021 Chemical denotes chemical entity http://purl.obolibrary.org/obo/CHEBI_24431
T34 2075-2079 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T35 2113-2118 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T36 2197-2201 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T37 2285-2289 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T38 2406-2410 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T39 2535-2543 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T40 2676-2684 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T41 2708-2712 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T42 2907-2914 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 2915-2922 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44 3059-3068 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T45 3313-3327 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T46 3313-3322 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T47 3323-3327 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T48 3417-3421 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T49 3534-3539 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T50 3711-3715 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51 3787-3791 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T52 3850-3855 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T53 3863-3867 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T54 4070-4075 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T55 4088-4092 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T56 4198-4212 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T57 4198-4207 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T58 4208-4212 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T59 4290-4298 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T60 4377-4381 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T61 4403-4406 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
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T124 11486-11490 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
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T225 18860-18865 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
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T242 20386-20394 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
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T262 21730-21742 Chemical denotes frovatriptan http://purl.obolibrary.org/obo/CHEBI_134991
T263 21748-21760 Chemical denotes zolmitriptan http://purl.obolibrary.org/obo/CHEBI_10124
T264 21838-21846 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
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T273 22430-22439 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
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T328 27100-27106 Chemical denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659
T330 27124-27128 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T331 27176-27185 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T332 27198-27203 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T333 27256-27270 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T334 27275-27289 Chemical denotes antimetabolite http://purl.obolibrary.org/obo/CHEBI_35221
T335 27290-27310 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T336 27316-27333 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T337 27348-27357 Chemical denotes Sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T338 27363-27375 Chemical denotes Dactinomycin http://purl.obolibrary.org/obo/CHEBI_27666
T339 27376-27385 Chemical denotes Sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T340 27390-27399 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T341 27418-27428 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T342 27433-27447 Chemical denotes antineoplastic http://purl.obolibrary.org/obo/CHEBI_35610
T343 27638-27650 Chemical denotes Dactinomycin http://purl.obolibrary.org/obo/CHEBI_27666
T344 27663-27676 Chemical denotes actinomycin D http://purl.obolibrary.org/obo/CHEBI_27666
T345 27663-27674 Chemical denotes actinomycin http://purl.obolibrary.org/obo/CHEBI_15369
T346 27707-27716 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T347 27905-27914 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T348 27976-27983 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T349 28109-28118 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T350 28205-28208 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T351 28225-28230 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T352 28243-28246 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T353 28263-28267 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T354 28328-28334 Chemical denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T355 28470-28480 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T356 28625-28635 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T357 28696-28702 Chemical denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T358 28707-28720 Chemical denotes anthraquinone http://purl.obolibrary.org/obo/CHEBI_22580|http://purl.obolibrary.org/obo/CHEBI_40448
T360 28951-28958 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T361 29065-29075 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T362 29165-29179 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T363 29185-29194 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T364 29232-29246 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T365 29251-29260 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T366 29319-29327 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T367 29409-29423 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T368 29439-29448 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T369 29519-29528 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T370 29555-29564 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T371 29605-29616 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T372 29631-29640 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T373 29794-29803 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T374 29999-30006 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T375 30077-30091 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T376 30096-30105 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T377 30215-30229 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T378 30234-30243 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T379 30490-30499 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T380 30669-30674 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T381 30679-30683 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T382 30761-30765 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T383 30865-30872 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T384 30873-30880 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T385 31016-31021 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T386 31047-31051 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T387 31249-31254 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T388 31259-31263 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T389 31510-31520 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T390 31646-31654 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T391 31762-31766 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T392 31881-31885 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T393 31933-31937 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T394 32042-32046 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T395 32142-32146 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T396 32281-32291 Chemical denotes flavagline http://purl.obolibrary.org/obo/CHEBI_71504
T397 32311-32320 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T398 32424-32434 Chemical denotes silvestrol http://purl.obolibrary.org/obo/CHEBI_66484
T399 32569-32573 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T400 32657-32661 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T401 33174-33179 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T402 33204-33211 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T403 33233-33244 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T404 33249-33257 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T405 33328-33337 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T406 33421-33425 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T407 33780-33784 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T408 33844-33849 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T409 33918-33923 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T410 33928-33932 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T411 34011-34021 Chemical denotes Mesalazine http://purl.obolibrary.org/obo/CHEBI_6775
T412 34035-34039 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T413 34112-34116 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T414 34260-34270 Chemical denotes mesalazine http://purl.obolibrary.org/obo/CHEBI_6775
T415 34359-34367 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T416 34461-34466 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T417 34470-34474 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T418 34644-34648 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T419 34829-34834 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T420 34886-34891 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T421 35015-35020 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T422 35057-35065 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T423 35133-35138 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T424 35168-35173 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T425 35192-35200 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T426 35252-35257 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T427 35321-35326 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T428 35339-35343 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T429 35617-35622 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T430 35627-35631 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T431 36250-36253 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T432 36268-36275 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T433 36459-36466 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T434 36711-36715 Chemical denotes MEGA http://purl.obolibrary.org/obo/CHEBI_6617
T435 36756-36763 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T436 36825-36829 Chemical denotes MEGA http://purl.obolibrary.org/obo/CHEBI_6617
T437 36895-36902 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T438 36997-37005 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T439 37108-37116 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T440 37156-37164 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T441 37330-37337 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T442 37494-37502 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T443 37524-37526 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T444 37754-37762 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T445 37834-37838 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T446 37873-37877 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T447 37975-37978 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T448 38102-38106 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T449 38163-38167 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T450 38508-38512 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T451 38592-38599 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T452 38600-38607 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T453 38895-38902 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T454 39195-39197 Chemical denotes AP http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686
T457 39198-39200 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T458 39416-39418 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T459 39566-39573 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T460 39574-39581 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T461 39677-39685 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T462 39819-39826 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T463 39827-39834 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T464 40006-40011 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T465 40171-40175 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T466 40254-40258 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T467 40923-40930 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T468 42024-42028 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T469 42155-42159 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T470 42209-42213 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T471 42309-42313 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T472 42448-42452 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T473 42486-42494 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T474 42496-42500 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T475 42501-42505 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T476 42548-42552 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T477 42596-42601 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T478 42666-42671 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T479 43046-43048 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T481 43084-43086 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109
T482 43547-43551 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T483 43734-43739 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T484 44435-44440 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T485 44501-44506 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T486 44606-44611 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T487 44622-44626 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T488 44670-44674 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T489 44726-44728 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T490 45092-45094 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T491 45142-45144 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T492 45173-45175 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T493 45227-45229 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T494 45296-45298 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T495 45385-45387 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T496 46544-46548 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T497 46676-46680 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T498 47006-47008 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T499 47077-47079 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 2708-2723 http://purl.obolibrary.org/obo/GO_0042493 denotes drug resistance
T2 4524-4539 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T3 8421-8434 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T4 8425-8434 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T5 8845-8860 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T6 11018-11031 http://purl.obolibrary.org/obo/GO_0050658 denotes RNA transport
T7 11022-11031 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T8 11044-11053 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9 11195-11210 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T10 11267-11283 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T11 11339-11352 http://purl.obolibrary.org/obo/GO_0016032 denotes viral process
T12 11354-11393 http://purl.obolibrary.org/obo/GO_1903902 denotes positive regulation of viral life cycle
T13 11354-11393 http://purl.obolibrary.org/obo/GO_0048524 denotes positive regulation of viral life cycle
T14 11363-11393 http://purl.obolibrary.org/obo/GO_1903900 denotes regulation of viral life cycle
T15 11363-11373 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T16 11377-11393 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T17 11395-11413 http://purl.obolibrary.org/obo/GO_0046794 denotes transport of virus
T18 11395-11404 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T19 11419-11449 http://purl.obolibrary.org/obo/GO_0019062 denotes virion attachment to host cell
T20 11803-11808 http://purl.obolibrary.org/obo/GO_0008384 denotes IKBKB
T21 12891-12906 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T22 13956-13965 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T23 16289-16304 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T24 18779-18795 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T25 18789-18795 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T26 18796-18801 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T27 19555-19583 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T28 19566-19583 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T29 19566-19583 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T30 19977-19993 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T31 20950-20965 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T32 21612-21627 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T33 23023-23039 http://purl.obolibrary.org/obo/GO_0019075 denotes viral maturation
T34 23535-23551 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T35 23925-23942 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T36 23925-23942 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T37 24262-24267 http://purl.obolibrary.org/obo/GO_0008384 denotes IKBKB
T38 24430-24441 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T39 26954-26967 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T40 26958-26967 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T41 27217-27233 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T42 27227-27233 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T43 27234-27239 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T44 27578-27587 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T45 27693-27706 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T46 27697-27706 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T47 27820-27826 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T48 28158-28167 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T49 28172-28185 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T50 28176-28185 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T51 28646-28652 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T52 29712-29727 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T53 30138-30147 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T54 30374-30383 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T55 32723-32746 http://purl.obolibrary.org/obo/GO_0019048 denotes virus–host interactions
T56 33473-33496 http://purl.obolibrary.org/obo/GO_0019048 denotes virus–host interactions
T57 35728-35741 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T58 35950-35963 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T59 36099-36115 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T60 37432-37454 http://purl.obolibrary.org/obo/GO_0019048 denotes virus–host interaction
T61 39028-39037 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T62 39313-39328 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T63 43934-43949 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T64 44001-44016 http://purl.obolibrary.org/obo/GO_0010467 denotes Gene Expression
T65 44455-44470 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 2708-2723 Phenotype denotes drug resistance http://purl.obolibrary.org/obo/HP_0020174
T2 16935-16961 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T3 18914-18923 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T4 18937-18946 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T5 18960-18969 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T6 19054-19070 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T7 20674-20690 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T8 21069-21081 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T9 21095-21106 Phenotype denotes nephropathy http://purl.obolibrary.org/obo/HP_0000112
T10 21443-21452 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T11 21475-21484 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T12 22484-22493 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 22504-22523 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T14 22706-22712 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T15 22769-22789 Phenotype denotes auto-immune diseases http://purl.obolibrary.org/obo/HP_0002960
T16 22801-22821 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T17 22823-22851 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T18 23628-23644 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T19 25484-25496 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T20 25501-25507 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T21 27150-27167 Phenotype denotes polycystic kidney http://purl.obolibrary.org/obo/HP_0000113
T22 27526-27535 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T23 27742-27748 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T24 30036-30046 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T25 34044-34070 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T26 34233-34242 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T12 0-12 Sentence denotes Introduction
T13 13-160 Sentence denotes Coronaviruses (CoVs) typically affect the respiratory tract of mammals, including humans, and lead to mild to severe respiratory tract infections1.
T14 161-453 Sentence denotes In the past two decades, two highly pathogenic human CoVs (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), emerging from animal reservoirs, have led to global epidemics with high morbidity and mortality2.
T15 454-608 Sentence denotes For example, 8098 individuals were infected and 774 died in the SARS-CoV pandemic, which cost the global economy with an estimated $30 to $100 billion3,4.
T16 609-779 Sentence denotes According to the World Health Organization (WHO), as of November 2019, MERS-CoV has had a total of 2494 diagnosed cases causing 858 deaths, the majority in Saudi Arabia2.
T17 780-973 Sentence denotes In December 2019, the third pathogenic HCoV, named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2), as the cause of coronavirus disease 2019 (abbreviated as COVID-19)5, was found in Wuhan, China.
T18 974-1179 Sentence denotes As of 24 February 2020, there have been over 79,000 cases with over 2600 deaths for the 2019-nCoV/SARS-CoV-2 outbreak worldwide; furthermore, human-to-human transmission has occurred among close contacts6.
T19 1180-1263 Sentence denotes However, there are currently no effective medications against 2019-nCoV/SARS-CoV-2.
T20 1264-1450 Sentence denotes Several national and international research groups are working on the development of vaccines to prevent and treat the 2019-nCoV/SARS-CoV-2, but effective vaccines are not available yet.
T21 1451-1578 Sentence denotes There is an urgent need for the development of effective prevention and treatment strategies for 2019-nCoV/SARS-CoV-2 outbreak.
T22 1579-1768 Sentence denotes Although investment in biomedical and pharmaceutical research and development has increased significantly over the past two decades, the annual number of new treatments approved by the U.S.
T23 1769-1850 Sentence denotes Food and Drug Administration (FDA) has remained relatively constant and limited7.
T24 1851-2028 Sentence denotes A recent study estimated that pharmaceutical companies spent $2.6 billion in 2015, up from $802 million in 2003, in the development of an FDA-approved new chemical entity drug8.
T25 2029-2247 Sentence denotes Drug repurposing, represented as an effective drug discovery strategy from existing drugs, could significantly shorten the time and reduce the cost compared to de novo drug discovery and randomized clinical trials9–11.
T26 2248-2333 Sentence denotes However, experimental approaches for drug repurposing is costly and time-consuming12.
T27 2334-2435 Sentence denotes Computational approaches offer novel testable hypotheses for systematic drug repositioning9–11,13,14.
T28 2436-2639 Sentence denotes However, traditional structure-based methods are limited when three-dimensional (3D) structures of proteins are unavailable, which, unfortunately, is the case for the majority of human and viral targets.
T29 2640-2765 Sentence denotes In addition, targeting single virus proteins often has high risk of drug resistance by the rapid evolution of virus genomes1.
T30 2766-2866 Sentence denotes Viruses (including HCoV) require host cellular factors for successful replication during infection1.
T31 2867-3025 Sentence denotes Systematic identification of virus–host protein–protein interactions (PPIs) offers an effective way toward elucidating the mechanisms of viral infection15,16.
T32 3026-3276 Sentence denotes Subsequently, targeting cellular antiviral targets, such as virus–host interactome, may offer a novel strategy for the development of effective treatments for viral infections1, including SARS-CoV17, MERS-CoV17, Ebola virus18, and Zika virus14,19–21.
T33 3277-3466 Sentence denotes We recently presented an integrated antiviral drug discovery pipeline that incorporated gene-trap insertional mutagenesis, known functional drug–gene network, and bioinformatics analyses14.
T34 3467-3561 Sentence denotes This methodology allows to identify several candidate repurposable drugs for Ebola virus11,14.
T35 3562-3759 Sentence denotes Our work over the last decade has demonstrated how network strategies can, for example, be used to identify effective repurposable drugs13,22–27 and drug combinations28 for multiple human diseases.
T36 3760-4156 Sentence denotes For example, network-based drug–disease proximity sheds light on the relationship between drugs (e.g., drug targets) and disease modules (molecular determinants in disease pathobiology modules within the PPIs), and can serve as a useful tool for efficient screening of potentially new indications for approved drugs, as well as drug combinations, as demonstrated in our recent studies13,23,27,28.
T37 4157-4415 Sentence denotes In this study, we present an integrative antiviral drug repurposing methodology, which combines a systems pharmacology-based network medicine platform that quantifies the interplay between the virus–host interactome and drug targets in the human PPI network.
T38 4416-4872 Sentence denotes The basis for these experiments rests on the notions that (i) the proteins that functionally associate with viral infection (including HCoV) are localized in the corresponding subnetwork within the comprehensive human PPI network and (ii) proteins that serve as drug targets for a specific disease may also be suitable drug targets for potential antiviral infection owing to common PPIs and functional pathways elucidated by the human interactome (Fig. 1).
T39 4873-5120 Sentence denotes We follow this analysis with bioinformatics validation of drug-induced gene signatures and HCoV-induced transcriptomics in human cell lines to inspect the postulated mechanism-of-action in a specific HCoV for which we propose repurposing (Fig. 1).
T40 5121-5159 Sentence denotes Fig. 1 Overall workflow of this study.
T41 5160-6465 Sentence denotes Our network-based methodology combines a systems pharmacology-based network medicine platform that quantifies the interplay between the virus–host interactome and drug targets in the human PPI network. a Human coronavirus (HCoV)-associated host proteins were collected from literatures and pooled to generate a pan-HCoV protein subnetwork. b Network proximity between drug targets and HCoV-associated proteins was calculated to screen for candidate repurposable drugs for HCoVs under the human protein interactome model. c, d Gene set enrichment analysis was utilized to validate the network-based prediction. e Top candidates were further prioritized for drug combinations using network-based method captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network. f Overall hypothesis of the network-based methodology: (i) the proteins that functionally associate with HCoVs are localized in the corresponding subnetwork within the comprehensive human interactome network; and (ii) proteins that serve as drug targets for a specific disease may also be suitable drug targets for potential antiviral infection owing to common protein–protein interactions elucidated by the human interactome.
T42 6467-6474 Sentence denotes Results
T43 6476-6521 Sentence denotes Phylogenetic analyses of 2019-nCoV/SARS-CoV-2
T44 6522-6719 Sentence denotes To date, seven pathogenic HCoVs (Fig. 2a, b) have been found:1,29 (i) 2019-nCoV/SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, and HCoV-HKU1 are β genera, and (ii) HCoV-NL63 and HCoV-229E are α genera.
T45 6720-6892 Sentence denotes We performed the phylogenetic analyses using the whole-genome sequence data from 15 HCoVs to inspect the evolutionary relationship of 2019-nCoV/SARS-CoV-2 with other HCoVs.
T46 6893-7047 Sentence denotes We found that the whole genomes of 2019-nCoV/SARS-CoV-2 had ~99.99% nucleotide sequence identity across three diagnosed patients (Supplementary Table S1).
T47 7048-7285 Sentence denotes The 2019-nCoV/SARS-CoV-2 shares the highest nucleotide sequence identity (79.7%) with SARS-CoV among the six other known pathogenic HCoVs, revealing conserved evolutionary relationship between 2019-nCoV/SARS-CoV-2 and SARS-CoV (Fig. 2a).
T48 7286-7332 Sentence denotes Fig. 2 Phylogenetic analysis of coronaviruses.
T49 7333-7374 Sentence denotes a Phylogenetic tree of coronavirus (CoV).
T50 7375-7473 Sentence denotes Phylogenetic algorithm analyzed evolutionary conservation among whole genomes of 15 coronaviruses.
T51 7474-7549 Sentence denotes Red color highlights the recent emergent coronavirus, 2019-nCoV/SARS-CoV-2.
T52 7550-7608 Sentence denotes Numbers on the branches indicate bootstrap support values.
T53 7609-7723 Sentence denotes The scale shows the evolutionary distance computed using the p-distance method. b Schematic plot for HCoV genomes.
T54 7724-7810 Sentence denotes The genus and host information of viruses was labeled on the left by different colors.
T55 7811-7929 Sentence denotes Empty dark gray boxes represent accessory open reading frames (ORFs). c–e The 3D structures of SARS-CoV nsp12 (PDB ID:
T56 7930-7955 Sentence denotes 6NUR) (c), spike (PDB ID:
T57 7956-7992 Sentence denotes 6ACK) (d), and nucleocapsid (PDB ID:
T58 7993-8041 Sentence denotes 2CJR) (e) shown were based on homology modeling.
T59 8042-8142 Sentence denotes Genome information and phylogenetic analysis results are provided in Supplementary Tables S1 and S2.
T60 8143-8353 Sentence denotes HCoVs have five major protein regions for virus structure assembly and viral replications29, including replicase complex (ORF1ab), spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins (Fig. 2b).
T61 8354-8476 Sentence denotes The ORF1ab gene encodes the non-structural proteins (nsp) of viral RNA synthesis complex through proteolytic processing30.
T62 8477-8603 Sentence denotes The nsp12 is a viral RNA-dependent RNA polymerase, together with co-factors nsp7 and nsp8 possessing high polymerase activity.
T63 8604-8763 Sentence denotes From the protein 3D structure view of SARS-CoV nsp12, it contains a larger N-terminal extension (which binds to nsp7 and nsp8) and polymerase domain (Fig. 2c).
T64 8764-8900 Sentence denotes The spike is a transmembrane glycoprotein that plays a pivotal role in mediating viral infection through binding the host receptor31,32.
T65 8901-9043 Sentence denotes Figure 2d shows the 3D structure of the spike protein bound with the host receptor angiotensin converting enznyme2 (ACE2) in SARS-CoV (PDB ID:
T66 9044-9050 Sentence denotes 6ACK).
T67 9051-9234 Sentence denotes A recent study showed that 2019-nCoV/SARS-CoV-2 is able to utilize ACE2 as an entry receptor in ACE2-expressing cells33, suggesting potential drug targets for therapeutic development.
T68 9235-9393 Sentence denotes Furthermore, cryo-EM structure of the spike and biophysical assays reveal that the 2019-nCoV/SARS-CoV-2 spike binds ACE2 with higher affinity than SARS-CoV34.
T69 9394-9577 Sentence denotes In addition, the nucleocapsid is also an important subunit for packaging the viral genome through protein oligomerization35, and the single nucleocapsid structure is shown in Fig. 2e.
T70 9578-9727 Sentence denotes Protein sequence alignment analyses indicated that the 2019-nCoV/SARS-CoV-2 was most evolutionarily conserved with SARS-CoV (Supplementary Table S2).
T71 9728-9950 Sentence denotes Specifically, the envelope and nucleocapsid proteins of 2019-nCoV/SARS-CoV-2 are two evolutionarily conserved regions, with sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV (Supplementary Table S2).
T72 9951-10090 Sentence denotes However, the spike protein exhibited the lowest sequence conservation (sequence identity of 77%) between 2019-nCoV/SARS-CoV-2 and SARS-CoV.
T73 10091-10198 Sentence denotes Meanwhile, the spike protein of 2019-nCoV/SARS-CoV-2 only has 31.9% sequence identity compared to MERS-CoV.
T74 10200-10229 Sentence denotes HCoV–host interactome network
T75 10230-10461 Sentence denotes To depict the HCoV–host interactome network, we assembled the CoV-associated host proteins from four known HCoVs (SARS-CoV, MERS-CoV, HCoV-229E, and HCoV-NL63), one mouse MHV, and one avian IBV (N protein) (Supplementary Table S3).
T76 10462-10558 Sentence denotes In total, we obtained 119 host proteins associated with CoVs with various experimental evidence.
T77 10559-10694 Sentence denotes Specifically, these host proteins are either the direct targets of HCoV proteins or are involved in crucial pathways of HCoV infection.
T78 10695-10749 Sentence denotes The HCoV–host interactome network is shown in Fig. 3a.
T79 10750-10888 Sentence denotes We identified several hub proteins including JUN, XPO1, NPM1, and HNRNPA1, with the highest number of connections within the 119 proteins.
T80 10889-11109 Sentence denotes KEGG pathway enrichment analysis revealed multiple significant biological pathways (adjusted P value < 0.05), including measles, RNA transport, NF-kappa B signaling, Epstein-Barr virus infection, and influenza (Fig. 3b).
T81 11110-11460 Sentence denotes Gene ontology (GO) biological process enrichment analysis further confirmed multiple viral infection-related processes (adjusted P value < 0.001), including viral life cycle, modulation by virus of host morphology or physiology, viral process, positive regulation of viral life cycle, transport of virus, and virion attachment to host cell (Fig. 3c).
T82 11461-11607 Sentence denotes We then mapped the known drug–target network (see Materials and methods) into the HCoV–host interactome to search for druggable, cellular targets.
T83 11608-11758 Sentence denotes We found that 47 human proteins (39%, blue nodes in Fig. 3a) can be targeted by at least one approved drug or experimental drug under clinical trials.
T84 11759-11842 Sentence denotes For example, GSK3B, DPP4, SMAD3, PARP1, and IKBKB are the most targetable proteins.
T85 11843-12056 Sentence denotes The high druggability of HCoV–host interactome motivates us to develop a drug repurposing strategy by specifically targeting cellular proteins associated with HCoVs for potential treatment of 2019-nCoV/SARS-CoV-2.
T86 12057-12122 Sentence denotes Fig. 3 Drug-target network analysis of the HCoV–host interactome.
T87 12123-12177 Sentence denotes a A subnetwork highlighting the HCoV–host interactome.
T88 12178-12435 Sentence denotes Nodes represent three types of HCoV-associated host proteins: targetgable (proteins can be targeted by approved drugs or drugs under clinical trials), non-targetable (proteins do not have any known ligands), neighbors (protein–protein interaction partners).
T89 12436-12557 Sentence denotes Edge colors indicate five types of experimental evidence of the protein–protein interactions (see Materials and methods).
T90 12558-12693 Sentence denotes 3D three-dimensional structure. b, c KEGG human pathway (b) and gene ontology enrichment analyses (c) for the HCoV-associated proteins.
T91 12695-12735 Sentence denotes Network-based drug repurposing for HCoVs
T92 12736-13014 Sentence denotes The basis for the proposed network-based drug repurposing methodologies rests on the notions that the proteins that associate with and functionally govern viral infection are localized in the corresponding subnetwork (Fig. 1a) within the comprehensive human interactome network.
T93 13015-13315 Sentence denotes For a drug with multiple targets to be effective against an HCoV, its target proteins should be within or in the immediate vicinity of the corresponding subnetwork in the human protein–protein interactome (Fig. 1), as we demonstrated in multiple diseases13,22,23,28 using this network-based strategy.
T94 13316-13483 Sentence denotes We used a state-of-the-art network proximity measure to quantify the relationship between HCoV-specific subnetwork (Fig. 3a) and drug targets in the human interactome.
T95 13484-13636 Sentence denotes We constructed a drug–target network by assembling target information for more than 2000 FDA-approved or experimental drugs (see Materials and methods).
T96 13637-14102 Sentence denotes To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods).
T97 14103-14340 Sentence denotes We used a Z-score (Z) measure and permutation test to reduce the study bias in network proximity analyses (including hub nodes in the human interactome network by literature-derived PPI data bias) as described in our recent studies13,28.
T98 14341-14526 Sentence denotes In total, we computationally identified 135 drugs that were associated (Z < −1.5 and P < 0.05, permutation test) with the HCoV–host interactome (Fig. 4a, Supplementary Tables S4 and 5).
T99 14527-14766 Sentence denotes To validate bias of the pooled cellular proteins from six CoVs, we further calculated the network proximities of all the drugs for four CoVs with a large number of know host proteins, including SARS-CoV, MERS-CoV, IBV, and MHV, separately.
T100 14767-14900 Sentence denotes We found that the Z-scores showed consistency among the pooled 119 HCoV-associated proteins and other four individual CoVs (Fig. 4b).
T101 14901-15135 Sentence denotes The Pearson correlation coefficients of the proximities of all the drugs for the pooled HCoV are 0.926 vs. SARS-CoV (P < 0.001, t distribution), 0.503 vs. MERS-CoV (P < 0.001), 0.694 vs. IBV (P < 0.001), and 0.829 vs. MHV (P < 0.001).
T102 15136-15256 Sentence denotes These network proximity analyses offer putative repurposable candidates for potential prevention and treatment of HCoVs.
T103 15257-15295 Sentence denotes Fig. 4 A discovered drug-HCoV network.
T104 15296-15396 Sentence denotes a A subnetwork highlighting network-predicted drug-HCoV associations connecting 135 drugs and HCoVs.
T105 15397-15557 Sentence denotes From the 2938 drugs evaluated, 135 ones achieved significant proximities between drug targets and the HCoV-associated proteins in the human interactome network.
T106 15558-15771 Sentence denotes Drugs are colored by their first-level of the Anatomical Therapeutic Chemical (ATC) classification system code. b A heatmap highlighting network proximity values for SARS-CoV, MERS-CoV, IBV, and MHV, respectively.
T107 15772-15905 Sentence denotes Color key denotes network proximity (Z-score) between drug targets and the HCoV-associated proteins in the human interactome network.
T108 15906-15947 Sentence denotes P value was computed by permutation test.
T109 15949-15989 Sentence denotes Discovery of repurposable drugs for HCoV
T110 15990-16191 Sentence denotes To further validate the 135 repurposable drugs against HCoVs, we first performed gene set enrichment analysis (GSEA) using transcriptome data of MERS-CoV and SARS-CoV infected host cells (see Methods).
T111 16192-16256 Sentence denotes These transcriptome data were used as gene signatures for HCoVs.
T112 16257-16418 Sentence denotes Additionally, we downloaded the gene expression data of drug-treated human cell lines from the Connectivity Map (CMAP) database36 to obtain drug–gene signatures.
T113 16419-16557 Sentence denotes We calculated a GSEA score (see Methods) for each drug and used this score as an indication of bioinformatics validation of the 135 drugs.
T114 16558-16792 Sentence denotes Specifically, an enrichment score (ES) was calculated for each HCoV data set, and ES > 0 and P < 0.05 (permutation test) was used as cut-off for a significant association of gene signatures between a drug and a specific HCoV data set.
T115 16793-16901 Sentence denotes The GSEA score, ranging from 0 to 3, is the number of data sets that met these criteria for a specific drug.
T116 16902-17193 Sentence denotes Mesalazine (an approved drug for inflammatory bowel disease), sirolimus (an approved immunosuppressive drug), and equilin (an approved agonist of the estrogen receptor for menopausal symptoms) achieved the highest GSEA scores of 3, followed by paroxetine and melatonin with GSEA scores of 2.
T117 17194-17593 Sentence denotes We next selected 16 high-confidence repurposable drugs (Fig. 5a and Table 1) against HCoVs using subject matter expertise based on a combination of factors: (i) strength of the network-predicted associations (a smaller network proximity score in Supplementary Table S4); (ii) validation by GSEA analyses; (iii) literature-reported antiviral evidence, and (iv) fewer clinically reported side effects.
T118 17594-17710 Sentence denotes Specifically, we showcased several selected repurposable drugs with literature-reported antiviral evidence as below.
T119 17711-17793 Sentence denotes Fig. 5 A discovered drug-protein-HCoV network for 16 candidate repurposable drugs.
T120 17794-17916 Sentence denotes a Network-predicted evidence and gene set enrichment analysis (GSEA) scores for 16 potential repurposable drugs for HCoVs.
T121 17917-18014 Sentence denotes The overall connectivity of the top drug candidates to the HCoV-associated proteins was examined.
T122 18015-18129 Sentence denotes Most of these drugs indirectly target HCoV-associated proteins via the human protein–protein interaction networks.
T123 18130-18261 Sentence denotes All the drug–target-HCoV-associated protein connections were examined, and those proteins with at least five connections are shown.
T124 18262-18330 Sentence denotes The box heights for the proteins indicate the number of connections.
T125 18331-18813 Sentence denotes GSEA scores for eight drugs were not available (NA) due to the lack of transcriptome profiles for the drugs. b–e Inferred mechanism-of-action networks for four selected drugs: b toremifene (first-generation nonsteroidal-selective estrogen receptor modulator), c irbesartan (an angiotensin receptor blocker), d mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties), and e melatonin (a biogenic amine for treating circadian rhythm sleep disorders).
T126 18814-18909 Sentence denotes Table 1 Top 16 network-predicted repurposable drugs with literature-derived antiviral evidence.
T127 18910-19310 Sentence denotes HBV hepatitis B virus, HCV hepatitis C virus, HDV hepatitis delta virus, EBOV Ebola viruses, ZEBOV-GP Zaire Ebola virus glycoprotein, HIV human immunodeficiency virus, EBV Epstein-Barr virus, ANDV Andes orthohantavirus, EMCV encephalomyocarditis virus, FECV feline enteric coronavirus, RSV respiratory syncytial virus, EV71 enterovirus 71, HSV-1 and -2 herpes simplex viruses, CVB4 Coxsackievirus B4.
T128 19312-19350 Sentence denotes Selective estrogen receptor modulators
T129 19351-19462 Sentence denotes An overexpression of estrogen receptor has been shown to play a crucial role in inhibiting viral replication37.
T130 19463-19655 Sentence denotes Selective estrogen receptor modulators (SERMs) have been reported to play a broader role in inhibiting viral replication through the non-classical pathways associated with estrogen receptor37.
T131 19656-19853 Sentence denotes SERMs interfere at the post viral entry step and affect the triggering of fusion, as the SERMs’ antiviral activity still can be observed in the absence of detectable estrogen receptor expression18.
T132 19854-20072 Sentence denotes Toremifene (Z = –3.23, Fig. 5a), the first generation of nonsteroidal SERM, exhibits potential effects in blocking various viral infections, including MERS-CoV, SARS-CoV, and Ebola virus in established cell lines17,38.
T133 20073-20316 Sentence denotes Compared to the classical ESR1-related antiviral pathway, toremifene prevents fusion between the viral and endosomal membrane by interacting with and destabilizing the virus membrane glycoprotein, and eventually inhibiting viral replication39.
T134 20317-20476 Sentence denotes As shown in Fig. 5b, toremifene potentially affects several key host proteins associated with HCoV, such as RPL19, HNRNPA1, NPM1, EIF3I, EIF3F, and EIF3E40,41.
T135 20477-20714 Sentence denotes Equilin (Z = –2.52 and GSEA score = 3), an estrogenic steroid produced by horses, also has been proven to have moderate activity in inhibiting the entry of Zaire Ebola virus glycoprotein and human immunodeficiency virus (ZEBOV-GP/HIV)18.
T136 20715-20844 Sentence denotes Altogether, network-predicted SERMs (such as toremifene and equilin) offer candidate repurposable drugs for 2019-nCoV/SARS-CoV-2.
T137 20846-20875 Sentence denotes Angiotensin receptor blockers
T138 20876-20988 Sentence denotes Angiotensin receptor blockers (ARBs) have been reported to associate with viral infection, including HCoVs42–44.
T139 20989-21107 Sentence denotes Irbesartan (Z = –5.98), a typical ARB, was approved by the FDA for treatment of hypertension and diabetic nephropathy.
T140 21108-21261 Sentence denotes Here, network proximity analysis shows a significant association between irbesartan’s targets and HCoV-associated host proteins in the human interactome.
T141 21262-21503 Sentence denotes As shown in Fig. 5c, irbesartan targets SLC10A1, encoding the sodium/bile acid cotransporter (NTCP) protein that has been identified as a functional preS1-specific receptor for the hepatitis B virus (HBV) and the hepatitis delta virus (HDV).
T142 21504-21566 Sentence denotes Irbesartan can inhibit NTCP, thus inhibiting viral entry45,46.
T143 21567-21679 Sentence denotes SLC10A1 interacts with C11orf74, a potential transcriptional repressor that interacts with nsp-10 of SARS-CoV47.
T144 21680-21872 Sentence denotes There are several other ARBs (such as eletriptan, frovatriptan, and zolmitriptan) in which their targets are potentially associated with HCoV-associated host proteins in the human interactome.
T145 21874-21916 Sentence denotes Immunosuppressant or antineoplastic agents
T146 21917-22118 Sentence denotes Previous studies have confirmed the mammalian target of rapamycin complex 1 (mTORC1) as the key factor in regulating various viruses’ replications, including Andes orthohantavirus and coronavirus48,49.
T147 22119-22307 Sentence denotes Sirolimus (Z = –2.35 and GSEA score = 3), an inhibitor of mammalian target of rapamycin (mTOR), was reported to effectively block viral protein expression and virion release effectively50.
T148 22308-22419 Sentence denotes Indeed, the latest study revealed the clinical application: sirolimus reduced MERS-CoV infection by over 60%51.
T149 22420-22578 Sentence denotes Moreover, sirolimus usage in managing patients with severe H1N1 pneumonia and acute respiratory failure can improve those patients’ prognosis significantly50.
T150 22579-22875 Sentence denotes Mercaptopurine (Z = –2.44 and GSEA score = 1), an antineoplastic agent with immunosuppressant property, has been used to treat cancer since the 1950s and expanded its application to several auto-immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Crohn’s disease52.
T151 22876-23086 Sentence denotes Mercaptopurine has been reported as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease which plays key roles in viral maturation and antagonism to interferon stimulation53,54.
T152 23087-23220 Sentence denotes Mechanistically, mercaptopurine potentially target several host proteins in HCoVs, such as JUN, PABPC1, NPM1, and NCL40,55 (Fig. 5d).
T153 23222-23246 Sentence denotes Anti-inflammatory agents
T154 23247-23315 Sentence denotes Inflammatory pathways play essential roles in viral infections56,57.
T155 23316-23534 Sentence denotes As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59.
T156 23535-23734 Sentence denotes Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60.
T157 23735-23965 Sentence denotes The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients’ clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62.
T158 23966-24147 Sentence denotes In addition, the application of melatonin may prolong patients’ survival time, which may provide a chance for patients’ immune systems to recover and eventually eradicate the virus.
T159 24148-24268 Sentence denotes As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB.
T160 24269-24397 Sentence denotes Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin.
T161 24398-24551 Sentence denotes By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63.
T162 24552-24740 Sentence denotes In summary, our network proximity analyses offer multiple candidate repurposable drugs that target diverse cellular pathways for potential prevention and treatment of 2019-nCoV/SARS-CoV-2.
T163 24741-24907 Sentence denotes However, further preclinical experiments64 and clinical trials are required to verify the clinical benefits of these network-predicted candidates before clinical use.
T164 24909-24993 Sentence denotes Network-based identification of potential drug combinations for 2019-nCoV/SARS-CoV-2
T165 24994-25137 Sentence denotes Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an important role in treating various viral infections65.
T166 25138-25318 Sentence denotes However, our ability to identify and validate effective combinations is limited by a combinatorial explosion, driven by both the large number of drug pairs and dosage combinations.
T167 25319-25441 Sentence denotes In our recent study, we proposed a novel network-based methodology to identify clinically efficacious drug combinations28.
T168 25442-25735 Sentence denotes Relying on approved drug combinations for hypertension and cancer, we found that a drug combination was therapeutically effective only if it was captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the disease module, but target separate neighborhoods (Fig. 6a).
T169 25736-25922 Sentence denotes Here we sought to identify drug combinations that may provide a synergistic effect in potentially treating 2019-nCoV/SARS-CoV-2 with well-defined mechanism-of-action by network analysis.
T170 25923-26073 Sentence denotes For the 16 potential repurposable drugs (Fig. 5a, Table 1), we showcased three network-predicted candidate drug combinations for 2019-nCoV/SARS-CoV-2.
T171 26074-26149 Sentence denotes All predicted possible combinations can be found in Supplementary Table S6.
T172 26150-26233 Sentence denotes Fig. 6 Network-based rational design of drug combinations for 2019-nCoV/SARS-CoV-2.
T173 26234-26335 Sentence denotes a The possible exposure mode of the HCoV-associated protein module to the pairwise drug combinations.
T174 26336-26551 Sentence denotes An effective drug combination will be captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network.
T175 26552-26655 Sentence denotes ZCA and ZCB denote the network proximity (Z-score) between targets (Drugs A and B) and a specific HCoV.
T176 26656-27346 Sentence denotes SAB denotes separation score (see Materials and methods) of targets between Drug A and Drug B. b–d Inferred mechanism-of-action networks for three selected pairwise drug combinations: b sirolimus (a potent immunosuppressant with both antifungal and antineoplastic properties) plus dactinomycin (an RNA synthesis inhibitor for treatment of various tumors), c toremifene (first-generation nonsteroidal-selective estrogen receptor modulator) plus emodin (an experimental drug for the treatment of polycystic kidney), and d melatonin (a biogenic amine for treating circadian rhythm sleep disorders) plus mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties).
T177 27348-27375 Sentence denotes Sirolimus plus Dactinomycin
T178 27376-27568 Sentence denotes Sirolimus, an inhibitor of mTOR with both antifungal and antineoplastic properties, has demonstrated to improve outcomes in patients with severe H1N1 pneumonia and acute respiratory failure50.
T179 27569-27637 Sentence denotes The mTOR signaling plays an essential role for MERS-CoV infection66.
T180 27638-27755 Sentence denotes Dactinomycin, also known actinomycin D, is an approved RNA synthesis inhibitor for treatment of various cancer types.
T181 27756-27851 Sentence denotes An early study showed that dactinomycin (1 μg/ml) inhibited the growth of feline enteric CoV67.
T182 27852-28094 Sentence denotes As shown in Fig. 6b, our network analysis shows that sirolimus and dactinomycin synergistically target HCoV-associated host protein subnetwork by “Complementary Exposure” pattern, offering potential combination regimens for treatment of HCoV.
T183 28095-28310 Sentence denotes Specifically, sirolimus and dactinomycin may inhibit both mTOR signaling and RNA synthesis pathway (including DNA topoisomerase 2-alpha (TOP2A) and DNA topoisomerase 2-beta (TOP2B)) in HCoV-infected cells (Fig. 6b).
T184 28312-28334 Sentence denotes Toremifene plus Emodin
T185 28335-28452 Sentence denotes Toremifene is among the approved first-generation nonsteroidal SERMs for the treatment of metastatic breast cancer68.
T186 28453-28585 Sentence denotes SERMs (including toremifene) inhibited Ebola virus infection18 by interacting with and destabilizing the Ebola virus glycoprotein39.
T187 28586-28695 Sentence denotes In vitro assays have demonstrated that toremifene inhibited growth of MERS-CoV17,69 and SARA-CoV38 (Table 1).
T188 28696-28831 Sentence denotes Emodin, an anthraquinone derivative extracted from the roots of rheum tanguticum, has been reported to have various anti-virus effects.
T189 28832-28973 Sentence denotes Specifically, emdoin inhibited SARS-CoV-associated 3a protein70, and blocked an interaction between the SARS-CoV spike protein and ACE2 (ref.
T190 28974-28978 Sentence denotes 71).
T191 28979-29163 Sentence denotes Altogether, network analyses and published experimental data suggested that combining toremifene and emdoin offered a potential therapeutic approach for 2019-nCoV/SARS-CoV-2 (Fig. 6c).
T192 29165-29194 Sentence denotes Mercaptopurine plus Melatonin
T193 29195-29361 Sentence denotes As shown in Fig. 5a, targets of both mercaptopurine and melatonin showed strong network proximity with HCoV-associated host proteins in the human interactome network.
T194 29362-29518 Sentence denotes Recent in vitro and in vivo studies identified mercaptopurine as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease53,54.
T195 29519-29630 Sentence denotes Melatonin was reported in potential antiviral infection via its anti-inflammatory and antioxidant effects58–62.
T196 29631-29774 Sentence denotes Melatonin indirectly regulates ACE2 expression, a key entry receptor involved in viral infection of HCoVs, including 2019-nCoV/SARS-CoV-2 (ref.
T197 29775-29779 Sentence denotes 33).
T198 29780-29958 Sentence denotes Specifically, melatonin was reported to inhibit calmodulin and calmodulin interacts with ACE2 by inhibiting shedding of its ectodomain, a key infectious process of SARS-CoV72,73.
T199 29959-30055 Sentence denotes JUN, also known as c-Jun, is a key host protein involving in HCoV infectious bronchitis virus74.
T200 30056-30187 Sentence denotes As shown in Fig. 6d, mercaptopurine and melatonin may synergistically block c-Jun signaling by targeting multiple cellular targets.
T201 30188-30426 Sentence denotes In summary, combination of mercaptopurine and melatonin may offer a potential combination therapy for 2019-nCoV/SARS-CoV-2 by synergistically targeting papain-like protease, ACE2, c-Jun signaling, and anti-inflammatory pathways (Fig. 6d).
T202 30427-30545 Sentence denotes However, further experimental observations on ACE2 pathways by melatonin in 2019-nCoV/SARS-CoV-2 are highly warranted.
T203 30547-30557 Sentence denotes Discussion
T204 30558-30745 Sentence denotes In this study, we presented a network-based methodology for systematic identification of putative repurposable drugs and drug combinations for potential treatment of 2019-nCoV/SARS-CoV-2.
T205 30746-30939 Sentence denotes Integration of drug–target networks, HCoV–host interactions, HCoV-induced transcriptome in human cell lines, and human protein–protein interactome network are essential for such identification.
T206 30940-31109 Sentence denotes Based on comprehensive evaluation, we prioritized 16 candidate repurposable drugs (Fig. 5) and 3 potential drug combinations (Fig. 6) for targeting 2019-nCoV/SARS-CoV-2.
T207 31110-31410 Sentence denotes However, although the majority of predictions have been validated by various literature data (Table 1), all network-predicted repurposable drugs and drug combinations must be validated in various 2019-nCoV/SARS-CoV-2 experimental assays64 and randomized clinical trials before being used in patients.
T208 31411-31467 Sentence denotes We acknowledge several limitations in the current study.
T209 31468-31679 Sentence denotes Although 2019-nCoV/SARS-CoV-2 shared high nucleotide sequence identity with other HCoVs (Fig. 2), our predictions are not 2019-nCoV/SARS-CoV-2 specific by lack of the known host proteins on 2019-nCoV/SARS-CoV-2.
T210 31680-31786 Sentence denotes We used a low binding affinity value of 10 μM as a threshold to define a physical drug–target interaction.
T211 31787-31953 Sentence denotes However, a stronger binding affinity threshold (e.g., 1 μM) may be a more suitable cut-off in drug discovery, although it will generate a smaller drug–target network.
T212 31954-32228 Sentence denotes Although sizeable efforts were made for assembling large scale, experimentally reported drug–target networks from publicly available databases, the network data may be incomplete and some drug–target interactions may be functional associations, instead of physical bindings.
T213 32229-32366 Sentence denotes For example, Silvestrol, a natural product from the flavagline, was found to have antiviral activity against Ebola75 and Coronaviruses76.
T214 32367-32544 Sentence denotes After adding its target, an RNA helicase enzyme EIF4A76, silvestrol was predicted to be significantly associated with HCoVs (Z = –1.24, P = 0.041) by network proximity analysis.
T215 32545-32695 Sentence denotes To increase coverage of drug–target networks, we may use computational approaches to systematically predict the drug-target interactions further25,26.
T216 32696-32895 Sentence denotes In addition, the collected virus–host interactions are far from completeness and the quality can be influenced by multiple factors, including different experimental assays and human cell line models.
T217 32896-33035 Sentence denotes We may computationally predict a new virus–host interactome for 2019-nCoV/SARS-CoV-2 using sequence-based and structure-based approaches77.
T218 33036-33259 Sentence denotes Drug targets representing nodes within cellular networks are often intrinsically coupled with both therapeutic and adverse profiles78, as drugs can inhibit or activate protein functions (including antagonists vs. agonists).
T219 33260-33497 Sentence denotes The current systems pharmacology model cannot separate therapeutic (antiviral) effects from those predictions due to lack of detailed pharmacological effects of drug targets and unknown functional consequences of virus–host interactions.
T220 33498-33747 Sentence denotes Comprehensive identification of the virus–host interactome for 2019-nCoV/SARS-CoV-2, with specific biological effects using functional genomics assays79,80, will significantly improve the accuracy of the proposed network-based methodologies further.
T221 33748-33997 Sentence denotes Owing to a lack of the complete drug-target information (such as the molecular “promiscuity” of drugs), the dose–response and dose–toxicity effects for both repurposable drugs and drug combinations cannot be identified in the current network models.
T222 33998-34149 Sentence denotes For example, Mesalazine, an approved drug for inflammatory bowel disease, is a top network-predicted repurposable drug associated with HCoVs (Fig. 5a).
T223 34150-34282 Sentence denotes Yet, several clinical studies showed the potential pulmonary toxicities (including pneumonia) associated with mesalazine usage81,82.
T224 34283-34488 Sentence denotes Integration of lung-specific gene expression23 of 2019-nCoV/SARS-CoV-2 host proteins and physiologically based pharmacokinetic modeling83 may reduce side effects of repurposable drugs or drug combinations.
T225 34489-34594 Sentence denotes Preclinical studies are warranted to evaluate in vivo efficiency and side effects before clinical trials.
T226 34595-34710 Sentence denotes Furthermore, we only limited to predict pairwise drug combinations based on our previous network-based framework28.
T227 34711-34956 Sentence denotes However, we expect that our methodology remain to be a useful network-based tool for prediction of combining multiple drugs toward exploring network relationships of multiple drugs’ targets with the HCoV–host subnetwork in the human interactome.
T228 34957-35071 Sentence denotes Finally, we aimed to systematically identify repurposable drugs by specifically targeting nCoV host proteins only.
T229 35072-35206 Sentence denotes Thus, our current network models cannot predict repurposable drugs from the existing anti-virus drugs that target virus proteins only.
T230 35207-35471 Sentence denotes Thus, combination of the existing anti-virus drugs (such as remdesivir64) with the network-predicted repurposable drugs (Fig. 5) or drug combinations (Fig. 6) may improve coverage of current network-based methodologies by utilizing multi-layer network framework16.
T231 35472-35697 Sentence denotes In conclusion, this study offers a powerful, integrative network-based systems pharmacology methodology for rapid identification of repurposable drugs and drug combinations for the potential treatment of 2019-nCoV/SARS-CoV-2.
T232 35698-35942 Sentence denotes Our approach can minimize the translational gap between preclinical testing results and clinical outcomes, which is a significant problem in the rapid development of efficient treatment strategies for the emerging 2019-nCoV/SARS-CoV-2 outbreak.
T233 35943-36157 Sentence denotes From a translational perspective, if broadly applied, the network tools developed here could help develop effective treatment strategies for other emerging viral infections and other human complex diseases as well.
T234 36159-36180 Sentence denotes Methods and materials
T235 36182-36226 Sentence denotes Genome information and phylogenetic analysis
T236 36227-36431 Sentence denotes In total, we collected DNA sequences and protein sequences for 15 HCoVs, including three most recent 2019-nCoV/SARS-CoV-2 genomes, from the NCBI GenBank database (28 January 2020, Supplementary Table S1).
T237 36432-36613 Sentence denotes Whole-genome alignment and protein sequence identity calculation were performed by Multiple Sequence Alignment in EMBL-EBI database (https://www.ebi.ac.uk/) with default parameters.
T238 36614-36751 Sentence denotes The neighbor joining (NJ) tree was computed from the pairwise phylogenetic distance matrix using MEGA X84 with 1000 bootstrap replicates.
T239 36752-36834 Sentence denotes The protein alignment and phylogenetic tree of HCoVs were constructed by MEGA X84.
T240 36836-36871 Sentence denotes Building the virus–host interactome
T241 36872-36971 Sentence denotes We collected HCoV–host protein interactions from various literatures based on our sizeable efforts.
T242 36972-37101 Sentence denotes The HCoV-associated host proteins of several HCoVs, including SARS-CoV, MERS-CoV, IBV, MHV, HCoV-229E, and HCoV-NL63 were pooled.
T243 37102-37417 Sentence denotes These proteins were either the direct targets of HCoV proteins or were involved in critical pathways of HCoV infection identified by multiple experimental sources, including high-throughput yeast-two-hybrid (Y2H) systems, viral protein pull-down assay, in vitro co-immunoprecipitation and RNA knock down experiment.
T244 37418-37528 Sentence denotes In total, the virus–host interaction network included 6 HCoVs with 119 host proteins (Supplementary Table S3).
T245 37530-37560 Sentence denotes Functional enrichment analysis
T246 37561-37763 Sentence denotes Next, we performed Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses to evaluate the biological relevance and functional pathways of the HCoV-associated proteins.
T247 37764-37819 Sentence denotes All functional analyses were performed using Enrichr85.
T248 37821-37853 Sentence denotes Building the drug–target network
T249 37854-38070 Sentence denotes Here, we collected drug–target interaction information from the DrugBank database (v4.3)86, Therapeutic Target Database (TTD)87, PharmGKB database, ChEMBL (v20)88, BindingDB89, and IUPHAR/BPS Guide to PHARMACOLOGY90.
T250 38071-38156 Sentence denotes The chemical structure of each drug with SMILES format was extracted from DrugBank86.
T251 38157-38453 Sentence denotes Here, drug–target interactions meeting the following three criteria were used: (i) binding affinities, including Ki, Kd, IC50, or EC50 each ≤10 μM; (ii) the target was marked as “reviewed” in the UniProt database91; and (iii) the human target was represented by a unique UniProt accession number.
T252 38454-38571 Sentence denotes The details for building the experimentally validated drug–target network are provided in our recent studies13,23,28.
T253 38573-38619 Sentence denotes Building the human protein–protein interactome
T254 38620-39260 Sentence denotes To build a comprehensive list of human PPIs, we assembled data from a total of 18 bioinformatics and systems biology databases with five types of experimental evidence: (i) binary PPIs tested by high-throughput yeast-two-hybrid (Y2H) systems; (ii) binary, physical PPIs from protein 3D structures; (iii) kinase-substrate interactions by literature-derived low-throughput or high-throughput experiments; (iv) signaling network by literature-derived low-throughput experiments; and (v) literature-curated PPIs identified by affinity purification followed by mass spectrometry (AP-MS), Y2H, or by literature-derived low-throughput experiments.
T255 39261-39377 Sentence denotes All inferred data, including evolutionary analysis, gene expression data, and metabolic associations, were excluded.
T256 39378-39535 Sentence denotes The genes were mapped to their Entrez ID based on the NCBI database92 as well as their official gene symbols based on GeneCards (https://www.genecards.org/).
T257 39536-39773 Sentence denotes In total, the resulting human protein–protein interactome used in this study includes 351,444 unique PPIs (edges or links) connecting 17,706 proteins (nodes), representing a 50% increase in the number of the PPIs we have used previously.
T258 39774-39895 Sentence denotes Detailed descriptions for building the human protein–protein interactome are provided in our previous studies13,23,28,93.
T259 39897-39922 Sentence denotes Network proximity measure
T260 39923-40088 Sentence denotes We posit that the human PPIs provide an unbiased, rational roadmap for repurposing drugs for potential treatment of HCoVs in which they were not originally approved.
T261 40089-40943 Sentence denotes Given C, the set of host genes associated with a specific HCoV, and T, the set of drug targets, we computed the network proximity of C with the target set T of each drug using the “closest” method:1 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left\langle d_{CT} \right\rangle = \frac{1}{\vert\vert C \vert\vert +\vert\vert T \vert\vert}\left({\sum\limits_{c \in C}} {\min}_{t \in T}\,d\left( {c,t} \right) + {\sum\limits_{t \in T}} {\min}_{c \in C}\,d\left(c,t\right) \right),$$\end{document}dCT=1∣∣C∣∣+∣∣T∣∣∑c∈Cmint∈Tdc,t+∑t∈Tminc∈Cdc,t,where d(c, t) is the shortest distance between gene c and t in the human protein interactome.
T262 40944-41876 Sentence denotes The network proximity was converted to Z-score based on permutation tests:2 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$Z_{d_{CT}} = \frac{{d_{CT} - \overline {d_r} }}{{\sigma _r}},$$\end{document}ZdCT=dCT−dr¯σr,where \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\overline {d_r}$$\end{document}dr¯ and σr were the mean and standard deviation of the permutation test repeated 1000 times, each time with two randomly selected gene lists with similar degree distributions to those of C and T.
T263 41877-41956 Sentence denotes The corresponding P value was calculated based on the permutation test results.
T264 41957-42047 Sentence denotes Z-score < −1.5 and P < 0.05 were considered significantly proximal drug–HCoV associations.
T265 42048-42116 Sentence denotes All networks were visualized using Gephi 0.9.2 (https://gephi.org/).
T266 42118-42172 Sentence denotes Network-based rational prediction of drug combinations
T267 42173-42525 Sentence denotes For this network-based approach for drug combinations to be effective, we need to establish if the topological relationship between two drug–target modules reflects biological and pharmacological relationships, while also quantifying their network-based relationship between drug targets and HCoV-associated host proteins (drug–drug–HCoV combinations).
T268 42526-42602 Sentence denotes To identify potential drug combinations, we combined the top lists of drugs.
T269 42603-43516 Sentence denotes Then, “separation” measure SAB was calculated for each pair of drugs A and B using the following method:3 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$S_{AB} = \left\langle {d_{AB}} \right\rangle - \frac{{\left\langle {d_{AA}} \right\rangle + \left\langle {d_{BB}} \right\rangle }}{2},$$\end{document}SAB=dAB−dAA+dBB2,where \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left\langle {d_ \cdot } \right\rangle$$\end{document}d⋅ was calculated based on the “closest” method.
T270 43517-43779 Sentence denotes Our key methodology is that a drug combination is therapeutically effective only if it follows a specific relationship to the disease module, as captured by Complementary Exposure patterns in targets’ modules of both drugs without overlapping toxic mechanisms28.
T271 43781-43809 Sentence denotes Gene set enrichment analysis
T272 43810-43895 Sentence denotes We performed the gene set enrichment analysis as an additional prioritization method.
T273 43896-44031 Sentence denotes We first collected three differential gene expression data sets of hosts infected by HCoVs from the NCBI Gene Expression Omnibus (GEO).
T274 44032-44191 Sentence denotes Among them, two transcriptome data sets were SARS-CoV-infected samples from patient’s peripheral blood94 (GSE1739) and Calu-3 cells95 (GSE33267), respectively.
T275 44192-44268 Sentence denotes One transcriptome data set was MERS-CoV-infected Calu-3 cells96 (GSE122876).
T276 44269-44347 Sentence denotes Adjusted P value less than 0.01 was defined as differentially expressed genes.
T277 44348-44441 Sentence denotes These data sets were used as HCoV–host signatures to evaluate the treatment effects of drugs.
T278 44442-44612 Sentence denotes Differential gene expression in cells treated with various drugs were retrieved from the Connectivity Map (CMAP) database36, and were used as gene profiles for the drugs.
T279 44613-45558 Sentence denotes For each drug that was in both the CMAP data set and our drug–target network, we calculated an enrichment score (ES) for each HCoV signature data set based on previously described methods97 as follows:4 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathrm {ES}} = \left\{ {\begin{array}{*{20}{c}} {{\mathrm{ES}_{\mathrm{up}}} - {\mathrm {ES}_{\mathrm{down}}},{\mathrm {sgn}}\left( {{\mathrm {ES}_{\mathrm{up}}}} \right)\, \ne \,{\mathrm {sgn}}\left( {{\mathrm {ES}_{\mathrm{down}}}} \right)} \\ {0,\mathrm {else}} \end{array}} \right.$$\end{document}ES=ESup−ESdown,sgnESup≠sgnESdown0,elseESup and ESdown were calculated separately for the up- and down-regulated genes from the HCoV signature data set using the same method.
T280 45559-46565 Sentence denotes We first computed aup/down and bup/down as5 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$a = \mathop{\max}\limits_{1 \le j \le s}\left( {\frac{j}{s} - \frac{{V\left( j \right)}}{r}} \right),$$\end{document}a=max1≤j≤sjs−Vjr,6 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$b = \mathop{\max}\limits_{1 \le j \le s}\left( {\frac{{V\left( j \right)}}{r} - \frac{{j - 1}}{s}} \right),$$\end{document}b=max1≤j≤sVjr−j−1s,where j = 1, 2, …, s were the genes of HCoV signature data set sorted in ascending order by their rank in the gene profiles of the drug being evaluated.
T281 46566-46689 Sentence denotes The rank of gene j is denoted by V(j), where 1 ≤ V(j) ≤ r, with r being the number of genes (12,849) from the drug profile.
T282 46690-46798 Sentence denotes Then, ESup/down was set to aup/down if aup/down > bup/down, and was set to −bup/down if bup/down > aup/down.
T283 46799-47016 Sentence denotes Permutation tests repeated 100 times using randomly generated gene lists with the same number of up- and down-regulated genes as the HCoV signature data set were performed to measure the significance of the ES scores.
T284 47017-47204 Sentence denotes Drugs were considered to have potential treatment effect if ES > 0 and P < 0.05, and the number of such HCoV signature data sets were used as the final GSEA score that ranges from 0 to 3.
T285 47206-47231 Sentence denotes Supplementary information
T286 47233-47258 Sentence denotes Supplementary Table S1-S6

2_test

Id Subject Object Predicate Lexical cue
32194980-26868298-19614142 158-159 26868298 denotes 1
32194980-27344959-19614143 604-605 27344959 denotes 3
32194980-28643204-19614144 606-607 28643204 denotes 4
32194980-32007143-19614145 944-945 32007143 denotes 5
32194980-29262277-19614146 1848-1849 29262277 denotes 7
32194980-25970049-19614147 2026-2027 25970049 denotes 8
32194980-30378081-19614148 2242-2243 30378081 denotes 9
32194980-27296652-19614148 2242-2243 27296652 denotes 9
32194980-27692879-19614148 2242-2243 27692879 denotes 9
32194980-27910877-19614149 2330-2332 27910877 denotes 12
32194980-30378081-19614150 2424-2425 30378081 denotes 9
32194980-27296652-19614150 2424-2425 27296652 denotes 9
32194980-27692879-19614150 2424-2425 27692879 denotes 9
32194980-30002366-19614151 2429-2431 30002366 denotes 13
32194980-27632082-19614152 2432-2434 27632082 denotes 14
32194980-26868298-19614153 2763-2764 26868298 denotes 1
32194980-26868298-19614154 2864-2865 26868298 denotes 1
32194980-30984872-19614155 3019-3021 30984872 denotes 15
32194980-26868298-19614156 3201-3202 26868298 denotes 1
32194980-24841273-19614157 3222-3224 24841273 denotes 17
32194980-24841273-19614158 3234-3236 24841273 denotes 17
32194980-27632082-19614159 3267-3269 27632082 denotes 14
32194980-27476412-19614160 3270-3272 27476412 denotes 19
32194980-27571349-19614160 3270-3272 27571349 denotes 19
32194980-27632082-19614161 3463-3465 27632082 denotes 14
32194980-27692879-19614162 3555-3557 27692879 denotes 11
32194980-27632082-19614163 3558-3560 27632082 denotes 14
32194980-30002366-19614164 3698-3700 30002366 denotes 13
32194980-22589709-19614165 3701-3703 22589709 denotes 22
32194980-31375661-19614165 3701-3703 31375661 denotes 22
32194980-31116390-19614165 3701-3703 31116390 denotes 22
32194980-30867426-19614166 3728-3730 30867426 denotes 28
32194980-30002366-19614167 4144-4146 30002366 denotes 13
32194980-31375661-19614168 4147-4149 31375661 denotes 23
32194980-30867426-19614169 4153-4155 30867426 denotes 28
32194980-26868298-19614170 6583-6584 26868298 denotes 1
32194980-27743750-19614171 6585-6587 27743750 denotes 29
32194980-27743750-19614172 8232-8234 27743750 denotes 29
32194980-31138817-19614173 8473-8475 31138817 denotes 30
32194980-16166518-19614174 8894-8896 16166518 denotes 31
32194980-32007145-19614175 8897-8899 32007145 denotes 32
32194980-32015507-19614176 9168-9170 32015507 denotes 33
32194980-32075877-19614177 9390-9392 32075877 denotes 34
32194980-23717688-19614178 9515-9517 23717688 denotes 35
32194980-30002366-19614179 13269-13271 30002366 denotes 13
32194980-22589709-19614180 13272-13274 22589709 denotes 22
32194980-31375661-19614181 13275-13277 31375661 denotes 23
32194980-30867426-19614182 13278-13280 30867426 denotes 28
32194980-30002366-19614183 14334-14336 30002366 denotes 13
32194980-30867426-19614184 14337-14339 30867426 denotes 28
32194980-17008526-19614185 16384-16386 17008526 denotes 36
32194980-31474372-19614186 19459-19461 31474372 denotes 37
32194980-31474372-19614187 19652-19654 31474372 denotes 37
32194980-24841273-19614188 20066-20068 24841273 denotes 17
32194980-24841269-19614189 20069-20071 24841269 denotes 38
32194980-27362232-19614190 20313-20315 27362232 denotes 39
32194980-23637410-19614191 20470-20472 23637410 denotes 40
32194980-30632963-19614192 20473-20475 30632963 denotes 41
32194980-15379656-19614193 20982-20984 15379656 denotes 42
32194980-16336207-19614193 20982-20984 16336207 denotes 42
32194980-29020174-19614193 20982-20984 29020174 denotes 42
32194980-26086883-19614194 21560-21562 26086883 denotes 45
32194980-25929767-19614195 21563-21565 25929767 denotes 46
32194980-18433331-19614196 21676-21678 18433331 denotes 47
32194980-23135723-19614197 22112-22114 23135723 denotes 48
32194980-26276683-19614198 22115-22117 26276683 denotes 49
32194980-24105455-19614199 22304-22306 24105455 denotes 50
32194980-29143192-19614200 22416-22418 29143192 denotes 51
32194980-24105455-19614201 22575-22577 24105455 denotes 50
32194980-18097462-19614202 22872-22874 18097462 denotes 52
32194980-19374142-19614203 23080-23082 19374142 denotes 53
32194980-25542975-19614204 23083-23085 25542975 denotes 54
32194980-23637410-19614205 23204-23206 23637410 denotes 40
32194980-11967337-19614206 23207-23209 11967337 denotes 55
32194980-16835706-19614207 23309-23311 16835706 denotes 56
32194980-21189219-19614208 23312-23314 21189219 denotes 57
32194980-24090288-19614209 23528-23530 24090288 denotes 58
32194980-22264213-19614210 23531-23533 22264213 denotes 59
32194980-25262626-19614211 23731-23733 25262626 denotes 60
32194980-17198536-19614212 23959-23961 17198536 denotes 61
32194980-22998574-19614213 23962-23964 22998574 denotes 62
32194980-19213804-19614214 24548-24550 19213804 denotes 63
32194980-32020029-19614215 24781-24783 32020029 denotes 64
32194980-23064238-19614216 25134-25136 23064238 denotes 65
32194980-30867426-19614217 25438-25440 30867426 denotes 28
32194980-24105455-19614218 27565-27567 24105455 denotes 50
32194980-25487801-19614219 27634-27636 25487801 denotes 66
32194980-1335030-19614220 27848-27850 1335030 denotes 67
32194980-21553116-19614221 28449-28451 21553116 denotes 68
32194980-27362232-19614222 28582-28584 27362232 denotes 39
32194980-24841273-19614223 28664-28666 24841273 denotes 17
32194980-29566060-19614224 28667-28669 29566060 denotes 69
32194980-24841269-19614225 28682-28684 24841269 denotes 38
32194980-21356245-19614226 28893-28895 21356245 denotes 70
32194980-16730806-19614227 28974-28976 16730806 denotes 71
32194980-19374142-19614228 29512-29514 19374142 denotes 53
32194980-25542975-19614229 29515-29517 25542975 denotes 54
32194980-24090288-19614230 29624-29626 24090288 denotes 58
32194980-22264213-19614230 29624-29626 22264213 denotes 58
32194980-25262626-19614230 29624-29626 25262626 denotes 58
32194980-17198536-19614230 29624-29626 17198536 denotes 58
32194980-22998574-19614230 29624-29626 22998574 denotes 58
32194980-32015507-19614231 29775-29777 32015507 denotes 33
32194980-18070603-19614232 29952-29954 18070603 denotes 72
32194980-12071468-19614233 29955-29957 12071468 denotes 73
32194980-29238080-19614234 30052-30054 29238080 denotes 74
32194980-32020029-19614235 31346-31348 32020029 denotes 64
32194980-27864075-19614236 32343-32345 27864075 denotes 75
32194980-29258862-19614237 32363-32365 29258862 denotes 76
32194980-29258862-19614238 32420-32422 29258862 denotes 76
32194980-29028879-19614239 33032-33034 29028879 denotes 77
32194980-27146293-19614240 33167-33169 27146293 denotes 78
32194980-24852294-19614241 33648-33650 24852294 denotes 79
32194980-23667838-19614242 34276-34278 23667838 denotes 81
32194980-28458997-19614243 34279-34281 28458997 denotes 82
32194980-31375661-19614244 34327-34329 31375661 denotes 23
32194980-29052226-19614245 34418-34420 29052226 denotes 83
32194980-30867426-19614246 34707-34709 30867426 denotes 28
32194980-32020029-19614247 35277-35279 32020029 denotes 64
32194980-29722887-19614248 36717-36719 29722887 denotes 84
32194980-29722887-19614249 36831-36833 29722887 denotes 84
32194980-27141961-19614250 37816-37818 27141961 denotes 85
32194980-24203711-19614251 37942-37944 24203711 denotes 86
32194980-26578601-19614252 37979-37981 26578601 denotes 87
32194980-21948594-19614253 38014-38016 21948594 denotes 88
32194980-17145705-19614254 38027-38029 17145705 denotes 89
32194980-24234439-19614255 38067-38069 24234439 denotes 90
32194980-24203711-19614256 38153-38155 24203711 denotes 86
32194980-14681372-19614257 38369-38371 14681372 denotes 91
32194980-30002366-19614258 38562-38564 30002366 denotes 13
32194980-31375661-19614259 38565-38567 31375661 denotes 23
32194980-30867426-19614260 38568-38570 30867426 denotes 28
32194980-26615191-19614261 39445-39447 26615191 denotes 92
32194980-30002366-19614262 39883-39885 30002366 denotes 13
32194980-31375661-19614263 39886-39888 31375661 denotes 23
32194980-30867426-19614264 39889-39891 30867426 denotes 28
32194980-31006514-19614265 39892-39894 31006514 denotes 93
32194980-30867426-19614266 43776-43778 30867426 denotes 28
32194980-15655079-19614267 44134-44136 15655079 denotes 94
32194980-23631916-19614268 44163-44165 23631916 denotes 95
32194980-30631056-19614269 44253-44255 30631056 denotes 96
32194980-17008526-19614270 44563-44565 17008526 denotes 36
32194980-21849665-19614271 44800-44802 21849665 denotes 97