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PMC:7073332 / 19760-20855 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
461 26-30 Species denotes HCoV Tax:694448
474 843-860 Gene denotes estrogen receptor Gene:2099
475 368-373 Species denotes human Tax:9606
476 258-262 Species denotes HCoV Tax:694448
477 335-339 Species denotes HCoV Tax:694448
478 432-436 Species denotes HCoV Tax:694448
479 613-617 Chemical denotes GSEA
480 791-801 Chemical denotes toremifene MESH:D017312
481 875-885 Chemical denotes irbesartan MESH:D000077405
482 923-937 Chemical denotes mercaptopurine MESH:D015122
483 1020-1029 Chemical denotes melatonin MESH:D008550
484 1042-1047 Chemical denotes amine MESH:D000588
485 1071-1093 Disease denotes rhythm sleep disorders MESH:D012893

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T98 18-25 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T99 109-113 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T100 274-282 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 351-359 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T102 374-381 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T103 382-389 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T104 448-455 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T105 493-501 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T106 568-576 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T107 843-851 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T108 1020-1029 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T109 1033-1047 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T71 1061-1093 Disease denotes circadian rhythm sleep disorders http://purl.obolibrary.org/obo/MONDO_0024361
T72 1078-1093 Disease denotes sleep disorders http://purl.obolibrary.org/obo/MONDO_0003406

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T137 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T138 76-77 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 109-113 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T140 368-381 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T141 722-723 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T142 789-790 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T143 843-860 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T144 1031-1032 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T195 13-17 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T196 18-25 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 69-74 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T198 182-187 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T199 235-239 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T200 274-282 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T201 311-316 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T202 351-359 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T203 374-381 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T204 382-389 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T205 420-424 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T206 448-455 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T207 493-501 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T208 568-576 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T209 635-640 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T210 661-663 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T211 715-720 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T212 782-787 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T213 791-801 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T214 843-870 Chemical denotes estrogen receptor modulator http://purl.obolibrary.org/obo/CHEBI_50739
T215 843-851 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T216 852-870 Chemical denotes receptor modulator http://purl.obolibrary.org/obo/CHEBI_90710
T217 875-885 Chemical denotes irbesartan http://purl.obolibrary.org/obo/CHEBI_5959
T218 890-901 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T219 923-937 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T220 942-956 Chemical denotes antimetabolite http://purl.obolibrary.org/obo/CHEBI_35221
T221 957-977 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T222 983-1000 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T223 1020-1029 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T224 1042-1047 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T24 1061-1077 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T25 1071-1077 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T26 1078-1083 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T120 76-198 Sentence denotes a Network-predicted evidence and gene set enrichment analysis (GSEA) scores for 16 potential repurposable drugs for HCoVs.
T121 199-296 Sentence denotes The overall connectivity of the top drug candidates to the HCoV-associated proteins was examined.
T122 297-411 Sentence denotes Most of these drugs indirectly target HCoV-associated proteins via the human protein–protein interaction networks.
T123 412-543 Sentence denotes All the drug–target-HCoV-associated protein connections were examined, and those proteins with at least five connections are shown.
T124 544-612 Sentence denotes The box heights for the proteins indicate the number of connections.
T125 613-1095 Sentence denotes GSEA scores for eight drugs were not available (NA) due to the lack of transcriptome profiles for the drugs. b–e Inferred mechanism-of-action networks for four selected drugs: b toremifene (first-generation nonsteroidal-selective estrogen receptor modulator), c irbesartan (an angiotensin receptor blocker), d mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties), and e melatonin (a biogenic amine for treating circadian rhythm sleep disorders).