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PMC:7073332 / 16383-17989 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
152 380-388 Species denotes SARS-CoV Tax:694009
153 390-398 Species denotes MERS-CoV Tax:1335626
423 941-945 Species denotes HCoV Tax:694448
431 1190-1195 Species denotes human Tax:9606
432 1383-1391 Species denotes SARS-CoV Tax:694009
433 1393-1401 Species denotes MERS-CoV Tax:1335626
434 1538-1543 Species denotes human Tax:9606
435 1006-1010 Species denotes HCoV Tax:694448
436 1158-1162 Species denotes HCoV Tax:694448
437 1506-1510 Species denotes HCoV Tax:694448
449 175-183 Gene denotes S4 and 5 Gene:6192
450 244-248 Species denotes CoVs Tax:11118
451 322-326 Species denotes CoVs Tax:11118
457 122-126 Species denotes HCoV Tax:694448

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T82 226-234 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T83 360-368 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T84 509-517 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T85 1174-1182 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T86 1522-1530 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T66 380-388 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 667-675 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 1383-1391 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T110 107-111 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T111 332-333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 923-924 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T113 955-958 http://purl.obolibrary.org/obo/CLO_0001627 denotes a A
T114 1190-1195 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T115 1329-1330 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T116 1331-1332 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T117 1538-1543 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T118 1601-1605 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T156 44-49 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T157 175-177 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T158 226-234 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T159 307-312 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T160 360-368 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T161 509-517 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T162 627-632 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T163 936-940 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T164 1001-1005 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T165 1039-1044 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T166 1070-1075 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T167 1137-1141 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T168 1174-1182 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T169 1485-1489 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T170 1522-1530 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T98 0-185 Sentence denotes In total, we computationally identified 135 drugs that were associated (Z < −1.5 and P < 0.05, permutation test) with the HCoV–host interactome (Fig. 4a, Supplementary Tables S4 and 5).
T99 186-425 Sentence denotes To validate bias of the pooled cellular proteins from six CoVs, we further calculated the network proximities of all the drugs for four CoVs with a large number of know host proteins, including SARS-CoV, MERS-CoV, IBV, and MHV, separately.
T100 426-559 Sentence denotes We found that the Z-scores showed consistency among the pooled 119 HCoV-associated proteins and other four individual CoVs (Fig. 4b).
T101 560-794 Sentence denotes The Pearson correlation coefficients of the proximities of all the drugs for the pooled HCoV are 0.926 vs. SARS-CoV (P < 0.001, t distribution), 0.503 vs. MERS-CoV (P < 0.001), 0.694 vs. IBV (P < 0.001), and 0.829 vs. MHV (P < 0.001).
T102 795-915 Sentence denotes These network proximity analyses offer putative repurposable candidates for potential prevention and treatment of HCoVs.
T103 916-954 Sentence denotes Fig. 4 A discovered drug-HCoV network.
T104 955-1055 Sentence denotes a A subnetwork highlighting network-predicted drug-HCoV associations connecting 135 drugs and HCoVs.
T105 1056-1216 Sentence denotes From the 2938 drugs evaluated, 135 ones achieved significant proximities between drug targets and the HCoV-associated proteins in the human interactome network.
T106 1217-1430 Sentence denotes Drugs are colored by their first-level of the Anatomical Therapeutic Chemical (ATC) classification system code. b A heatmap highlighting network proximity values for SARS-CoV, MERS-CoV, IBV, and MHV, respectively.
T107 1431-1564 Sentence denotes Color key denotes network proximity (Z-score) between drug targets and the HCoV-associated proteins in the human interactome network.
T108 1565-1606 Sentence denotes P value was computed by permutation test.