PMC:7073332 / 16383-17989
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
152 | 380-388 | Species | denotes | SARS-CoV | Tax:694009 |
153 | 390-398 | Species | denotes | MERS-CoV | Tax:1335626 |
423 | 941-945 | Species | denotes | HCoV | Tax:694448 |
431 | 1190-1195 | Species | denotes | human | Tax:9606 |
432 | 1383-1391 | Species | denotes | SARS-CoV | Tax:694009 |
433 | 1393-1401 | Species | denotes | MERS-CoV | Tax:1335626 |
434 | 1538-1543 | Species | denotes | human | Tax:9606 |
435 | 1006-1010 | Species | denotes | HCoV | Tax:694448 |
436 | 1158-1162 | Species | denotes | HCoV | Tax:694448 |
437 | 1506-1510 | Species | denotes | HCoV | Tax:694448 |
449 | 175-183 | Gene | denotes | S4 and 5 | Gene:6192 |
450 | 244-248 | Species | denotes | CoVs | Tax:11118 |
451 | 322-326 | Species | denotes | CoVs | Tax:11118 |
457 | 122-126 | Species | denotes | HCoV | Tax:694448 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T82 | 226-234 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T83 | 360-368 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T84 | 509-517 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T85 | 1174-1182 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T86 | 1522-1530 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T66 | 380-388 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T67 | 667-675 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T68 | 1383-1391 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T110 | 107-111 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
T111 | 332-333 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T112 | 923-924 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T113 | 955-958 | http://purl.obolibrary.org/obo/CLO_0001627 | denotes | a A |
T114 | 1190-1195 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T115 | 1329-1330 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T116 | 1331-1332 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T117 | 1538-1543 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T118 | 1601-1605 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T156 | 44-49 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T157 | 175-177 | Chemical | denotes | S4 | http://purl.obolibrary.org/obo/CHEBI_29401 |
T158 | 226-234 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T159 | 307-312 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T160 | 360-368 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T161 | 509-517 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T162 | 627-632 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T163 | 936-940 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T164 | 1001-1005 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T165 | 1039-1044 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T166 | 1070-1075 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T167 | 1137-1141 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T168 | 1174-1182 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T169 | 1485-1489 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T170 | 1522-1530 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T98 | 0-185 | Sentence | denotes | In total, we computationally identified 135 drugs that were associated (Z < −1.5 and P < 0.05, permutation test) with the HCoV–host interactome (Fig. 4a, Supplementary Tables S4 and 5). |
T99 | 186-425 | Sentence | denotes | To validate bias of the pooled cellular proteins from six CoVs, we further calculated the network proximities of all the drugs for four CoVs with a large number of know host proteins, including SARS-CoV, MERS-CoV, IBV, and MHV, separately. |
T100 | 426-559 | Sentence | denotes | We found that the Z-scores showed consistency among the pooled 119 HCoV-associated proteins and other four individual CoVs (Fig. 4b). |
T101 | 560-794 | Sentence | denotes | The Pearson correlation coefficients of the proximities of all the drugs for the pooled HCoV are 0.926 vs. SARS-CoV (P < 0.001, t distribution), 0.503 vs. MERS-CoV (P < 0.001), 0.694 vs. IBV (P < 0.001), and 0.829 vs. MHV (P < 0.001). |
T102 | 795-915 | Sentence | denotes | These network proximity analyses offer putative repurposable candidates for potential prevention and treatment of HCoVs. |
T103 | 916-954 | Sentence | denotes | Fig. 4 A discovered drug-HCoV network. |
T104 | 955-1055 | Sentence | denotes | a A subnetwork highlighting network-predicted drug-HCoV associations connecting 135 drugs and HCoVs. |
T105 | 1056-1216 | Sentence | denotes | From the 2938 drugs evaluated, 135 ones achieved significant proximities between drug targets and the HCoV-associated proteins in the human interactome network. |
T106 | 1217-1430 | Sentence | denotes | Drugs are colored by their first-level of the Anatomical Therapeutic Chemical (ATC) classification system code. b A heatmap highlighting network proximity values for SARS-CoV, MERS-CoV, IBV, and MHV, respectively. |
T107 | 1431-1564 | Sentence | denotes | Color key denotes network proximity (Z-score) between drug targets and the HCoV-associated proteins in the human interactome network. |
T108 | 1565-1606 | Sentence | denotes | P value was computed by permutation test. |