PMC:7073332 / 15679-16144 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"417","span":{"begin":47,"end":52},"obj":"Species"}],"attributes":[{"id":"A417","pred":"tao:has_database_id","subj":"417","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T80","span":{"begin":53,"end":60},"obj":"Body_part"},{"id":"T81","span":{"begin":163,"end":170},"obj":"Body_part"}],"attributes":[{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T105","span":{"begin":47,"end":60},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T106","span":{"begin":319,"end":328},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T152","span":{"begin":53,"end":60},"obj":"Chemical"},{"id":"T153","span":{"begin":163,"end":170},"obj":"Chemical"}],"attributes":[{"id":"A152","pred":"chebi_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A153","pred":"chebi_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T22","span":{"begin":319,"end":328},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T96","span":{"begin":0,"end":465},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods)."}