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PMC:7073332 / 10185-11619 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
287 122-128 Gene denotes ORF1ab Gene:43740578
288 131-136 Gene denotes spike Gene:43740568
289 138-139 Gene denotes S Gene:43740568
290 152-153 Gene denotes E Gene:43740570
291 156-164 Gene denotes membrane Gene:43740571
292 166-167 Gene denotes M Gene:43740571
293 215-221 Gene denotes ORF1ab Gene:43740578
294 410-414 Gene denotes nsp7 Gene:43740578
295 419-423 Gene denotes nsp8 Gene:43740578
296 573-577 Gene denotes nsp7 Gene:43740578
297 582-586 Gene denotes nsp8 Gene:43740578
298 625-630 Gene denotes spike Gene:43740568
299 798-803 Gene denotes spike Gene:43740568
300 874-878 Gene denotes ACE2 Gene:59272
301 975-979 Gene denotes ACE2 Gene:59272
302 1004-1008 Gene denotes ACE2 Gene:59272
303 1196-1201 Gene denotes spike Gene:43740568
304 1208-1212 Gene denotes ACE2 Gene:59272
305 1130-1135 Gene denotes spike Gene:43740568
306 499-507 Species denotes SARS-CoV Tax:694009
307 883-891 Species denotes SARS-CoV Tax:694009
308 935-944 Species denotes 2019-nCoV Tax:2697049
309 945-955 Species denotes SARS-CoV-2 Tax:2697049
310 1175-1184 Species denotes 2019-nCoV Tax:2697049
311 1185-1195 Species denotes SARS-CoV-2 Tax:2697049
312 1239-1247 Species denotes SARS-CoV Tax:694009
313 702-717 Disease denotes viral infection MESH:D001102

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T38 22-29 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T39 191-199 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T40 222-226 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T41 254-262 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T42 278-281 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T43 355-358 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T44 369-372 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T45 470-477 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 650-662 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T47 804-811 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 1334-1340 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T49 1349-1356 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T4 547-556 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T40 499-507 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 702-717 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T42 708-717 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T43 883-891 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 945-953 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 1185-1193 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 1239-1243 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T70 42-47 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T71 156-164 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T72 222-226 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T73 347-348 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 451-459 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T75 527-528 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 634-635 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 674-675 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 908-909 http://purl.obolibrary.org/obo/CLO_0001020 denotes A

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T96 22-29 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T97 191-199 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T98 254-262 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T99 470-477 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 650-662 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T101 804-811 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T102 841-852 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T103 897-899 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T104 1050-1054 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T105 1110-1112 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T106 1349-1356 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 278-291 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T4 282-291 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T5 702-717 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T60 0-210 Sentence denotes HCoVs have five major protein regions for virus structure assembly and viral replications29, including replicase complex (ORF1ab), spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins (Fig. 2b).
T61 211-333 Sentence denotes The ORF1ab gene encodes the non-structural proteins (nsp) of viral RNA synthesis complex through proteolytic processing30.
T62 334-460 Sentence denotes The nsp12 is a viral RNA-dependent RNA polymerase, together with co-factors nsp7 and nsp8 possessing high polymerase activity.
T63 461-620 Sentence denotes From the protein 3D structure view of SARS-CoV nsp12, it contains a larger N-terminal extension (which binds to nsp7 and nsp8) and polymerase domain (Fig. 2c).
T64 621-757 Sentence denotes The spike is a transmembrane glycoprotein that plays a pivotal role in mediating viral infection through binding the host receptor31,32.
T65 758-900 Sentence denotes Figure 2d shows the 3D structure of the spike protein bound with the host receptor angiotensin converting enznyme2 (ACE2) in SARS-CoV (PDB ID:
T66 901-907 Sentence denotes 6ACK).
T67 908-1091 Sentence denotes A recent study showed that 2019-nCoV/SARS-CoV-2 is able to utilize ACE2 as an entry receptor in ACE2-expressing cells33, suggesting potential drug targets for therapeutic development.
T68 1092-1250 Sentence denotes Furthermore, cryo-EM structure of the spike and biophysical assays reveal that the 2019-nCoV/SARS-CoV-2 spike binds ACE2 with higher affinity than SARS-CoV34.
T69 1251-1434 Sentence denotes In addition, the nucleocapsid is also an important subunit for packaging the viral genome through protein oligomerization35, and the single nucleocapsid structure is shown in Fig. 2e.

2_test

Id Subject Object Predicate Lexical cue
32194980-27743750-19614172 89-91 27743750 denotes 29
32194980-31138817-19614173 330-332 31138817 denotes 30
32194980-16166518-19614174 751-753 16166518 denotes 31
32194980-32007145-19614175 754-756 32007145 denotes 32
32194980-32015507-19614176 1025-1027 32015507 denotes 33
32194980-32075877-19614177 1247-1249 32075877 denotes 34
32194980-23717688-19614178 1372-1374 23717688 denotes 35