> top > docs > PMC:7073332 > annotations

PMC:7073332 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 35-52 Species denotes novel coronavirus Tax:2697049
3 53-62 Species denotes 2019-nCoV Tax:2697049
38 84-89 Species denotes Human Tax:9606
39 90-103 Species denotes coronaviruses Tax:11118
40 123-168 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
41 170-178 Species denotes SARS-CoV Tax:694009
42 184-206 Species denotes 2019 novel coronavirus Tax:2697049
43 208-217 Species denotes 2019-nCoV Tax:2697049
44 233-243 Species denotes SARS-CoV-2 Tax:2697049
45 361-370 Species denotes 2019-nCoV Tax:2697049
46 371-381 Species denotes SARS-CoV-2 Tax:2697049
47 788-793 Species denotes human Tax:9606
48 890-899 Species denotes 2019-nCoV Tax:2697049
49 900-910 Species denotes SARS-CoV-2 Tax:2697049
50 964-972 Species denotes SARS-CoV Tax:694009
51 1038-1047 Species denotes 2019-nCoV Tax:2697049
52 1048-1058 Species denotes SARS-CoV-2 Tax:2697049
53 1176-1184 Species denotes SARS-CoV Tax:694009
54 1269-1274 Species denotes human Tax:9606
55 1508-1513 Species denotes human Tax:9606
56 1826-1831 Species denotes human Tax:9606
57 2019-2028 Species denotes 2019-nCoV Tax:2697049
58 2029-2039 Species denotes SARS-CoV-2 Tax:2697049
59 742-746 Species denotes HCoV Tax:694448
60 859-863 Species denotes HCoV Tax:694448
61 1239-1243 Species denotes HCoV Tax:694448
62 1320-1324 Species denotes HCoV Tax:694448
63 1471-1475 Species denotes HCoV Tax:694448
64 1763-1767 Species denotes HCoV Tax:694448
65 1587-1596 Chemical denotes sirolimus MESH:D020123
66 1602-1614 Chemical denotes dactinomycin MESH:D003609
67 1616-1630 Chemical denotes mercaptopurine MESH:D015122
68 1636-1645 Chemical denotes melatonin MESH:D008550
69 1651-1661 Chemical denotes toremifene MESH:D017312
70 1667-1673 Chemical denotes emodin MESH:D004642
71 292-301 Disease denotes mortality MESH:D003643
104 2055-2068 Species denotes Coronaviruses Tax:11118
105 2070-2074 Species denotes CoVs Tax:11118
106 2137-2143 Species denotes humans Tax:9606
107 2250-2255 Species denotes human Tax:9606
108 2256-2260 Species denotes CoVs Tax:11118
109 2280-2325 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
110 2327-2335 Species denotes SARS-CoV Tax:694009
111 2341-2396 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
112 2560-2568 Species denotes SARS-CoV Tax:694009
113 2722-2730 Species denotes MERS-CoV Tax:1335626
114 2873-2895 Species denotes 2019 novel coronavirus Tax:2697049
115 2897-2906 Species denotes 2019-nCoV Tax:2697049
116 2907-2917 Species denotes SARS-CoV-2 Tax:2697049
117 3104-3113 Species denotes 2019-nCoV Tax:2697049
118 3114-3124 Species denotes SARS-CoV-2 Tax:2697049
119 3158-3163 Species denotes human Tax:9606
120 3167-3172 Species denotes human Tax:9606
121 3284-3293 Species denotes 2019-nCoV Tax:2697049
122 3294-3304 Species denotes SARS-CoV-2 Tax:2697049
123 3425-3434 Species denotes 2019-nCoV Tax:2697049
124 3435-3445 Species denotes SARS-CoV-2 Tax:2697049
125 3590-3599 Species denotes 2019-nCoV Tax:2697049
126 3600-3610 Species denotes SARS-CoV-2 Tax:2697049
127 2097-2108 Species denotes respiratory Tax:12814
128 2861-2865 Species denotes HCoV Tax:694448
129 2172-2200 Disease denotes respiratory tract infections MESH:D012141
130 2484-2493 Disease denotes mortality MESH:D003643
131 2531-2539 Disease denotes infected MESH:D007239
132 2783-2789 Disease denotes deaths MESH:D003643
133 2936-2960 Disease denotes coronavirus disease 2019 MESH:C000657245
134 2977-2985 Disease denotes COVID-19 MESH:C000657245
135 3089-3095 Disease denotes deaths MESH:D003643
138 3808-3809 Gene denotes S Gene:43740568
139 4657-4662 Species denotes human Tax:9606
152 16763-16771 Species denotes SARS-CoV Tax:694009
153 16773-16781 Species denotes MERS-CoV Tax:1335626
158 4827-4831 Species denotes HCoV Tax:694448
159 4897-4906 Disease denotes infection MESH:D007239
160 5046-5061 Disease denotes viral infection MESH:D001102
161 5227-5243 Disease denotes viral infections MESH:D001102
173 7385-7390 Species denotes human Tax:9606
174 7406-7423 Species denotes Human coronavirus Tax:694448
175 7690-7695 Species denotes human Tax:9606
176 8054-8059 Species denotes human Tax:9606
177 8263-8268 Species denotes human Tax:9606
178 8489-8494 Species denotes human Tax:9606
179 7425-7429 Species denotes HCoV Tax:694448
180 7517-7521 Species denotes HCoV Tax:694448
181 7587-7591 Species denotes HCoV Tax:694448
182 7991-7995 Species denotes HCoV Tax:694448
183 8416-8425 Disease denotes infection MESH:D007239
193 6439-6444 Species denotes human Tax:9606
194 6670-6675 Species denotes human Tax:9606
195 6887-6892 Species denotes human Tax:9606
196 7038-7043 Species denotes human Tax:9606
197 6593-6597 Species denotes HCoV Tax:694448
198 7006-7010 Species denotes HCoV Tax:694448
199 7115-7119 Species denotes HCoV Tax:694448
200 6566-6581 Disease denotes viral infection MESH:D001102
201 6814-6823 Disease denotes infection MESH:D007239
203 8543-8552 Species denotes 2019-nCoV Tax:2697049
205 9360-9373 Species denotes coronaviruses Tax:11118
214 9983-9988 Gene denotes spike Gene:43740568
215 9398-9409 Species denotes coronavirus Tax:11118
216 9411-9414 Species denotes CoV Tax:11118
217 9501-9514 Species denotes coronaviruses Tax:11118
218 9557-9579 Species denotes coronavirus, 2019-nCoV Tax:2697049
219 9580-9590 Species denotes SARS-CoV-2 Tax:2697049
220 9948-9956 Species denotes SARS-CoV Tax:694009
221 9752-9756 Species denotes HCoV Tax:694448
241 8634-8643 Species denotes 2019-nCoV Tax:2697049
242 8644-8654 Species denotes SARS-CoV-2 Tax:2697049
243 8656-8664 Species denotes SARS-CoV Tax:694009
244 8666-8674 Species denotes MERS-CoV Tax:1335626
245 8676-8685 Species denotes HCoV-OC43 Tax:31631
246 8691-8700 Species denotes HCoV-HKU1 Tax:290028
247 8724-8733 Species denotes HCoV-NL63 Tax:277944
248 8738-8747 Species denotes HCoV-229E Tax:11137
249 8896-8905 Species denotes 2019-nCoV Tax:2697049
250 8906-8916 Species denotes SARS-CoV-2 Tax:2697049
251 8970-8979 Species denotes 2019-nCoV Tax:2697049
252 8980-8990 Species denotes SARS-CoV-2 Tax:2697049
253 9055-9063 Species denotes patients Tax:9606
254 9094-9103 Species denotes 2019-nCoV Tax:2697049
255 9104-9114 Species denotes SARS-CoV-2 Tax:2697049
256 9176-9184 Species denotes SARS-CoV Tax:694009
257 9283-9292 Species denotes 2019-nCoV Tax:2697049
258 9293-9303 Species denotes SARS-CoV-2 Tax:2697049
259 9308-9316 Species denotes SARS-CoV Tax:694009
287 10307-10313 Gene denotes ORF1ab Gene:43740578
288 10316-10321 Gene denotes spike Gene:43740568
289 10323-10324 Gene denotes S Gene:43740568
290 10337-10338 Gene denotes E Gene:43740570
291 10341-10349 Gene denotes membrane Gene:43740571
292 10351-10352 Gene denotes M Gene:43740571
293 10400-10406 Gene denotes ORF1ab Gene:43740578
294 10595-10599 Gene denotes nsp7 Gene:43740578
295 10604-10608 Gene denotes nsp8 Gene:43740578
296 10758-10762 Gene denotes nsp7 Gene:43740578
297 10767-10771 Gene denotes nsp8 Gene:43740578
298 10810-10815 Gene denotes spike Gene:43740568
299 10983-10988 Gene denotes spike Gene:43740568
300 11059-11063 Gene denotes ACE2 Gene:59272
301 11160-11164 Gene denotes ACE2 Gene:59272
302 11189-11193 Gene denotes ACE2 Gene:59272
303 11381-11386 Gene denotes spike Gene:43740568
304 11393-11397 Gene denotes ACE2 Gene:59272
305 11315-11320 Gene denotes spike Gene:43740568
306 10684-10692 Species denotes SARS-CoV Tax:694009
307 11068-11076 Species denotes SARS-CoV Tax:694009
308 11120-11129 Species denotes 2019-nCoV Tax:2697049
309 11130-11140 Species denotes SARS-CoV-2 Tax:2697049
310 11360-11369 Species denotes 2019-nCoV Tax:2697049
311 11370-11380 Species denotes SARS-CoV-2 Tax:2697049
312 11424-11432 Species denotes SARS-CoV Tax:694009
313 10887-10902 Disease denotes viral infection MESH:D001102
328 12006-12011 Gene denotes spike Gene:43740568
329 12148-12153 Gene denotes spike Gene:43740568
330 11675-11684 Species denotes 2019-nCoV Tax:2697049
331 11685-11695 Species denotes SARS-CoV-2 Tax:2697049
332 11735-11743 Species denotes SARS-CoV Tax:694009
333 11826-11835 Species denotes 2019-nCoV Tax:2697049
334 11836-11846 Species denotes SARS-CoV-2 Tax:2697049
335 11958-11966 Species denotes SARS-CoV Tax:694009
336 12098-12107 Species denotes 2019-nCoV Tax:2697049
337 12108-12118 Species denotes SARS-CoV-2 Tax:2697049
338 12123-12131 Species denotes SARS-CoV Tax:694009
339 12165-12174 Species denotes 2019-nCoV Tax:2697049
340 12175-12185 Species denotes SARS-CoV-2 Tax:2697049
341 12231-12239 Species denotes MERS-CoV Tax:1335626
343 12242-12246 Species denotes HCoV Tax:694448
345 14142-14146 Species denotes HCoV Tax:694448
350 14642-14647 Species denotes human Tax:9606
351 14197-14201 Species denotes HCoV Tax:694448
352 14251-14255 Species denotes HCoV Tax:694448
353 14710-14714 Species denotes HCoV Tax:694448
380 12842-12846 Gene denotes XPO1 Gene:7514
381 12848-12852 Gene denotes NPM1 Gene:4869
382 12858-12865 Gene denotes HNRNPA1 Gene:3178
383 13814-13819 Gene denotes GSK3B Gene:2932
384 13821-13825 Gene denotes DPP4 Gene:1803
385 13827-13832 Gene denotes SMAD3 Gene:4088
386 13834-13839 Gene denotes PARP1 Gene:142
387 13845-13850 Gene denotes IKBKB Gene:3551
388 12334-12337 Species denotes CoV Tax:11118
389 12386-12394 Species denotes SARS-CoV Tax:694009
390 12396-12404 Species denotes MERS-CoV Tax:1335626
391 12406-12415 Species denotes HCoV-229E Tax:11137
392 12421-12430 Species denotes HCoV-NL63 Tax:277944
393 12437-12442 Species denotes mouse Tax:10090
394 12560-12564 Species denotes CoVs Tax:11118
395 13667-13672 Species denotes human Tax:9606
396 14077-14086 Species denotes 2019-nCoV Tax:2697049
397 14087-14097 Species denotes SARS-CoV-2 Tax:2697049
398 12286-12290 Species denotes HCoV Tax:694448
399 12668-12672 Species denotes HCoV Tax:694448
400 12741-12745 Species denotes HCoV Tax:694448
401 13585-13589 Species denotes HCoV Tax:694448
402 13910-13914 Species denotes HCoV Tax:694448
403 12721-12735 Disease denotes HCoV infection MESH:D007239
404 13097-13125 Disease denotes Epstein-Barr virus infection MESH:D020031
405 13237-13252 Disease denotes viral infection MESH:D001102
414 15030-15035 Species denotes human Tax:9606
415 15228-15233 Species denotes human Tax:9606
416 15507-15512 Species denotes human Tax:9606
417 15726-15731 Species denotes human Tax:9606
418 16279-16284 Species denotes human Tax:9606
419 15117-15121 Species denotes HCoV Tax:694448
420 15448-15452 Species denotes HCoV Tax:694448
421 14933-14948 Disease denotes viral infection MESH:D001102
423 17324-17328 Species denotes HCoV Tax:694448
431 17573-17578 Species denotes human Tax:9606
432 17766-17774 Species denotes SARS-CoV Tax:694009
433 17776-17784 Species denotes MERS-CoV Tax:1335626
434 17921-17926 Species denotes human Tax:9606
435 17389-17393 Species denotes HCoV Tax:694448
436 17541-17545 Species denotes HCoV Tax:694448
437 17889-17893 Species denotes HCoV Tax:694448
449 16558-16566 Gene denotes S4 and 5 Gene:6192
450 16627-16631 Species denotes CoVs Tax:11118
451 16705-16709 Species denotes CoVs Tax:11118
452 39076-39084 Species denotes SARS-CoV Tax:694009
453 39086-39094 Species denotes MERS-CoV Tax:1335626
457 16505-16509 Species denotes HCoV Tax:694448
458 39780-39784 Species denotes HCoV Tax:694448
461 19786-19790 Species denotes HCoV Tax:694448
474 20603-20620 Gene denotes estrogen receptor Gene:2099
475 20128-20133 Species denotes human Tax:9606
476 20018-20022 Species denotes HCoV Tax:694448
477 20095-20099 Species denotes HCoV Tax:694448
478 20192-20196 Species denotes HCoV Tax:694448
479 20373-20377 Chemical denotes GSEA
480 20551-20561 Chemical denotes toremifene MESH:D017312
481 20635-20645 Chemical denotes irbesartan MESH:D000077405
482 20683-20697 Chemical denotes mercaptopurine MESH:D015122
483 20780-20789 Chemical denotes melatonin MESH:D008550
484 20802-20807 Chemical denotes amine MESH:D000588
485 20831-20853 Disease denotes rhythm sleep disorders MESH:D012893
504 21292-21304 Gene denotes HSV-1 and -2
505 21002-21023 Species denotes hepatitis delta virus Tax:12475
506 21025-21029 Species denotes EBOV Tax:1570291
507 21030-21035 Species denotes Ebola Tax:1570291
508 21045-21050 Species denotes ZEBOV Tax:186538
509 21054-21071 Species denotes Zaire Ebola virus Tax:186538
510 21124-21142 Species denotes Epstein-Barr virus Tax:10376
511 21149-21170 Species denotes Andes orthohantavirus Tax:1980456
512 21172-21176 Species denotes EMCV Tax:12104
513 21177-21203 Species denotes encephalomyocarditis virus Tax:12104
514 21205-21209 Species denotes FECV Tax:12663
515 21210-21236 Species denotes feline enteric coronavirus Tax:12663
516 21242-21269 Species denotes respiratory syncytial virus Tax:12814
517 21271-21275 Species denotes EV71 Tax:39054
518 21276-21290 Species denotes enterovirus 71 Tax:39054
519 21329-21333 Species denotes CVB4 Tax:12073
520 21334-21351 Species denotes Coxsackievirus B4 Tax:12073
521 21086-21118 Disease denotes HIV human immunodeficiency virus MESH:D015658
538 19094-19111 Gene denotes estrogen receptor Gene:2099
539 18177-18185 Species denotes MERS-CoV Tax:1335626
540 18368-18373 Species denotes human Tax:9606
541 18663-18667 Species denotes HCoV Tax:694448
542 18820-18824 Species denotes HCoV Tax:694448
543 18477-18481 Chemical denotes GSEA
544 18839-18843 Chemical denotes GSEA
545 18944-18954 Chemical denotes Mesalazine MESH:D019804
546 19006-19015 Chemical denotes sirolimus MESH:D020123
547 19058-19065 Chemical denotes equilin MESH:D004857
548 19158-19162 Chemical denotes GSEA
549 19188-19198 Chemical denotes paroxetine MESH:D017374
550 19203-19212 Chemical denotes melatonin MESH:D008550
551 19526-19530 Chemical denotes GSEA
552 18190-18207 Disease denotes SARS-CoV infected MESH:C000657245
553 18977-19003 Disease denotes inflammatory bowel disease MESH:D015212
555 21364-21381 Gene denotes estrogen receptor Gene:2099
588 21414-21431 Gene denotes estrogen receptor Gene:2099
589 21677-21694 Gene denotes estrogen receptor Gene:2099
590 21864-21881 Gene denotes estrogen receptor Gene:2099
591 22141-22145 Gene denotes ESR1 Gene:2099
592 22467-22472 Gene denotes RPL19 Gene:6143
593 22474-22481 Gene denotes HNRNPA1 Gene:3178
594 22483-22487 Gene denotes NPM1 Gene:4869
595 22489-22494 Gene denotes EIF3I Gene:8668
596 22496-22501 Gene denotes EIF3F Gene:8665
597 22507-22512 Gene denotes EIF3E Gene:3646
598 22289-22297 Gene denotes membrane Gene:43740571
599 22232-22240 Gene denotes membrane Gene:43740571
600 22047-22055 Species denotes MERS-CoV Tax:1335626
601 22057-22065 Species denotes SARS-CoV Tax:694009
602 22071-22082 Species denotes Ebola virus Tax:1570291
603 22675-22692 Species denotes Zaire Ebola virus Tax:186538
604 22710-22738 Species denotes human immunodeficiency virus Tax:12721
605 22740-22745 Species denotes ZEBOV Tax:186538
608 22453-22457 Species denotes HCoV Tax:694448
609 21515-21532 Gene denotes estrogen receptor Gene:2099
610 21896-21906 Chemical denotes Toremifene MESH:D017312
611 22173-22183 Chemical denotes toremifene MESH:D017312
612 22380-22390 Chemical denotes toremifene MESH:D017312
613 22542-22546 Chemical denotes GSEA
614 22573-22580 Chemical denotes steroid MESH:D013256
615 22802-22812 Chemical denotes toremifene MESH:D017312
616 22817-22824 Chemical denotes equilin MESH:D004857
617 22019-22035 Disease denotes viral infections MESH:D001102
618 22593-22599 Disease denotes horses MESH:D006734
619 22749-22752 Disease denotes HIV MESH:D015658
647 23344-23351 Gene denotes SLC10A1 Gene:6554
648 23398-23402 Gene denotes NTCP Gene:6554
649 23453-23458 Gene denotes preS1 Gene:944569
650 23569-23573 Gene denotes NTCP Gene:6554
651 23609-23616 Gene denotes SLC10A1 Gene:6554
652 23632-23640 Gene denotes C11orf74 Gene:119710
653 23285-23290 Species denotes human Tax:9606
654 23485-23502 Species denotes hepatitis B virus Tax:10407
655 23517-23538 Species denotes hepatitis delta virus Tax:12475
656 23710-23718 Species denotes SARS-CoV Tax:694009
657 23896-23901 Species denotes human Tax:9606
658 23248-23252 Species denotes HCoV Tax:694448
659 23504-23507 Species denotes HBV Tax:10407
660 23540-23543 Species denotes HDV Tax:12475
661 23859-23863 Species denotes HCoV Tax:694448
662 23031-23041 Chemical denotes Irbesartan MESH:D000077405
663 23223-23233 Chemical denotes irbesartan MESH:D000077405
664 23325-23335 Chemical denotes irbesartan MESH:D000077405
665 23366-23372 Chemical denotes sodium MESH:D012964
666 23373-23382 Chemical denotes bile acid MESH:D001647
667 23546-23556 Chemical denotes Irbesartan MESH:D000077405
668 23760-23770 Chemical denotes eletriptan MESH:C115647
669 23772-23784 Chemical denotes frovatriptan MESH:C108128
670 23790-23802 Chemical denotes zolmitriptan MESH:C089750
671 22992-23007 Disease denotes viral infection MESH:D001102
672 23111-23123 Disease denotes hypertension MESH:D006973
673 23128-23148 Disease denotes diabetic nephropathy MESH:D003928
703 24036-24042 Gene denotes mTORC1 Gene:382056
704 24219-24248 Gene denotes mammalian target of rapamycin Gene:2475
705 24250-24254 Gene denotes mTOR Gene:2475
706 25225-25231 Gene denotes PABPC1 Gene:26986
707 25233-25237 Gene denotes NPM1 Gene:4869
708 25243-25246 Gene denotes NCL Gene:4691
709 24117-24138 Species denotes Andes orthohantavirus Tax:1980456
710 24143-24154 Species denotes coronavirus Tax:11118
711 24500-24508 Species denotes patients Tax:9606
712 24521-24525 Species denotes H1N1 Tax:114727
713 24584-24592 Species denotes patients Tax:9606
714 24984-24992 Species denotes SARS-CoV Tax:694009
715 24997-25005 Species denotes MERS-CoV Tax:1335626
716 24015-24024 Chemical denotes rapamycin MESH:D020123
717 24161-24170 Chemical denotes Sirolimus MESH:D020123
718 24186-24190 Chemical denotes GSEA
719 24410-24419 Chemical denotes sirolimus MESH:D020123
720 24472-24481 Chemical denotes sirolimus MESH:D020123
721 24621-24635 Chemical denotes Mercaptopurine MESH:D015122
722 24651-24655 Chemical denotes GSEA
723 24918-24932 Chemical denotes Mercaptopurine MESH:D015122
724 25146-25160 Chemical denotes mercaptopurine MESH:D015122
725 24428-24446 Disease denotes MERS-CoV infection MESH:D018352
726 24526-24535 Disease denotes pneumonia MESH:D011014
727 24546-24565 Disease denotes respiratory failure MESH:D012131
728 24748-24754 Disease denotes cancer MESH:D009369
729 24843-24863 Disease denotes rheumatoid arthritis MESH:D001172
730 24865-24893 Disease denotes systemic lupus erythematosus MESH:D008180
731 24899-24914 Disease denotes Crohn’s disease MESH:D003424
758 26281-26285 Gene denotes ACE2 Gene:59272
759 26287-26293 Gene denotes BCL2L1 Gene:598
760 26304-26309 Gene denotes IKBKB Gene:3551
761 25859-25867 Species denotes patients Tax:9606
762 26062-26070 Species denotes patients Tax:9606
763 26118-26126 Species denotes patients Tax:9606
764 26545-26549 Species denotes mice Tax:10090
765 26564-26590 Species denotes encephalomyocarditis virus Tax:12104
766 26248-26252 Species denotes HCoV Tax:694448
767 25372-25377 Chemical denotes amine MESH:D000588
768 25379-25388 Chemical denotes melatonin MESH:D008550
769 25390-25418 Chemical denotes N-acetyl-5-methoxytryptamine
770 25435-25439 Chemical denotes GSEA
771 25803-25812 Chemical denotes melatonin MESH:D008550
772 25923-25932 Chemical denotes melatonin MESH:D008550
773 26040-26049 Chemical denotes melatonin MESH:D008550
774 26211-26220 Chemical denotes melatonin MESH:D008550
775 26311-26321 Chemical denotes Eplerenone MESH:D000077545
776 26338-26349 Chemical denotes aldosterone MESH:D000450
777 26429-26438 Chemical denotes melatonin MESH:D008550
778 26510-26520 Chemical denotes eplerenone MESH:D000077545
779 25335-25351 Disease denotes viral infections MESH:D001102
780 25554-25570 Disease denotes viral infections MESH:D001102
781 25577-25593 Disease denotes Viral infections MESH:D001102
782 26500-26508 Disease denotes fibrosis MESH:D005355
783 26550-26558 Disease denotes infected MESH:D007239
786 26761-26770 Species denotes 2019-nCoV Tax:2697049
787 26771-26781 Species denotes SARS-CoV-2 Tax:2697049
789 27015-27024 Species denotes 2019-nCoV Tax:2697049
792 28254-28263 Species denotes 2019-nCoV Tax:2697049
793 28264-28274 Species denotes SARS-CoV-2 Tax:2697049
803 29108-29125 Gene denotes estrogen receptor Gene:2099
804 28662-28675 Gene denotes Drugs A and B
805 28567-28572 Species denotes human Tax:9606
806 28312-28316 Species denotes HCoV Tax:694448
807 28504-28508 Species denotes HCoV Tax:694448
808 28692-28696 Species denotes HCoV Tax:694448
809 29045-29051 Disease denotes tumors MESH:D009369
810 29192-29209 Disease denotes polycystic kidney MESH:D007690
811 29269-29291 Disease denotes rhythm sleep disorders MESH:D012893
820 27885-27894 Species denotes 2019-nCoV Tax:2697049
821 27895-27905 Species denotes SARS-CoV-2 Tax:2697049
822 28094-28103 Species denotes 2019-nCoV Tax:2697049
823 28104-28114 Species denotes SARS-CoV-2 Tax:2697049
824 27107-27115 Disease denotes toxicity MESH:D064420
825 27160-27176 Disease denotes viral infections MESH:D001102
826 27526-27538 Disease denotes hypertension MESH:D006973
827 27543-27549 Disease denotes cancer MESH:D009369
830 29390-29399 Chemical denotes Sirolimus MESH:D020123
831 29405-29417 Chemical denotes Dactinomycin MESH:D003609
852 29445-29449 Gene denotes mTOR Gene:2475
853 29615-29619 Gene denotes mTOR Gene:2475
854 30195-30199 Gene denotes mTOR Gene:2475
855 30247-30272 Gene denotes DNA topoisomerase 2-alpha Gene:7153
856 30274-30279 Gene denotes TOP2A Gene:7153
857 30285-30309 Gene denotes DNA topoisomerase 2-beta Gene:7155
858 30311-30316 Gene denotes TOP2B Gene:7155
859 29542-29550 Species denotes patients Tax:9606
860 29563-29567 Species denotes H1N1 Tax:114727
861 29887-29890 Species denotes CoV Tax:11118
862 29997-30001 Species denotes HCoV Tax:694448
863 30131-30135 Species denotes HCoV Tax:694448
864 29418-29427 Chemical denotes Sirolimus MESH:D020123
865 29680-29692 Chemical denotes Dactinomycin MESH:D003609
866 29705-29718 Chemical denotes actinomycin D MESH:D003609
867 29568-29577 Disease denotes pneumonia MESH:D011014
868 29588-29607 Disease denotes respiratory failure MESH:D012131
869 29663-29676 Disease denotes CoV infection MESH:D018352
870 29784-29790 Disease denotes cancer MESH:D009369
871 30322-30335 Disease denotes HCoV-infected MESH:D007239
874 30354-30364 Chemical denotes Toremifene MESH:D017312
875 30370-30376 Chemical denotes Emodin MESH:D004642
896 31005-31009 Gene denotes ACE2 Gene:59272
897 30987-30992 Gene denotes spike Gene:43740568
898 30600-30611 Species denotes Ebola virus Tax:1570291
899 30698-30706 Species denotes MERS-CoV Tax:1335626
900 30721-30724 Species denotes CoV Tax:11118
901 30802-30818 Species denotes rheum tanguticum Tax:137226
902 30905-30913 Species denotes SARS-CoV Tax:694009
903 30978-30986 Species denotes SARS-CoV Tax:694009
904 31174-31183 Species denotes 2019-nCoV Tax:2697049
905 31184-31194 Species denotes SARS-CoV-2 Tax:2697049
906 30377-30387 Chemical denotes Toremifene MESH:D017312
907 30512-30522 Chemical denotes toremifene MESH:D017312
908 30667-30677 Chemical denotes toremifene MESH:D017312
909 30738-30744 Chemical denotes Emodin MESH:D004642
910 30749-30762 Chemical denotes anthraquinone MESH:D000880
911 30888-30894 Chemical denotes emdoin
912 31107-31117 Chemical denotes toremifene MESH:D017312
913 31122-31128 Chemical denotes emdoin
914 30478-30491 Disease denotes breast cancer MESH:D001943
915 30540-30555 Disease denotes virus infection MESH:D001102
918 31207-31221 Chemical denotes Mercaptopurine MESH:D015122
919 31227-31236 Chemical denotes Melatonin MESH:D008550
956 31704-31708 Gene denotes ACE2 Gene:59272
957 31870-31880 Gene denotes calmodulin Gene:801
958 31885-31895 Gene denotes calmodulin Gene:801
959 31911-31915 Gene denotes ACE2 Gene:59272
960 32020-32025 Gene denotes c-Jun Gene:3725
961 32174-32179 Gene denotes c-Jun Gene:3725
962 32404-32408 Gene denotes ACE2 Gene:59272
963 32410-32415 Gene denotes c-Jun Gene:3725
964 32515-32519 Gene denotes ACE2 Gene:59272
965 31377-31382 Species denotes human Tax:9606
966 31499-31507 Species denotes SARS-CoV Tax:694009
967 31512-31520 Species denotes MERS-CoV Tax:1335626
968 31790-31799 Species denotes 2019-nCoV Tax:2697049
969 31800-31810 Species denotes SARS-CoV-2 Tax:2697049
970 31986-31994 Species denotes SARS-CoV Tax:694009
971 32067-32094 Species denotes infectious bronchitis virus Tax:11120
972 32332-32341 Species denotes 2019-nCoV Tax:2697049
973 32342-32352 Species denotes SARS-CoV-2 Tax:2697049
974 32545-32554 Species denotes 2019-nCoV Tax:2697049
975 32555-32565 Species denotes SARS-CoV-2 Tax:2697049
976 31964-31974 Species denotes infectious Tax:11120
977 31340-31344 Species denotes HCoV Tax:694448
978 32062-32066 Species denotes HCoV Tax:694448
979 31274-31288 Chemical denotes mercaptopurine MESH:D015122
980 31293-31302 Chemical denotes melatonin MESH:D008550
981 31451-31465 Chemical denotes mercaptopurine MESH:D015122
982 31561-31570 Chemical denotes Melatonin MESH:D008550
983 31673-31682 Chemical denotes Melatonin MESH:D008550
984 31836-31845 Chemical denotes melatonin MESH:D008550
985 32119-32133 Chemical denotes mercaptopurine MESH:D015122
986 32138-32147 Chemical denotes melatonin MESH:D008550
987 32257-32271 Chemical denotes mercaptopurine MESH:D015122
988 32276-32285 Chemical denotes melatonin MESH:D008550
989 32532-32541 Chemical denotes melatonin MESH:D008550
990 31607-31616 Disease denotes infection MESH:D007239
991 31754-31769 Disease denotes viral infection MESH:D001102
1003 37718-37727 Species denotes 2019-nCoV Tax:2697049
1004 37728-37738 Species denotes SARS-CoV-2 Tax:2697049
1031 34457-34462 Gene denotes EIF4A Gene:1974
1032 33519-33528 Species denotes 2019-nCoV Tax:2697049
1033 33529-33539 Species denotes SARS-CoV-2 Tax:2697049
1034 33632-33641 Species denotes 2019-nCoV Tax:2697049
1035 33642-33652 Species denotes SARS-CoV-2 Tax:2697049
1036 33700-33709 Species denotes 2019-nCoV Tax:2697049
1037 33710-33720 Species denotes SARS-CoV-2 Tax:2697049
1038 34380-34385 Species denotes Ebola Tax:1570291
1039 34392-34405 Species denotes Coronaviruses Tax:11118
1040 34914-34919 Species denotes human Tax:9606
1041 35002-35011 Species denotes 2019-nCoV Tax:2697049
1042 35012-35022 Species denotes SARS-CoV-2 Tax:2697049
1043 35603-35612 Species denotes 2019-nCoV Tax:2697049
1044 35613-35623 Species denotes SARS-CoV-2 Tax:2697049
1045 34284-34294 Chemical denotes Silvestrol MESH:C489897
1046 34323-34333 Chemical denotes flavagline
1047 34466-34476 Chemical denotes silvestrol MESH:C489897
1060 36375-36384 Species denotes 2019-nCoV Tax:2697049
1061 36385-36395 Species denotes SARS-CoV-2 Tax:2697049
1062 36980-36985 Species denotes human Tax:9606
1063 37089-37093 Species denotes nCoV Tax:2697049
1064 36952-36956 Species denotes HCoV Tax:694448
1065 36053-36063 Chemical denotes Mesalazine MESH:D019804
1066 36302-36312 Chemical denotes mesalazine MESH:D019804
1067 37309-37319 Chemical denotes remdesivir MESH:C000606551
1068 35921-35929 Disease denotes toxicity MESH:D064420
1069 36086-36112 Disease denotes inflammatory bowel disease MESH:D015212
1070 36243-36263 Disease denotes pulmonary toxicities MESH:D008171
1071 36275-36284 Disease denotes pneumonia MESH:D011014
1087 38619-38622 Gene denotes ebi Gene:6907
1088 38370-38379 Species denotes 2019-nCoV Tax:2697049
1089 38380-38390 Species denotes SARS-CoV-2 Tax:2697049
1100 39106-39115 Species denotes HCoV-229E Tax:11137
1101 39121-39130 Species denotes HCoV-NL63 Tax:277944
1102 38927-38931 Species denotes HCoV Tax:694448
1103 39018-39022 Species denotes HCoV Tax:694448
1104 39193-39197 Species denotes HCoV Tax:694448
1105 39248-39262 Disease denotes HCoV infection MESH:D007239
1109 40429-40434 Species denotes human Tax:9606
1111 40628-40633 Species denotes human Tax:9606
1115 40695-40700 Species denotes human Tax:9606
1116 41602-41607 Species denotes human Tax:9606
1117 41855-41860 Species denotes human Tax:9606
1122 41983-41988 Species denotes human Tax:9606
1123 42959-42964 Species denotes human Tax:9606
1124 42189-42193 Species denotes HCoV Tax:694448
1125 44071-44075 Species denotes HCoV Tax:694448
1129 44708-44721 Gene denotes drugs A and B
1130 44507-44511 Species denotes HCoV Tax:694448
1131 44548-44552 Species denotes HCoV Tax:694448
1145 46150-46157 Species denotes patient Tax:9606
1146 46419-46423 Species denotes HCoV Tax:694448
1147 46781-46785 Species denotes HCoV Tax:694448
1148 47554-47558 Species denotes HCoV Tax:694448
1149 48494-48498 Species denotes HCoV Tax:694448
1150 48974-48978 Species denotes HCoV Tax:694448
1151 49163-49167 Species denotes HCoV Tax:694448
1152 49211-49215 Chemical denotes GSEA
1153 46011-46019 Disease denotes infected MESH:D007239
1154 46119-46136 Disease denotes SARS-CoV-infected MESH:C000657245
1155 46270-46282 Disease denotes CoV-infected MESH:D018352
1156 46193-46199 CellLine denotes Calu-3 CVCL:0609
1157 46283-46289 CellLine denotes Calu-3 CVCL:0609
1160 50052-50053 Gene denotes M Gene:43740571
1161 50030-50031 Gene denotes S Gene:43740568
1163 50431-50440 Species denotes 2019-nCoV Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 794-801 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 802-809 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T3 870-877 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T4 930-940 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T5 1026-1034 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T6 1351-1360 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T7 1451-1455 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T8 1514-1518 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 1636-1645 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T10 2097-2114 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T11 2172-2189 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T12 4577-4585 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T13 4718-4726 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T14 4949-4956 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 4957-4964 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 5407-5411 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T17 5464-5468 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T18 6524-6532 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T19 6697-6705 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T20 6986-6990 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T21 7044-7048 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 7447-7455 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T23 7522-7529 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T24 7603-7611 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T25 7696-7703 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 7728-7732 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T27 8144-8152 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T28 8299-8307 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T29 8442-8449 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 8450-8457 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 8817-8823 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T32 8959-8966 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T33 9003-9013 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T34 9134-9144 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T35 9487-9494 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T36 9757-9764 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T37 10084-10090 Body_part denotes Genome http://purl.org/sig/ont/fma/fma84116
T38 10207-10214 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T39 10376-10384 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T40 10407-10411 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T41 10439-10447 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T42 10463-10466 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T43 10540-10543 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T44 10554-10557 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T45 10655-10662 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 10835-10847 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T47 10989-10996 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T48 11519-11525 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T49 11534-11541 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T50 11620-11627 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T51 11814-11822 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T52 12012-12019 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T53 12154-12161 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T54 12354-12362 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T55 12469-12476 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 12535-12543 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T57 12626-12634 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T58 12673-12681 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T59 12818-12826 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T60 12921-12929 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T61 13060-13063 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T62 13152-13156 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T63 13487-13491 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T64 13673-13681 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 13875-13883 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T66 14019-14027 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T67 14272-14280 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T68 14295-14303 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T69 14387-14395 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T70 14439-14446 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T71 14447-14454 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 14542-14549 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T73 14550-14557 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 14664-14668 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T75 14726-14734 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T76 14880-14888 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T77 15134-15142 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T78 15234-15241 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T79 15242-15249 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T80 15732-15739 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T81 15842-15849 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T82 16609-16617 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T83 16743-16751 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T84 16892-16900 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T85 17557-17565 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T86 17905-17913 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T87 18113-18117 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T88 18213-18218 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T89 18272-18276 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T90 18331-18335 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T91 18374-18378 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T92 18407-18410 Body_part denotes Map http://purl.org/sig/ont/fma/fma67847
T93 18444-18448 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T94 18774-18778 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T95 18990-18995 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T96 19094-19102 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T97 19203-19212 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T98 19778-19785 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T99 19869-19873 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T100 20034-20042 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 20111-20119 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T102 20134-20141 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T103 20142-20149 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T104 20208-20215 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T105 20253-20261 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T106 20328-20336 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T107 20603-20611 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T108 20780-20789 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T109 20793-20807 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T110 21072-21084 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T111 21086-21089 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T112 21364-21372 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T113 21414-21422 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T114 21515-21523 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T115 21677-21685 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T116 21864-21872 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T117 22098-22102 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T118 22222-22231 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T119 22298-22310 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T120 22428-22436 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T121 22562-22572 Body_part denotes estrogenic http://purl.org/sig/ont/fma/fma83376
T122 22693-22705 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T123 22749-22752 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T124 23269-23277 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T125 23373-23377 Body_part denotes bile http://purl.org/sig/ont/fma/fma62971
T126 23404-23411 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T127 23880-23888 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T128 24297-24304 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T129 25193-25201 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T130 25363-25377 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T131 25379-25388 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T132 25803-25812 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T133 25923-25932 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T134 26040-26049 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T135 26128-26142 Body_part denotes immune systems http://purl.org/sig/ont/fma/fma9825
T136 26211-26220 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T137 26429-26438 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T138 26454-26463 Body_part denotes mast-cell http://purl.org/sig/ont/fma/fma66784
T139 26459-26463 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T140 28328-28335 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T141 28996-28999 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T142 29108-29116 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T143 29203-29209 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T144 29218-29227 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T145 29231-29245 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161
T146 29735-29738 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T147 30018-30025 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T148 30214-30217 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T149 30247-30250 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T150 30285-30288 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T151 30336-30341 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T152 30478-30484 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T153 30993-31000 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T154 31227-31236 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T155 31293-31302 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T156 31361-31369 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T157 31561-31570 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T158 31673-31682 Body_part denotes Melatonin http://purl.org/sig/ont/fma/fma74644
T159 31836-31845 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T160 31870-31880 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T161 31885-31895 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T162 32041-32048 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T163 32138-32147 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T164 32276-32285 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T165 32532-32541 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T166 32885-32889 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T167 32907-32914 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T168 32915-32922 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 33552-33562 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T170 33688-33696 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T171 34437-34440 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T172 34920-34924 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T173 35246-35253 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 36099-36104 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T175 36340-36344 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T176 36354-36358 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T177 36401-36409 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T178 37099-37107 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T179 37234-37242 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T180 38224-38230 Body_part denotes Genome http://purl.org/sig/ont/fma/fma84116
T181 38292-38295 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T182 38310-38317 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 38391-38398 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T184 38480-38486 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T185 38501-38508 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T186 38798-38805 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T187 38937-38944 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T188 39039-39047 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T189 39150-39158 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T190 39198-39206 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T191 39372-39379 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T192 39433-39436 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T193 39536-39544 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T194 39654-39661 Body_part denotes Genomes http://purl.org/sig/ont/fma/fma84116
T195 39673-39677 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T196 39796-39804 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T197 40634-40641 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T198 40642-40649 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T199 40937-40944 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T200 41355-41359 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T201 41516-41520 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T202 41608-41615 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T203 41616-41623 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T204 41719-41727 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T205 41861-41868 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T206 41869-41876 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T207 42939-42943 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T208 42965-42972 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T209 43853-43857 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T210 44528-44536 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T211 45823-45827 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T212 45869-45873 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T213 45976-45980 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T214 46043-46047 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T215 46497-46501 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T216 46516-46521 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T217 46586-46589 Body_part denotes Map http://purl.org/sig/ont/fma/fma67847
T218 46626-46630 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T219 47946-47950 Body_part denotes le s http://purl.org/sig/ont/fma/fma63048
T220 48348-48352 Body_part denotes le s http://purl.org/sig/ont/fma/fma63048
T221 48565-48569 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T222 48620-48624 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T223 48903-48907 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T224 49658-49663 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T225 49665-49669 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T226 49675-49680 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2097-2114 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T2 2172-2189 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T3 9655-9660 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T4 10732-10741 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T5 23373-23377 Body_part denotes bile http://purl.obolibrary.org/obo/UBERON_0001970
T6 26128-26142 Body_part denotes immune systems http://purl.obolibrary.org/obo/UBERON_0002405
T7 29203-29209 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T8 30478-30484 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T9 34053-34058 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T10 36340-36344 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T11 49658-49663 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T12 49665-49669 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T13 49675-49680 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p14966s22 25722-25730 NegReg denotes negative

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 63-71 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 123-156 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T3 170-178 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 233-241 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 371-379 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 900-908 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 964-972 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 1048-1056 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1176-1184 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 2029-2037 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 2280-2313 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T12 2327-2335 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 2560-2568 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 2907-2915 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 2936-2960 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T16 2977-2985 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 3114-3122 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 3294-3302 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 3435-3443 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 3600-3608 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 5256-5260 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T22 5280-5285 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T23 5299-5303 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661
T24 5586-5591 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T25 6566-6581 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T26 6572-6581 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T27 6814-6823 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T28 8416-8425 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 8553-8561 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 8644-8652 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 8656-8664 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 8906-8914 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 8980-8988 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 9104-9112 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 9176-9184 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 9293-9301 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 9308-9316 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 9580-9588 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 9948-9956 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 10684-10692 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 10887-10902 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T42 10893-10902 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T43 11068-11076 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 11130-11138 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 11370-11378 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 11424-11428 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T47 11685-11693 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 11735-11743 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 11836-11844 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 11958-11966 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 12108-12116 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T52 12123-12131 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T53 12175-12183 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 12386-12394 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 12726-12735 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T56 13051-13058 Disease denotes measles http://purl.obolibrary.org/obo/MONDO_0004619
T57 13097-13125 Disease denotes Epstein-Barr virus infection http://purl.obolibrary.org/obo/MONDO_0005111
T58 13110-13125 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T59 13116-13125 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 13131-13140 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T61 13237-13252 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T62 13243-13252 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T63 14087-14095 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 14933-14948 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T65 14939-14948 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 16763-16771 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 17050-17058 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 17766-17774 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 18190-18198 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T70 18977-19003 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T71 20821-20853 Disease denotes circadian rhythm sleep disorders http://purl.obolibrary.org/obo/MONDO_0024361
T72 20838-20853 Disease denotes sleep disorders http://purl.obolibrary.org/obo/MONDO_0003406
T73 20956-20967 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T74 20956-20965 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T75 20979-20990 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T76 20979-20988 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T77 20998-21001 Disease denotes HDV http://purl.obolibrary.org/obo/MONDO_0005789
T78 21002-21017 Disease denotes hepatitis delta http://purl.obolibrary.org/obo/MONDO_0005789
T79 21002-21011 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T80 21030-21035 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T81 21060-21065 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T82 21096-21112 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T83 21305-21319 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T84 22019-22035 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T85 22057-22065 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 22071-22076 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T87 22681-22686 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T88 22716-22732 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T89 22875-22883 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T90 22992-23007 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T91 22998-23007 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T92 23065-23068 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T93 23111-23123 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T94 23128-23148 Disease denotes diabetic nephropathy http://purl.obolibrary.org/obo/MONDO_0005016
T95 23137-23148 Disease denotes nephropathy http://purl.obolibrary.org/obo/MONDO_0005240
T96 23485-23496 Disease denotes hepatitis B http://purl.obolibrary.org/obo/MONDO_0005344
T97 23485-23494 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T98 23517-23532 Disease denotes hepatitis delta http://purl.obolibrary.org/obo/MONDO_0005789
T99 23517-23526 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T100 23540-23543 Disease denotes HDV http://purl.obolibrary.org/obo/MONDO_0005789
T101 23710-23714 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T102 24437-24446 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 24526-24535 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T104 24540-24565 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T106 24748-24754 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T107 24811-24831 Disease denotes auto-immune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T108 24843-24863 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T109 24854-24863 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T110 24865-24893 Disease denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0007915
T111 24874-24893 Disease denotes lupus erythematosus http://purl.obolibrary.org/obo/MONDO_0004670
T112 24984-24992 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T113 25577-25593 Disease denotes Viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T114 25640-25646 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T115 26771-26779 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T116 27025-27033 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T117 27526-27538 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T118 27543-27549 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T119 27895-27903 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T120 28104-28112 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T121 28264-28272 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T122 29045-29051 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T123 29259-29291 Disease denotes circadian rhythm sleep disorders http://purl.obolibrary.org/obo/MONDO_0024361
T124 29276-29291 Disease denotes sleep disorders http://purl.obolibrary.org/obo/MONDO_0003406
T125 29568-29577 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T126 29784-29790 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T127 30534-30539 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T128 30600-30605 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T129 30905-30913 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T130 30978-30986 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T131 31184-31192 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T132 31499-31507 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 31607-31616 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T134 31754-31769 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T135 31760-31769 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T136 31800-31808 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 31964-31974 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T138 31986-31990 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T139 32067-32077 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T140 32078-32088 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T141 32342-32350 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 32555-32563 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 32776-32784 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 33140-33148 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 33358-33366 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 33529-33537 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T147 33642-33650 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T148 33710-33718 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T149 35012-35020 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T150 35613-35621 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 36086-36112 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T152 36275-36284 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T153 36385-36393 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T154 37728-37736 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 37964-37972 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T156 38141-38157 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T157 38380-38388 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T158 39076-39084 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 39253-39262 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T160 40084-40087 Disease denotes BPS http://purl.obolibrary.org/obo/MONDO_0009901
T161 46119-46127 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 84-89 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T2 648-649 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 788-801 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T4 1269-1274 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T5 1451-1455 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T6 1508-1524 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T7 1826-1831 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T8 2137-2143 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T9 2250-2255 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T10 2412-2418 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T11 2681-2693 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T12 2731-2734 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T13 2739-2740 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 3158-3163 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T15 3167-3172 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T16 3186-3189 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T17 3699-3702 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T18 3846-3849 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T19 3893-3894 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T20 4048-4063 http://purl.obolibrary.org/obo/CHEBI_24431 denotes chemical entity
T21 4286-4288 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T22 4657-4662 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T23 4712-4717 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T24 4733-4736 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T25 4792-4797 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 4808-4815 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Viruses
T27 4938-4943 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T28 5128-5133 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T29 5162-5163 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 5407-5411 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T31 5464-5468 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T32 5634-5637 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T33 5746-5748 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T34 5786-5791 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T35 6030-6031 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 6295-6296 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 6392-6397 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T38 6439-6444 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T39 6670-6675 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T40 6737-6738 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 6887-6892 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T42 6986-6990 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T43 7038-7054 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T44 7104-7105 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 7241-7242 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 7338-7343 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T47 7385-7390 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T48 7404-7405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 7406-7411 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T50 7511-7512 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 7513-7516 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T52 7542-7543 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T53 7690-7703 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T54 7728-7732 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T55 8054-8059 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T56 8263-8268 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T57 8339-8340 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 8489-8494 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T59 8602-8604 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2a
T60 8606-8607 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T61 9085-9087 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T62 9323-9325 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2a
T63 9375-9376 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T64 9731-9732 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T65 9800-9807 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T66 9812-9819 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T67 10174-10176 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T68 10181-10183 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T69 10181-10183 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T70 10227-10232 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T71 10341-10349 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T72 10407-10411 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T73 10532-10533 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 10636-10644 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T75 10712-10713 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 10819-10820 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77 10859-10860 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 11093-11094 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T79 11765-11767 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T80 11765-11767 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T81 11988-11990 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T82 11988-11990 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T83 12191-12194 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T84 12437-12442 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T85 13084-13085 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T86 13086-13095 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T87 13110-13115 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T88 13152-13156 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T89 13341-13346 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T90 13450-13455 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T91 13487-13491 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T92 13667-13681 http://purl.obolibrary.org/obo/PR_000029067 denotes human proteins
T93 13956-13957 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 14165-14168 http://purl.obolibrary.org/obo/CLO_0001627 denotes a A
T95 14632-14633 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T96 14642-14647 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T97 14657-14658 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T98 14664-14668 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T99 15030-15035 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T100 15061-15062 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 15228-15241 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T102 15366-15367 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 15507-15512 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T104 15541-15542 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T105 15726-15739 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T106 15998-16007 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T107 16153-16154 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 16191-16195 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T109 16279-16284 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T110 16490-16494 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T111 16715-16716 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T112 17306-17307 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T113 17338-17341 http://purl.obolibrary.org/obo/CLO_0001627 denotes a A
T114 17573-17578 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T115 17712-17713 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T116 17714-17715 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T117 17921-17926 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T118 17984-17988 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T119 18113-18117 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T120 18213-18218 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T121 18272-18276 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T122 18331-18335 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T123 18368-18384 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T124 18444-18448 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T125 18475-18476 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T126 18635-18637 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T127 18682-18684 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T128 18715-18719 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T129 18745-18746 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 18774-18778 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T131 18798-18799 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 18809-18810 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T133 18927-18928 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 19094-19111 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T135 19367-19368 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 19445-19446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 19760-19761 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T138 19836-19837 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 19869-19873 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T140 20128-20141 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T141 20482-20483 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T142 20549-20550 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T143 20603-20620 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T144 20791-20792 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T145 20966-20967 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T146 20968-20973 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T147 20991-20996 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T148 21018-21023 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T149 21036-21043 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T150 21066-21071 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T151 21090-21095 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T152 21113-21118 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T153 21137-21142 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 21198-21203 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T155 21264-21269 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T156 21288-21290 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T157 21320-21327 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T158 21364-21381 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T159 21414-21431 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T160 21432-21435 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T161 21455-21456 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 21515-21532 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T163 21579-21580 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 21804-21812 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T165 21864-21881 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T166 22077-22082 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T167 22098-22102 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T168 22232-22240 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T169 22283-22288 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T170 22289-22297 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T171 22593-22599 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes horses
T172 22606-22609 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T173 22639-22647 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T174 22687-22692 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T175 22710-22715 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T176 22733-22738 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T177 22753-22755 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T178 23055-23056 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T179 23189-23190 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T180 23285-23290 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T181 23417-23420 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T182 23440-23441 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 23495-23496 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T184 23497-23502 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T185 23533-23538 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T186 23642-23643 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 23896-23901 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T188 24084-24091 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T189 24725-24728 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T190 24933-24936 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T191 24954-24955 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 25361-25362 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 25457-25458 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 25512-25513 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 25822-25823 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T196 26105-26106 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 26128-26142 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune systems
T198 26183-26188 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 26391-26392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 26459-26463 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T201 27263-27264 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 27394-27395 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T203 27565-27566 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T204 27840-27841 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 28276-28277 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T206 28567-28572 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T207 28668-28669 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T208 28674-28675 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T209 28681-28682 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 28779-28780 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T211 28790-28794 http://purl.obolibrary.org/obo/CLO_0001869 denotes B. b
T212 28882-28883 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T213 28895-28896 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T214 29108-29125 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T215 29203-29209 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T216 29203-29209 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T217 29203-29209 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T218 29229-29230 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 29502-29505 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T220 29620-29629 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T221 30200-30209 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T222 30336-30341 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T223 30478-30484 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T224 30540-30545 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T225 30606-30611 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T226 30820-30823 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T227 30859-30864 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T228 31016-31018 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T229 31137-31138 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 31377-31382 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T231 31469-31470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T232 31721-31722 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 31958-31959 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 32030-32031 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 32180-32189 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T236 32296-32297 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 32416-32425 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T238 32628-32629 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 32879-32895 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T240 32901-32914 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T241 33730-33731 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 33771-33772 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 33793-33794 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T244 33838-33839 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 33896-33897 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 33965-33966 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 34296-34297 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 34363-34371 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T249 34765-34770 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T250 34914-34929 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell line
T251 34969-34970 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T252 34975-34980 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T253 35237-35245 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T254 35515-35520 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T255 35576-35581 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T256 35799-35800 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 36117-36118 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 36340-36344 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T259 36340-36344 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T260 36354-36358 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T261 36806-36807 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T262 36980-36985 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T263 37204-37209 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T264 37228-37233 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T265 37288-37293 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T266 37547-37548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T267 37808-37815 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T268 37856-37857 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T269 37990-37991 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 38168-38173 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T271 38469-38471 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T272 38891-38896 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T273 39474-39479 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T274 39644-39649 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Genes
T275 39673-39677 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T276 40429-40434 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T277 40461-40462 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 40628-40641 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T279 40671-40672 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 40695-40700 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T281 40730-40731 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 40741-40743 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T283 40847-40853 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T284 41070-41079 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T285 41237-41239 http://purl.obolibrary.org/obo/CLO_0001547 denotes AP
T286 41240-41242 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T287 41355-41359 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T288 41424-41429 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T289 41516-41520 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T290 41602-41615 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T291 41750-41751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T292 41855-41868 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T293 41983-41988 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T294 42156-42161 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T295 42178-42179 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T296 42875-42879 http://purl.obolibrary.org/obo/CLO_0009421 denotes t+∑t
T297 42875-42879 http://purl.obolibrary.org/obo/CLO_0009935 denotes t+∑t
T298 42875-42879 http://purl.obolibrary.org/obo/CLO_0052184 denotes t+∑t
T299 42875-42879 http://purl.obolibrary.org/obo/CLO_0052185 denotes t+∑t
T300 42886-42889 http://purl.obolibrary.org/obo/CL_0000990 denotes Cdc
T301 42939-42943 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T302 42959-42972 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T303 43054-43059 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T304 43790-43794 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T305 43853-43857 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T306 43985-43989 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T307 44714-44715 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T308 44720-44721 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T309 45088-45090 http://purl.obolibrary.org/obo/CLO_0001627 denotes AA
T310 45126-45128 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T311 45587-45588 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T312 45654-45655 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T313 45823-45827 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T314 45869-45873 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T315 45976-45980 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T316 46043-46047 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T317 46193-46199 http://purl.obolibrary.org/obo/CLO_0002192 denotes Calu-3
T318 46283-46289 http://purl.obolibrary.org/obo/CLO_0002192 denotes Calu-3
T319 46383-46388 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T320 46497-46501 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T321 46516-46521 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T322 46626-46630 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T323 46768-46770 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T324 47134-47136 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T325 47184-47186 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T326 47215-47217 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T327 47269-47271 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T328 47300-47302 http://purl.obolibrary.org/obo/CLO_0008149 denotes ne
T329 47338-47340 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T330 47427-47429 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T331 47539-47544 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T332 47911-47912 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T333 48028-48029 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T334 48313-48314 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T335 48400-48405 http://purl.obolibrary.org/obo/CLO_0006985 denotes j - 1
T336 48400-48405 http://purl.obolibrary.org/obo/CLO_0006987 denotes j - 1
T337 48436-48437 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T338 48461-48466 http://purl.obolibrary.org/obo/CLO_0006985 denotes j = 1
T339 48461-48466 http://purl.obolibrary.org/obo/CLO_0006987 denotes j = 1
T340 48485-48490 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T341 48565-48569 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T342 48620-48624 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T343 48694-48699 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T344 48853-48858 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T345 48903-48907 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T346 48961-48966 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T347 49048-49050 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T348 49119-49121 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T349 49295-49297 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T350 49658-49663 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T351 49658-49663 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T352 49658-49663 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T353 49658-49663 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T354 49665-49669 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T355 49665-49669 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T356 49675-49680 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T357 49675-49680 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 14-18 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T2 345-350 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T3 430-434 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T4 468-473 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T5 538-542 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T6 596-610 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T7 596-605 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T8 606-610 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T9 685-693 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T10 768-772 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T11 794-801 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 802-809 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13 930-940 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T14 1026-1034 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T15 1222-1226 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T16 1338-1343 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T17 1351-1360 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T18 1362-1376 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T19 1382-1391 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T20 1446-1450 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T21 1562-1566 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T22 1587-1596 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T23 1616-1630 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T24 1636-1645 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T25 1651-1661 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T26 1667-1673 Chemical denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659
T28 1744-1749 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T29 1971-1976 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T30 1991-1995 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T31 3659-3673 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T32 3923-3937 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T33 4048-4063 Chemical denotes chemical entity http://purl.obolibrary.org/obo/CHEBI_24431
T34 4117-4121 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T35 4155-4160 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T36 4239-4243 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T37 4327-4331 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T38 4448-4452 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T39 4577-4585 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T40 4718-4726 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T41 4750-4754 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T42 4949-4956 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 4957-4964 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T44 5101-5110 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T45 5355-5369 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T46 5355-5364 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T47 5365-5369 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T48 5459-5463 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T49 5576-5581 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T50 5753-5757 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51 5829-5833 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T52 5892-5897 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T53 5905-5909 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T54 6112-6117 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T55 6130-6134 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T56 6240-6254 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T57 6240-6249 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T58 6250-6254 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T59 6332-6340 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T60 6419-6423 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T61 6445-6448 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T63 6524-6532 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T64 6676-6679 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T66 6697-6705 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T67 6720-6724 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T68 6777-6781 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T69 6804-6813 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T70 6973-6977 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T71 7278-7286 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T72 7365-7369 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T73 7391-7394 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T75 7447-7455 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T76 7522-7529 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 7570-7574 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T78 7603-7611 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T79 7664-7669 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T80 7696-7703 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 7858-7862 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T82 7972-7977 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T83 8144-8152 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T84 8299-8307 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T85 8322-8326 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T86 8379-8383 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T87 8406-8415 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T88 8442-8449 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 8450-8457 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T90 9003-9013 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T91 9134-9144 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T92 9968-9970 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T93 9994-9996 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T94 10031-10033 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T95 10181-10183 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T96 10207-10214 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T97 10376-10384 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T98 10439-10447 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T99 10655-10662 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T100 10835-10847 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T101 10989-10996 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T102 11026-11037 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T103 11082-11084 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T104 11235-11239 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T105 11295-11297 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T106 11534-11541 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T107 11620-11627 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T108 11765-11767 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T109 11814-11822 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T110 11988-11990 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T111 12012-12019 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T112 12154-12161 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T113 12354-12362 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T114 12469-12476 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 12499-12501 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T116 12535-12543 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T117 12626-12634 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T118 12673-12681 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T119 12818-12826 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T120 12921-12929 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T121 13075-13077 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T124 13528-13532 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T125 13673-13681 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T126 13752-13756 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T127 13773-13777 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T128 13875-13883 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T129 13958-13962 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T130 14019-14027 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T131 14272-14280 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T132 14295-14303 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T133 14332-14337 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T134 14341-14346 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T135 14387-14395 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T136 14418-14425 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T137 14439-14446 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 14447-14454 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T139 14542-14549 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T140 14550-14557 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T141 14726-14734 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T142 14751-14755 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T143 14819-14823 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T144 14880-14888 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T145 15063-15067 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T146 15134-15142 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T147 15234-15241 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T148 15242-15249 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 15487-15491 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T150 15543-15547 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T151 15644-15649 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T152 15732-15739 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T153 15842-15849 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T154 16327-16330 Chemical denotes PPI http://purl.obolibrary.org/obo/CHEBI_53266|http://purl.obolibrary.org/obo/CHEBI_60614
T156 16427-16432 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T157 16558-16560 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T158 16609-16617 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T159 16690-16695 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T160 16743-16751 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T161 16892-16900 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T162 17010-17015 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T163 17319-17323 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T164 17384-17388 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T165 17422-17427 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T166 17453-17458 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T167 17520-17524 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T168 17557-17565 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T169 17868-17872 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T170 17905-17913 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T171 18017-18022 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T172 18073-18078 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T173 18355-18359 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T174 18439-18443 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T175 18511-18515 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T176 18593-18598 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T177 18635-18637 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T178 18682-18684 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T179 18800-18804 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T180 18938-18942 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T181 18944-18954 Chemical denotes Mesalazine http://purl.obolibrary.org/obo/CHEBI_6775
T182 18968-18972 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T183 19006-19015 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T184 19047-19051 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T185 19058-19065 Chemical denotes equilin http://purl.obolibrary.org/obo/CHEBI_42309
T186 19079-19086 Chemical denotes agonist http://purl.obolibrary.org/obo/CHEBI_48705
T187 19094-19102 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T188 19188-19198 Chemical denotes paroxetine http://purl.obolibrary.org/obo/CHEBI_7936
T189 19203-19212 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T190 19285-19290 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T191 19502-19504 Chemical denotes S4 http://purl.obolibrary.org/obo/CHEBI_29401
T192 19567-19576 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T193 19693-19698 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T194 19724-19733 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T195 19773-19777 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T196 19778-19785 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 19829-19834 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T198 19942-19947 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T199 19995-19999 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T200 20034-20042 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T201 20071-20076 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T202 20111-20119 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T203 20134-20141 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T204 20142-20149 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T205 20180-20184 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T206 20208-20215 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T207 20253-20261 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T208 20328-20336 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T209 20395-20400 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T210 20421-20423 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T211 20475-20480 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T212 20542-20547 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T213 20551-20561 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T214 20603-20630 Chemical denotes estrogen receptor modulator http://purl.obolibrary.org/obo/CHEBI_50739
T215 20603-20611 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T216 20612-20630 Chemical denotes receptor modulator http://purl.obolibrary.org/obo/CHEBI_90710
T217 20635-20645 Chemical denotes irbesartan http://purl.obolibrary.org/obo/CHEBI_5959
T218 20650-20661 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T219 20683-20697 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T220 20702-20716 Chemical denotes antimetabolite http://purl.obolibrary.org/obo/CHEBI_35221
T221 20717-20737 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T222 20743-20760 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T223 20780-20789 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T224 20802-20807 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T225 20902-20907 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T226 20932-20941 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T227 20998-21001 Chemical denotes HDV http://purl.obolibrary.org/obo/CHEBI_59113
T228 21051-21053 Chemical denotes GP http://purl.obolibrary.org/obo/CHEBI_70744
T229 21072-21084 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T230 21364-21372 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T231 21373-21392 Chemical denotes receptor modulators http://purl.obolibrary.org/obo/CHEBI_90710
T232 21414-21422 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T233 21515-21523 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T234 21524-21543 Chemical denotes receptor modulators http://purl.obolibrary.org/obo/CHEBI_90710
T235 21677-21685 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T236 21794-21803 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T237 21864-21872 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T238 22154-22163 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T239 22173-22183 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T240 22298-22310 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T241 22380-22390 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T242 22428-22436 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T243 22519-22526 Chemical denotes Equilin http://purl.obolibrary.org/obo/CHEBI_42309
T244 22573-22580 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T245 22693-22705 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T246 22746-22748 Chemical denotes GP http://purl.obolibrary.org/obo/CHEBI_70744
T247 22802-22812 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T248 22817-22824 Chemical denotes equilin http://purl.obolibrary.org/obo/CHEBI_42309
T249 22855-22860 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T250 22888-22899 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T251 22918-22929 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T252 23031-23041 Chemical denotes Irbesartan http://purl.obolibrary.org/obo/CHEBI_5959
T253 23269-23277 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T254 23325-23335 Chemical denotes irbesartan http://purl.obolibrary.org/obo/CHEBI_5959
T255 23366-23372 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T256 23373-23382 Chemical denotes bile acid http://purl.obolibrary.org/obo/CHEBI_3098
T257 23378-23382 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T258 23404-23411 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T259 23540-23543 Chemical denotes HDV http://purl.obolibrary.org/obo/CHEBI_59113
T260 23546-23556 Chemical denotes Irbesartan http://purl.obolibrary.org/obo/CHEBI_5959
T261 23760-23770 Chemical denotes eletriptan http://purl.obolibrary.org/obo/CHEBI_50922
T262 23772-23784 Chemical denotes frovatriptan http://purl.obolibrary.org/obo/CHEBI_134991
T263 23790-23802 Chemical denotes zolmitriptan http://purl.obolibrary.org/obo/CHEBI_10124
T264 23880-23888 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T265 23937-23958 Chemical denotes antineoplastic agents http://purl.obolibrary.org/obo/CHEBI_35610
T266 24015-24024 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T267 24161-24170 Chemical denotes Sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T268 24206-24215 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T269 24239-24248 Chemical denotes rapamycin http://purl.obolibrary.org/obo/CHEBI_9168
T270 24297-24304 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T271 24397-24408 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T272 24410-24419 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T273 24472-24481 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T274 24621-24635 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T275 24671-24691 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T276 24697-24714 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T277 24788-24799 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T278 24918-24932 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T279 24966-24975 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T280 25100-25110 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T281 25146-25160 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T282 25193-25201 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T283 25264-25288 Chemical denotes Anti-inflammatory agents http://purl.obolibrary.org/obo/CHEBI_67079
T284 25372-25377 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T285 25379-25388 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T286 25390-25418 Chemical denotes N-acetyl-5-methoxytryptamine http://purl.obolibrary.org/obo/CHEBI_16796
T287 25392-25398 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T289 25781-25792 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T290 25803-25812 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T291 25843-25847 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T292 25890-25899 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T293 25923-25932 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T294 26025-26036 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T295 26040-26049 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T296 26211-26220 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T297 26311-26321 Chemical denotes Eplerenone http://purl.obolibrary.org/obo/CHEBI_31547
T298 26338-26349 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T300 26359-26369 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T301 26429-26438 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T302 26510-26520 Chemical denotes eplerenone http://purl.obolibrary.org/obo/CHEBI_31547
T303 26675-26680 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T304 26993-26997 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T305 27325-27329 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T306 27463-27467 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T307 27504-27508 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T308 27567-27571 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T309 27698-27703 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T310 27805-27809 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T311 27999-28004 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T312 28072-28076 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T313 28232-28236 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T314 28328-28335 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T315 28359-28363 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T316 28391-28395 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T317 28485-28490 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T318 28863-28867 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T319 28884-28893 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T320 28904-28921 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T321 28932-28942 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T322 28947-28961 Chemical denotes antineoplastic http://purl.obolibrary.org/obo/CHEBI_35610
T323 29010-29019 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T324 29056-29066 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T325 29108-29135 Chemical denotes estrogen receptor modulator http://purl.obolibrary.org/obo/CHEBI_50739
T326 29108-29116 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T327 29117-29135 Chemical denotes receptor modulator http://purl.obolibrary.org/obo/CHEBI_90710
T328 29142-29148 Chemical denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659
T330 29166-29170 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T331 29218-29227 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T332 29240-29245 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T333 29298-29312 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T334 29317-29331 Chemical denotes antimetabolite http://purl.obolibrary.org/obo/CHEBI_35221
T335 29332-29352 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T336 29358-29375 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T337 29390-29399 Chemical denotes Sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T338 29405-29417 Chemical denotes Dactinomycin http://purl.obolibrary.org/obo/CHEBI_27666
T339 29418-29427 Chemical denotes Sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T340 29432-29441 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T341 29460-29470 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T342 29475-29489 Chemical denotes antineoplastic http://purl.obolibrary.org/obo/CHEBI_35610
T343 29680-29692 Chemical denotes Dactinomycin http://purl.obolibrary.org/obo/CHEBI_27666
T344 29705-29718 Chemical denotes actinomycin D http://purl.obolibrary.org/obo/CHEBI_27666
T345 29705-29716 Chemical denotes actinomycin http://purl.obolibrary.org/obo/CHEBI_15369
T346 29749-29758 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T347 29947-29956 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T348 30018-30025 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T349 30151-30160 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T350 30247-30250 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T351 30267-30272 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T352 30285-30288 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T353 30305-30309 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T354 30370-30376 Chemical denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T355 30512-30522 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T356 30667-30677 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T357 30738-30744 Chemical denotes Emodin http://purl.obolibrary.org/obo/CHEBI_42223
T358 30749-30762 Chemical denotes anthraquinone http://purl.obolibrary.org/obo/CHEBI_22580|http://purl.obolibrary.org/obo/CHEBI_40448
T360 30993-31000 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T361 31107-31117 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T362 31207-31221 Chemical denotes Mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T363 31227-31236 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T364 31274-31288 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T365 31293-31302 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T366 31361-31369 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T367 31451-31465 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T368 31481-31490 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T369 31561-31570 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T370 31597-31606 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T371 31647-31658 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T372 31673-31682 Chemical denotes Melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T373 31836-31845 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T374 32041-32048 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T375 32119-32133 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T376 32138-32147 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T377 32257-32271 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T378 32276-32285 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T379 32532-32541 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T380 32711-32716 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T381 32721-32725 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T382 32803-32807 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T383 32907-32914 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T384 32915-32922 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T385 33058-33063 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T386 33089-33093 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T387 33291-33296 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T388 33301-33305 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T389 33552-33562 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T390 33688-33696 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T391 33804-33808 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T392 33923-33927 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T393 33975-33979 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T394 34084-34088 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T395 34184-34188 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T396 34323-34333 Chemical denotes flavagline http://purl.obolibrary.org/obo/CHEBI_71504
T397 34353-34362 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T398 34466-34476 Chemical denotes silvestrol http://purl.obolibrary.org/obo/CHEBI_66484
T399 34611-34615 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T400 34699-34703 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T401 35216-35221 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T402 35246-35253 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T403 35275-35286 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T404 35291-35299 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705
T405 35370-35379 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T406 35463-35467 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T407 35822-35826 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T408 35886-35891 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T409 35960-35965 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T410 35970-35974 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T411 36053-36063 Chemical denotes Mesalazine http://purl.obolibrary.org/obo/CHEBI_6775
T412 36077-36081 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T413 36154-36158 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T414 36302-36312 Chemical denotes mesalazine http://purl.obolibrary.org/obo/CHEBI_6775
T415 36401-36409 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T416 36503-36508 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T417 36512-36516 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T418 36686-36690 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T419 36871-36876 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T420 36928-36933 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T421 37057-37062 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T422 37099-37107 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T423 37175-37180 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T424 37210-37215 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T425 37234-37242 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T426 37294-37299 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T427 37363-37368 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T428 37381-37385 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T429 37659-37664 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T430 37669-37673 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T431 38292-38295 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T432 38310-38317 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T433 38501-38508 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T434 38753-38757 Chemical denotes MEGA http://purl.obolibrary.org/obo/CHEBI_6617
T435 38798-38805 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T436 38867-38871 Chemical denotes MEGA http://purl.obolibrary.org/obo/CHEBI_6617
T437 38937-38944 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T438 39039-39047 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T439 39150-39158 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T440 39198-39206 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T441 39372-39379 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T442 39536-39544 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T443 39566-39568 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T444 39796-39804 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T445 39876-39880 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T446 39915-39919 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T447 40017-40020 Chemical denotes TTD http://purl.obolibrary.org/obo/CHEBI_73659
T448 40144-40148 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T449 40205-40209 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T450 40550-40554 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T451 40634-40641 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T452 40642-40649 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T453 40937-40944 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T454 41237-41239 Chemical denotes AP http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686
T457 41240-41242 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T458 41458-41460 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T459 41608-41615 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T460 41616-41623 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T461 41719-41727 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T462 41861-41868 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T463 41869-41876 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T464 42048-42053 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T465 42213-42217 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T466 42296-42300 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T467 42965-42972 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T468 44066-44070 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T469 44197-44201 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T470 44251-44255 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T471 44351-44355 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T472 44490-44494 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T473 44528-44536 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T474 44538-44542 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T475 44543-44547 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T476 44590-44594 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T477 44638-44643 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T478 44708-44713 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T479 45088-45090 Chemical denotes AA http://purl.obolibrary.org/obo/CHEBI_15843|http://purl.obolibrary.org/obo/CHEBI_72816
T481 45126-45128 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109
T482 45589-45593 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T483 45776-45781 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T484 46477-46482 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T485 46543-46548 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T486 46648-46653 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T487 46664-46668 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T488 46712-46716 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T489 46768-46770 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T490 47134-47136 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T491 47184-47186 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T492 47215-47217 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T493 47269-47271 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T494 47338-47340 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T495 47427-47429 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T496 48586-48590 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T497 48718-48722 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T498 49048-49050 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T499 49119-49121 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509
T20761 50233-50238 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T27287 50261-50265 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 4750-4765 http://purl.obolibrary.org/obo/GO_0042493 denotes drug resistance
T2 6566-6581 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T3 10463-10476 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T4 10467-10476 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T5 10887-10902 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T6 13060-13073 http://purl.obolibrary.org/obo/GO_0050658 denotes RNA transport
T7 13064-13073 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T8 13086-13095 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9 13237-13252 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T10 13309-13325 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T11 13381-13394 http://purl.obolibrary.org/obo/GO_0016032 denotes viral process
T12 13396-13435 http://purl.obolibrary.org/obo/GO_1903902 denotes positive regulation of viral life cycle
T13 13396-13435 http://purl.obolibrary.org/obo/GO_0048524 denotes positive regulation of viral life cycle
T14 13405-13435 http://purl.obolibrary.org/obo/GO_1903900 denotes regulation of viral life cycle
T15 13405-13415 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T16 13419-13435 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T17 13437-13455 http://purl.obolibrary.org/obo/GO_0046794 denotes transport of virus
T18 13437-13446 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T19 13461-13491 http://purl.obolibrary.org/obo/GO_0019062 denotes virion attachment to host cell
T20 13845-13850 http://purl.obolibrary.org/obo/GO_0008384 denotes IKBKB
T21 14933-14948 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T22 15998-16007 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T23 18331-18346 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T24 20821-20837 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T25 20831-20837 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T26 20838-20843 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T27 21597-21625 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibiting viral replication
T28 21608-21625 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T29 21608-21625 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T30 22019-22035 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T31 22992-23007 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T32 23654-23669 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T33 25065-25081 http://purl.obolibrary.org/obo/GO_0019075 denotes viral maturation
T34 25577-25593 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infections
T35 25967-25984 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T36 25967-25984 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T37 26304-26309 http://purl.obolibrary.org/obo/GO_0008384 denotes IKBKB
T38 26472-26483 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T39 28996-29009 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T40 29000-29009 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T41 29259-29275 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T42 29269-29275 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T43 29276-29281 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep
T44 29620-29629 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T45 29735-29748 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T46 29739-29748 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T47 29862-29868 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T48 30200-30209 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T49 30214-30227 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T50 30218-30227 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T51 30688-30694 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T52 31754-31769 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T53 32180-32189 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T54 32416-32425 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T55 34765-34788 http://purl.obolibrary.org/obo/GO_0019048 denotes virus–host interactions
T56 35515-35538 http://purl.obolibrary.org/obo/GO_0019048 denotes virus–host interactions
T57 37770-37783 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T58 37992-38005 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T59 38141-38157 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T60 39474-39496 http://purl.obolibrary.org/obo/GO_0019048 denotes virus–host interaction
T61 41070-41079 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T62 41355-41370 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T63 45976-45991 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T64 46043-46058 http://purl.obolibrary.org/obo/GO_0010467 denotes Gene Expression
T65 46497-46512 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 4750-4765 Phenotype denotes drug resistance http://purl.obolibrary.org/obo/HP_0020174
T2 18977-19003 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T3 20956-20965 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T4 20979-20988 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T5 21002-21011 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T6 21096-21112 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T7 22716-22732 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T8 23111-23123 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T9 23137-23148 Phenotype denotes nephropathy http://purl.obolibrary.org/obo/HP_0000112
T10 23485-23494 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T11 23517-23526 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T12 24526-24535 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T13 24546-24565 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T14 24748-24754 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T15 24811-24831 Phenotype denotes auto-immune diseases http://purl.obolibrary.org/obo/HP_0002960
T16 24843-24863 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T17 24865-24893 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T18 25670-25686 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T19 27526-27538 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T20 27543-27549 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T21 29192-29209 Phenotype denotes polycystic kidney http://purl.obolibrary.org/obo/HP_0000113
T22 29568-29577 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T23 29784-29790 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T24 32078-32088 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T25 36086-36112 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T26 36275-36284 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
T2 75-83 Sentence denotes Abstract
T3 84-302 Sentence denotes Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality.
T4 303-382 Sentence denotes However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2.
T5 383-553 Sentence denotes Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery.
T6 554-830 Sentence denotes In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network.
T7 831-981 Sentence denotes Phylogenetic analyses of 15 HCoV whole genomes reveal that 2019-nCoV/SARS-CoV-2 shares the highest nucleotide sequence identity with SARS-CoV (79.7%).
T8 982-1185 Sentence denotes Specifically, the envelope and nucleocapsid proteins of 2019-nCoV/SARS-CoV-2 are two evolutionarily conserved regions, having the sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV.
T9 1186-1525 Sentence denotes Using network proximity analyses of drug targets and HCoV–host interactions in the human interactome, we prioritize 16 potential anti-HCoV repurposable drugs (e.g., melatonin, mercaptopurine, and sirolimus) that are further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines.
T10 1526-1852 Sentence denotes We further identify three potential drug combinations (e.g., sirolimus plus dactinomycin, mercaptopurine plus melatonin, and toremifene plus emodin) captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network.
T11 1853-2040 Sentence denotes In summary, this study offers powerful network-based methodologies for rapid identification of candidate repurposable drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.
T12 2042-2054 Sentence denotes Introduction
T13 2055-2202 Sentence denotes Coronaviruses (CoVs) typically affect the respiratory tract of mammals, including humans, and lead to mild to severe respiratory tract infections1.
T14 2203-2495 Sentence denotes In the past two decades, two highly pathogenic human CoVs (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), emerging from animal reservoirs, have led to global epidemics with high morbidity and mortality2.
T15 2496-2650 Sentence denotes For example, 8098 individuals were infected and 774 died in the SARS-CoV pandemic, which cost the global economy with an estimated $30 to $100 billion3,4.
T16 2651-2821 Sentence denotes According to the World Health Organization (WHO), as of November 2019, MERS-CoV has had a total of 2494 diagnosed cases causing 858 deaths, the majority in Saudi Arabia2.
T17 2822-3015 Sentence denotes In December 2019, the third pathogenic HCoV, named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2), as the cause of coronavirus disease 2019 (abbreviated as COVID-19)5, was found in Wuhan, China.
T18 3016-3221 Sentence denotes As of 24 February 2020, there have been over 79,000 cases with over 2600 deaths for the 2019-nCoV/SARS-CoV-2 outbreak worldwide; furthermore, human-to-human transmission has occurred among close contacts6.
T19 3222-3305 Sentence denotes However, there are currently no effective medications against 2019-nCoV/SARS-CoV-2.
T20 3306-3492 Sentence denotes Several national and international research groups are working on the development of vaccines to prevent and treat the 2019-nCoV/SARS-CoV-2, but effective vaccines are not available yet.
T21 3493-3620 Sentence denotes There is an urgent need for the development of effective prevention and treatment strategies for 2019-nCoV/SARS-CoV-2 outbreak.
T22 3621-3810 Sentence denotes Although investment in biomedical and pharmaceutical research and development has increased significantly over the past two decades, the annual number of new treatments approved by the U.S.
T23 3811-3892 Sentence denotes Food and Drug Administration (FDA) has remained relatively constant and limited7.
T24 3893-4070 Sentence denotes A recent study estimated that pharmaceutical companies spent $2.6 billion in 2015, up from $802 million in 2003, in the development of an FDA-approved new chemical entity drug8.
T25 4071-4289 Sentence denotes Drug repurposing, represented as an effective drug discovery strategy from existing drugs, could significantly shorten the time and reduce the cost compared to de novo drug discovery and randomized clinical trials9–11.
T26 4290-4375 Sentence denotes However, experimental approaches for drug repurposing is costly and time-consuming12.
T27 4376-4477 Sentence denotes Computational approaches offer novel testable hypotheses for systematic drug repositioning9–11,13,14.
T28 4478-4681 Sentence denotes However, traditional structure-based methods are limited when three-dimensional (3D) structures of proteins are unavailable, which, unfortunately, is the case for the majority of human and viral targets.
T29 4682-4807 Sentence denotes In addition, targeting single virus proteins often has high risk of drug resistance by the rapid evolution of virus genomes1.
T30 4808-4908 Sentence denotes Viruses (including HCoV) require host cellular factors for successful replication during infection1.
T31 4909-5067 Sentence denotes Systematic identification of virus–host protein–protein interactions (PPIs) offers an effective way toward elucidating the mechanisms of viral infection15,16.
T32 5068-5318 Sentence denotes Subsequently, targeting cellular antiviral targets, such as virus–host interactome, may offer a novel strategy for the development of effective treatments for viral infections1, including SARS-CoV17, MERS-CoV17, Ebola virus18, and Zika virus14,19–21.
T33 5319-5508 Sentence denotes We recently presented an integrated antiviral drug discovery pipeline that incorporated gene-trap insertional mutagenesis, known functional drug–gene network, and bioinformatics analyses14.
T34 5509-5603 Sentence denotes This methodology allows to identify several candidate repurposable drugs for Ebola virus11,14.
T35 5604-5801 Sentence denotes Our work over the last decade has demonstrated how network strategies can, for example, be used to identify effective repurposable drugs13,22–27 and drug combinations28 for multiple human diseases.
T36 5802-6198 Sentence denotes For example, network-based drug–disease proximity sheds light on the relationship between drugs (e.g., drug targets) and disease modules (molecular determinants in disease pathobiology modules within the PPIs), and can serve as a useful tool for efficient screening of potentially new indications for approved drugs, as well as drug combinations, as demonstrated in our recent studies13,23,27,28.
T37 6199-6457 Sentence denotes In this study, we present an integrative antiviral drug repurposing methodology, which combines a systems pharmacology-based network medicine platform that quantifies the interplay between the virus–host interactome and drug targets in the human PPI network.
T38 6458-6914 Sentence denotes The basis for these experiments rests on the notions that (i) the proteins that functionally associate with viral infection (including HCoV) are localized in the corresponding subnetwork within the comprehensive human PPI network and (ii) proteins that serve as drug targets for a specific disease may also be suitable drug targets for potential antiviral infection owing to common PPIs and functional pathways elucidated by the human interactome (Fig. 1).
T39 6915-7162 Sentence denotes We follow this analysis with bioinformatics validation of drug-induced gene signatures and HCoV-induced transcriptomics in human cell lines to inspect the postulated mechanism-of-action in a specific HCoV for which we propose repurposing (Fig. 1).
T40 7163-7201 Sentence denotes Fig. 1 Overall workflow of this study.
T41 7202-8507 Sentence denotes Our network-based methodology combines a systems pharmacology-based network medicine platform that quantifies the interplay between the virus–host interactome and drug targets in the human PPI network. a Human coronavirus (HCoV)-associated host proteins were collected from literatures and pooled to generate a pan-HCoV protein subnetwork. b Network proximity between drug targets and HCoV-associated proteins was calculated to screen for candidate repurposable drugs for HCoVs under the human protein interactome model. c, d Gene set enrichment analysis was utilized to validate the network-based prediction. e Top candidates were further prioritized for drug combinations using network-based method captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network. f Overall hypothesis of the network-based methodology: (i) the proteins that functionally associate with HCoVs are localized in the corresponding subnetwork within the comprehensive human interactome network; and (ii) proteins that serve as drug targets for a specific disease may also be suitable drug targets for potential antiviral infection owing to common protein–protein interactions elucidated by the human interactome.
T42 8509-8516 Sentence denotes Results
T43 8518-8563 Sentence denotes Phylogenetic analyses of 2019-nCoV/SARS-CoV-2
T44 8564-8761 Sentence denotes To date, seven pathogenic HCoVs (Fig. 2a, b) have been found:1,29 (i) 2019-nCoV/SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, and HCoV-HKU1 are β genera, and (ii) HCoV-NL63 and HCoV-229E are α genera.
T45 8762-8934 Sentence denotes We performed the phylogenetic analyses using the whole-genome sequence data from 15 HCoVs to inspect the evolutionary relationship of 2019-nCoV/SARS-CoV-2 with other HCoVs.
T46 8935-9089 Sentence denotes We found that the whole genomes of 2019-nCoV/SARS-CoV-2 had ~99.99% nucleotide sequence identity across three diagnosed patients (Supplementary Table S1).
T47 9090-9327 Sentence denotes The 2019-nCoV/SARS-CoV-2 shares the highest nucleotide sequence identity (79.7%) with SARS-CoV among the six other known pathogenic HCoVs, revealing conserved evolutionary relationship between 2019-nCoV/SARS-CoV-2 and SARS-CoV (Fig. 2a).
T48 9328-9374 Sentence denotes Fig. 2 Phylogenetic analysis of coronaviruses.
T49 9375-9416 Sentence denotes a Phylogenetic tree of coronavirus (CoV).
T50 9417-9515 Sentence denotes Phylogenetic algorithm analyzed evolutionary conservation among whole genomes of 15 coronaviruses.
T51 9516-9591 Sentence denotes Red color highlights the recent emergent coronavirus, 2019-nCoV/SARS-CoV-2.
T52 9592-9650 Sentence denotes Numbers on the branches indicate bootstrap support values.
T53 9651-9765 Sentence denotes The scale shows the evolutionary distance computed using the p-distance method. b Schematic plot for HCoV genomes.
T54 9766-9852 Sentence denotes The genus and host information of viruses was labeled on the left by different colors.
T55 9853-9971 Sentence denotes Empty dark gray boxes represent accessory open reading frames (ORFs). c–e The 3D structures of SARS-CoV nsp12 (PDB ID:
T56 9972-9997 Sentence denotes 6NUR) (c), spike (PDB ID:
T57 9998-10034 Sentence denotes 6ACK) (d), and nucleocapsid (PDB ID:
T58 10035-10083 Sentence denotes 2CJR) (e) shown were based on homology modeling.
T59 10084-10184 Sentence denotes Genome information and phylogenetic analysis results are provided in Supplementary Tables S1 and S2.
T60 10185-10395 Sentence denotes HCoVs have five major protein regions for virus structure assembly and viral replications29, including replicase complex (ORF1ab), spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins (Fig. 2b).
T61 10396-10518 Sentence denotes The ORF1ab gene encodes the non-structural proteins (nsp) of viral RNA synthesis complex through proteolytic processing30.
T62 10519-10645 Sentence denotes The nsp12 is a viral RNA-dependent RNA polymerase, together with co-factors nsp7 and nsp8 possessing high polymerase activity.
T63 10646-10805 Sentence denotes From the protein 3D structure view of SARS-CoV nsp12, it contains a larger N-terminal extension (which binds to nsp7 and nsp8) and polymerase domain (Fig. 2c).
T64 10806-10942 Sentence denotes The spike is a transmembrane glycoprotein that plays a pivotal role in mediating viral infection through binding the host receptor31,32.
T65 10943-11085 Sentence denotes Figure 2d shows the 3D structure of the spike protein bound with the host receptor angiotensin converting enznyme2 (ACE2) in SARS-CoV (PDB ID:
T66 11086-11092 Sentence denotes 6ACK).
T67 11093-11276 Sentence denotes A recent study showed that 2019-nCoV/SARS-CoV-2 is able to utilize ACE2 as an entry receptor in ACE2-expressing cells33, suggesting potential drug targets for therapeutic development.
T68 11277-11435 Sentence denotes Furthermore, cryo-EM structure of the spike and biophysical assays reveal that the 2019-nCoV/SARS-CoV-2 spike binds ACE2 with higher affinity than SARS-CoV34.
T69 11436-11619 Sentence denotes In addition, the nucleocapsid is also an important subunit for packaging the viral genome through protein oligomerization35, and the single nucleocapsid structure is shown in Fig. 2e.
T70 11620-11769 Sentence denotes Protein sequence alignment analyses indicated that the 2019-nCoV/SARS-CoV-2 was most evolutionarily conserved with SARS-CoV (Supplementary Table S2).
T71 11770-11992 Sentence denotes Specifically, the envelope and nucleocapsid proteins of 2019-nCoV/SARS-CoV-2 are two evolutionarily conserved regions, with sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV (Supplementary Table S2).
T72 11993-12132 Sentence denotes However, the spike protein exhibited the lowest sequence conservation (sequence identity of 77%) between 2019-nCoV/SARS-CoV-2 and SARS-CoV.
T73 12133-12240 Sentence denotes Meanwhile, the spike protein of 2019-nCoV/SARS-CoV-2 only has 31.9% sequence identity compared to MERS-CoV.
T74 12242-12271 Sentence denotes HCoV–host interactome network
T75 12272-12503 Sentence denotes To depict the HCoV–host interactome network, we assembled the CoV-associated host proteins from four known HCoVs (SARS-CoV, MERS-CoV, HCoV-229E, and HCoV-NL63), one mouse MHV, and one avian IBV (N protein) (Supplementary Table S3).
T76 12504-12600 Sentence denotes In total, we obtained 119 host proteins associated with CoVs with various experimental evidence.
T77 12601-12736 Sentence denotes Specifically, these host proteins are either the direct targets of HCoV proteins or are involved in crucial pathways of HCoV infection.
T78 12737-12791 Sentence denotes The HCoV–host interactome network is shown in Fig. 3a.
T79 12792-12930 Sentence denotes We identified several hub proteins including JUN, XPO1, NPM1, and HNRNPA1, with the highest number of connections within the 119 proteins.
T80 12931-13151 Sentence denotes KEGG pathway enrichment analysis revealed multiple significant biological pathways (adjusted P value < 0.05), including measles, RNA transport, NF-kappa B signaling, Epstein-Barr virus infection, and influenza (Fig. 3b).
T81 13152-13502 Sentence denotes Gene ontology (GO) biological process enrichment analysis further confirmed multiple viral infection-related processes (adjusted P value < 0.001), including viral life cycle, modulation by virus of host morphology or physiology, viral process, positive regulation of viral life cycle, transport of virus, and virion attachment to host cell (Fig. 3c).
T82 13503-13649 Sentence denotes We then mapped the known drug–target network (see Materials and methods) into the HCoV–host interactome to search for druggable, cellular targets.
T83 13650-13800 Sentence denotes We found that 47 human proteins (39%, blue nodes in Fig. 3a) can be targeted by at least one approved drug or experimental drug under clinical trials.
T84 13801-13884 Sentence denotes For example, GSK3B, DPP4, SMAD3, PARP1, and IKBKB are the most targetable proteins.
T85 13885-14098 Sentence denotes The high druggability of HCoV–host interactome motivates us to develop a drug repurposing strategy by specifically targeting cellular proteins associated with HCoVs for potential treatment of 2019-nCoV/SARS-CoV-2.
T86 14099-14164 Sentence denotes Fig. 3 Drug-target network analysis of the HCoV–host interactome.
T87 14165-14219 Sentence denotes a A subnetwork highlighting the HCoV–host interactome.
T88 14220-14477 Sentence denotes Nodes represent three types of HCoV-associated host proteins: targetgable (proteins can be targeted by approved drugs or drugs under clinical trials), non-targetable (proteins do not have any known ligands), neighbors (protein–protein interaction partners).
T89 14478-14599 Sentence denotes Edge colors indicate five types of experimental evidence of the protein–protein interactions (see Materials and methods).
T90 14600-14735 Sentence denotes 3D three-dimensional structure. b, c KEGG human pathway (b) and gene ontology enrichment analyses (c) for the HCoV-associated proteins.
T91 14737-14777 Sentence denotes Network-based drug repurposing for HCoVs
T92 14778-15056 Sentence denotes The basis for the proposed network-based drug repurposing methodologies rests on the notions that the proteins that associate with and functionally govern viral infection are localized in the corresponding subnetwork (Fig. 1a) within the comprehensive human interactome network.
T93 15057-15357 Sentence denotes For a drug with multiple targets to be effective against an HCoV, its target proteins should be within or in the immediate vicinity of the corresponding subnetwork in the human protein–protein interactome (Fig. 1), as we demonstrated in multiple diseases13,22,23,28 using this network-based strategy.
T94 15358-15525 Sentence denotes We used a state-of-the-art network proximity measure to quantify the relationship between HCoV-specific subnetwork (Fig. 3a) and drug targets in the human interactome.
T95 15526-15678 Sentence denotes We constructed a drug–target network by assembling target information for more than 2000 FDA-approved or experimental drugs (see Materials and methods).
T96 15679-16144 Sentence denotes To improve the quality and completeness of the human protein interactome network, we integrated PPIs with five types of experimental data: (1) binary PPIs from 3D protein structures; (2) binary PPIs from unbiased high-throughput yeast-two-hybrid assays; (3) experimentally identified kinase-substrate interactions; (4) signaling networks derived from experimental data; and (5) literature-derived PPIs with various experimental evidence (see Materials and methods).
T97 16145-16382 Sentence denotes We used a Z-score (Z) measure and permutation test to reduce the study bias in network proximity analyses (including hub nodes in the human interactome network by literature-derived PPI data bias) as described in our recent studies13,28.
T98 16383-16568 Sentence denotes In total, we computationally identified 135 drugs that were associated (Z < −1.5 and P < 0.05, permutation test) with the HCoV–host interactome (Fig. 4a, Supplementary Tables S4 and 5).
T99 16569-16808 Sentence denotes To validate bias of the pooled cellular proteins from six CoVs, we further calculated the network proximities of all the drugs for four CoVs with a large number of know host proteins, including SARS-CoV, MERS-CoV, IBV, and MHV, separately.
T100 16809-16942 Sentence denotes We found that the Z-scores showed consistency among the pooled 119 HCoV-associated proteins and other four individual CoVs (Fig. 4b).
T101 16943-17177 Sentence denotes The Pearson correlation coefficients of the proximities of all the drugs for the pooled HCoV are 0.926 vs. SARS-CoV (P < 0.001, t distribution), 0.503 vs. MERS-CoV (P < 0.001), 0.694 vs. IBV (P < 0.001), and 0.829 vs. MHV (P < 0.001).
T102 17178-17298 Sentence denotes These network proximity analyses offer putative repurposable candidates for potential prevention and treatment of HCoVs.
T103 17299-17337 Sentence denotes Fig. 4 A discovered drug-HCoV network.
T104 17338-17438 Sentence denotes a A subnetwork highlighting network-predicted drug-HCoV associations connecting 135 drugs and HCoVs.
T105 17439-17599 Sentence denotes From the 2938 drugs evaluated, 135 ones achieved significant proximities between drug targets and the HCoV-associated proteins in the human interactome network.
T106 17600-17813 Sentence denotes Drugs are colored by their first-level of the Anatomical Therapeutic Chemical (ATC) classification system code. b A heatmap highlighting network proximity values for SARS-CoV, MERS-CoV, IBV, and MHV, respectively.
T107 17814-17947 Sentence denotes Color key denotes network proximity (Z-score) between drug targets and the HCoV-associated proteins in the human interactome network.
T108 17948-17989 Sentence denotes P value was computed by permutation test.
T109 17991-18031 Sentence denotes Discovery of repurposable drugs for HCoV
T110 18032-18233 Sentence denotes To further validate the 135 repurposable drugs against HCoVs, we first performed gene set enrichment analysis (GSEA) using transcriptome data of MERS-CoV and SARS-CoV infected host cells (see Methods).
T111 18234-18298 Sentence denotes These transcriptome data were used as gene signatures for HCoVs.
T112 18299-18460 Sentence denotes Additionally, we downloaded the gene expression data of drug-treated human cell lines from the Connectivity Map (CMAP) database36 to obtain drug–gene signatures.
T113 18461-18599 Sentence denotes We calculated a GSEA score (see Methods) for each drug and used this score as an indication of bioinformatics validation of the 135 drugs.
T114 18600-18834 Sentence denotes Specifically, an enrichment score (ES) was calculated for each HCoV data set, and ES > 0 and P < 0.05 (permutation test) was used as cut-off for a significant association of gene signatures between a drug and a specific HCoV data set.
T115 18835-18943 Sentence denotes The GSEA score, ranging from 0 to 3, is the number of data sets that met these criteria for a specific drug.
T116 18944-19235 Sentence denotes Mesalazine (an approved drug for inflammatory bowel disease), sirolimus (an approved immunosuppressive drug), and equilin (an approved agonist of the estrogen receptor for menopausal symptoms) achieved the highest GSEA scores of 3, followed by paroxetine and melatonin with GSEA scores of 2.
T117 19236-19635 Sentence denotes We next selected 16 high-confidence repurposable drugs (Fig. 5a and Table 1) against HCoVs using subject matter expertise based on a combination of factors: (i) strength of the network-predicted associations (a smaller network proximity score in Supplementary Table S4); (ii) validation by GSEA analyses; (iii) literature-reported antiviral evidence, and (iv) fewer clinically reported side effects.
T118 19636-19752 Sentence denotes Specifically, we showcased several selected repurposable drugs with literature-reported antiviral evidence as below.
T119 19753-19835 Sentence denotes Fig. 5 A discovered drug-protein-HCoV network for 16 candidate repurposable drugs.
T120 19836-19958 Sentence denotes a Network-predicted evidence and gene set enrichment analysis (GSEA) scores for 16 potential repurposable drugs for HCoVs.
T121 19959-20056 Sentence denotes The overall connectivity of the top drug candidates to the HCoV-associated proteins was examined.
T122 20057-20171 Sentence denotes Most of these drugs indirectly target HCoV-associated proteins via the human protein–protein interaction networks.
T123 20172-20303 Sentence denotes All the drug–target-HCoV-associated protein connections were examined, and those proteins with at least five connections are shown.
T124 20304-20372 Sentence denotes The box heights for the proteins indicate the number of connections.
T125 20373-20855 Sentence denotes GSEA scores for eight drugs were not available (NA) due to the lack of transcriptome profiles for the drugs. b–e Inferred mechanism-of-action networks for four selected drugs: b toremifene (first-generation nonsteroidal-selective estrogen receptor modulator), c irbesartan (an angiotensin receptor blocker), d mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties), and e melatonin (a biogenic amine for treating circadian rhythm sleep disorders).
T126 20856-20951 Sentence denotes Table 1 Top 16 network-predicted repurposable drugs with literature-derived antiviral evidence.
T127 20952-21352 Sentence denotes HBV hepatitis B virus, HCV hepatitis C virus, HDV hepatitis delta virus, EBOV Ebola viruses, ZEBOV-GP Zaire Ebola virus glycoprotein, HIV human immunodeficiency virus, EBV Epstein-Barr virus, ANDV Andes orthohantavirus, EMCV encephalomyocarditis virus, FECV feline enteric coronavirus, RSV respiratory syncytial virus, EV71 enterovirus 71, HSV-1 and -2 herpes simplex viruses, CVB4 Coxsackievirus B4.
T128 21354-21392 Sentence denotes Selective estrogen receptor modulators
T129 21393-21504 Sentence denotes An overexpression of estrogen receptor has been shown to play a crucial role in inhibiting viral replication37.
T130 21505-21697 Sentence denotes Selective estrogen receptor modulators (SERMs) have been reported to play a broader role in inhibiting viral replication through the non-classical pathways associated with estrogen receptor37.
T131 21698-21895 Sentence denotes SERMs interfere at the post viral entry step and affect the triggering of fusion, as the SERMs’ antiviral activity still can be observed in the absence of detectable estrogen receptor expression18.
T132 21896-22114 Sentence denotes Toremifene (Z = –3.23, Fig. 5a), the first generation of nonsteroidal SERM, exhibits potential effects in blocking various viral infections, including MERS-CoV, SARS-CoV, and Ebola virus in established cell lines17,38.
T133 22115-22358 Sentence denotes Compared to the classical ESR1-related antiviral pathway, toremifene prevents fusion between the viral and endosomal membrane by interacting with and destabilizing the virus membrane glycoprotein, and eventually inhibiting viral replication39.
T134 22359-22518 Sentence denotes As shown in Fig. 5b, toremifene potentially affects several key host proteins associated with HCoV, such as RPL19, HNRNPA1, NPM1, EIF3I, EIF3F, and EIF3E40,41.
T135 22519-22756 Sentence denotes Equilin (Z = –2.52 and GSEA score = 3), an estrogenic steroid produced by horses, also has been proven to have moderate activity in inhibiting the entry of Zaire Ebola virus glycoprotein and human immunodeficiency virus (ZEBOV-GP/HIV)18.
T136 22757-22886 Sentence denotes Altogether, network-predicted SERMs (such as toremifene and equilin) offer candidate repurposable drugs for 2019-nCoV/SARS-CoV-2.
T137 22888-22917 Sentence denotes Angiotensin receptor blockers
T138 22918-23030 Sentence denotes Angiotensin receptor blockers (ARBs) have been reported to associate with viral infection, including HCoVs42–44.
T139 23031-23149 Sentence denotes Irbesartan (Z = –5.98), a typical ARB, was approved by the FDA for treatment of hypertension and diabetic nephropathy.
T140 23150-23303 Sentence denotes Here, network proximity analysis shows a significant association between irbesartan’s targets and HCoV-associated host proteins in the human interactome.
T141 23304-23545 Sentence denotes As shown in Fig. 5c, irbesartan targets SLC10A1, encoding the sodium/bile acid cotransporter (NTCP) protein that has been identified as a functional preS1-specific receptor for the hepatitis B virus (HBV) and the hepatitis delta virus (HDV).
T142 23546-23608 Sentence denotes Irbesartan can inhibit NTCP, thus inhibiting viral entry45,46.
T143 23609-23721 Sentence denotes SLC10A1 interacts with C11orf74, a potential transcriptional repressor that interacts with nsp-10 of SARS-CoV47.
T144 23722-23914 Sentence denotes There are several other ARBs (such as eletriptan, frovatriptan, and zolmitriptan) in which their targets are potentially associated with HCoV-associated host proteins in the human interactome.
T145 23916-23958 Sentence denotes Immunosuppressant or antineoplastic agents
T146 23959-24160 Sentence denotes Previous studies have confirmed the mammalian target of rapamycin complex 1 (mTORC1) as the key factor in regulating various viruses’ replications, including Andes orthohantavirus and coronavirus48,49.
T147 24161-24349 Sentence denotes Sirolimus (Z = –2.35 and GSEA score = 3), an inhibitor of mammalian target of rapamycin (mTOR), was reported to effectively block viral protein expression and virion release effectively50.
T148 24350-24461 Sentence denotes Indeed, the latest study revealed the clinical application: sirolimus reduced MERS-CoV infection by over 60%51.
T149 24462-24620 Sentence denotes Moreover, sirolimus usage in managing patients with severe H1N1 pneumonia and acute respiratory failure can improve those patients’ prognosis significantly50.
T150 24621-24917 Sentence denotes Mercaptopurine (Z = –2.44 and GSEA score = 1), an antineoplastic agent with immunosuppressant property, has been used to treat cancer since the 1950s and expanded its application to several auto-immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Crohn’s disease52.
T151 24918-25128 Sentence denotes Mercaptopurine has been reported as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease which plays key roles in viral maturation and antagonism to interferon stimulation53,54.
T152 25129-25262 Sentence denotes Mechanistically, mercaptopurine potentially target several host proteins in HCoVs, such as JUN, PABPC1, NPM1, and NCL40,55 (Fig. 5d).
T153 25264-25288 Sentence denotes Anti-inflammatory agents
T154 25289-25357 Sentence denotes Inflammatory pathways play essential roles in viral infections56,57.
T155 25358-25576 Sentence denotes As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59.
T156 25577-25776 Sentence denotes Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60.
T157 25777-26007 Sentence denotes The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients’ clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62.
T158 26008-26189 Sentence denotes In addition, the application of melatonin may prolong patients’ survival time, which may provide a chance for patients’ immune systems to recover and eventually eradicate the virus.
T159 26190-26310 Sentence denotes As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB.
T160 26311-26439 Sentence denotes Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin.
T161 26440-26593 Sentence denotes By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63.
T162 26594-26782 Sentence denotes In summary, our network proximity analyses offer multiple candidate repurposable drugs that target diverse cellular pathways for potential prevention and treatment of 2019-nCoV/SARS-CoV-2.
T163 26783-26949 Sentence denotes However, further preclinical experiments64 and clinical trials are required to verify the clinical benefits of these network-predicted candidates before clinical use.
T164 26951-27035 Sentence denotes Network-based identification of potential drug combinations for 2019-nCoV/SARS-CoV-2
T165 27036-27179 Sentence denotes Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an important role in treating various viral infections65.
T166 27180-27360 Sentence denotes However, our ability to identify and validate effective combinations is limited by a combinatorial explosion, driven by both the large number of drug pairs and dosage combinations.
T167 27361-27483 Sentence denotes In our recent study, we proposed a novel network-based methodology to identify clinically efficacious drug combinations28.
T168 27484-27777 Sentence denotes Relying on approved drug combinations for hypertension and cancer, we found that a drug combination was therapeutically effective only if it was captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the disease module, but target separate neighborhoods (Fig. 6a).
T169 27778-27964 Sentence denotes Here we sought to identify drug combinations that may provide a synergistic effect in potentially treating 2019-nCoV/SARS-CoV-2 with well-defined mechanism-of-action by network analysis.
T170 27965-28115 Sentence denotes For the 16 potential repurposable drugs (Fig. 5a, Table 1), we showcased three network-predicted candidate drug combinations for 2019-nCoV/SARS-CoV-2.
T171 28116-28191 Sentence denotes All predicted possible combinations can be found in Supplementary Table S6.
T172 28192-28275 Sentence denotes Fig. 6 Network-based rational design of drug combinations for 2019-nCoV/SARS-CoV-2.
T173 28276-28377 Sentence denotes a The possible exposure mode of the HCoV-associated protein module to the pairwise drug combinations.
T174 28378-28593 Sentence denotes An effective drug combination will be captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network.
T175 28594-28697 Sentence denotes ZCA and ZCB denote the network proximity (Z-score) between targets (Drugs A and B) and a specific HCoV.
T176 28698-29388 Sentence denotes SAB denotes separation score (see Materials and methods) of targets between Drug A and Drug B. b–d Inferred mechanism-of-action networks for three selected pairwise drug combinations: b sirolimus (a potent immunosuppressant with both antifungal and antineoplastic properties) plus dactinomycin (an RNA synthesis inhibitor for treatment of various tumors), c toremifene (first-generation nonsteroidal-selective estrogen receptor modulator) plus emodin (an experimental drug for the treatment of polycystic kidney), and d melatonin (a biogenic amine for treating circadian rhythm sleep disorders) plus mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties).
T177 29390-29417 Sentence denotes Sirolimus plus Dactinomycin
T178 29418-29610 Sentence denotes Sirolimus, an inhibitor of mTOR with both antifungal and antineoplastic properties, has demonstrated to improve outcomes in patients with severe H1N1 pneumonia and acute respiratory failure50.
T179 29611-29679 Sentence denotes The mTOR signaling plays an essential role for MERS-CoV infection66.
T180 29680-29797 Sentence denotes Dactinomycin, also known actinomycin D, is an approved RNA synthesis inhibitor for treatment of various cancer types.
T181 29798-29893 Sentence denotes An early study showed that dactinomycin (1 μg/ml) inhibited the growth of feline enteric CoV67.
T182 29894-30136 Sentence denotes As shown in Fig. 6b, our network analysis shows that sirolimus and dactinomycin synergistically target HCoV-associated host protein subnetwork by “Complementary Exposure” pattern, offering potential combination regimens for treatment of HCoV.
T183 30137-30352 Sentence denotes Specifically, sirolimus and dactinomycin may inhibit both mTOR signaling and RNA synthesis pathway (including DNA topoisomerase 2-alpha (TOP2A) and DNA topoisomerase 2-beta (TOP2B)) in HCoV-infected cells (Fig. 6b).
T184 30354-30376 Sentence denotes Toremifene plus Emodin
T185 30377-30494 Sentence denotes Toremifene is among the approved first-generation nonsteroidal SERMs for the treatment of metastatic breast cancer68.
T186 30495-30627 Sentence denotes SERMs (including toremifene) inhibited Ebola virus infection18 by interacting with and destabilizing the Ebola virus glycoprotein39.
T187 30628-30737 Sentence denotes In vitro assays have demonstrated that toremifene inhibited growth of MERS-CoV17,69 and SARA-CoV38 (Table 1).
T188 30738-30873 Sentence denotes Emodin, an anthraquinone derivative extracted from the roots of rheum tanguticum, has been reported to have various anti-virus effects.
T189 30874-31015 Sentence denotes Specifically, emdoin inhibited SARS-CoV-associated 3a protein70, and blocked an interaction between the SARS-CoV spike protein and ACE2 (ref.
T190 31016-31020 Sentence denotes 71).
T191 31021-31205 Sentence denotes Altogether, network analyses and published experimental data suggested that combining toremifene and emdoin offered a potential therapeutic approach for 2019-nCoV/SARS-CoV-2 (Fig. 6c).
T192 31207-31236 Sentence denotes Mercaptopurine plus Melatonin
T193 31237-31403 Sentence denotes As shown in Fig. 5a, targets of both mercaptopurine and melatonin showed strong network proximity with HCoV-associated host proteins in the human interactome network.
T194 31404-31560 Sentence denotes Recent in vitro and in vivo studies identified mercaptopurine as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease53,54.
T195 31561-31672 Sentence denotes Melatonin was reported in potential antiviral infection via its anti-inflammatory and antioxidant effects58–62.
T196 31673-31816 Sentence denotes Melatonin indirectly regulates ACE2 expression, a key entry receptor involved in viral infection of HCoVs, including 2019-nCoV/SARS-CoV-2 (ref.
T197 31817-31821 Sentence denotes 33).
T198 31822-32000 Sentence denotes Specifically, melatonin was reported to inhibit calmodulin and calmodulin interacts with ACE2 by inhibiting shedding of its ectodomain, a key infectious process of SARS-CoV72,73.
T199 32001-32097 Sentence denotes JUN, also known as c-Jun, is a key host protein involving in HCoV infectious bronchitis virus74.
T200 32098-32229 Sentence denotes As shown in Fig. 6d, mercaptopurine and melatonin may synergistically block c-Jun signaling by targeting multiple cellular targets.
T201 32230-32468 Sentence denotes In summary, combination of mercaptopurine and melatonin may offer a potential combination therapy for 2019-nCoV/SARS-CoV-2 by synergistically targeting papain-like protease, ACE2, c-Jun signaling, and anti-inflammatory pathways (Fig. 6d).
T202 32469-32587 Sentence denotes However, further experimental observations on ACE2 pathways by melatonin in 2019-nCoV/SARS-CoV-2 are highly warranted.
T203 32589-32599 Sentence denotes Discussion
T204 32600-32787 Sentence denotes In this study, we presented a network-based methodology for systematic identification of putative repurposable drugs and drug combinations for potential treatment of 2019-nCoV/SARS-CoV-2.
T205 32788-32981 Sentence denotes Integration of drug–target networks, HCoV–host interactions, HCoV-induced transcriptome in human cell lines, and human protein–protein interactome network are essential for such identification.
T206 32982-33151 Sentence denotes Based on comprehensive evaluation, we prioritized 16 candidate repurposable drugs (Fig. 5) and 3 potential drug combinations (Fig. 6) for targeting 2019-nCoV/SARS-CoV-2.
T207 33152-33452 Sentence denotes However, although the majority of predictions have been validated by various literature data (Table 1), all network-predicted repurposable drugs and drug combinations must be validated in various 2019-nCoV/SARS-CoV-2 experimental assays64 and randomized clinical trials before being used in patients.
T208 33453-33509 Sentence denotes We acknowledge several limitations in the current study.
T209 33510-33721 Sentence denotes Although 2019-nCoV/SARS-CoV-2 shared high nucleotide sequence identity with other HCoVs (Fig. 2), our predictions are not 2019-nCoV/SARS-CoV-2 specific by lack of the known host proteins on 2019-nCoV/SARS-CoV-2.
T210 33722-33828 Sentence denotes We used a low binding affinity value of 10 μM as a threshold to define a physical drug–target interaction.
T211 33829-33995 Sentence denotes However, a stronger binding affinity threshold (e.g., 1 μM) may be a more suitable cut-off in drug discovery, although it will generate a smaller drug–target network.
T212 33996-34270 Sentence denotes Although sizeable efforts were made for assembling large scale, experimentally reported drug–target networks from publicly available databases, the network data may be incomplete and some drug–target interactions may be functional associations, instead of physical bindings.
T213 34271-34408 Sentence denotes For example, Silvestrol, a natural product from the flavagline, was found to have antiviral activity against Ebola75 and Coronaviruses76.
T214 34409-34586 Sentence denotes After adding its target, an RNA helicase enzyme EIF4A76, silvestrol was predicted to be significantly associated with HCoVs (Z = –1.24, P = 0.041) by network proximity analysis.
T215 34587-34737 Sentence denotes To increase coverage of drug–target networks, we may use computational approaches to systematically predict the drug-target interactions further25,26.
T216 34738-34937 Sentence denotes In addition, the collected virus–host interactions are far from completeness and the quality can be influenced by multiple factors, including different experimental assays and human cell line models.
T217 34938-35077 Sentence denotes We may computationally predict a new virus–host interactome for 2019-nCoV/SARS-CoV-2 using sequence-based and structure-based approaches77.
T218 35078-35301 Sentence denotes Drug targets representing nodes within cellular networks are often intrinsically coupled with both therapeutic and adverse profiles78, as drugs can inhibit or activate protein functions (including antagonists vs. agonists).
T219 35302-35539 Sentence denotes The current systems pharmacology model cannot separate therapeutic (antiviral) effects from those predictions due to lack of detailed pharmacological effects of drug targets and unknown functional consequences of virus–host interactions.
T220 35540-35789 Sentence denotes Comprehensive identification of the virus–host interactome for 2019-nCoV/SARS-CoV-2, with specific biological effects using functional genomics assays79,80, will significantly improve the accuracy of the proposed network-based methodologies further.
T221 35790-36039 Sentence denotes Owing to a lack of the complete drug-target information (such as the molecular “promiscuity” of drugs), the dose–response and dose–toxicity effects for both repurposable drugs and drug combinations cannot be identified in the current network models.
T222 36040-36191 Sentence denotes For example, Mesalazine, an approved drug for inflammatory bowel disease, is a top network-predicted repurposable drug associated with HCoVs (Fig. 5a).
T223 36192-36324 Sentence denotes Yet, several clinical studies showed the potential pulmonary toxicities (including pneumonia) associated with mesalazine usage81,82.
T224 36325-36530 Sentence denotes Integration of lung-specific gene expression23 of 2019-nCoV/SARS-CoV-2 host proteins and physiologically based pharmacokinetic modeling83 may reduce side effects of repurposable drugs or drug combinations.
T225 36531-36636 Sentence denotes Preclinical studies are warranted to evaluate in vivo efficiency and side effects before clinical trials.
T226 36637-36752 Sentence denotes Furthermore, we only limited to predict pairwise drug combinations based on our previous network-based framework28.
T227 36753-36998 Sentence denotes However, we expect that our methodology remain to be a useful network-based tool for prediction of combining multiple drugs toward exploring network relationships of multiple drugs’ targets with the HCoV–host subnetwork in the human interactome.
T228 36999-37113 Sentence denotes Finally, we aimed to systematically identify repurposable drugs by specifically targeting nCoV host proteins only.
T229 37114-37248 Sentence denotes Thus, our current network models cannot predict repurposable drugs from the existing anti-virus drugs that target virus proteins only.
T230 37249-37513 Sentence denotes Thus, combination of the existing anti-virus drugs (such as remdesivir64) with the network-predicted repurposable drugs (Fig. 5) or drug combinations (Fig. 6) may improve coverage of current network-based methodologies by utilizing multi-layer network framework16.
T231 37514-37739 Sentence denotes In conclusion, this study offers a powerful, integrative network-based systems pharmacology methodology for rapid identification of repurposable drugs and drug combinations for the potential treatment of 2019-nCoV/SARS-CoV-2.
T232 37740-37984 Sentence denotes Our approach can minimize the translational gap between preclinical testing results and clinical outcomes, which is a significant problem in the rapid development of efficient treatment strategies for the emerging 2019-nCoV/SARS-CoV-2 outbreak.
T233 37985-38199 Sentence denotes From a translational perspective, if broadly applied, the network tools developed here could help develop effective treatment strategies for other emerging viral infections and other human complex diseases as well.
T234 38201-38222 Sentence denotes Methods and materials
T235 38224-38268 Sentence denotes Genome information and phylogenetic analysis
T236 38269-38473 Sentence denotes In total, we collected DNA sequences and protein sequences for 15 HCoVs, including three most recent 2019-nCoV/SARS-CoV-2 genomes, from the NCBI GenBank database (28 January 2020, Supplementary Table S1).
T237 38474-38655 Sentence denotes Whole-genome alignment and protein sequence identity calculation were performed by Multiple Sequence Alignment in EMBL-EBI database (https://www.ebi.ac.uk/) with default parameters.
T238 38656-38793 Sentence denotes The neighbor joining (NJ) tree was computed from the pairwise phylogenetic distance matrix using MEGA X84 with 1000 bootstrap replicates.
T239 38794-38876 Sentence denotes The protein alignment and phylogenetic tree of HCoVs were constructed by MEGA X84.
T240 38878-38913 Sentence denotes Building the virus–host interactome
T241 38914-39013 Sentence denotes We collected HCoV–host protein interactions from various literatures based on our sizeable efforts.
T242 39014-39143 Sentence denotes The HCoV-associated host proteins of several HCoVs, including SARS-CoV, MERS-CoV, IBV, MHV, HCoV-229E, and HCoV-NL63 were pooled.
T243 39144-39459 Sentence denotes These proteins were either the direct targets of HCoV proteins or were involved in critical pathways of HCoV infection identified by multiple experimental sources, including high-throughput yeast-two-hybrid (Y2H) systems, viral protein pull-down assay, in vitro co-immunoprecipitation and RNA knock down experiment.
T244 39460-39570 Sentence denotes In total, the virus–host interaction network included 6 HCoVs with 119 host proteins (Supplementary Table S3).
T245 39572-39602 Sentence denotes Functional enrichment analysis
T246 39603-39805 Sentence denotes Next, we performed Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses to evaluate the biological relevance and functional pathways of the HCoV-associated proteins.
T247 39806-39861 Sentence denotes All functional analyses were performed using Enrichr85.
T248 39863-39895 Sentence denotes Building the drug–target network
T249 39896-40112 Sentence denotes Here, we collected drug–target interaction information from the DrugBank database (v4.3)86, Therapeutic Target Database (TTD)87, PharmGKB database, ChEMBL (v20)88, BindingDB89, and IUPHAR/BPS Guide to PHARMACOLOGY90.
T250 40113-40198 Sentence denotes The chemical structure of each drug with SMILES format was extracted from DrugBank86.
T251 40199-40495 Sentence denotes Here, drug–target interactions meeting the following three criteria were used: (i) binding affinities, including Ki, Kd, IC50, or EC50 each ≤10 μM; (ii) the target was marked as “reviewed” in the UniProt database91; and (iii) the human target was represented by a unique UniProt accession number.
T252 40496-40613 Sentence denotes The details for building the experimentally validated drug–target network are provided in our recent studies13,23,28.
T253 40615-40661 Sentence denotes Building the human protein–protein interactome
T254 40662-41302 Sentence denotes To build a comprehensive list of human PPIs, we assembled data from a total of 18 bioinformatics and systems biology databases with five types of experimental evidence: (i) binary PPIs tested by high-throughput yeast-two-hybrid (Y2H) systems; (ii) binary, physical PPIs from protein 3D structures; (iii) kinase-substrate interactions by literature-derived low-throughput or high-throughput experiments; (iv) signaling network by literature-derived low-throughput experiments; and (v) literature-curated PPIs identified by affinity purification followed by mass spectrometry (AP-MS), Y2H, or by literature-derived low-throughput experiments.
T255 41303-41419 Sentence denotes All inferred data, including evolutionary analysis, gene expression data, and metabolic associations, were excluded.
T256 41420-41577 Sentence denotes The genes were mapped to their Entrez ID based on the NCBI database92 as well as their official gene symbols based on GeneCards (https://www.genecards.org/).
T257 41578-41815 Sentence denotes In total, the resulting human protein–protein interactome used in this study includes 351,444 unique PPIs (edges or links) connecting 17,706 proteins (nodes), representing a 50% increase in the number of the PPIs we have used previously.
T258 41816-41937 Sentence denotes Detailed descriptions for building the human protein–protein interactome are provided in our previous studies13,23,28,93.
T259 41939-41964 Sentence denotes Network proximity measure
T260 41965-42130 Sentence denotes We posit that the human PPIs provide an unbiased, rational roadmap for repurposing drugs for potential treatment of HCoVs in which they were not originally approved.
T261 42131-42985 Sentence denotes Given C, the set of host genes associated with a specific HCoV, and T, the set of drug targets, we computed the network proximity of C with the target set T of each drug using the “closest” method:1 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left\langle d_{CT} \right\rangle = \frac{1}{\vert\vert C \vert\vert +\vert\vert T \vert\vert}\left({\sum\limits_{c \in C}} {\min}_{t \in T}\,d\left( {c,t} \right) + {\sum\limits_{t \in T}} {\min}_{c \in C}\,d\left(c,t\right) \right),$$\end{document}dCT=1∣∣C∣∣+∣∣T∣∣∑c∈Cmint∈Tdc,t+∑t∈Tminc∈Cdc,t,where d(c, t) is the shortest distance between gene c and t in the human protein interactome.
T262 42986-43918 Sentence denotes The network proximity was converted to Z-score based on permutation tests:2 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$Z_{d_{CT}} = \frac{{d_{CT} - \overline {d_r} }}{{\sigma _r}},$$\end{document}ZdCT=dCT−dr¯σr,where \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\overline {d_r}$$\end{document}dr¯ and σr were the mean and standard deviation of the permutation test repeated 1000 times, each time with two randomly selected gene lists with similar degree distributions to those of C and T.
T263 43919-43998 Sentence denotes The corresponding P value was calculated based on the permutation test results.
T264 43999-44089 Sentence denotes Z-score < −1.5 and P < 0.05 were considered significantly proximal drug–HCoV associations.
T265 44090-44158 Sentence denotes All networks were visualized using Gephi 0.9.2 (https://gephi.org/).
T266 44160-44214 Sentence denotes Network-based rational prediction of drug combinations
T267 44215-44567 Sentence denotes For this network-based approach for drug combinations to be effective, we need to establish if the topological relationship between two drug–target modules reflects biological and pharmacological relationships, while also quantifying their network-based relationship between drug targets and HCoV-associated host proteins (drug–drug–HCoV combinations).
T268 44568-44644 Sentence denotes To identify potential drug combinations, we combined the top lists of drugs.
T269 44645-45558 Sentence denotes Then, “separation” measure SAB was calculated for each pair of drugs A and B using the following method:3 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$S_{AB} = \left\langle {d_{AB}} \right\rangle - \frac{{\left\langle {d_{AA}} \right\rangle + \left\langle {d_{BB}} \right\rangle }}{2},$$\end{document}SAB=dAB−dAA+dBB2,where \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left\langle {d_ \cdot } \right\rangle$$\end{document}d⋅ was calculated based on the “closest” method.
T270 45559-45821 Sentence denotes Our key methodology is that a drug combination is therapeutically effective only if it follows a specific relationship to the disease module, as captured by Complementary Exposure patterns in targets’ modules of both drugs without overlapping toxic mechanisms28.
T271 45823-45851 Sentence denotes Gene set enrichment analysis
T272 45852-45937 Sentence denotes We performed the gene set enrichment analysis as an additional prioritization method.
T273 45938-46073 Sentence denotes We first collected three differential gene expression data sets of hosts infected by HCoVs from the NCBI Gene Expression Omnibus (GEO).
T274 46074-46233 Sentence denotes Among them, two transcriptome data sets were SARS-CoV-infected samples from patient’s peripheral blood94 (GSE1739) and Calu-3 cells95 (GSE33267), respectively.
T275 46234-46310 Sentence denotes One transcriptome data set was MERS-CoV-infected Calu-3 cells96 (GSE122876).
T276 46311-46389 Sentence denotes Adjusted P value less than 0.01 was defined as differentially expressed genes.
T277 46390-46483 Sentence denotes These data sets were used as HCoV–host signatures to evaluate the treatment effects of drugs.
T278 46484-46654 Sentence denotes Differential gene expression in cells treated with various drugs were retrieved from the Connectivity Map (CMAP) database36, and were used as gene profiles for the drugs.
T279 46655-47600 Sentence denotes For each drug that was in both the CMAP data set and our drug–target network, we calculated an enrichment score (ES) for each HCoV signature data set based on previously described methods97 as follows:4 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathrm {ES}} = \left\{ {\begin{array}{*{20}{c}} {{\mathrm{ES}_{\mathrm{up}}} - {\mathrm {ES}_{\mathrm{down}}},{\mathrm {sgn}}\left( {{\mathrm {ES}_{\mathrm{up}}}} \right)\, \ne \,{\mathrm {sgn}}\left( {{\mathrm {ES}_{\mathrm{down}}}} \right)} \\ {0,\mathrm {else}} \end{array}} \right.$$\end{document}ES=ESup−ESdown,sgnESup≠sgnESdown0,elseESup and ESdown were calculated separately for the up- and down-regulated genes from the HCoV signature data set using the same method.
T280 47601-48607 Sentence denotes We first computed aup/down and bup/down as5 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$a = \mathop{\max}\limits_{1 \le j \le s}\left( {\frac{j}{s} - \frac{{V\left( j \right)}}{r}} \right),$$\end{document}a=max1≤j≤sjs−Vjr,6 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$b = \mathop{\max}\limits_{1 \le j \le s}\left( {\frac{{V\left( j \right)}}{r} - \frac{{j - 1}}{s}} \right),$$\end{document}b=max1≤j≤sVjr−j−1s,where j = 1, 2, …, s were the genes of HCoV signature data set sorted in ascending order by their rank in the gene profiles of the drug being evaluated.
T281 48608-48731 Sentence denotes The rank of gene j is denoted by V(j), where 1 ≤ V(j) ≤ r, with r being the number of genes (12,849) from the drug profile.
T282 48732-48840 Sentence denotes Then, ESup/down was set to aup/down if aup/down > bup/down, and was set to −bup/down if bup/down > aup/down.
T283 48841-49058 Sentence denotes Permutation tests repeated 100 times using randomly generated gene lists with the same number of up- and down-regulated genes as the HCoV signature data set were performed to measure the significance of the ES scores.
T284 49059-49246 Sentence denotes Drugs were considered to have potential treatment effect if ES > 0 and P < 0.05, and the number of such HCoV signature data sets were used as the final GSEA score that ranges from 0 to 3.
T285 49248-49273 Sentence denotes Supplementary information
T286 49275-49300 Sentence denotes Supplementary Table S1-S6
T287 49302-49437 Sentence denotes Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
T288 49438-49472 Sentence denotes These authors contributed equally:
T289 49473-49492 Sentence denotes Yadi Zhou, Yuan Hou
T290 49494-49519 Sentence denotes Supplementary information
T291 49520-49599 Sentence denotes Supplementary Information accompanies the paper at (10.1038/s41421-020-0153-3).
T292 49601-49617 Sentence denotes Acknowledgements
T293 49618-49790 Sentence denotes This work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) under Award Number K99 HL138272 and R00 HL138272 to F.C.
T294 49791-49886 Sentence denotes The content of this publication does not necessarily reflect the views of the Cleveland Clinic.
T295 49888-49908 Sentence denotes Author contributions
T296 49909-49934 Sentence denotes F.C. conceived the study.
T297 49935-50027 Sentence denotes Y.Z. and Y.H. developed the network methodology and performed all computational experiments.
T298 50028-50079 Sentence denotes J.S., Y.Z., Y.H., and W.M. performed data analysis.
T299 50080-50186 Sentence denotes F.C., Y.Z., and Y.H. wrote and critically revised the manuscript with contributions from other co-authors.
T300 50188-50205 Sentence denotes Data availability
T301 50206-50345 Sentence denotes All predicted repurposable drugs and network-predicted drug combinations can be freely accessed at https://github.com/ChengF-Lab/2019-nCoV.
T302 50347-50364 Sentence denotes Code availability
T303 50365-50441 Sentence denotes All codes can be freely accessed at https://github.com/ChengF-Lab/2019-nCoV.
T304 50443-50463 Sentence denotes Conflict of interest
T305 50464-50523 Sentence denotes The authors declare that they have no conflict of interest.

2_test

Id Subject Object Predicate Lexical cue
32194980-26868298-19614142 2200-2201 26868298 denotes 1
32194980-27344959-19614143 2646-2647 27344959 denotes 3
32194980-28643204-19614144 2648-2649 28643204 denotes 4
32194980-32007143-19614145 2986-2987 32007143 denotes 5
32194980-29262277-19614146 3890-3891 29262277 denotes 7
32194980-25970049-19614147 4068-4069 25970049 denotes 8
32194980-30378081-19614148 4284-4285 30378081 denotes 9
32194980-27296652-19614148 4284-4285 27296652 denotes 9
32194980-27692879-19614148 4284-4285 27692879 denotes 9
32194980-27910877-19614149 4372-4374 27910877 denotes 12
32194980-30378081-19614150 4466-4467 30378081 denotes 9
32194980-27296652-19614150 4466-4467 27296652 denotes 9
32194980-27692879-19614150 4466-4467 27692879 denotes 9
32194980-30002366-19614151 4471-4473 30002366 denotes 13
32194980-27632082-19614152 4474-4476 27632082 denotes 14
32194980-26868298-19614153 4805-4806 26868298 denotes 1
32194980-26868298-19614154 4906-4907 26868298 denotes 1
32194980-30984872-19614155 5061-5063 30984872 denotes 15
32194980-26868298-19614156 5243-5244 26868298 denotes 1
32194980-24841273-19614157 5264-5266 24841273 denotes 17
32194980-24841273-19614158 5276-5278 24841273 denotes 17
32194980-27632082-19614159 5309-5311 27632082 denotes 14
32194980-27476412-19614160 5312-5314 27476412 denotes 19
32194980-27571349-19614160 5312-5314 27571349 denotes 19
32194980-27632082-19614161 5505-5507 27632082 denotes 14
32194980-27692879-19614162 5597-5599 27692879 denotes 11
32194980-27632082-19614163 5600-5602 27632082 denotes 14
32194980-30002366-19614164 5740-5742 30002366 denotes 13
32194980-22589709-19614165 5743-5745 22589709 denotes 22
32194980-31375661-19614165 5743-5745 31375661 denotes 22
32194980-31116390-19614165 5743-5745 31116390 denotes 22
32194980-30867426-19614166 5770-5772 30867426 denotes 28
32194980-30002366-19614167 6186-6188 30002366 denotes 13
32194980-31375661-19614168 6189-6191 31375661 denotes 23
32194980-30867426-19614169 6195-6197 30867426 denotes 28
32194980-26868298-19614170 8625-8626 26868298 denotes 1
32194980-27743750-19614171 8627-8629 27743750 denotes 29
32194980-27743750-19614172 10274-10276 27743750 denotes 29
32194980-31138817-19614173 10515-10517 31138817 denotes 30
32194980-16166518-19614174 10936-10938 16166518 denotes 31
32194980-32007145-19614175 10939-10941 32007145 denotes 32
32194980-32015507-19614176 11210-11212 32015507 denotes 33
32194980-32075877-19614177 11432-11434 32075877 denotes 34
32194980-23717688-19614178 11557-11559 23717688 denotes 35
32194980-30002366-19614179 15311-15313 30002366 denotes 13
32194980-22589709-19614180 15314-15316 22589709 denotes 22
32194980-31375661-19614181 15317-15319 31375661 denotes 23
32194980-30867426-19614182 15320-15322 30867426 denotes 28
32194980-30002366-19614183 16376-16378 30002366 denotes 13
32194980-30867426-19614184 16379-16381 30867426 denotes 28
32194980-17008526-19614185 18426-18428 17008526 denotes 36
32194980-31474372-19614186 21501-21503 31474372 denotes 37
32194980-31474372-19614187 21694-21696 31474372 denotes 37
32194980-24841273-19614188 22108-22110 24841273 denotes 17
32194980-24841269-19614189 22111-22113 24841269 denotes 38
32194980-27362232-19614190 22355-22357 27362232 denotes 39
32194980-23637410-19614191 22512-22514 23637410 denotes 40
32194980-30632963-19614192 22515-22517 30632963 denotes 41
32194980-15379656-19614193 23024-23026 15379656 denotes 42
32194980-16336207-19614193 23024-23026 16336207 denotes 42
32194980-29020174-19614193 23024-23026 29020174 denotes 42
32194980-26086883-19614194 23602-23604 26086883 denotes 45
32194980-25929767-19614195 23605-23607 25929767 denotes 46
32194980-18433331-19614196 23718-23720 18433331 denotes 47
32194980-23135723-19614197 24154-24156 23135723 denotes 48
32194980-26276683-19614198 24157-24159 26276683 denotes 49
32194980-24105455-19614199 24346-24348 24105455 denotes 50
32194980-29143192-19614200 24458-24460 29143192 denotes 51
32194980-24105455-19614201 24617-24619 24105455 denotes 50
32194980-18097462-19614202 24914-24916 18097462 denotes 52
32194980-19374142-19614203 25122-25124 19374142 denotes 53
32194980-25542975-19614204 25125-25127 25542975 denotes 54
32194980-23637410-19614205 25246-25248 23637410 denotes 40
32194980-11967337-19614206 25249-25251 11967337 denotes 55
32194980-16835706-19614207 25351-25353 16835706 denotes 56
32194980-21189219-19614208 25354-25356 21189219 denotes 57
32194980-24090288-19614209 25570-25572 24090288 denotes 58
32194980-22264213-19614210 25573-25575 22264213 denotes 59
32194980-25262626-19614211 25773-25775 25262626 denotes 60
32194980-17198536-19614212 26001-26003 17198536 denotes 61
32194980-22998574-19614213 26004-26006 22998574 denotes 62
32194980-19213804-19614214 26590-26592 19213804 denotes 63
32194980-32020029-19614215 26823-26825 32020029 denotes 64
32194980-23064238-19614216 27176-27178 23064238 denotes 65
32194980-30867426-19614217 27480-27482 30867426 denotes 28
32194980-24105455-19614218 29607-29609 24105455 denotes 50
32194980-25487801-19614219 29676-29678 25487801 denotes 66
32194980-1335030-19614220 29890-29892 1335030 denotes 67
32194980-21553116-19614221 30491-30493 21553116 denotes 68
32194980-27362232-19614222 30624-30626 27362232 denotes 39
32194980-24841273-19614223 30706-30708 24841273 denotes 17
32194980-29566060-19614224 30709-30711 29566060 denotes 69
32194980-24841269-19614225 30724-30726 24841269 denotes 38
32194980-21356245-19614226 30935-30937 21356245 denotes 70
32194980-16730806-19614227 31016-31018 16730806 denotes 71
32194980-19374142-19614228 31554-31556 19374142 denotes 53
32194980-25542975-19614229 31557-31559 25542975 denotes 54
32194980-24090288-19614230 31666-31668 24090288 denotes 58
32194980-22264213-19614230 31666-31668 22264213 denotes 58
32194980-25262626-19614230 31666-31668 25262626 denotes 58
32194980-17198536-19614230 31666-31668 17198536 denotes 58
32194980-22998574-19614230 31666-31668 22998574 denotes 58
32194980-32015507-19614231 31817-31819 32015507 denotes 33
32194980-18070603-19614232 31994-31996 18070603 denotes 72
32194980-12071468-19614233 31997-31999 12071468 denotes 73
32194980-29238080-19614234 32094-32096 29238080 denotes 74
32194980-32020029-19614235 33388-33390 32020029 denotes 64
32194980-27864075-19614236 34385-34387 27864075 denotes 75
32194980-29258862-19614237 34405-34407 29258862 denotes 76
32194980-29258862-19614238 34462-34464 29258862 denotes 76
32194980-29028879-19614239 35074-35076 29028879 denotes 77
32194980-27146293-19614240 35209-35211 27146293 denotes 78
32194980-24852294-19614241 35690-35692 24852294 denotes 79
32194980-23667838-19614242 36318-36320 23667838 denotes 81
32194980-28458997-19614243 36321-36323 28458997 denotes 82
32194980-31375661-19614244 36369-36371 31375661 denotes 23
32194980-29052226-19614245 36460-36462 29052226 denotes 83
32194980-30867426-19614246 36749-36751 30867426 denotes 28
32194980-32020029-19614247 37319-37321 32020029 denotes 64
32194980-29722887-19614248 38759-38761 29722887 denotes 84
32194980-29722887-19614249 38873-38875 29722887 denotes 84
32194980-27141961-19614250 39858-39860 27141961 denotes 85
32194980-24203711-19614251 39984-39986 24203711 denotes 86
32194980-26578601-19614252 40021-40023 26578601 denotes 87
32194980-21948594-19614253 40056-40058 21948594 denotes 88
32194980-17145705-19614254 40069-40071 17145705 denotes 89
32194980-24234439-19614255 40109-40111 24234439 denotes 90
32194980-24203711-19614256 40195-40197 24203711 denotes 86
32194980-14681372-19614257 40411-40413 14681372 denotes 91
32194980-30002366-19614258 40604-40606 30002366 denotes 13
32194980-31375661-19614259 40607-40609 31375661 denotes 23
32194980-30867426-19614260 40610-40612 30867426 denotes 28
32194980-26615191-19614261 41487-41489 26615191 denotes 92
32194980-30002366-19614262 41925-41927 30002366 denotes 13
32194980-31375661-19614263 41928-41930 31375661 denotes 23
32194980-30867426-19614264 41931-41933 30867426 denotes 28
32194980-31006514-19614265 41934-41936 31006514 denotes 93
32194980-30867426-19614266 45818-45820 30867426 denotes 28
32194980-15655079-19614267 46176-46178 15655079 denotes 94
32194980-23631916-19614268 46205-46207 23631916 denotes 95
32194980-30631056-19614269 46295-46297 30631056 denotes 96
32194980-17008526-19614270 46605-46607 17008526 denotes 36
32194980-21849665-19614271 46842-46844 21849665 denotes 97